Published in J Biol Chem on January 26, 2004
Viral manipulation of DNA repair and cell cycle checkpoints. DNA Repair (Amst) (2009) 1.37
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase. Proc Natl Acad Sci U S A (2005) 1.29
Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer. Annu Rev Pathol (2009) 1.20
Pathogenesis of hepatitis C virus infection in Tupaia belangeri. J Virol (2010) 1.17
Hepatitis C virus impairs p53 via persistent overexpression of 3beta-hydroxysterol Delta24-reductase. J Biol Chem (2009) 1.04
Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. Blood (2010) 1.01
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner. J Virol (2010) 0.95
Hepatitis C virus causes uncoupling of mitotic checkpoint and chromosomal polyploidy through the Rb pathway. J Virol (2009) 0.91
Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus. Int J Mol Sci (2012) 0.88
Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver. PLoS One (2012) 0.87
Reconstructing dynamic gene regulatory networks from sample-based transcriptional data. Nucleic Acids Res (2012) 0.86
The hepatic transcriptome in human liver disease. Comp Hepatol (2006) 0.82
In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus. Sci Rep (2014) 0.82
Hepatitis C virus-related hepatocellular carcinoma: An insight into molecular mechanisms and therapeutic strategies. World J Hepatol (2012) 0.81
B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling. PLoS One (2014) 0.81
Identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine. Immunogenetics (2007) 0.79
Establishment of infectious HCV virion-producing cells with newly designed full-genome replicon RNA. Arch Virol (2011) 0.78
Protein O-glucosyltransferase 1 overexpression downregulates p16 in BT474 human breast cancer cells. Oncol Lett (2014) 0.76
Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain HCV-RMT. PLoS One (2013) 0.75
The Phospholipid:Diacylglycerol Acyltransferase Lro1 Is Responsible for Hepatitis C Virus Core-Induced Lipid Droplet Formation in a Yeast Model System. PLoS One (2016) 0.75
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol (2002) 6.66
Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity (2006) 3.74
Retracted Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2004) 3.12
Yin Yang 1 is a critical regulator of B-cell development. Genes Dev (2007) 3.06
A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 2.95
Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors. Eur J Immunol (2005) 2.46
The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat Immunol (2002) 2.35
Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res (2003) 2.31
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol (2008) 2.29
NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J (2003) 2.24
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med (2002) 2.23
Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat Rev Immunol (2009) 2.19
Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep (2003) 2.16
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol Cell (2002) 2.10
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol (2003) 2.04
Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo. Hepatology (2007) 1.95
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene (2004) 1.76
Retracted Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase. EMBO Rep (2002) 1.72
Increased rate of death related to presence of viremia among hepatitis C virus antibody-positive subjects in a community-based cohort study. Hepatology (2009) 1.66
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res (2005) 1.65
Upper gastrointestinal bleeding in patients receiving dual antiplatelet therapy after coronary stenting. Intern Med (2009) 1.64
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones (2002) 1.61
Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. J Biol Chem (2005) 1.60
Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem (2004) 1.60
Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE. Eur J Immunol (2014) 1.49
The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA. Chem Rev (1998) 1.49
Host sphingolipid biosynthesis as a target for hepatitis C virus therapy. Nat Chem Biol (2005) 1.47
A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytes. Gastroenterology (2013) 1.47
Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients. Clin Gastroenterol Hepatol (2005) 1.47
Telomerase activity and expression of human telomerase catalytic subunit gene in esophageal tissues. J Gastroenterol (2002) 1.47
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. Proc Natl Acad Sci U S A (2002) 1.45
Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem (2006) 1.44
Monocyte trans-endothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions. Int J Cardiol (2010) 1.44
Retracted Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature (2003) 1.44
Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection. Hepatology (2006) 1.43
Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells. J Gene Med (2004) 1.43
B cell signaling and tumorigenesis. Annu Rev Immunol (2005) 1.40
Possible prevention of fulminant hepatic failure in four children with acute severe hepatitis. J Gastroenterol (2004) 1.39
Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Nature (2003) 1.39
The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. J Cell Biol (2006) 1.39
Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice. Biochem Biophys Res Commun (2006) 1.38
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO J (2008) 1.37
Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf. Oncogene (2003) 1.37
Importance of TRF1 for functional telomere structure. J Biol Chem (2003) 1.37
MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 1.36
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J Immunol (2006) 1.35
Sequence-specific interference by small RNAs derived from adenovirus VAI RNA. FEBS Lett (2006) 1.31
Acute necrotizing esophagitis: role of nonsteroidal anti-inflammatory drugs. J Gastroenterol (2006) 1.30
Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev (2003) 1.28
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein. Mol Cell (2011) 1.28
Oligomeric organization of the B-cell antigen receptor on resting cells. Nature (2010) 1.27
Functional analysis of microRNAs during the retinoic acid-induced neuronal differentiation of human NT2 cells. Nucleic Acids Res Suppl (2003) 1.27
Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther (2004) 1.26
Effects on RNAi of the tight structure, sequence and position of the targeted region. Nucleic Acids Res (2004) 1.26
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell (2013) 1.25
p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. Cancer Res (2005) 1.25
Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. Oncogene (2005) 1.25
Control of siRNA expression using the Cre-loxP recombination system. Nucleic Acids Res (2004) 1.24
Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration. J Virol (2006) 1.21
Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood (2009) 1.21
Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J (2002) 1.19
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology (2005) 1.19
Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nat Struct Mol Biol (2008) 1.18
Exploration of human miRNA target genes in neuronal differentiation. Nucleic Acids Symp Ser (Oxf) (2005) 1.18
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J (2004) 1.18
B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol (2002) 1.18
A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2003) 1.17
Pathogenesis of hepatitis C virus infection in Tupaia belangeri. J Virol (2010) 1.17
Autoinhibition and adapter function of Syk. Immunol Rev (2009) 1.16
Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs. Antisense Nucleic Acid Drug Dev (2002) 1.15
Retracted siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res (2003) 1.14
Essential role of ATF-1 in induction of NOX1, a catalytic subunit of NADPH oxidase: involvement of mitochondrial respiratory chain. Biochem J (2005) 1.13
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol (2006) 1.12
Involvement of template-activating factor I/SET in transcription of adenovirus early genes as a positive-acting factor. J Virol (2006) 1.12
Functional analysis of histone methyltransferase g9a in B and T lymphocytes. J Immunol (2008) 1.12
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res (2003) 1.12
Perspectives on the nature of BCR-mediated survival signals. Mol Cell (2004) 1.12
PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via nuclear factor-kappaB activation. Mol Cancer Res (2009) 1.12
N-linked glycosylation selectively regulates autonomous precursor BCR function. Nat Immunol (2010) 1.11
MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells. Nucleic Acids Symp Ser (Oxf) (2004) 1.10
Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells. J Exp Med (2003) 1.10
Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis. Exp Cell Res (2007) 1.10
Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi. Int J Cancer (2006) 1.09
Enhanced B-cell activation mediated by TLR4 and BCR crosstalk. Eur J Immunol (2008) 1.09
B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2. Proc Natl Acad Sci U S A (2010) 1.08
Retracted Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries. Nat Biotechnol (2002) 1.08
Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells. J Virol (2004) 1.08
Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model. Biochem Biophys Res Commun (2006) 1.08
Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1. J Cell Biol (2006) 1.07
Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV. J Immunol (2008) 1.07
Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors. Exp Mol Med (2009) 1.07