Published in Bioorg Med Chem on January 21, 2009
Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivo. Mol Ther (2013) 0.91
Computational analysis of siRNA recognition by the Ago2 PAZ domain and identification of the determinants of RNA-induced gene silencing. PLoS One (2013) 0.80
In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference. J Comput Aided Mol Des (2013) 0.79
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition. ACS Med Chem Lett (2012) 0.77
Synthesis and gene silencing properties of siRNAs containing terminal amide linkages. Biomed Res Int (2014) 0.76
Bioenergetics and gene silencing approaches for unraveling nucleotide recognition by the human EIF2C2/Ago2 PAZ domain. PLoS One (2014) 0.75
Downregulation of microRNAs-143 and -145 in B-cell malignancies. Cancer Sci (2007) 2.61
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med (2002) 2.23
Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo. Hepatology (2007) 1.95
Increased rate of death related to presence of viremia among hepatitis C virus antibody-positive subjects in a community-based cohort study. Hepatology (2009) 1.66
A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytes. Gastroenterology (2013) 1.47
Host sphingolipid biosynthesis as a target for hepatitis C virus therapy. Nat Chem Biol (2005) 1.47
Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients. Clin Gastroenterol Hepatol (2005) 1.47
MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells. Cancer Lett (2011) 1.42
Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice. Biochem Biophys Res Commun (2006) 1.38
Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration. J Virol (2006) 1.21
Pathogenesis of hepatitis C virus infection in Tupaia belangeri. J Virol (2010) 1.17
Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L. EMBO J (2004) 1.13
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol (2006) 1.12
Possible involvement of mast cells in collagen remodeling in the late phase of cutaneous wound healing in mice. Int Immunopharmacol (2004) 1.12
Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells. J Virol (2004) 1.08
Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model. Biochem Biophys Res Commun (2006) 1.08
Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells. J Biol Chem (2004) 1.07
Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV. J Immunol (2008) 1.07
Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum. J Mol Biol (2004) 1.05
Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination. J Hepatol (2007) 1.04
Hepatitis C virus impairs p53 via persistent overexpression of 3beta-hydroxysterol Delta24-reductase. J Biol Chem (2009) 1.04
Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. J Control Release (2005) 1.03
Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption. Am J Pathol (2002) 1.03
Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma. Am J Gastroenterol (2003) 1.03
Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. Blood (2010) 1.01
Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model. Int J Cancer (2011) 1.01
Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids. Arch Biochem Biophys (2009) 0.99
Three-dimensional structure of AzoR from Escherichia coli. An oxidereductase conserved in microorganisms. J Biol Chem (2006) 0.97
Therapeutic application of RNA interference for hepatitis C virus. Adv Drug Deliv Rev (2007) 0.97
Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome. J Hepatol (2007) 0.96
Rescue system for measles virus from cloned cDNA driven by vaccinia virus Lister vaccine strain. J Virol Methods (2006) 0.96
Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis. PLoS Pathog (2012) 0.96
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes. J Hepatol (2010) 0.96
Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection. PLoS One (2013) 0.95
Expansion of substrate specificity and catalytic mechanism of azoreductase by X-ray crystallography and site-directed mutagenesis. J Biol Chem (2008) 0.95
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner. J Virol (2010) 0.95
Endovascular Repair of a Kommerell's Diverticulum and Aneurysmal Right-sided Aortic Arch: A Case Report. Ann Vasc Dis (2009) 0.93
Spontaneous elimination of hepatitis C virus RNA in individuals with persistent infection in a hyperendemic area of Japan. Hepatol Res (2005) 0.93
Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA. Mol Biosyst (2005) 0.92
Virological significance of low-level hepatitis B virus infection in patients with hepatitis C virus associated liver disease. J Med Virol (2004) 0.92
Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein tyrosine kinase Syk. J Gen Virol (2008) 0.92
2-5A induces a conformational change in the ankyrin-repeat domain of RNase L. Proteins (2005) 0.91
Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivo. Mol Ther (2013) 0.91
Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum. Sci Rep (2011) 0.91
Impaired function of antigen-presenting dendritic cells in patients with chronic hepatitis B: localization of HBV DNA and HBV RNA in blood DC by in situ hybridization. Int J Mol Med (2003) 0.91
Interferon-alpha and antisense K-ras RNA combination gene therapy against pancreatic cancer. J Gene Med (2004) 0.90
Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins. Gastroenterology (2009) 0.90
Broad-spectrum detection of H5 subtype influenza A viruses with a new fluorescent immunochromatography system. PLoS One (2013) 0.90
Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin. J Biochem (2008) 0.89
Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line. FEBS J (2010) 0.88
Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a/X1 and 7a/X4 proteins through NF-kappaB activation. FEBS Lett (2006) 0.88
Induction of hepatic injury by hepatitis C virus-specific CD8+ murine cytotoxic T lymphocytes in transgenic mice expressing the viral structural genes. Biochem Biophys Res Commun (2003) 0.88
Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization. J Clin Microbiol (2010) 0.88
Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. Chem Biol Interact (2010) 0.88
Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver. PLoS One (2012) 0.87
Rational design of dual-functional aptamers that inhibit the protease and helicase activities of HCV NS3. J Biochem (2005) 0.87
Substrate specificity and nucleotides binding properties of NM23H2/nucleoside diphosphate kinase homolog from Plasmodium falciparum. J Bioenerg Biomembr (2010) 0.86
Morphology of hepatitis C and hepatitis B virus particles as detected by immunogold electron microscopy. Med Mol Morphol (2006) 0.86
Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance. Mol Pharm (2011) 0.86
Antiviral effects of glycosylation and glucose trimming inhibitors on human parainfluenza virus type 3. Antiviral Res (2006) 0.86
Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating alpha 1,3-fucosyltransferase IX expression. J Biol Chem (2001) 0.86
Bioinformatics, enzymologic properties, and comprehensive tracking of Plasmodium falciparum nucleoside diphosphate kinase. Biol Pharm Bull (2009) 0.86
Maintenance of mouse, rat, and pig pancreatic islet functions by coculture with human islet-derived fibroblasts. Cell Transplant (2006) 0.86
Binding dynamics and energetic insight into the molecular forces driving nucleotide binding by guanylate kinase. J Mol Recognit (2010) 0.85
Prevalence of Listeria monocytogenes in retailed meat in the Tokyo metropolitan area. J Food Prot (2010) 0.85
Mutational analyses of Plasmodium falciparum and human S-adenosylhomocysteine hydrolases. Mol Biochem Parasitol (2005) 0.85
HCV core antigen as an alternative to NAT to detect HCV viremia. Transfusion (2004) 0.85
An orally available, small-molecule interferon inhibits viral replication. Sci Rep (2012) 0.84
Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1. J Med Virol (2012) 0.84
Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3. Nucleic Acids Symp Ser (Oxf) (2004) 0.84
Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy. J Am Chem Soc (2011) 0.84
Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain. Arch Virol (2009) 0.84
SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus. Vaccine (2006) 0.84
Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg Med Chem (2010) 0.83
Incorporation of biaryl units into the 5' and 3' ends of sense and antisense strands of siRNA duplexes improves strand selectivity and nuclease resistance. Bioconjug Chem (2010) 0.83
Production of infectious hepatitis C virus particles in three-dimensional cultures of the cell line carrying the genome-length dicistronic viral RNA of genotype 1b. Virology (2006) 0.83
Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1. Biochem Biophys Res Commun (2012) 0.83
Promoter/origin structure of the complementary strand of hepatitis C virus genome. J Biol Chem (2002) 0.83
Characterization of a new fluorogenic substrate for microsomal glutathione transferase 1. Anal Biochem (2009) 0.83
Crystallization and preliminary X-ray crystallographic study of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.83
Monoclonal antibody 2-152a suppresses hepatitis C virus infection through betaine/GABA transporter-1. J Infect Dis (2011) 0.83
Kinetic analysis of C-terminally truncated RNA-dependent RNA polymerase of hepatitis C virus. Biochem Biophys Res Commun (2002) 0.83
Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem Lett (2008) 0.83
Tupaia belangeri as an experimental animal model for viral infection. Exp Anim (2014) 0.83
Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein. Cell Signal (2012) 0.82
Contribution of Tyr712 and Phe716 to the activity of human RNase L. Eur J Biochem (2004) 0.82
Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway. J Neurochem (2007) 0.82
Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10). Arch Biochem Biophys (2010) 0.82
A specific substrate-inhibitor, a 2'-deoxy-2'-fluorouridine-containing oligoribonucleotide, against human RNase L. Bioorg Med Chem (2003) 0.82
Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd, TAS-106). Nucleic Acids Res Suppl (2002) 0.82
Role of RNase L in apoptosis induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine. Cancer Chemother Pharmacol (2008) 0.81
Gray matter volumetric MRI differences late-preterm and term infants. Brain Dev (2012) 0.81
Comparative study on the biological properties of 2',5'-oligoadenylate derivatives with purified human RNase L expressed in E. coli. J Biochem (2002) 0.81
Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA. J Gastroenterol Hepatol (2007) 0.81
Reactivity of Thioaldehyde: Cyclization Reaction of 6-Amino-1,3-dimethyl-5- thioformyluracil with Enamines into Pyrido[2,3-d]pyrimidine-2,4-(1H,3H)-diones. J Org Chem (1997) 0.81
Three-dimensional structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum. Nucleic Acids Symp Ser (Oxf) (2004) 0.81