Published in Cell Metab on January 07, 2009
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Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell Metab (2013) 1.12
Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell (2015) 1.11
Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature. Proc Natl Acad Sci U S A (2009) 1.08
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The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev (2016) 0.85
Tumor-derived VEGF modulates hematopoiesis. J Angiogenes Res (2009) 0.84
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Hypoxia-independent drivers of melanoma angiogenesis. Front Oncol (2015) 0.82
A new procedure for determining the genetic basis of a physiological process in a non-model species, illustrated by cold induced angiogenesis in the carp. BMC Genomics (2009) 0.82
Segmentation and characterization of interscapular brown adipose tissue in rats by multi-parametric magnetic resonance imaging. MAGMA (2016) 0.81
Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation. Mol Cell Biol (2015) 0.81
VEGF189 expression is highly related to adaptation of the plateau pika (Ochotona curzoniae) inhabiting high altitudes. High Alt Med Biol (2013) 0.80
Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles. Proc Natl Acad Sci U S A (2016) 0.79
Cardiovascular response to thermoregulatory challenges. Am J Physiol Heart Circ Physiol (2015) 0.79
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Synergism between cAMP and PPARγ Signalling in the Initiation of UCP1 Gene Expression in HIB1B Brown Adipocytes. PPAR Res (2013) 0.78
Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals. J Lipid Res (2015) 0.78
Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine. Adipocyte (2014) 0.77
The great roundleaf bat (Hipposideros armiger) as a good model for cold-induced browning of intra-abdominal white adipose tissue. PLoS One (2014) 0.77
Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis. Oncotarget (2016) 0.76
Intravitreally Injected Anti-VEGF Antibody Reduces Brown Fat in Neonatal Mice. PLoS One (2015) 0.76
Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions. JCI Insight (2017) 0.75
Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality. Front Physiol (2017) 0.75
Cold Exposure Induces Proliferation of Mature Brown Adipocyte in a ß3-Adrenergic Receptor-Mediated Pathway. PLoS One (2016) 0.75
Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans. Int J Obes (Lond) (2017) 0.75
Transient hypoxia reprograms differentiating adipocytes for enhanced insulin sensitivity and triglyceride accumulation. Int J Obes (Lond) (2015) 0.75
Analysis of differentially expressed genes in cold-exposed mice to investigate the potential causes of cold-induced hypertension. Exp Ther Med (2014) 0.75
Regulation of glycolysis in brown adipocytes by HIF-1α. Sci Rep (2017) 0.75
Tongxinluo mitigates atherogenesis by regulating angiogenic factors and inhibiting vasa vasorum neovascularization in apolipoprotein E-deficient mice. Oncotarget (2016) 0.75
Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EBioMedicine (2017) 0.75
Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metabolism (2015) 0.75
Metabolic regulation and the anti-obesity perspectives of human brown fat. Redox Biol (2017) 0.75
Inter-organ regulation of adipose tissue browning. Cell Mol Life Sci (2016) 0.75
Mild cold induced thermogenesis: Are BAT and skeletal muscle synergistic partners? Biosci Rep (2017) 0.75
Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. J Biol Chem (2017) 0.75
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UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab (2009) 8.16
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (2010) 4.81
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J (2009) 4.78
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A (2007) 4.69
Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell (2009) 4.52
Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell (2008) 4.51
Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res (2003) 4.29
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell (2004) 4.12
Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1. Mol Cell (2008) 4.11
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med (2002) 4.00
Nonshivering thermogenesis and its adequate measurement in metabolic studies. J Exp Biol (2011) 3.69
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A (2004) 3.45
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med (2003) 3.16
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A (2010) 3.13
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res (2003) 3.09
Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. Cell Metab (2009) 2.96
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol (2006) 2.86
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A (2004) 2.85
Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res (2009) 2.80
The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab (2010) 2.80
Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues. Am J Physiol Endocrinol Metab (2011) 2.78
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science (2013) 2.74
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab (2013) 2.54
Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One (2007) 2.35
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proc Natl Acad Sci U S A (2002) 2.30
Translational control of the innate immune response through IRF-7. Nature (2008) 2.30
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest (2007) 2.28
A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Res (2005) 2.27
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell (2012) 2.20
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res (2005) 2.20
Improved precision and accuracy for microarrays using updated probe set definitions. BMC Bioinformatics (2007) 2.17
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res (2004) 2.04
Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe (2011) 2.01
A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes (2005) 1.94
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VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy. FASEB J (2005) 1.85
Deletion of the laminin alpha4 chain leads to impaired microvessel maturation. Mol Cell Biol (2002) 1.81
Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci U S A (2009) 1.81
Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat. Circ Res (2003) 1.81
UCP1 is essential for adaptive adrenergic nonshivering thermogenesis. Am J Physiol Endocrinol Metab (2006) 1.76
Lack of correct data format and comparability limits future integrative microarray research. Nat Biotechnol (2006) 1.75
Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability. Circ Res (2004) 1.74
Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo. Proc Natl Acad Sci U S A (2005) 1.72
Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers. Cancer Cell (2002) 1.71
Arteriogenic therapy by intramyocardial sustained delivery of a novel growth factor combination prevents chronic heart failure. Circulation (2011) 1.69
Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J Clin Invest (2005) 1.68
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest (2008) 1.68
Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes. J Cell Physiol (2009) 1.67
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis. Dev Cell (2012) 1.65
Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis. Cancer Res (2005) 1.64
UCP1 mRNA does not produce heat. Biochim Biophys Acta (2013) 1.63
Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors. Mol Endocrinol (2003) 1.58
Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension. Am J Respir Crit Care Med (2009) 1.58
Insulin receptor expression by human prostate cancers. Prostate (2009) 1.57
IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. J Immunol (2005) 1.56
Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils. FASEB J (2005) 1.56
Fibrotic extracellular matrix activates a profibrotic positive feedback loop. J Clin Invest (2014) 1.54
Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis. Arthritis Rheum (2009) 1.54
Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids. J Biol Chem (2004) 1.53
Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis. Cancer Res (2008) 1.53
Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member. Cancer Res (2006) 1.52
Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Blood (2006) 1.52
Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure. PLoS One (2008) 1.52