Published in Chemistry on January 01, 2009
Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures. Acc Chem Res (2010) 1.75
Structure-switching biosensors: inspired by Nature. Curr Opin Struct Biol (2010) 1.40
Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors. Proc Natl Acad Sci U S A (2009) 1.40
Biosensor diagnosis of urinary tract infections: a path to better treatment? Trends Pharmacol Sci (2011) 1.28
Switch-based biosensors: a new approach towards real-time, in vivo molecular detection. Trends Biotechnol (2010) 1.27
Converting a protein into a switch for biosensing and functional regulation. Protein Sci (2011) 1.06
Protein unfolding with a steric trap. J Am Chem Soc (2009) 0.96
Assisted peptide folding by surface pattern recognition. Biophys J (2011) 0.87
Universality in the timescales of internal loop formation in unfolded proteins and single-stranded oligonucleotides. Biophys J (2010) 0.80
Designing redox potential-controlled protein switches based on mutually exclusive proteins. Protein Sci (2012) 0.80
Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol (1996) 21.49
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature (1997) 18.83
Multicolor molecular beacons for allele discrimination. Nat Biotechnol (1998) 9.40
Present and future of surface plasmon resonance biosensors. Anal Bioanal Chem (2003) 4.07
Measuring the rate of intramolecular contact formation in polypeptides. Proc Natl Acad Sci U S A (2000) 3.64
Probing individual molecules with confocal fluorescence microscopy. Science (1994) 2.71
Label-free screening of bio-molecular interactions. Anal Bioanal Chem (2003) 2.43
Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex. Science (1995) 2.35
Periplasmic binding proteins: a versatile superfamily for protein engineering. Curr Opin Struct Biol (2004) 2.33
Probing protein-protein interactions in real time. Nat Struct Biol (2000) 2.12
Construction of a fluorescent biosensor family. Protein Sci (2002) 2.07
Residual structure in large fragments of staphylococcal nuclease: effects of amino acid substitutions. Biochemistry (1989) 1.87
Cooperativity principles in protein folding. Methods Enzymol (2004) 1.70
Rapid isolation of high-affinity protein binding peptides using bacterial display. Protein Eng Des Sel (2004) 1.63
Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria. Philos Trans R Soc Lond B Biol Sci (1990) 1.63
Fluorescent biosensors of protein function. Curr Opin Chem Biol (2008) 1.60
A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme. Proc Natl Acad Sci U S A (1996) 1.56
Structure and dynamics of a denatured 131-residue fragment of staphylococcal nuclease: a heteronuclear NMR study. Biochemistry (1994) 1.55
A close look at fluorescence quenching of organic dyes by tryptophan. Chemphyschem (2005) 1.52
Cantilever-based biosensors. Anal Bioanal Chem (2004) 1.51
Flow cytometry for high-throughput, high-content screening. Curr Opin Chem Biol (2004) 1.50
NMR studies of unfolded states of an SH3 domain in aqueous solution and denaturing conditions. Biochemistry (1997) 1.46
Novel fluorescent indicator proteins for monitoring free intracellular Ca2+. Cell Calcium (1997) 1.39
Conversion of a maltose receptor into a zinc biosensor by computational design. Proc Natl Acad Sci U S A (2001) 1.37
The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors. Proc Natl Acad Sci U S A (1997) 1.37
Engineering a signal transduction mechanism for protein-based biosensors. Proc Natl Acad Sci U S A (2005) 1.29
Characterization of the interaction of natural proline-rich peptides with five different SH3 domains. Biochemistry (1994) 1.25
A Ca2+-sensing molecular switch based on alternate frame protein folding. ACS Chem Biol (2008) 1.24
Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminus in vitro. Parallels with the protein folding pathway. J Mol Biol (1995) 1.19
Exploring the folding funnel of a polypeptide chain by biophysical studies on protein fragments. J Mol Biol (1999) 1.18
Optimization of excimer-forming two-probe nucleic acid hybridization method with pyrene as a fluorophore. Nucleic Acids Res (1998) 1.07
Human antibodies by design. Nat Biotechnol (1998) 1.06
Importance of minor-groove contacts for recognition of DNA by the binding domain of Hin recombinase. Biochemistry (1990) 1.05
Intramolecular pyrene excimer fluorescence: a probe of proximity and protein conformational change. Methods Enzymol (1997) 1.03
Phage display: applications, innovations, and issues in phage and host biology. Can J Microbiol (1998) 1.02
Excimer-based peptide beacons: a convenient experimental approach for monitoring polypeptide-protein and polypeptide-oligonucleotide interactions. J Am Chem Soc (2006) 1.01
Analysis of ligand binding to a ribose biosensor using site-directed mutagenesis and fluorescence spectroscopy. Protein Sci (2007) 0.98
Acquisition of native-like interactions in C-terminal fragments of barnase. J Mol Biol (1999) 0.96
Peptide beacons: a new design for polypeptide-based optical biosensors. Bioconjug Chem (2007) 0.96
Real-time PCR assay using molecular beacon for quantitation of hepatitis B virus DNA. J Clin Microbiol (2004) 0.95
A thermodynamic and kinetic analysis of the folding pathway of an SH3 domain entropically stabilised by a redesigned hydrophobic core. J Mol Biol (2003) 0.94
Regenerable biosensor platform: a total internal reflection fluorescence cell with electrochemical control. Anal Chem (1998) 0.93
Use of sequence duplication to engineer a ligand-triggered, long-distance molecular switch in T4 lysozyme. Proc Natl Acad Sci U S A (2004) 0.90
Structural basis of HIV-1 and HIV-2 protease inhibition by a monoclonal antibody. Structure (2001) 0.89
Detection of individual p53-autoantibodies by using quenched peptide-based molecular probes. Angew Chem Int Ed Engl (2002) 0.89
Engineering of non-natural receptors. Curr Opin Struct Biol (2004) 0.88
Sensitivity comparison of real-time PCR probe designs on a model DNA plasmid. Anal Biochem (2005) 0.88
Coupling ligand recognition to protein folding in an engineered variant of rabbit ileal lipid binding protein. Chem Commun (Camb) (2006) 0.87
Hairpin peptide beacon: dual-labeled PNA-peptide-hybrids for protein detection. J Am Chem Soc (2007) 0.85
Role of arginine-43 and arginine-69 of the Hin recombinase catalytic domain in the binding of Hin to the hix DNA recombination sites. Mol Microbiol (1997) 0.84
Identification of structured peptide segments in folding proteins. Biopolymers (1992) 0.83
Conformational biosensor for diagnosis of prion diseases. Biotechnol Lett (2005) 0.83
Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons. Chem Commun (Camb) (2007) 0.81
Dye-pair reporter systems for protein-peptide molecular interactions. Bioconjug Chem (2000) 0.80
Antibody-mediated fluorescence enhancement based on shifting the intramolecular dimer<-->monomer equilibrium of fluorescent dyes. Anal Chem (1994) 0.79
Antisense molecular beacon strategy for in situ visualization of snRNA and fibrillarin protein interaction in Giardia lamblia. RNA Biol (2004) 0.76
Random-coil behavior and the dimensions of chemically unfolded proteins. Proc Natl Acad Sci U S A (2004) 4.44
Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA. Proc Natl Acad Sci U S A (2003) 2.95
Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor. Angew Chem Int Ed Engl (2005) 2.47
An electronic, aptamer-based small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids. J Am Chem Soc (2006) 2.40
Contact order revisited: influence of protein size on the folding rate. Protein Sci (2003) 2.37
Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing. Nat Protoc (2007) 2.04
Toward a taxonomy of the denatured state: small angle scattering studies of unfolded proteins. Adv Protein Chem (2002) 2.02
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci (2005) 1.91
Effect of molecular crowding on the response of an electrochemical DNA sensor. Langmuir (2007) 1.87
Electrochemical detection of parts-per-billion lead via an electrode-bound DNAzyme assembly. J Am Chem Soc (2007) 1.85
Real-time, aptamer-based tracking of circulating therapeutic agents in living animals. Sci Transl Med (2013) 1.79
Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures. Acc Chem Res (2010) 1.75
A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement. J Am Chem Soc (2005) 1.73
Sequence-specific, electronic detection of oligonucleotides in blood, soil, and foodstuffs with the reagentless, reusable E-DNA sensor. Anal Chem (2006) 1.66
Beyond superquenching: hyper-efficient energy transfer from conjugated polymers to gold nanoparticles. Proc Natl Acad Sci U S A (2003) 1.64
Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor. J Am Chem Soc (2009) 1.63
Aptamer-based electrochemical detection of picomolar platelet-derived growth factor directly in blood serum. Anal Chem (2007) 1.59
Is there or isn't there? The case for (and against) residual structure in chemically denatured proteins. Crit Rev Biochem Mol Biol (2005) 1.47
Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistry. Langmuir (2008) 1.40
Structure-switching biosensors: inspired by Nature. Curr Opin Struct Biol (2010) 1.40
Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors. Proc Natl Acad Sci U S A (2009) 1.40
How the folding rate constant of simple, single-domain proteins depends on the number of native contacts. Proc Natl Acad Sci U S A (2002) 1.38
High specificity, electrochemical sandwich assays based on single aptamer sequences and suitable for the direct detection of small-molecule targets in blood and other complex matrices. J Am Chem Soc (2009) 1.38
The topomer search model: A simple, quantitative theory of two-state protein folding kinetics. Protein Sci (2003) 1.37
Linear, redox modified DNA probes as electrochemical DNA sensors. Chem Commun (Camb) (2007) 1.37
CheapStat: an open-source, "do-it-yourself" potentiostat for analytical and educational applications. PLoS One (2011) 1.32
Biosensors based on binding-modulated donor-acceptor distances. Trends Biotechnol (2005) 1.29
Engineering a signal transduction mechanism for protein-based biosensors. Proc Natl Acad Sci U S A (2005) 1.29
Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex. Proc Natl Acad Sci U S A (2006) 1.27
Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes. Proc Natl Acad Sci U S A (2010) 1.27
Site-specific dimensions across a highly denatured protein; a single molecule study. J Mol Biol (2005) 1.25
An electrochemical sensor for the detection of protein-small molecule interactions directly in serum and other complex matrices. J Am Chem Soc (2009) 1.25
Comparison of the signaling and stability of electrochemical DNA sensors fabricated from 6- or 11-carbon self-assembled monolayers. Langmuir (2006) 1.18
Northern Rivers Ecosystem Initiative: nutrients and dissolved oxygen - issues and impacts. Environ Monit Assess (2006) 1.18
Label-free electrochemical detection of DNA in blood serum via target-induced resolution of an electrode-bound DNA pseudoknot. J Am Chem Soc (2007) 1.17
Rapid, sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor. Proc Natl Acad Sci U S A (2006) 1.16
Using protein folding rates to test protein folding theories. Annu Rev Biochem (2004) 1.12
Effects of probe length, probe geometry, and redox-tag placement on the performance of the electrochemical E-DNA sensor. Anal Chem (2009) 1.12
Microfluidic device architecture for electrochemical patterning and detection of multiple DNA sequences. Langmuir (2008) 1.09
Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins. Anal Chem (2009) 1.08
High-efficiency fluorescence quenching of conjugated polymers by proteins. J Am Chem Soc (2002) 1.07
Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy. Protein Sci (2006) 1.06
On the precision of experimentally determined protein folding rates and phi-values. Protein Sci (2006) 1.06
The protein folding transition state: what are Phi-values really telling us? Protein Pept Lett (2005) 1.05
Engineering biosensors with extended, narrowed, or arbitrarily edited dynamic range. J Am Chem Soc (2012) 1.04
Improving the stability and sensing of electrochemical biosensors by employing trithiol-anchoring groups in a six-carbon self-assembled monolayer. Anal Chem (2009) 1.04
Fluorescence detection of single-nucleotide polymorphisms with a single, self-complementary, triple-stem DNA probe. Angew Chem Int Ed Engl (2009) 1.04
Absorption spectra of liquid water and aqueous buffers between 0.3 and 3.72 THz. J Chem Phys (2006) 1.04
Reagentless measurement of aminoglycoside antibiotics in blood serum via an electrochemical, ribonucleic acid aptamer-based biosensor. Anal Chem (2010) 1.03
Optimization of a reusable, DNA pseudoknot-based electrochemical sensor for sequence-specific DNA detection in blood serum. Anal Chem (2009) 1.03
Residues participating in the protein folding nucleus do not exhibit preferential evolutionary conservation. J Mol Biol (2002) 1.02
Excimer-based peptide beacons: a convenient experimental approach for monitoring polypeptide-protein and polypeptide-oligonucleotide interactions. J Am Chem Soc (2006) 1.01
Using triplex-forming oligonucleotide probes for the reagentless, electrochemical detection of double-stranded DNA. Anal Chem (2010) 1.01
Using distal-site mutations and allosteric inhibition to tune, extend, and narrow the useful dynamic range of aptamer-based sensors. J Am Chem Soc (2012) 1.01
Quantification of transcription factor binding in cell extracts using an electrochemical, structure-switching biosensor. J Am Chem Soc (2012) 0.99
Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care through microfluidic electrochemical quantitative loop-mediated isothermal amplification. Angew Chem Int Ed Engl (2012) 0.99
On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based Mechanisms. Electroanalysis (2009) 0.99
Cooperativity, smooth energy landscapes and the origins of topology-dependent protein folding rates. J Mol Biol (2003) 0.98
Equilibrium collapse and the kinetic 'foldability' of proteins. Biochemistry (2002) 0.97
The backbone conformational entropy of protein folding: experimental measures from atomic force microscopy. J Mol Biol (2002) 0.97
Sensitive and selective amplified fluorescence DNA detection based on exonuclease III-aided target recycling. J Am Chem Soc (2010) 0.96
Comparing the properties of electrochemical-based DNA sensors employing different redox tags. Anal Chem (2009) 0.96
Apparent Debye-Huckel electrostatic effects in the folding of a simple, single domain protein. Biochemistry (2005) 0.96
Influence of local and residual structures on the scaling behavior and dimensions of unfolded proteins. Biopolymers (2007) 0.96
Differential labeling of closely spaced biosensor electrodes via electrochemical lithography. Langmuir (2006) 0.96
Peptide beacons: a new design for polypeptide-based optical biosensors. Bioconjug Chem (2007) 0.96
An electrochemical supersandwich assay for sensitive and selective DNA detection in complex matrices. J Am Chem Soc (2010) 0.96
Cooperativity and the origins of rapid, single-exponential kinetics in protein folding. Protein Sci (2006) 0.95
High-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networks. PLoS Comput Biol (2011) 0.95
Surface chemistry effects on the performance of an electrochemical DNA sensor. Bioelectrochemistry (2009) 0.94
Re-engineering aptamers to support reagentless, self-reporting electrochemical sensors. Analyst (2010) 0.94
The design and development of fluorescent nano-optodes for in vivo glucose monitoring. J Diabetes Sci Technol (2011) 0.94
The length and viscosity dependence of end-to-end collision rates in single-stranded DNA. Biophys J (2009) 0.93
NMR and temperature-jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit selection for kinetics. J Mol Biol (2003) 0.93
Exploiting binding-induced changes in probe flexibility for the optimization of electrochemical biosensors. Anal Chem (2010) 0.92
Measuring distances within unfolded biopolymers using fluorescence resonance energy transfer: The effect of polymer chain dynamics on the observed fluorescence resonance energy transfer efficiency. J Chem Phys (2009) 0.92
Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding. J Mol Biol (2003) 0.91
A mechanistic study of electron transfer from the distal termini of electrode-bound, single-stranded DNAs. J Am Chem Soc (2010) 0.90
Methods for the accurate estimation of confidence intervals on protein folding phi-values. Protein Sci (2006) 0.90
Transcription factor beacons for the quantitative detection of DNA binding activity. J Am Chem Soc (2011) 0.90
Re-engineering electrochemical biosensors to narrow or extend their useful dynamic range. Angew Chem Int Ed Engl (2012) 0.89
An electrochemical sensor for single nucleotide polymorphism detection in serum based on a triple-stem DNA probe. J Am Chem Soc (2009) 0.89
Experimental investigation of the frequency and substitution dependence of negative phi-values in two-state proteins. Biochemistry (2005) 0.89
Electrochemical biosensors employing an internal electrode attachment site and achieving reversible, high gain detection of specific nucleic acid sequences. Anal Chem (2011) 0.88
On the binding of cationic, water-soluble conjugated polymers to DNA: electrostatic and hydrophobic interactions. J Am Chem Soc (2010) 0.87
Effects of pulp mill effluent on benthic assemblages in mesocosms along the Saint John River, Canada. Environ Toxicol Chem (2003) 0.87
Bioelectrochemical switches for the quantitative detection of antibodies directly in whole blood. J Am Chem Soc (2012) 0.86
Rational design of allosteric inhibitors and activators using the population-shift model: in vitro validation and application to an artificial biosensor. J Am Chem Soc (2012) 0.86
Non-sequence-specific interactions can account for the compaction of proteins unfolded under "native" conditions. J Mol Biol (2009) 0.86
Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA clamp nanoswitches. ACS Nano (2013) 0.85
Engineering New Aptamer Geometries for Electrochemical Aptamer-Based Sensors. Proc SPIE Int Soc Opt Eng (2009) 0.85
A general electrochemical method for label-free screening of protein-small molecule interactions. Chem Commun (Camb) (2009) 0.85
Increasing the resolution of single pair fluorescence resonance energy transfer measurements in solution via molecular cytometry. Anal Chem (2007) 0.84
Wash-free, electrochemical platform for the quantitative, multiplexed detection of specific antibodies. Anal Chem (2012) 0.84
Determinants of the detection limit and specificity of surface-based biosensors. Anal Chem (2013) 0.84