Published in Nature on August 22, 2002
Bacteriophage T4 genome. Microbiol Mol Biol Rev (2003) 5.20
Phage_Finder: automated identification and classification of prophage regions in complete bacterial genome sequences. Nucleic Acids Res (2006) 3.99
The changing face of infective endocarditis. Heart (2005) 3.15
Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biol (2003) 3.02
Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins. Microbiol Mol Biol Rev (2004) 2.60
Structural engineering of a phage lysin that targets gram-negative pathogens. Proc Natl Acad Sci U S A (2012) 2.36
Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens. Int J Med Microbiol (2010) 2.31
Bacteriophage lysins as effective antibacterials. Curr Opin Microbiol (2008) 2.18
Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia. Infect Immun (2003) 2.06
Bioterrorism: what can we do? J R Soc Med (2002) 2.04
Removal of group B streptococci colonizing the vagina and oropharynx of mice with a bacteriophage lytic enzyme. Antimicrob Agents Chemother (2005) 1.79
The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations. PLoS One (2009) 1.73
Bacteriophage endolysins as novel antimicrobials. Future Microbiol (2012) 1.68
In vitro and in vivo bacteriolytic activities of Escherichia coli phages: implications for phage therapy. Antimicrob Agents Chemother (2004) 1.68
Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium. J Bacteriol (2004) 1.67
The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant staphylococci, including methicillin-resistant Staphylococcus aureus. J Bacteriol (2005) 1.63
A novel FtsZ-like protein is involved in replication of the anthrax toxin-encoding pXO1 plasmid in Bacillus anthracis. J Bacteriol (2006) 1.54
PlyC: a multimeric bacteriophage lysin. Proc Natl Acad Sci U S A (2006) 1.53
Bacteriophage Tuc2009 encodes a tail-associated cell wall-degrading activity. J Bacteriol (2004) 1.49
Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2010) 1.48
Importance of prophages to evolution and virulence of bacterial pathogens. Virulence (2013) 1.48
Detailed genomic analysis of the Wbeta and gamma phages infecting Bacillus anthracis: implications for evolution of environmental fitness and antibiotic resistance. J Bacteriol (2006) 1.46
The Bacillus subtilis spore coat provides "eat resistance" during phagocytic predation by the protozoan Tetrahymena thermophila. Proc Natl Acad Sci U S A (2005) 1.42
The First Paenibacillus larvae Bacteriophage Endolysin (PlyPl23) with High Potential to Control American Foulbrood. PLoS One (2015) 1.40
Prevention and cure of systemic Escherichia coli K1 infection by modification of the bacterial phenotype. Antimicrob Agents Chemother (2004) 1.38
Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase. Mol Microbiol (2009) 1.35
Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2013) 1.31
Bacillus anthracis physiology and genetics. Mol Aspects Med (2009) 1.29
Molecular characterization of a Clostridium difficile bacteriophage and its cloned biologically active endolysin. J Bacteriol (2008) 1.28
Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci. Appl Environ Microbiol (2008) 1.26
LambdaSa1 and LambdaSa2 prophage lysins of Streptococcus agalactiae. Appl Environ Microbiol (2007) 1.25
Production and validation of the use of gamma phage for identification of Bacillus anthracis. J Clin Microbiol (2005) 1.21
Phage Therapy - Everything Old is New Again. Can J Infect Dis Med Microbiol (2006) 1.17
Identification of the Bacillus anthracis (gamma) phage receptor. J Bacteriol (2005) 1.17
Isolation and characterization of temperate bacteriophages of Clostridium difficile. Appl Environ Microbiol (2005) 1.15
Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance. Antimicrob Agents Chemother (2005) 1.15
Sequencing Bacillus anthracis typing phages gamma and cherry reveals a common ancestry. J Bacteriol (2006) 1.14
Recombinant bacteriophage lysins as antibacterials. Bioeng Bugs (2011) 1.13
Plastid production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins. Proc Natl Acad Sci U S A (2009) 1.12
Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia. J Infect Dis (2013) 1.09
Molecular characterization of a variant of Bacillus anthracis-specific phage AP50 with improved bacteriolytic activity. Appl Environ Microbiol (2008) 1.09
LysGH15, a novel bacteriophage lysin, protects a murine bacteremia model efficiently against lethal methicillin-resistant Staphylococcus aureus infection. J Clin Microbiol (2010) 1.07
Engineered endolysin-based "Artilysins" to combat multidrug-resistant gram-negative pathogens. MBio (2014) 1.06
A century of the phage: past, present and future. Nat Rev Microbiol (2015) 1.05
Role of net charge on catalytic domain and influence of cell wall binding domain on bactericidal activity, specificity, and host range of phage lysins. J Biol Chem (2011) 1.05
Pseudomonas aeruginosa keratitis in mice: effects of topical bacteriophage KPP12 administration. PLoS One (2012) 1.05
Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2014) 1.02
Phages preying on Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis: past, present and future. Viruses (2014) 1.02
Treatment of experimental anthrax with recombinant capsule depolymerase. Antimicrob Agents Chemother (2007) 1.02
Lytic activity of the virion-associated peptidoglycan hydrolase HydH5 of Staphylococcus aureus bacteriophage vB_SauS-phiIPLA88. BMC Microbiol (2011) 1.01
Characterization of a T7-like lytic bacteriophage (phiSG-JL2) of Salmonella enterica serovar gallinarum biovar gallinarum. Appl Environ Microbiol (2008) 1.01
PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis. J Bacteriol (2006) 1.01
Learning from bacteriophages - advantages and limitations of phage and phage-encoded protein applications. Curr Protein Pept Sci (2012) 1.00
Phage taxonomy: we agree to disagree. J Bacteriol (2004) 1.00
Phage-based platforms for the clinical detection of human bacterial pathogens. Bacteriophage (2012) 0.98
Isolation and expression of the lysis genes of Actinomyces naeslundii phage Av-1. Appl Environ Microbiol (2006) 0.97
The tubulin-like RepX protein encoded by the pXO1 plasmid forms polymers in vivo in Bacillus anthracis. J Bacteriol (2009) 0.96
Domain shuffling and module engineering of Listeria phage endolysins for enhanced lytic activity and binding affinity. Microb Biotechnol (2011) 0.96
Prevalence of Bacillus anthracis-like organisms and bacteriophages in the intestinal tract of the earthworm Eisenia fetida. Appl Environ Microbiol (2010) 0.96
Cathelicidin administration protects mice from Bacillus anthracis spore challenge. J Immunol (2008) 0.95
Mycobacteriophage Ms6 LysB specifically targets the outer membrane of Mycobacterium smegmatis. Microbiology (2010) 0.95
Engineered bacteriophage lysins as novel anti-infectives. Front Microbiol (2014) 0.95
Improving the lethal effect of cpl-7, a pneumococcal phage lysozyme with broad bactericidal activity, by inverting the net charge of its cell wall-binding module. Antimicrob Agents Chemother (2013) 0.94
Nonhemolytic, nonmotile gram-positive rods indicative of Bacillus anthracis. Emerg Infect Dis (2003) 0.94
The truncated phage lysin CHAP(k) eliminates Staphylococcus aureus in the nares of mice. Bioeng Bugs (2011) 0.94
Different approaches for using bacteriophages against antibiotic-resistant bacteria. Bacteriophage (2014) 0.94
Use of a bacteriophage lysin to identify a novel target for antimicrobial development. PLoS One (2013) 0.93
Purified recombinant phage lysin LySMP: an extensive spectrum of lytic activity for swine streptococci. Curr Microbiol (2009) 0.93
Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracis. PLoS One (2008) 0.93
Genomic sequence of C1, the first streptococcal phage. J Bacteriol (2003) 0.93
Identifying active phage lysins through functional viral metagenomics. Appl Environ Microbiol (2010) 0.93
Antimicrobial bacteriophage-derived proteins and therapeutic applications. Bacteriophage (2015) 0.92
A novel bacteriophage Tail-Associated Muralytic Enzyme (TAME) from Phage K and its development into a potent antistaphylococcal protein. BMC Microbiol (2011) 0.92
Characterization of LytA-like N-acetylmuramoyl-L-alanine amidases from two new Streptococcus mitis bacteriophages provides insights into the properties of the major pneumococcal autolysin. J Bacteriol (2004) 0.92
A genetic screen to identify bacteriophage lysins. Methods Mol Biol (2009) 0.92
Phage lysin to supplement phagebiotics to decontaminate processed sputum specimens. Eur J Clin Microbiol Infect Dis (2010) 0.91
Endolysins of Bacillus anthracis bacteriophages recognize unique carbohydrate epitopes of vegetative cell wall polysaccharides with high affinity and selectivity. J Am Chem Soc (2012) 0.91
Novel phage lysin capable of killing the multidrug-resistant gram-negative bacterium Acinetobacter baumannii in a mouse bacteremia model. Antimicrob Agents Chemother (2015) 0.91
Characterization of Salmonella bacteriophages isolated from swine lagoon effluent. Curr Microbiol (2007) 0.90
The phage lytic proteins from the Staphylococcus aureus bacteriophage vB_SauS-phiIPLA88 display multiple active catalytic domains and do not trigger staphylococcal resistance. PLoS One (2013) 0.90
Characterization of LysB4, an endolysin from the Bacillus cereus-infecting bacteriophage B4. BMC Microbiol (2012) 0.90
Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin. Bioorg Med Chem (2007) 0.89
Application of a bacteriophage lysin to disrupt biofilms formed by the animal pathogen Streptococcus suis. Appl Environ Microbiol (2011) 0.89
Use of a bacteriophage lysin, PlyC, as an enzyme disinfectant against Streptococcus equi. Appl Environ Microbiol (2009) 0.88
A novel spore protein, ExsM, regulates formation of the exosporium in Bacillus cereus and Bacillus anthracis and affects spore size and shape. J Bacteriol (2010) 0.87
Thermal stability of Cpl-7 endolysin from the streptococcus pneumoniae bacteriophage Cp-7; cell wall-targeting of its CW_7 motifs. PLoS One (2012) 0.87
A second endolysin gene is fully embedded in-frame with the lysA gene of mycobacteriophage Ms6. PLoS One (2011) 0.86
Recombinant expression of two bacteriophage proteins that lyse clostridium perfringens and share identical sequences in the C-terminal cell wall binding domain of the molecules but are dissimilar in their N-terminal active domains. J Agric Food Chem (2010) 0.86
Lytic enzyme discovery through multigenomic sequence analysis in Clostridium perfringens. Appl Microbiol Biotechnol (2010) 0.86
Bacteriophage-Derived Peptidase CHAP(K) Eliminates and Prevents Staphylococcal Biofilms. Int J Microbiol (2013) 0.86
Gamma-phage lysin PlyG sequence-based synthetic peptides coupled with Qdot-nanocrystals are useful for developing detection methods for Bacillus anthracis by using its surrogates, B. anthracis-Sterne and B. cereus-4342. BMC Biotechnol (2009) 0.86
A highly active and negatively charged Streptococcus pyogenes lysin with a rare D-alanyl-L-alanine endopeptidase activity protects mice against streptococcal bacteremia. Antimicrob Agents Chemother (2014) 0.86
Natural solution to antibiotic resistance: bacteriophages 'The Living Drugs'. World J Microbiol Biotechnol (2014) 0.85
Bacteriophage-encoded lytic enzymes control growth of contaminating Lactobacillus found in fuel ethanol fermentations. Biotechnol Biofuels (2013) 0.85
Novel chimeric lysin with high-level antimicrobial activity against methicillin-resistant Staphylococcus aureus in vitro and in vivo. Antimicrob Agents Chemother (2013) 0.85
Existence of separate domains in lysin PlyG for recognizing Bacillus anthracis spores and vegetative cells. Antimicrob Agents Chemother (2012) 0.85
Turning a new phage. Nat Med (2012) 0.84
Staphylococcus haemolyticus prophage ΦSH2 endolysin relies on cysteine, histidine-dependent amidohydrolases/peptidases activity for lysis 'from without'. J Biotechnol (2012) 0.84
Bacteria, phages and septicemia. PLoS One (2007) 0.84
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24
Genetic diversity among Enterococcus faecalis. PLoS One (2007) 2.32
Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia. Infect Immun (2003) 2.06
Removal of group B streptococci colonizing the vagina and oropharynx of mice with a bacteriophage lytic enzyme. Antimicrob Agents Chemother (2005) 1.79
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Crit Care Med (2009) 1.74
The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations. PLoS One (2009) 1.73
Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium. J Bacteriol (2004) 1.67
PlyC: a multimeric bacteriophage lysin. Proc Natl Acad Sci U S A (2006) 1.53
Reinventing phage therapy: are the parts greater than the sum? Nat Biotechnol (2006) 1.49
Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2010) 1.48
Detailed genomic analysis of the Wbeta and gamma phages infecting Bacillus anthracis: implications for evolution of environmental fitness and antibiotic resistance. J Bacteriol (2006) 1.46
Novel strategy to prevent otitis media caused by colonizing Streptococcus pneumoniae. PLoS Pathog (2007) 1.45
Lysins: the arrival of pathogen-directed anti-infectives. J Med Microbiol (2013) 1.43
The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity. Invest Ophthalmol Vis Sci (2003) 1.34
Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2013) 1.31
A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains. Antimicrob Agents Chemother (2010) 1.29
The in vitro interaction of Streptococcus pyogenes with human pharyngeal cells induces a phage-encoded extracellular DNase. Infect Immun (2002) 1.26
The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis. J Mol Biol (2006) 1.23
First complete genome sequence of two Staphylococcus epidermidis bacteriophages. J Bacteriol (2006) 1.21
Lysogeny of Streptococcus pneumoniae with MM1 phage: improved adherence and other phenotypic changes. Infect Immun (2006) 1.21
Sortase A localizes to distinct foci on the Streptococcus pyogenes membrane. Proc Natl Acad Sci U S A (2008) 1.20
Role of the C-terminal lysine residues of streptococcal surface enolase in Glu- and Lys-plasminogen-binding activities of group A streptococci. Infect Immun (2004) 1.19
Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis. J Infect Dis (2008) 1.19
Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance. Antimicrob Agents Chemother (2005) 1.15
Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PLoS One (2013) 1.14
A novel secreted endoglycosidase from Enterococcus faecalis with activity on human immunoglobulin G and ribonuclease B. J Biol Chem (2004) 1.12
Group A streptococcal vaccines: paving a path for accelerated development. Vaccine (2013) 1.12
X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc Natl Acad Sci U S A (2012) 1.11
Mutagenesis of a bacteriophage lytic enzyme PlyGBS significantly increases its antibacterial activity against group B streptococci. Appl Microbiol Biotechnol (2006) 1.10
Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia. J Infect Dis (2013) 1.09
T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease. J Immunol (2005) 1.09
M.SpyI, a DNA methyltransferase encoded on a mefA chimeric element, modifies the genome of Streptococcus pyogenes. J Bacteriol (2006) 1.04
Biochemical analysis of a common human polymorphism associated with age-related macular degeneration. Biochemistry (2007) 1.03
In vivo lysogenic conversion of Tox(-) Streptococcus pyogenes to Tox(+) with Lysogenic Streptococci or free phage. Infect Immun (2003) 1.02
PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis. J Bacteriol (2006) 1.01
Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever. Int Immunol (2008) 0.99
Characterization of a unique glycosylated anchor endopeptidase that cleaves the LPXTG sequence motif of cell surface proteins of Gram-positive bacteria. J Biol Chem (2002) 0.96
Group A streptococcus (GAS) carbohydrate as an immunogen for protection against GAS infection. J Infect Dis (2005) 0.95
A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases. EMBO Rep (2008) 0.95
Interactions between temperature and nutrients across levels of ecological organization. Glob Chang Biol (2014) 0.94
Use of a bacteriophage lysin to identify a novel target for antimicrobial development. PLoS One (2013) 0.93
Identifying active phage lysins through functional viral metagenomics. Appl Environ Microbiol (2010) 0.93
Genomic sequence of C1, the first streptococcal phage. J Bacteriol (2003) 0.93
Rapid DNA library construction for functional genomic and metagenomic screening. Appl Environ Microbiol (2007) 0.92
A genetic screen to identify bacteriophage lysins. Methods Mol Biol (2009) 0.92
Characterization of a bacteriophage lysin (Ply700) from Streptococcus uberis. Vet Microbiol (2007) 0.91
Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine. Infect Immun (2005) 0.88
A stable phage lysin (Cpl-1) dimer with increased antipneumococcal activity and decreased plasma clearance. Int J Antimicrob Agents (2011) 0.88
A novel spore protein, ExsM, regulates formation of the exosporium in Bacillus cereus and Bacillus anthracis and affects spore size and shape. J Bacteriol (2010) 0.87
Cellular aspects of the distinct M protein and SfbI anchoring pathways in Streptococcus pyogenes. Mol Microbiol (2012) 0.87
PlyC, a novel bacteriophage lysin for compartment-dependent proteomics of group A streptococci. Proteomics (2008) 0.87
Lytic enzyme discovery through multigenomic sequence analysis in Clostridium perfringens. Appl Microbiol Biotechnol (2010) 0.86
Cysteine protease activity and histamine release from the human mast cell line HMC-1 stimulated by recombinant streptococcal pyrogenic exotoxin B/streptococcal cysteine protease. Infect Immun (2002) 0.85
Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors. Infect Immun (2002) 0.84
Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages. J Biol Chem (2013) 0.83
Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia. J Antimicrob Chemother (2013) 0.83
Novel algorithms reveal streptococcal transcriptomes and clues about undefined genes. PLoS Comput Biol (2007) 0.83
Presence of D-alanine in an endopeptidase from Streptococcus pyogenes. J Biol Chem (2003) 0.82
Purification and characterization of LPXTGase from Staphylococcus aureus: the amino acid composition mirrors that found in the peptidoglycan. J Bacteriol (2006) 0.81
Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry. Proc Natl Acad Sci U S A (2012) 0.80
Attenuated neutrophil axis in atopic dermatitis compared to psoriasis reflects TH17 pathway differences between these diseases. J Allergy Clin Immunol (2013) 0.79
Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on Bacillus anthracis. J Bacteriol (2013) 0.79
Studies of recombinant streptococcal pyrogenic exotoxin B/cysteine protease (rSPE B/SCP) in the skin of guinea pigs & the release of histamine from cultured mast cells & basophilic leukocytes. Indian J Med Res (2004) 0.78
Hemostasis in a noncompressible hemorrhage model: an end-user evaluation of hemostatic agents in a proximal arterial injury. J Surg Educ (2013) 0.78
A tubulin polymerization microassay used to compare ligand efficacy. Methods Cell Biol (2010) 0.78
Impulsive aggression with irritability and responsive to divalproex: a pediatric bipolar spectrum disorder phenotype? J Affect Disord (2005) 0.77
Characterization of recombinant Streptococcus mitis-derived human platelet aggregation factor. APMIS (2011) 0.77
Effects of modality presentation on working memory in school-age children: evidence for the pictorial superiority hypothesis. Child Neuropsychol (2011) 0.77
PEGylating a bacteriophage endolysin inhibits its bactericidal activity. AMB Express (2011) 0.77
The career of Maclyn McCarty. J Exp Med (2005) 0.76
Bactericidal synergism between daptomycin and the phage lysin Cpl-1 in a mouse model of pneumococcal bacteraemia. Int J Antimicrob Agents (2013) 0.75
An NSQIP evaluation of practice patterns and outcomes following surgery for anorectal abscess and fistula in patients with and without Crohn's disease. Gastroenterol Rep (Oxf) (2013) 0.75
The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis. J Trauma Acute Care Surg (2013) 0.75
Violence against elderly people: a neglected problem. Lancet (2002) 0.75
Optimum cystic duct closure: a comparative study using metallic clips, ENSEAL, and ENDOLOOP in swine. Am J Surg (2013) 0.75
Reduced IFN-gamma responses associated with HLA-DR15 presentation of streptococcal cell wall proteins to dermal Th-1 cells in psoriasis. J Clin Immunol (2003) 0.75