The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia.

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Published in Leukemia on January 22, 2009

Authors

N Gallay1, C Dos Santos, L Cuzin, M Bousquet, V Simmonet Gouy, C Chaussade, M Attal, B Payrastre, C Demur, C Récher

Author Affiliations

1: Inserm, U563, Centre de Physiopathologie de Toulouse Purpan, Département d'Oncogenèse, Signalisation et Innovation Thérapeutique, Toulouse, France.

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[Ultrastructural aspects of the rabbit mammary gland during lactogenesis]. Z Zellforsch Mikrosk Anat (1969) 1.01

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Minimally differentiated erythroleukaemia (AML M6 'variant'): a rare subset of AML distinct from AML M6. Groupe Français d'Hématologie Cellulaire. Br J Haematol (1995) 0.92

[NADIS 2000, development of an electronic medical record for patients infected by HIV, HBV and HCV]. Presse Med (2003) 0.92

Hepatitis C virus co-infection is a negative prognostic factor for clinical evolution in human immunodeficiency virus-positive patients. J Viral Hepat (2000) 0.92

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Familial multiple myeloma: report of fifteen families. Br J Haematol (1999) 0.90

Diagnosis of acute basophilic leukemia. Leuk Lymphoma (1999) 0.90

Tyrosine kinases and phosphoinositide metabolism in thrombin-stimulated human platelets. Biochem J (1993) 0.90

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The CD24 antigen discriminates between pre-B and B cells in human bone marrow. J Immunol (1990) 0.89

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