PubRank

Ramnik J Xavier

Author PubWeight™ 324.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008 30.20
2 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
3 Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007 19.08
4 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012 16.13
5 Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008 12.44
6 A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008 10.84
7 Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 2008 9.52
8 Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009 8.71
9 Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet 2009 8.39
10 Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011 7.98
11 The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 2009 7.88
12 Genetics and pathogenesis of inflammatory bowel disease. Nature 2011 7.79
13 Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008 7.61
14 Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet 2011 6.20
15 IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 2008 6.17
16 Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol 2012 5.66
17 Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet 2011 5.58
18 RNA interference screen for human genes associated with West Nile virus infection. Nature 2008 4.93
19 Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 2010 4.65
20 A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe 2009 4.24
21 Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet 2009 3.82
22 Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc Natl Acad Sci U S A 2012 3.62
23 A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A 2009 3.37
24 Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One 2008 3.36
25 IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci U S A 2014 2.86
26 An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res 2009 2.69
27 Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 2011 2.58
28 A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell 2010 2.40
29 Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest 2014 2.39
30 Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci U S A 2013 2.33
31 Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol 2010 2.32
32 Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol 2009 2.23
33 Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A 2010 2.10
34 LRRK2 is involved in the IFN-gamma response and host response to pathogens. J Immunol 2010 1.85
35 NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis 2010 1.84
36 Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome. Gut 2013 1.83
37 Autophagy and the immune system. Annu Rev Immunol 2012 1.80
38 Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev 2010 1.71
39 Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. Blood 2010 1.69
40 The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium. Cell Host Microbe 2012 1.67
41 Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease. PLoS One 2012 1.66
42 Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma. Cell Host Microbe 2012 1.61
43 HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer 2009 1.54
44 Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. Clin Cancer Res 2013 1.53
45 Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Nat Genet 2013 1.52
46 Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 2013 1.47
47 Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Proc Natl Acad Sci U S A 2010 1.46
48 Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology 2002 1.45
49 Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients. Inflamm Bowel Dis 2011 1.41
50 Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology 2013 1.38
51 Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A 2006 1.36
52 Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet 2013 1.34
53 Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. Nat Commun 2013 1.31
54 Differential requirement for CARMA1 in agonist-selected T-cell development. Eur J Immunol 2009 1.29
55 Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine. Ann Med 2007 1.29
56 Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 2003 1.29
57 Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. Mol Cell Biol 2006 1.28
58 Autophagy, immunity and human disease. Curr Opin Gastroenterol 2009 1.26
59 Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy 2011 1.26
60 Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology 2003 1.25
61 Recurrent chromosomal copy number alterations in sporadic chordomas. PLoS One 2011 1.24
62 Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. Clin Cancer Res 2013 1.21
63 Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc Natl Acad Sci U S A 2008 1.20
64 Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice. Gastroenterology 2013 1.19
65 Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity. J Innate Immun 2013 1.16
66 Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell 2013 1.14
67 The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem 2004 1.13
68 HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS One 2011 1.13
69 Genome-wide siRNA screen for mediators of NF-κB activation. Proc Natl Acad Sci U S A 2012 1.12
70 Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer 2008 1.11
71 A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. J Immunol 2009 1.10
72 AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling. J Biol Chem 2007 1.08
73 ATG5 regulates plasma cell differentiation. Autophagy 2013 1.06
74 MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol 2011 1.04
75 Skin microbiome imbalance in patients with STAT1/STAT3 defects impairs innate host defense responses. J Innate Immun 2013 1.02
76 SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry 2008 1.01
77 Characterization and analysis of human chordoma cell lines. Spine (Phila Pa 1976) 2010 0.97
78 Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions. PLoS One 2010 0.96
79 CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol 2008 0.96
80 Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy. Blood Cells Mol Dis 2002 0.96
81 From genetics of inflammatory bowel disease towards mechanistic insights. Trends Immunol 2013 0.94
82 Enhanced Tim3 activity improves survival after influenza infection. J Immunol 2012 0.94
83 A Francisella tularensis locus required for spermine responsiveness is necessary for virulence. Infect Immun 2011 0.92
84 p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation. J Immunol 2012 0.91
85 A systems biology viewpoint on autophagy in health and disease. Curr Opin Gastroenterol 2010 0.90
86 Human IRGM gene "to be or not to be". Semin Immunopathol 2010 0.88
87 Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease. Inflamm Bowel Dis 2016 0.87
88 Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling. Inflamm Bowel Dis 2012 0.87
89 Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci U S A 2008 0.86
90 Common alleles that influence autophagy and the risk for inflammatory bowel disease. Curr Opin Immunol 2012 0.86
91 Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β). J Biol Chem 2013 0.85
92 Polarity gene discs large homolog 1 regulates the generation of memory T cells. Eur J Immunol 2013 0.84
93 CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma. J Immunol 2011 0.84
94 DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. Cell Signal 2007 0.83
95 On the level: IRGM gene function is all about expression. Autophagy 2009 0.83
96 Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology 2008 0.83
97 Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases. Inflamm Bowel Dis 2010 0.83
98 Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. Cell 2016 0.82
99 Common Genetic Variants Influence Circulating Vitamin D Levels in Inflammatory Bowel Diseases. Inflamm Bowel Dis 2015 0.81
100 How does genotype influence disease phenotype in inflammatory bowel disease? Inflamm Bowel Dis 2013 0.81
101 Autophagy at the crossroads of metabolism and cellular defense. Curr Opin Gastroenterol 2013 0.80
102 Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells. J Immunol 2013 0.80
103 Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging. J Vis Exp 2011 0.80
104 Genetic polymorphisms in metabolizing enzymes modifying the association between smoking and inflammatory bowel diseases. Inflamm Bowel Dis 2014 0.80
105 Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival. Semin Immunopathol 2010 0.79
106 Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL. Cancer Immunol Res 2013 0.79
107 Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. FEBS Lett 2005 0.78
108 Autophagy and checkpoints for intracellular pathogen defense. Curr Opin Gastroenterol 2015 0.78
109 The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Exp Cell Res 2009 0.78
110 Genome-wide analysis of immune system genes by expressed sequence Tag profiling. J Immunol 2013 0.77
111 Corrigendum. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest 2015 0.77
112 Corrigendum: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nat Med 2016 0.76
113 Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3. PLoS Pathog 2011 0.76
114 Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity. Autophagy 2011 0.76
115 Neither hide nor hair: the difficulty of identifying useful disease biomarkers. Gastroenterology 2008 0.75
116 Visceral Adiposity, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease. Inflamm Bowel Dis 2016 0.75
117 Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines. Am J Physiol Gastrointest Liver Physiol 2012 0.75
118 SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway. Inflamm Bowel Dis 2017 0.75
119 Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity. Cell 2016 0.75
120 Corrigendum: SIKs control osteocyte responses to parathyroid hormone. Nat Commun 2017 0.75
121 Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis. Nat Commun 2016 0.75
122 SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway. Inflamm Bowel Dis 2017 0.75
123 The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense. Cell Host Microbe 2017 0.75
124 Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. Nat Commun 2017 0.75