Published in Nat Genet on November 15, 2009
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet (2011) 3.68
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet (2011) 3.65
Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat Genet (2011) 3.15
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52
Use of genome-wide association studies for drug repositioning. Nat Biotechnol (2012) 2.51
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet (2012) 2.29
The pathophysiology of IgA nephropathy. J Am Soc Nephrol (2011) 2.27
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Metagenomics and personalized medicine. Cell (2011) 2.00
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet (2010) 1.81
SHIP deficiency causes Crohn's disease-like ileitis. Gut (2010) 1.76
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nat Genet (2014) 1.74
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nat Genet (2010) 1.69
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nat Med (2015) 1.66
The diagnostic approach to monogenic very early onset inflammatory bowel disease. Gastroenterology (2014) 1.63
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet (2012) 1.61
Genome-wide association identifies diverse causes of common variable immunodeficiency. J Allergy Clin Immunol (2011) 1.60
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis (2013) 1.59
Interleukin-27: balancing protective and pathological immunity. Immunity (2012) 1.58
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New directions in the basic and translational biology of interleukin-27. Trends Immunol (2011) 1.54
Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS One (2010) 1.54
IL-27 promotes T cell-dependent colitis through multiple mechanisms. J Exp Med (2010) 1.54
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A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol (2010) 1.44
Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes. Gut (2012) 1.39
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol (2014) 1.38
Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression. Proc Natl Acad Sci U S A (2014) 1.37
Genome-wide meta-analysis for severe diabetic retinopathy. Hum Mol Genet (2011) 1.36
Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11. J Immunol (2011) 1.33
Improved risk prediction for Crohn's disease with a multi-locus approach. Hum Mol Genet (2011) 1.28
Genetic predictors of medically refractory ulcerative colitis. Inflamm Bowel Dis (2010) 1.25
Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology (2011) 1.24
Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27. Semin Immunol (2011) 1.24
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Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis. Inflamm Bowel Dis (2010) 1.22
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Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum Mol Genet (2012) 1.20
CD4(+) T-cell subsets in intestinal inflammation. Immunol Rev (2013) 1.17
Crohn's and colitis in children and adolescents. World J Gastroenterol (2012) 1.10
Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease. PLoS One (2013) 1.10
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Personalizing medicine for autoimmune and inflammatory diseases. Nat Immunol (2013) 1.05
New developments in the genetics, pathogenesis, and therapy of IgA nephropathy. Kidney Int (2015) 1.04
Crohn's disease and genetic hitchhiking at IBD5. Mol Biol Evol (2011) 1.03
The microaerophilic microbiota of de-novo paediatric inflammatory bowel disease: the BISCUIT study. PLoS One (2013) 1.03
Why interleukin-10 supplementation does not work in Crohn's disease patients. World J Gastroenterol (2013) 1.02
Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. Ann Hum Genet (2010) 1.01
Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients. PLoS One (2011) 1.00
Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets. Antioxid Redox Signal (2013) 0.99
Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope. Arthritis Rheum (2012) 0.98
Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. J Med Chem (2011) 0.98
GPR35 as a Novel Therapeutic Target. Front Endocrinol (Lausanne) (2011) 0.98
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. Gastroenterology (2011) 0.97
Genetics of childhood obesity. J Obes (2011) 0.97
Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping. PLoS One (2015) 0.96
CC Chemokine Ligand 20 and Its Cognate Receptor CCR6 in Mucosal T Cell Immunology and Inflammatory Bowel Disease: Odd Couple or Axis of Evil? Front Immunol (2013) 0.96
Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases. Curr Genomics (2010) 0.95
Exome sequencing identifies a novel FOXP3 mutation in a 2-generation family with inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2014) 0.92
Deletion of intestinal epithelial cell STAT3 promotes T-lymphocyte STAT3 activation and chronic colitis following acute dextran sodium sulfate injury in mice. Inflamm Bowel Dis (2013) 0.92
Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens. Inflamm Bowel Dis (2011) 0.92
The history of genetics in inflammatory bowel disease. Ann Gastroenterol (2014) 0.92
Genome-wide association analysis of ischemic stroke in young adults. G3 (Bethesda) (2011) 0.92
Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice. Gastroenterology (2013) 0.91
Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A (2013) 0.91
STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease. J Pediatr Gastroenterol Nutr (2012) 0.90
Activation of HIF-1α does not increase intestinal tumorigenesis. Am J Physiol Gastrointest Liver Physiol (2014) 0.90
Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population. Arthritis Res Ther (2015) 0.89
Genetic comorbidities in Parkinson's disease. Hum Mol Genet (2013) 0.89
Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease. PLoS Genet (2012) 0.88
Impact of exome sequencing in inflammatory bowel disease. World J Gastroenterol (2013) 0.88
A two-locus system controls susceptibility to colitis-associated colon cancer in mice. Oncotarget (2010) 0.88
A review of study designs and statistical methods for genomic epidemiology studies using next generation sequencing. Front Genet (2015) 0.88
B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells. J Immunol (2012) 0.88
Genetic Epidemiology of Psoriasis. Curr Dermatol Rep (2014) 0.87
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. Pharmacogenomics J (2014) 0.87
The impact of genomics on pediatric research and medicine. Pediatrics (2012) 0.87
Early life factors and risk of inflammatory bowel disease in adulthood. Inflamm Bowel Dis (2013) 0.87
Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3(+) Treg cell function in the intestine. Mucosal Immunol (2015) 0.87
Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease. Clin Transl Gastroenterol (2014) 0.87
Genetics of inflammatory bowel disease from multifactorial to monogenic forms. World J Gastroenterol (2015) 0.86
SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis. Am J Pathol (2011) 0.86
Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics. PLoS Comput Biol (2016) 0.86
Update in pediatric inflammatory bowel disease. Rheum Dis Clin North Am (2013) 0.86
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. Arthritis Rheumatol (2014) 0.85
Probiotics in inflammatory bowel diseases and associated conditions. Nutrients (2011) 0.85
Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease. PLoS Genet (2016) 0.85
A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology (2016) 0.84
IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice. Mucosal Immunol (2013) 0.84
Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: finding the right balance in response to danger signals. Clin Immunol (2010) 0.84
Refinement in localization and identification of gene regions associated with Crohn disease. Am J Hum Genet (2012) 0.84
Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children. Hum Genet (2010) 0.84
NOX2-dependent regulation of inflammation. Clin Sci (Lond) (2016) 0.82
Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review. PLoS One (2011) 0.82
Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults. PLoS One (2010) 0.82
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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol (2007) 12.20
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med (2007) 8.97
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol (2008) 7.91
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet (2008) 5.05
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet (2008) 4.96
Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology (2008) 4.05
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet (2008) 3.36
Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology (2008) 2.52
The genetics of Crohn's disease. Annu Rev Genomics Hum Genet (2009) 2.07
The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. J Biol Chem (2006) 1.22
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
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A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Finding the missing heritability of complex diseases. Nature (2009) 67.95
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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
The structure of haplotype blocks in the human genome. Science (2002) 50.88
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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88
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A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49