Published in Crit Care Med on February 01, 2009
Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens. Int J Med Microbiol (2010) 2.31
Bacteriophage endolysins as novel antimicrobials. Future Microbiol (2012) 1.68
Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2010) 1.48
Recombinant bacteriophage lysins as antibacterials. Bioeng Bugs (2011) 1.13
Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia. J Infect Dis (2013) 1.09
Role of net charge on catalytic domain and influence of cell wall binding domain on bactericidal activity, specificity, and host range of phage lysins. J Biol Chem (2011) 1.05
In vitro destruction of Streptococcus pneumoniae biofilms with bacterial and phage peptidoglycan hydrolases. Antimicrob Agents Chemother (2011) 0.96
Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: host-microbe interactions in intraocular infection. Prog Retin Eye Res (2012) 0.96
Engineered bacteriophage lysins as novel anti-infectives. Front Microbiol (2014) 0.95
Antimicrobial bacteriophage-derived proteins and therapeutic applications. Bacteriophage (2015) 0.92
Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin. Crit Care (2014) 0.92
Characterization of LysB4, an endolysin from the Bacillus cereus-infecting bacteriophage B4. BMC Microbiol (2012) 0.90
Cpl-7, a lysozyme encoded by a pneumococcal bacteriophage with a novel cell wall-binding motif. J Biol Chem (2010) 0.88
Intravitreal injection of the chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis. Antimicrob Agents Chemother (2014) 0.87
P-27/HP endolysin as antibacterial agent for antibiotic resistant Staphylococcus aureus of human infections. Curr Microbiol (2011) 0.87
CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis. Am J Respir Crit Care Med (2011) 0.86
LysGH15 kills Staphylococcus aureus without being affected by the humoral immune response or inducing inflammation. Sci Rep (2016) 0.84
Bacteriophages and phage-derived proteins--application approaches. Curr Med Chem (2015) 0.83
The post-antibiotic era: promising developments in the therapy of infectious diseases. Int J Biomed Sci (2010) 0.83
Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection. J Antimicrob Chemother (2015) 0.82
Depolymerase improves gentamicin efficacy during Klebsiella pneumoniae induced murine infection. BMC Infect Dis (2014) 0.80
Choline Binding Proteins from Streptococcus pneumoniae: A Dual Role as Enzybiotics and Targets for the Design of New Antimicrobials. Antibiotics (Basel) (2016) 0.79
Diverse virulent pneumophages infect Streptococcus mitis. PLoS One (2015) 0.76
A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages. BMC Genomics (2015) 0.76
Role for bacteriophages in the preparedness for fighting against pneumonia in the postantibiotic era. Crit Care Med (2009) 0.75
Antibiofilm Activities of a Novel Chimeolysin against Streptococcus mutans under Physiological and Cariogenic Conditions. Antimicrob Agents Chemother (2016) 0.75
Wall Teichoic Acids Are Involved in the Medium-Induced Loss of Function of the Autolysin CD11 against Clostridium difficile. Sci Rep (2016) 0.75
A bacteriolytic agent that detects and kills Bacillus anthracis. Nature (2002) 5.63
Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med (2006) 5.49
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein. Cell Microbiol (2006) 2.93
Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infect Immun (2005) 2.60
Influenza A viruses target type II pneumocytes in the human lung. J Infect Dis (2012) 2.38
A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q. Cell (2006) 2.37
Genetic diversity among Enterococcus faecalis. PLoS One (2007) 2.32
Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3. J Immunol (2009) 2.28
Community-acquired Legionella pneumonia: new insights from the German competence network for community acquired pneumonia. Clin Infect Dis (2008) 2.20
Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: Results from the German Competence Network, CAPNETZ. Am J Respir Crit Care Med (2010) 2.19
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem (2004) 2.18
Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia. Infect Immun (2003) 2.06
Pro-atrial natriuretic peptide and pro-vasopressin to predict severity and prognosis in community-acquired pneumonia: results from the German competence network CAPNETZ. Intensive Care Med (2007) 2.06
Intravenous artesunate for severe malaria in travelers, Europe. Emerg Infect Dis (2011) 1.99
Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. J Biol Chem (2006) 1.97
Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma. J Allergy Clin Immunol (2006) 1.96
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Proc Natl Acad Sci U S A (2003) 1.91
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med (2011) 1.87
Removal of group B streptococci colonizing the vagina and oropharynx of mice with a bacteriophage lytic enzyme. Antimicrob Agents Chemother (2005) 1.79
Naturally occurring anti-IFN-gamma autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans. Blood (2003) 1.76
The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations. PLoS One (2009) 1.73
Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium. J Bacteriol (2004) 1.67
Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. Am J Physiol Heart Circ Physiol (2002) 1.67
Adult patients with nosocomial pneumonia: epidemiology, diagnosis, and treatment. Dtsch Arztebl Int (2013) 1.65
Noninvasive measurement of midexpiratory flow indicates bronchoconstriction in allergic rats. J Appl Physiol (1985) (2002) 1.64
Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration. J Invest Dermatol (2009) 1.60
Innate immune recognition in infectious and noninfectious diseases of the lung. Am J Respir Crit Care Med (2010) 1.59
The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol (2011) 1.54
Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J Immunol (2006) 1.53
PlyC: a multimeric bacteriophage lysin. Proc Natl Acad Sci U S A (2006) 1.53
IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol (2008) 1.52
Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ Res (2005) 1.50
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A. Proc Natl Acad Sci U S A (2006) 1.48
Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2010) 1.48
Detailed genomic analysis of the Wbeta and gamma phages infecting Bacillus anthracis: implications for evolution of environmental fitness and antibiotic resistance. J Bacteriol (2006) 1.46
Simvastatin reduces Chlamydophila pneumoniae-mediated histone modifications and gene expression in cultured human endothelial cells. Circ Res (2008) 1.46
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. Crit Care Med (2009) 1.46
p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. FASEB J (2002) 1.46
Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011. PLoS One (2011) 1.45
Outcomes of Endobronchial Valve Treatment Based on the Precise Criteria of an Endobronchial Catheter for Detection of Collateral Ventilation under Spontaneous Breathing. Respiration (2015) 1.45
Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice. Infect Immun (2006) 1.45
Novel strategy to prevent otitis media caused by colonizing Streptococcus pneumoniae. PLoS Pathog (2007) 1.45
Lysins: the arrival of pathogen-directed anti-infectives. J Med Microbiol (2013) 1.43
Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation. Intensive Care Med (2012) 1.41
Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res (2006) 1.39
Simvastatin attenuates ventilator-induced lung injury in mice. Crit Care (2010) 1.34
Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2013) 1.31
Adrenomedullin reduces endothelial hyperpermeability. Circ Res (2002) 1.31
A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains. Antimicrob Agents Chemother (2010) 1.29
NAIP and Ipaf control Legionella pneumophila replication in human cells. J Immunol (2008) 1.28
The in vitro interaction of Streptococcus pyogenes with human pharyngeal cells induces a phage-encoded extracellular DNase. Infect Immun (2002) 1.26
CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells. Nat Immunol (2008) 1.26
Rho protein inactivation induced apoptosis of cultured human endothelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.26
Recognition of Streptococcus pneumoniae by the innate immune system. Cell Microbiol (2012) 1.24
Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles. Infect Immun (2008) 1.24
Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia. Crit Care Med (2006) 1.23