Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 2789742)

Published in Cancer Lett on February 06, 2009

Authors

Mark A Feitelson1, Helena M G P V Reis, N Lale Tufan, Bill Sun, Jingbo Pan, Zhaorui Lian

Author Affiliations

1: Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA. feitelso@temple.edu

Articles cited by this

(truncated to the top 100)

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell (1998) 16.08

How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol (2001) 14.05

Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet (1981) 13.54

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07

Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA (2006) 10.58

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell (1995) 9.81

Lethal effect of the anti-Fas antibody in mice. Nature (1993) 9.20

Hepatitis B virus immunopathogenesis. Annu Rev Immunol (1995) 8.62

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (1994) 7.34

HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (1991) 5.34

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature (1990) 4.10

Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest (1998) 3.54

Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol (1994) 3.34

Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy. N Engl J Med (1991) 3.14

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J Virol (1993) 2.84

Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J Hepatol (1999) 2.46

Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene (2003) 2.37

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc Natl Acad Sci U S A (2005) 2.28

Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med (2007) 2.14

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am J Pathol (2002) 2.02

Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma. Am J Pathol (1997) 1.95

Chronic type B hepatitis and the "healthy" HBsAg carrier state. Hepatology (1987) 1.94

Hepatocarcinogenicity of the woodchuck hepatitis virus. Proc Natl Acad Sci U S A (1987) 1.93

IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J Immunol (1996) 1.85

Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J (2004) 1.84

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements. J Biol Chem (1991) 1.84

High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice. Hepatology (1994) 1.74

The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. Am J Pathol (2000) 1.73

Molecular functions and biological roles of hepatitis B virus x protein. Cancer Sci (2006) 1.72

Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat. Proc Natl Acad Sci U S A (1984) 1.71

Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis. J Exp Med (1994) 1.66

Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut (2005) 1.66

Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett (2006) 1.66

Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol Biol Cell (1995) 1.60

Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol Cell Biol (1997) 1.58

The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. J Clin Invest (2002) 1.55

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO J (1990) 1.54

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene (1988) 1.54

Hepatitis B virus replication and liver disease progression: the impact of antiviral therapy. Antivir Ther (2006) 1.53

Hepatitis B virus immunopathology. Springer Semin Immunopathol (1995) 1.52

Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell Immunol (1996) 1.49

Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization. EMBO J (1992) 1.43

Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp Cell Res (1994) 1.41

Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. J Biol Chem (2000) 1.40

Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis. Mol Biol Med (1990) 1.40

Expanding the lysyl hydroxylase toolbox: new insights into the localization and activities of lysyl hydroxylase 3 (LH3). J Cell Physiol (2007) 1.33

Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis. J Clin Invest (1996) 1.33

X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis. Cytokine Growth Factor Rev (2001) 1.27

The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes. Hepatology (1998) 1.27

Matrix metalloproteinases, the pros and cons, in liver fibrosis. J Gastroenterol Hepatol (2006) 1.27

Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo. J Virol (2006) 1.27

Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer. Cancer Res (1991) 1.25

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. Hepatology (1995) 1.22

Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues. Proc Natl Acad Sci U S A (1990) 1.20

Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice. J Immunol (1997) 1.19

HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis. Hepatology (1991) 1.19

Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci (2001) 1.17

The hepatitis B virus HBx protein inhibits caspase 3 activity. J Biol Chem (1998) 1.16

Molecular basis of hepatic fibrosis. Expert Rev Mol Med (2003) 1.14

TGF-beta antagonists: why suppress a tumor suppressor? J Clin Invest (2002) 1.11

In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA. J Clin Invest (2000) 1.10

Cross-talk in cell death signaling. J Exp Med (2000) 1.09

Hepatitis B virus transcriptional activators: mechanisms and possible role in oncogenesis. J Viral Hepat (1996) 1.07

Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis. Cancer Res (2006) 1.07

Fibronectin of human liver sinusoids binds hepatitis B virus: identification by an anti-idiotypic antibody bearing the internal image of the pre-S2 domain. J Virol (1995) 1.06

In vitro tumorigenicity of hepatitis B virus DNA and HBx protein. J Hepatol (1991) 1.06

Involvement of Fas system-mediated apoptosis in pathogenesis of viral hepatitis. J Viral Hepat (1999) 1.06

The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis. J Hepatol (2003) 1.05

Effect of the hepatitis B virus HBx protein on integrin-mediated adhesion to and migration on extracellular matrix. J Hepatol (2001) 1.05

Lysyl hydroxylase 3 (LH3) modifies proteins in the extracellular space, a novel mechanism for matrix remodeling. J Cell Physiol (2006) 1.04

The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells. Hepatology (2008) 1.04

The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases. Int J Cancer (2007) 1.04

Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells. Clin Cancer Res (1998) 1.02

How to modulate inflammatory cytokines in liver diseases. Liver Int (2006) 1.02

Hepatitis B X-gene expression in hepatocellular carcinoma. J Hepatol (1992) 1.00

The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene (2001) 1.00

Plasma tissue inhibitor of metalloproteinases-1 and transforming growth factor beta 1--possible non-invasive biomarkers of hepatic fibrosis in patients with chronic B and C hepatitis. Hepatogastroenterology (2002) 0.99

Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas. Int J Cancer (1999) 0.99

Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma. World J Gastroenterol (2005) 0.97

Expression of hepatitis B virus X protein is closely correlated with the high periportal inflammatory activity of liver diseases. J Viral Hepat (2001) 0.97

Expression of fas ligand in human hepatoma cell lines: role of hepatitis-B virus X (HBX) in induction of Fas ligand. Int J Cancer (1999) 0.96

Decreased expression of Bid in human hepatocellular carcinoma is related to hepatitis B virus X protein. Eur J Cancer (2001) 0.96

Apoptosis and proliferation in hepatocarcinogenesis related to cirrhosis. Cancer (2001) 0.96

Diagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis. World J Gastroenterol (2003) 0.95

Hepatitis B virus X protein induced expression of interleukin 18 (IL-18): a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection. J Hepatol (2002) 0.94

Perforin and Fas/Fas ligand-mediated cytotoxicity in acute and chronic woodchuck viral hepatitis. Clin Exp Immunol (1999) 0.94

Activation of the tumor necrosis factor-alpha system in the liver in chronic hepatitis B virus infection. Am J Gastroenterol (1996) 0.94

Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B. J Gen Virol (2001) 0.93

Early hepatocellular carcinoma that develops within macroregenerative nodules: growth rate depicted at serial MR imaging. Radiology (1995) 0.92

Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms. FASEB J (2001) 0.90

Fas and Fas ligand: strong co-expression in human hepatocytes surrounding hepatocellular carcinoma; can cancer induce suicide in peritumoural cells? J Pathol (2000) 0.90

Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. J Hepatol (2005) 0.90

Immunohistochemical analysis of pro-apoptotic Bid level in chronic hepatitis, hepatocellular carcinoma and liver metastases. Cancer Lett (2001) 0.90

Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein. Am J Pathol (2006) 0.89

Delayed Fas-mediated hepatocyte apoptosis during liver regeneration in mice: hepatoprotective role of TNF alpha. Hepatology (1998) 0.89

Liver fibrosis and chronic viral hepatitis. Arch Med Res (2007) 0.89

Association of a high activity of matrix metalloproteinase-9 to low levels of tissue inhibitors of metalloproteinase-1 and -3 in human hepatitis B-viral hepatoma cells. Int J Biochem Cell Biol (2004) 0.87

Effect of lamivudine treatment on plasma levels of transforming growth factor beta1, tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B. World J Gastroenterol (2004) 0.86

Management of chronic hepatitis B virus infection: a new era of disease control. Intern Med J (2006) 0.86

Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism. Cell Mol Immunol (2005) 0.86

Articles by these authors

Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer (2013) 2.87

Genetic mechanisms of hepatocarcinogenesis. Oncogene (2002) 2.21

Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? Cancer Res (2011) 1.33

Role of miR-148a in hepatitis B associated hepatocellular carcinoma. PLoS One (2012) 1.15

Early molecular and genetic determinants of primary liver malignancy. Surg Clin North Am (2004) 1.08

Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival. Neoplasia (2002) 1.06

Enhanced cell survival of gastric cancer cells by a novel gene URG4. Neoplasia (2006) 1.03

The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol Cell Biol (2011) 0.94

URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. J Cell Mol Med (2008) 0.89

Hepatitis C virus replication in stably transfected HepG2 cells promotes hepatocellular growth and tumorigenesis. J Cell Physiol (2004) 0.87

Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesis. Int J Cancer (2009) 0.87

The expression of novel gene URG4 in osteosarcoma: correlation with patients' prognosis. Pathology (2009) 0.85

The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin. J Gen Virol (2007) 0.83

Hepatitis B virus X antigen (HBxAg) and cell cycle control in chronic infection and hepatocarcinogenesis. Front Biosci (2005) 0.81

The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. Mol Cell Biol (2013) 0.81

Development of a novel mouse model to evaluate drug candidates against hepatitis B virus. Antivir Chem Chemother (2007) 0.80

Adenoviral-mediated RNA interference targeting URG11 inhibits growth of human hepatocellular carcinoma. Int J Cancer (2010) 0.80

Preparation and characterization of a specific monoclonal antibody against a new gene product: URG11. Hybridoma (Larchmt) (2006) 0.79

Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication. Antimicrob Agents Chemother (2012) 0.78

Paradigms for conditional expression of RNA interference molecules for use against viral targets. Methods Enzymol (2005) 0.78