Metabolic regulation and the anti-obesity perspectives of human brown fat.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28431377)

Published in Redox Biol on April 11, 2017

Authors

Camilla Scheele1, Søren Nielsen2

Author Affiliations

1: Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen N, Denmark; The Centre of Inflammation and Metabolism and Centre for Physical Activity Research Rigshospitalet, University Hospital of Copenhagen, Denmark. Electronic address: cs@sund.ku.dk.
2: The Centre of Inflammation and Metabolism and Centre for Physical Activity Research Rigshospitalet, University Hospital of Copenhagen, Denmark.

Articles cited by this

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Brown adipose tissue: function and physiological significance. Physiol Rev (2004) 23.00

Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 20.57

Cold-activated brown adipose tissue in healthy men. N Engl J Med (2009) 17.58

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51

Functional brown adipose tissue in healthy adults. N Engl J Med (2009) 16.22

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67

PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03

Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab (2007) 10.40

High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes (2009) 8.81

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab (2009) 8.16

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem (2009) 6.51

Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43

Brown and beige fat: development, function and therapeutic potential. Nat Med (2013) 5.29

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J (2009) 4.78

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A (2007) 4.69

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest (2012) 4.13

The distribution of brown adipose tissue in the human. J Anat (1972) 3.76

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A (2010) 3.54

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A (2004) 3.45

Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest (2013) 3.38

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab (2005) 3.38

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med (2013) 3.36

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest (2013) 3.25

Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes (2014) 3.21

Evidence for two types of brown adipose tissue in humans. Nat Med (2013) 2.97

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature (2013) 2.70

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab (2013) 2.54

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature (2014) 2.37

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature (2014) 2.22

A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Cell Metab (2014) 2.18

Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab (2009) 2.11

Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring) (2011) 1.97

Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab (2015) 1.91

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature (2016) 1.73

Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med (2015) 1.71

Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes (2014) 1.61

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab (2016) 1.58

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity. Nature (2013) 1.35

White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma. Biochim Biophys Acta (2013) 1.33

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress. Cell Metab (2015) 1.18

Vascular rarefaction mediates whitening of brown fat in obesity. J Clin Invest (2014) 1.15

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med (2015) 1.08

Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int J Obes (Lond) (2012) 1.04

Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice. Nat Med (2016) 1.03

Energy balance following sympathetic denervation of brown adipose tissue. Can J Physiol Pharmacol (1984) 1.01

Brown adipose tissue as a secretory organ. Nat Rev Endocrinol (2016) 0.99

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. Cell Metab (2016) 0.99

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes (2015) 0.96

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans. Diabetes (2015) 0.94

Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans. Cell Metab (2016) 0.91

Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: relationship with outdoor temperature. J Clin Endocrinol Metab (2013) 0.88

Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function. Cell Metab (2016) 0.83

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metab (2016) 0.83

Of mice and men: novel insights regarding constitutive and recruitable brown adipocytes. Int J Obes Suppl (2015) 0.82

Chronic adrenergic stimulation induces brown adipose tissue differentiation in visceral adipose tissue. Diabet Med (2015) 0.81

Adipose adaptation to exercise training -increased metabolic rate but no signs of browning. Acta Physiol (Oxf) (2014) 0.77

Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity. Biochimie (2016) 0.77

Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans. Cell Metab (2017) 0.76

Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men. Nat Commun (2017) 0.76

Adipocyte Browning and Higher Mitochondrial Function in Periadrenal But Not SC Fat in Pheochromocytoma. J Clin Endocrinol Metab (2016) 0.76