Published in Biochim Biophys Acta on October 29, 2009
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell (2011) 2.35
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat Rev Cancer (2013) 2.17
Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol (2010) 1.95
Aurora A kinase (AURKA) in normal and pathological cell division. Cell Mol Life Sci (2012) 1.84
Eukaryote-like serine/threonine kinases and phosphatases in bacteria. Microbiol Mol Biol Rev (2011) 1.82
Sequence determinants of a specific inactive protein kinase conformation. Chem Biol (2013) 1.78
Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.65
Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization. PLoS Genet (2016) 1.43
Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism. Science (2015) 1.30
Energetic dissection of Gleevec's selectivity toward human tyrosine kinases. Nat Struct Mol Biol (2014) 1.24
Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem (2012) 1.14
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat Chem Biol (2013) 1.10
Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases. PLoS Comput Biol (2011) 1.06
Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Genes Dev (2011) 1.03
Solution NMR insights into docking interactions involving inactive ERK2. Biochemistry (2011) 1.03
Phosphosite mapping of P-type plasma membrane H+-ATPase in homologous and heterologous environments. J Biol Chem (2011) 1.02
Bacterial serine/threonine protein kinases in host-pathogen interactions. J Biol Chem (2014) 1.00
NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding. Phys Chem Chem Phys (2014) 0.99
Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop. J Mol Biol (2013) 0.98
Crystal structure of the Golgi casein kinase. Proc Natl Acad Sci U S A (2013) 0.97
A measured approach: determining the PLCγ1 docking site on Itk using a biochemical ruler. J Mol Biol (2012) 0.95
Allosteric communication across the native and mutated KIT receptor tyrosine kinase. PLoS Comput Biol (2012) 0.94
NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity. J Biol Chem (2011) 0.93
Allostery and binding cooperativity of the catalytic subunit of protein kinase A by NMR spectroscopy and molecular dynamics simulations. Adv Protein Chem Struct Biol (2012) 0.93
The neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo. Transl Oncol (2011) 0.91
The ins and outs of bcr-abl inhibition. Genes Cancer (2012) 0.91
Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry (2012) 0.88
Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases. Proc Natl Acad Sci U S A (2012) 0.88
Mutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64. PLoS One (2011) 0.87
Solution NMR Spectroscopy for the Study of Enzyme Allostery. Chem Rev (2016) 0.87
Nucleotide release sequences in the protein kinase SRPK1 accelerate substrate phosphorylation. Biochemistry (2012) 0.87
ProKinO: a unified resource for mining the cancer kinome. Hum Mutat (2015) 0.83
A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life. PLoS One (2012) 0.82
Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK. Philos Trans R Soc Lond B Biol Sci (2012) 0.81
Computational study of the "DFG-flip" conformational transition in c-Abl and c-Src tyrosine kinases. J Phys Chem B (2015) 0.81
Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery. Drug Discov Today (2014) 0.81
Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src. ACS Chem Biol (2013) 0.80
Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors. ACS Chem Biol (2014) 0.80
A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. J Mol Biol (2014) 0.80
Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA). PLoS One (2012) 0.80
Modeling conformational transitions in kinases by molecular dynamics simulations: achievements, difficulties, and open challenges. Front Genet (2014) 0.80
An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure (2015) 0.79
Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases. PLoS Comput Biol (2016) 0.79
Structural analysis of Staphylococcus aureus serine/threonine kinase PknB. PLoS One (2012) 0.79
Expression and purification of Src-family kinases for solution NMR studies. Methods Mol Biol (2012) 0.78
Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16. Biochem J (2015) 0.76
Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. Structure (2016) 0.76
Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases. Sci Rep (2015) 0.76
Impact of Serine/Threonine Protein Kinases on the Regulation of Sporulation in Bacillus subtilis. Front Microbiol (2016) 0.76
Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A (2017) 0.76
Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization. Nat Commun (2015) 0.76
An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase. Sci Rep (2016) 0.76
Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nat Commun (2016) 0.76
Specificity rendering 'hot-spots' for aurora kinase inhibitor design: the role of non-covalent interactions and conformational transitions. PLoS One (2014) 0.76
Multiple steps to activate FAK's kinase domain: adaptation to confined environments? Biophys J (2013) 0.75
Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist. Structure (2016) 0.75
The Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape. J Phys Chem B (2016) 0.75
The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase. Sci Rep (2015) 0.75
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms. PLoS One (2017) 0.75
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep (2017) 0.75
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99
Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell (2004) 6.92
Evolutionarily conserved networks of residues mediate allosteric communication in proteins. Nat Struct Biol (2003) 6.50
Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci (2002) 5.28
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A (2006) 4.09
Structural basis for control by phosphorylation. Chem Rev (2001) 3.53
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
Dynamics of cAMP-dependent protein kinase. Chem Rev (2001) 3.18
A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A (2008) 2.51
Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model? Biochemistry (2003) 2.23
The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity. Proc Natl Acad Sci U S A (2006) 1.58
Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55
The structure of CDK4/cyclin D3 has implications for models of CDK activation. Proc Natl Acad Sci U S A (2009) 1.45
Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation. Sci Signal (2009) 1.35
Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry (1999) 1.29
Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem (2009) 1.29
A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families. J Biol Chem (2005) 1.28
A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src. Bioorg Med Chem (1998) 1.23
Comparative surface geometry of the protein kinase family. Protein Sci (2009) 1.08
A quantitative comparison of wild-type and gatekeeper mutant cdk2 for chemical genetic studies with ATP analogues. Chembiochem (2009) 0.92
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A (2006) 4.09
Structural and functional diversity of the microbial kinome. PLoS Biol (2007) 3.74
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science (2005) 3.28
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell (2007) 3.19
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A (2007) 2.65
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature (2005) 2.54
A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A (2008) 2.51
The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A (2004) 2.32
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell (2006) 2.27
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol (2002) 2.07
Allosteric cooperativity in protein kinase A. Proc Natl Acad Sci U S A (2008) 1.99
Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol (2010) 1.95
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem (2010) 1.91
cAMP activation of PKA defines an ancient signaling mechanism. Proc Natl Acad Sci U S A (2006) 1.79
Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol (2013) 1.75
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J Mol Biol (2003) 1.68
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.65
Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A (2003) 1.61
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science (2007) 1.61
Allosteric activation of functionally asymmetric RAF kinase dimers. Cell (2013) 1.60
Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55
Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Mol Biol (2004) 1.51
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem (2008) 1.47
Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins (2002) 1.45
Evolution of allostery in the cyclic nucleotide binding module. Genome Biol (2007) 1.44
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A (2011) 1.44
A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci U S A (2005) 1.43
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev (2013) 1.40
Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J Mol Evol (2002) 1.38
Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. J Mol Biol (2002) 1.36
Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure (2010) 1.36
Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. J Mol Biol (2005) 1.35
PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int (2003) 1.35
Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science (2012) 1.35
Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol (2014) 1.34
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci U S A (2003) 1.33
Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. J Mol Biol (2004) 1.32
Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Sci (2005) 1.32
Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol (2007) 1.31
Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem (2002) 1.30
Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem (2009) 1.29
A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol (2008) 1.29
Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). J Mol Biol (2003) 1.29
Signaling through dynamic linkers as revealed by PKA. Proc Natl Acad Sci U S A (2013) 1.28
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A (2011) 1.27
Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. J Biol Chem (2004) 1.27
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chem Biol (2007) 1.23
Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase. J Biol Chem (2004) 1.23
Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem (2009) 1.21
Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. J Mol Biol (2003) 1.20
Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem (2002) 1.20
cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. J Biol Chem (2003) 1.17
RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure (2004) 1.16
Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem (2012) 1.14
Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A (2003) 1.12
Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Mol Cell Proteomics (2010) 1.12
C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. J Biol Chem (2004) 1.12
RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. Cancer Res (2006) 1.12
A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Sci (2009) 1.11
Congenital disease SNPs target lineage specific structural elements in protein kinases. Proc Natl Acad Sci U S A (2008) 1.11
Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci (2005) 1.11
A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry (2009) 1.10
Kinases and pseudokinases: lessons from RAF. Mol Cell Biol (2014) 1.10
Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem (2012) 1.08
Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. J Biol Chem (2002) 1.08
Comparative surface geometry of the protein kinase family. Protein Sci (2009) 1.08
Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry (2004) 1.07
Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. J Mol Biol (2004) 1.07
Dynamic binding of PKA regulatory subunit RI alpha. Structure (2006) 1.07
D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem (2009) 1.06
Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. J Biol Chem (2010) 1.05
A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. J Biol Chem (2008) 1.05
Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem (2010) 1.04
Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. J Mol Biol (2009) 1.03
Localization and quaternary structure of the PKA RIβ holoenzyme. Proc Natl Acad Sci U S A (2012) 1.02
Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. J Mol Biol (2006) 1.02
A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem (2012) 1.02
A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Sci (2005) 1.01
Protein kinase resource: an integrated environment for phosphorylation research. Proteins (2006) 1.01
Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc (2013) 1.01
Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. Structure (2011) 1.01
Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure (2011) 1.01
Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Mol Cell Proteomics (2010) 1.00
Conserved spatial patterns across the protein kinase family. Biochim Biophys Acta (2007) 1.00
Pseudokinases: functional insights gleaned from structure. Structure (2009) 0.99
The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS One (2011) 0.99
Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem (2011) 0.98
Structure and dynamics of PKA signaling proteins. Eur J Cell Biol (2006) 0.98
Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol (2012) 0.98
Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. J Biol Chem (2007) 0.97
Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics. Biochemistry (2007) 0.96
Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation. J Biol Chem (2007) 0.95
Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Biochemistry (2003) 0.94
Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Sci (2010) 0.94
Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase. J Mol Biol (2002) 0.94