Published in Sci Signal on January 20, 2009
Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum. Nat Commun (2011) 1.77
Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta (2009) 1.76
Allosteric activation of functionally asymmetric RAF kinase dimers. Cell (2013) 1.60
Activating mutations of TOR (target of rapamycin). Genes Cells (2011) 1.31
Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases. Proc Natl Acad Sci U S A (2011) 1.24
Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4(+) T lymphocytes. J Leukoc Biol (2009) 1.19
Regulation of protein kinase D1 activity. Mol Pharmacol (2011) 1.13
A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases. J Am Chem Soc (2010) 1.05
Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2. Elife (2014) 1.01
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1. Nat Struct Mol Biol (2013) 1.01
T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes. J Cell Physiol (2010) 1.00
The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look. Open Rheumatol J (2012) 0.99
The cytosolic kinases STY8, STY17, and STY46 are involved in chloroplast differentiation in Arabidopsis. Plant Physiol (2011) 0.92
Identification of direct target engagement biomarkers for kinase-targeted therapeutics. PLoS One (2011) 0.92
Synthetic phosphorylation of p38α recapitulates protein kinase activity. J Am Chem Soc (2014) 0.87
Differential inhibitor sensitivity between human kinases VRK1 and VRK2. PLoS One (2011) 0.87
An evolutionary perspective on the kinome of malaria parasites. Philos Trans R Soc Lond B Biol Sci (2012) 0.85
Structural basis and functions of abscisic acid receptors PYLs. Front Plant Sci (2015) 0.85
Computational insights for the discovery of non-ATP competitive inhibitors of MAP kinases. Curr Pharm Des (2012) 0.85
Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria. Protein Expr Purif (2011) 0.85
The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert. J Biol Chem (2014) 0.83
Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun (2016) 0.82
Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38α. PLoS One (2012) 0.81
Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proc Natl Acad Sci U S A (2016) 0.79
Completing the structural family portrait of the human EphB tyrosine kinase domains. Protein Sci (2014) 0.79
Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification. J Biol Chem (2010) 0.79
Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation. PLoS One (2014) 0.77
Autoregulatory characteristics of a Bacillus anthracis serine/threonine kinase. J Bacteriol (2011) 0.77
Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. Sci Rep (2015) 0.77
Protein phosphorylation and its role in archaeal signal transduction. FEMS Microbiol Rev (2016) 0.76
Dysregulation of positive transcription elongation factor B and myocardial hypertrophy. Circ Res (2009) 0.76
Tighter αC-helix-αL16-helix interactions seem to make p38α less prone to activation by autophosphorylation than Hog1. Biosci Rep (2016) 0.75