Published in Protein Expr Purif on January 11, 2009
Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell (2009) 3.24
XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region. Proc Natl Acad Sci U S A (2011) 1.56
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies. Nat Protoc (2014) 1.16
GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. PLoS One (2012) 1.12
Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins. ACS Nano (2011) 1.11
Baculovirus: an insect-derived vector for diverse gene transfer applications. Mol Ther (2013) 1.07
Reproducible high yields of recombinant adeno-associated virus produced using invertebrate cells in 0.02- to 200-liter cultures. Hum Gene Ther (2011) 1.02
Large-scale recombinant adeno-associated virus production. Hum Mol Genet (2011) 0.96
The Kinesin-12 Kif15 is a processive track-switching tetramer. Elife (2014) 0.94
Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins. PLoS One (2010) 0.93
A new method to customize protein expression vectors for fast, efficient and background free parallel cloning. BMC Biotechnol (2013) 0.93
The structure of the NPC1L1 N-terminal domain in a closed conformation. PLoS One (2011) 0.90
The Atg1-kinase complex tethers Atg9-vesicles to initiate autophagy. Nat Commun (2016) 0.90
Multi-host expression system for recombinant production of challenging proteins. PLoS One (2013) 0.80
Dissection of Cdk1-cyclin complexes in vivo. Proc Natl Acad Sci U S A (2013) 0.79
Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans. Org Biomol Chem (2016) 0.79
Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2. J Cell Sci (2015) 0.78
The multiBac protein complex production platform at the EMBL. J Vis Exp (2013) 0.78
Rapid, scalable, and low-cost purification of recombinant adeno-associated virus produced by baculovirus expression vector system. Mol Ther Methods Clin Dev (2016) 0.77
Simultaneous protein expression and modification: an efficient approach for production of unphosphorylated and biotinylated receptor tyrosine kinases by triple infection in the baculovirus expression system. J Biomol Tech (2010) 0.76
DICER-ARGONAUTE2 complex in continuous fluorogenic assays of RNA interference enzymes. PLoS One (2015) 0.76
Efficient production and purification of recombinant murine kindlin-3 from insect cells for biophysical studies. J Vis Exp (2014) 0.75
Identification of Essential Genetic Baculoviral Elements for Recombinant Protein Expression by Transactivation in Sf21 Insect Cells. PLoS One (2016) 0.75
A re-usable wave bioreactor for protein production in insect cells. MethodsX (2016) 0.75
Highly efficient transduction of primary adult CNS and PNS neurons. Sci Rep (2016) 0.75
Expression, Purification, and Monitoring of Conformational Changes of hCB2 TMH67H8 in Different Membrane-Mimetic Lipid Mixtures Using Circular Dichroism and NMR Techniques. Membranes (Basel) (2017) 0.75
Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase. Nucleic Acids Res (2017) 0.75
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nat Struct Mol Biol (2007) 2.76
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat Struct Mol Biol (2007) 2.62
Employing a superior BACE1 cleavage sequence to probe cellular APP processing. J Neurochem (2003) 1.35
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. J Mol Biol (2010) 1.29
X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase. Structure (2003) 1.08
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2). J Biol Chem (2007) 1.05
Human beta-secretase (BACE) and BACE inhibitors. J Med Chem (2003) 1.00
2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg Med Chem Lett (2008) 0.94
Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase. J Med Chem (2007) 0.92
Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem (2010) 0.91
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors. J Biol Chem (2009) 0.90
An efficient method to express and refold a truncated human procaspase-9: a caspase with activity toward Glu-X bonds. Protein Expr Purif (2005) 0.89
Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain. Protein Expr Purif (2009) 0.87
Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity. Biosci Rep (2009) 0.85
Development of a fluorescence-based enzyme assay of human 5-lipoxygenase. Anal Biochem (2007) 0.85
Design of potent inhibitors of human beta-secretase. Part 1. Bioorg Med Chem Lett (2006) 0.84
Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors. Biochim Biophys Acta (2010) 0.84
Electrophoretic mobility of Alzheimer's amyloid-beta peptides in urea-sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Anal Biochem (2003) 0.83
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1. Bioorg Med Chem Lett (2007) 0.82
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode. Bioorg Med Chem Lett (2010) 0.80
Structure of human ADAM-8 catalytic domain complexed with batimastat. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.80
The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther (2012) 0.79
Design of potent inhibitors of human beta-secretase. Part 2. Bioorg Med Chem Lett (2006) 0.79
Structure analysis reveals the flexibility of the ADAMTS-5 active site. Protein Sci (2011) 0.78
Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family. Biochem Biophys Res Commun (2010) 0.78
Large-scale gene expression analysis of cholesterol dependence in NS0 cells. Biotechnol Bioeng (2005) 0.78
ADAM8 substrate specificity: influence of pH on pre-processing and proteoglycan degradation. Arch Biochem Biophys (2009) 0.77
High yield purification of soluble guanylate cyclase from bovine lung. Protein Expr Purif (2008) 0.76
Expression, purification and functional characterization of IkappaB kinase-2 (IKK-2) mutants. Protein Expr Purif (2010) 0.76
Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells. Protein Expr Purif (2009) 0.76
Expression and characterization of functional dog flavin-containing monooxygenase 3. Drug Metab Dispos (2009) 0.76
Cloning and expression of cyclooxygenase-1 and cyclooxygenase-2. Methods Mol Biol (2010) 0.75
Mammalian cell production and purification of progenipoietin, a dual-agonist chimaeric haematopoietic growth factor. Biotechnol Appl Biochem (2003) 0.75
Cloning, expression, and selective inhibition of canine cyclooxygenase-1 and cyclooxygenase-2. Vet Ther (2002) 0.75
A high performance liquid chromatography assay for monitoring proprotein convertase activity. J Chromatogr A (2007) 0.75
Purification and characterization of progenipoietins produced in Escherichia. coli. Protein Expr Purif (2002) 0.75
Differential kinetics and inhibition of purified recombinant tyrosine kinase 2 (TYK-2) and its catalytic domain JH-1. Protein Pept Lett (2012) 0.75
MMP-13 selective α-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres. Bioorg Med Chem Lett (2011) 0.75
Affinity purification of a chimeric nicotinic acetylcholine receptor in the agonist and antagonist bound states. Protein Expr Purif (2011) 0.75