Published in Lancet on November 21, 1981
The causal relation between human papillomavirus and cervical cancer. J Clin Pathol (2002) 14.73
Mapping by admixture linkage disequilibrium in human populations: limits and guidelines. Am J Hum Genet (1994) 7.16
The global burden of disease in 1990: summary results, sensitivity analysis and future directions. Bull World Health Organ (1994) 6.99
The Global Burden of Cancer 2013. JAMA Oncol (2015) 5.93
Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma. Hepatol Int (2010) 5.02
Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg (2000) 3.97
Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues. Proc Natl Acad Sci U S A (1991) 3.82
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci U S A (1994) 3.76
Does risk factor epidemiology put epidemiology at risk? Peering into the future. J Epidemiol Community Health (1998) 3.64
Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol (2008) 3.34
NCCN clinical practice guidelines in oncology: hepatobiliary cancers. J Natl Compr Canc Netw (2009) 3.25
The global epidemiology of hepatocellular carcinoma: present and future. Clin Liver Dis (2011) 2.96
Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer (2013) 2.87
Transcription of hepatitis B virus by RNA polymerase II. Mol Cell Biol (1983) 2.81
Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci U S A (2002) 2.71
The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J (1995) 2.68
Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer (2010) 2.68
Epidemiology and Prevention of Hepatitis B Virus Infection. Int J Med Sci (2005) 2.61
Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut (2004) 2.59
5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles. J Virol (1987) 2.54
Polymorphic admixture typing in human ethnic populations. Am J Hum Genet (1994) 2.37
Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B. Am J Pathol (2000) 2.23
Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J Clin Invest (1992) 2.20
Hepatitis B virus DNA contains a glucocorticoid-responsive element. Proc Natl Acad Sci U S A (1986) 2.18
Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc Natl Acad Sci U S A (1995) 2.11
Expression and replication of hepatitis B virus genome in transgenic mice. Proc Natl Acad Sci U S A (1989) 2.10
Viral and cellular determinants involved in hepadnaviral entry. World J Gastroenterol (2007) 2.07
Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. J Virol (1992) 2.04
Glypicans: proteoglycans with a surprise. J Clin Invest (2001) 1.99
Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol (1998) 1.96
Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma. Am J Pathol (1997) 1.95
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol (2001) 1.93
Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J Virol (2000) 1.93
Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int (2015) 1.92
Isolation of a hepadnavirus from the woolly monkey, a New World primate. Proc Natl Acad Sci U S A (1998) 1.90
In vitro and in vivo comparison of the abilities of purine and pyrimidine 2',3'-dideoxynucleosides to inhibit duck hepadnavirus. Antimicrob Agents Chemother (1989) 1.90
A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin. Proc Natl Acad Sci U S A (1985) 1.89
Should homosexuals be vaccinated against hepatitis B virus? Cost and benefit assessment. Br Med J (Clin Res Ed) (1983) 1.85
Hepatitis B virus-induced oncogenesis. World J Gastroenterol (2007) 1.82
DNA methylation in hepatocellular carcinoma. World J Gastroenterol (2008) 1.77
Validity of diagnostic codes and liver-related laboratory abnormalities to identify hepatic decompensation events in the Veterans Aging Cohort Study. Pharmacoepidemiol Drug Saf (2011) 1.76
Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus. J Virol (1992) 1.76
Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A (2009) 1.76
Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proc Natl Acad Sci U S A (1995) 1.72
Requirement of heat shock protein 90 for human hepatitis B virus reverse transcriptase function. J Virol (2004) 1.72
Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat. Proc Natl Acad Sci U S A (1984) 1.71
Development of hepatocellular carcinoma in autoimmune hepatitis patients: a case series. Dig Dis Sci (2010) 1.70
A niche for infectious disease in environmental health: rethinking the toxicological paradigm. Environ Health Perspect (2010) 1.69
Barriers to screening for hepatitis B virus infection in Asian Americans. Dig Dis Sci (2011) 1.69
Cancer risks and prevention practices among Vietnamese refugees. West J Med (1990) 1.68
Cancer burden from arsenic in drinking water in Bangladesh. Am J Public Health (2004) 1.68
Production of infectious duck hepatitis B virus in a human hepatoma cell line. J Virol (1988) 1.62
Hepatitis B virus and hepatocellular carcinoma. Int J Exp Pathol (2001) 1.59
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol Cell Biol (1997) 1.58
Cloning and analysis of integrated hepatitis virus sequences from a human hepatoma cell line. J Virol (1984) 1.57
Medical therapies for hepatocellular carcinoma: a critical view of the evidence. Nat Rev Gastroenterol Hepatol (2012) 1.57
The genome of hepatitis B virus contains a second enhancer: cooperation of two elements within this enhancer is required for its function. J Virol (1990) 1.55
Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei. Br J Cancer (1985) 1.54
The serology of chronic hepatitis B infection revisited. J Clin Invest (1993) 1.54
Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2'-deoxyguanosine. Proc Natl Acad Sci U S A (1989) 1.54
A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan. J Gastroenterol (2010) 1.53
HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study. Am J Gastroenterol (2008) 1.53
Sero-prevalence of hepatitis B virus infection in Balochistan Province of Pakistan. Saudi J Gastroenterol (2011) 1.53
In vitro reconstitution of a functional duck hepatitis B virus reverse transcriptase: posttranslational activation by Hsp90. J Virol (2000) 1.52
Properties of the human hepatitis B virus enhancer: position effects and cell-type nonspecificity. J Virol (1988) 1.51
Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. Br J Cancer (2001) 1.51
Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver. Proc Natl Acad Sci U S A (1994) 1.49
Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation. Proc Natl Acad Sci U S A (1986) 1.48
Viruses associated with human cancer. Biochim Biophys Acta (2007) 1.47
Molecular biology of hepatitis B virus infection. Virology (2015) 1.47
Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma. World J Gastroenterol (2001) 1.47
Regulation of hepatitis B virus gene expression by its two enhancers. Proc Natl Acad Sci U S A (1992) 1.45
Successful promotion of hepatitis B vaccinations among Vietnamese-American children ages 3 to 18: results of a controlled trial. Pediatrics (2003) 1.45
Hepatitis B and hepatocellular carcinoma. Hepatology (2009) 1.44
Significant influence of accompanying chronic hepatitis status on recurrence of hepatocellular carcinoma after hepatectomy. Result of multivariate analysis. Ann Surg (1996) 1.43
Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. J Virol (1987) 1.42
Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil. Antimicrob Agents Chemother (1996) 1.42
Epidemiological patterns of hepatitis B virus (HBV) in highly endemic areas. Epidemiol Infect (1996) 1.42
Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol (2010) 1.40
Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line. J Virol (1985) 1.39
Binding of nuclear factor EF-C to a functional domain of the hepatitis B virus enhancer region. Mol Cell Biol (1989) 1.39
Primary hepatocellular carcinoma following perinatal transmission of hepatitis B. West J Med (1988) 1.38
Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses. Mol Cell Biol (1993) 1.38
Epidemiology of hepatitis B infection in the Western Pacific and South East Asia. Gut (1996) 1.38
Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion. J Virol (2012) 1.36
Hepatitis B virus reverse transcriptase and epsilon RNA sequences required for specific interaction in vitro. J Virol (2006) 1.36
Hepatitis B virus pX activates NF-kappa B-dependent transcription through a Raf-independent pathway. J Virol (1996) 1.35
Adherence to screening for hepatocellular carcinoma among patients with cirrhosis or chronic hepatitis B in a community setting. Dig Dis Sci (2009) 1.34
Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma. Proc Natl Acad Sci U S A (1989) 1.34
Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors. J Virol (1992) 1.34
Medical virology of hepatitis B: how it began and where we are now. Virol J (2013) 1.34
Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells. Antimicrob Agents Chemother (1994) 1.33
Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis. J Clin Invest (1996) 1.33
Epidemiology and surveillance of hepatocellular carcinoma. Liver Cancer (2012) 1.32
Complex segregation analysis of primary hepatocellular carcinoma in Chinese families: interaction of inherited susceptibility and hepatitis B viral infection. Am J Hum Genet (1991) 1.30
Molecular mechanisms underlying occult hepatitis B virus infection. Clin Microbiol Rev (2012) 1.30
Persistence of infectious hepadnavirus in the offspring of woodchuck mothers recovered from viral hepatitis. J Clin Invest (1999) 1.29
Immunisation of infants at high risk of hepatitis B. Br Med J (Clin Res Ed) (1982) 1.27
Alternate translation initiation on hepatitis B virus X mRNA produces multiple polypeptides that differentially transactivate class II and III promoters. J Virol (1992) 1.27
The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice. EMBO J (2002) 1.27
Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet (1996) 12.96
Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer (1988) 7.05
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci U S A (1983) 7.01
Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med (1975) 5.49
Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine. Lancet (1983) 4.01
The e antigen and vertical transmission of hepatitis B surface antigen. Am J Epidemiol (1977) 3.07
Correlation of circulating capsular polysaccharide with bacteremia in pneumococcal pneumonia. Infect Immun (1972) 2.93
Unstable spiral modes in disk-shaped galaxies. Proc Natl Acad Sci U S A (1976) 2.30
GTP hydrolysis by arf-1 mediates sorting and concentration of Golgi resident enzymes into functional COP I vesicles. EMBO J (1999) 2.30
Efficacy of hepatitis B immune globulin for prevention of perinatal transmission of the hepatitis B virus carrier state: final report of a randomized double-blind, placebo-controlled trial. Hepatology (1983) 2.22
The chromosome constitution of 1000 human spermatozoa. Hum Genet (1983) 2.21
Life expectancy of patients with newly-diagnosed HIV infection in the era of highly active antiretroviral therapy. QJM (2007) 2.21
Postnatal infectivity of hepatitis B surface antigen-carrier mothers. J Infect Dis (1983) 2.20
Radial loops and helical coils coexist in metaphase chromosomes. Cell (1985) 2.09
HBeAg and anti-HBe detection by radioimmunoassay: correlation with vertical transmission of hepatitis B virus in Taiwan. J Med Virol (1979) 2.06
Surgical treatment of 109 patients with symptomatic and asymptomatic hepatocellular carcinoma. Surgery (1986) 1.98
Human centromeric DNAs. Hum Genet (1997) 1.94
cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway. Circulation (1997) 1.93
The prevalence of antibody to hepatitis A antigen in various parts of the world: a pilot study. Am J Epidemiol (1977) 1.86
Incidence of hepatitis B virus infections in preschool children in Taiwan. J Infect Dis (1982) 1.74
Outbreak of paralytic poliomyelitis, Taiwan. Lancet (1984) 1.68
Hepatitis B virus markers in Chinese twins. Anticancer Res (1989) 1.68
Pharmacokinetics of SCH 56592, a new azole broad-spectrum antifungal agent, in mice, rats, rabbits, dogs, and cynomolgus monkeys. Antimicrob Agents Chemother (2000) 1.64
Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma. Proc Natl Acad Sci U S A (1984) 1.59
Evidence against breast-feeding as a mechanism for vertical transmission of hepatitis B. Lancet (1975) 1.59
Denture stomatitis--a review of the aetiology, diagnosis and management. Aust Dent J (1992) 1.55
Exogenous adenosine 3': 5'-monophosphate can release yeast from catabolite repression. Biochem Biophys Res Commun (1978) 1.53
Pleomorphic adenoma with extensive necrosis: report of two cases. Oral Dis (2004) 1.51
Two human X-autosome translocations identified by autoradiography and fluorescence. Am J Hum Genet (1972) 1.48
Problems in the current case definitions of congenital syphilis. J Pediatr (1996) 1.46
Isolation of functional Golgi-derived vesicles with a possible role in retrograde transport. J Cell Biol (1998) 1.45
Haplotype analysis of the myotonic dystrophy type 1 (DM1) locus in Taiwan: implications for low prevalence and founder mutations of Taiwanese myotonic dystrophy type 1. Eur J Hum Genet (2001) 1.44
Prevention of clinical and subclinical rubella infection. Efficacy of three HPV-77 derivative vaccines. Am J Dis Child (1969) 1.43
Outcome of perinatal hepatitis B virus exposure is dependent on maternal virus load. J Infect Dis (1994) 1.41
Endolymphatic sac ballooning surgery for Menière's disease. Ann Otol Rhinol Laryngol (1994) 1.41
Serial changes of serum interleukin-6, interleukin-8, and tumor necrosis factor alpha among patients with Kawasaki disease. J Pediatr (1992) 1.40
Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect. Proc Natl Acad Sci U S A (1981) 1.40
Absorption of subcutaneous injection of Tc-99m pertechnetate via acupuncture points and non-acupuncture points. Am J Chin Med (1994) 1.40
HIV-related malignancies: community-based study using linkage of cancer registry and HIV registry data. Int J STD AIDS (1999) 1.38
Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. Oncogene (1993) 1.36
Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral Oncol (1999) 1.35
Purification and properties of a nicotinamide adenine dinucleotide-linked dehydrogenase that serves an Escherichia coli mutant for glycerol catabolism. J Bacteriol (1979) 1.35
Chromosome analysis on 930 consecutive newborn children using quinacrine fluorescent banding technique. Hum Genet (1976) 1.33
Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. J Clin Invest (1991) 1.32
The role of hepatitis C in hepatocellular carcinoma: a case control study among Egyptian patients. J Clin Gastroenterol (2001) 1.32
Ring formation of chromosomes nos. 19 and 20. Cytogenetics (1972) 1.30
The incidence of congenital malformations in a Chinese population: the Taipei collaborative study. Teratology (1972) 1.30
Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance. Am J Transplant (2009) 1.29
NADP + -specific isocitrate dehydrogenase of Escherichia coli. I. Purification and characterization. Biochim Biophys Acta (1972) 1.29
Radical scavenger and antihepatotoxic activity of Ganoderma formosanum, Ganoderma lucidum and Ganoderma neo-japonicum. J Ethnopharmacol (1995) 1.28
Myxoid tumor of the oral cavity with features of superficial angiomyxoma: report of a case. J Oral Maxillofac Surg (1998) 1.26
Comparative studies on aetiology and epidemiology of viral conjunctivitis in three countries of East Asia--Japan, Taiwan and South Korea. Int J Epidemiol (1987) 1.26
Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res (2000) 1.24
Nitric oxide modulates epicardial coronary basal vasomotor tone in awake dogs. Am J Physiol (1990) 1.24
Changing trends of prostate cancer in Asia. Aging Male (2004) 1.24
Anti-inflammatory effects of emodin from ventilago leiocarpa. Am J Chin Med (1996) 1.23
Shigellosis in the United States: ten-year review of nationwide surveillance, 1964-1973. Am J Epidemiol (1976) 1.21
Carcinosarcoma of the renal pelvis: a case report with immunohistochemical study. Changgeng Yi Xue Za Zhi (1996) 1.20
Antiviral activity of Plantago major extracts and related compounds in vitro. Antiviral Res (2002) 1.20
[Clinical experience of laryngeal mask airway in lateral position during anesthesia]. Acta Anaesthesiol Sin (1995) 1.19
Prognostic histologic features of resected small hepatocellular carcinoma (HCC) in Taiwan. A comparison with resected large HCC. Cancer (1985) 1.18
Detection of alpha-foetoprotein messenger RNA in human hepatocellular carcinoma and hepatoblastoma tissue. Br J Cancer (1986) 1.17
Molecular events during the release of delta-aminolevulinate dehydratase from catabolite repression. J Bacteriol (1978) 1.14
Discrete spiral modes in disk galaxies: Some numerical examples based on density wave theory. Proc Natl Acad Sci U S A (1977) 1.13
Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab (2001) 1.13
Comparing whole body (18)F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphonate bone scan to detect bone metastases in patients with breast cancer. J Cancer Res Clin Oncol (2002) 1.12
Incidence and inheritance of the 1/29 and 14/20 Robertsonian translocations in Canadian beef cattle. Genome (1987) 1.12
Colorectal cancer in Egyptian patients under 40 years of age. Int J Cancer (1997) 1.11
In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids. J Antimicrob Chemother (2003) 1.11
Retrospective study on nasopharyngeal carcinoma. J Natl Cancer Inst (1973) 1.11
Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis. Phytother Res (2001) 1.10
Sexual behaviour, STDs and drug use in a crack house population. Int J STD AIDS (1999) 1.10
[9-14C]Fluorene hydroperoxide as a possible intermediate in the hydroxylation of [9-14C]fluorene by rat liver homogenate. Biochim Biophys Acta (1969) 1.10
Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res (1998) 1.10
Low prevalence of rheumatoid arthritis in Chinese. Prevalence survey in a rural community. J Rheumatol Suppl (1983) 1.08
Application of FTA sample collection and DNA purification system on the determination of CTG trinucleotide repeat size by PCR-based Southern blotting. J Clin Lab Anal (1999) 1.08
Schizotypy in community samples: the three-factor structure and correlation with sustained attention. J Abnorm Psychol (1997) 1.08
Conservation of human gamma-X centromeric satellite DNA among primates with an autosomal localization in certain Old World monkeys. Chromosome Res (1999) 1.08
Mechanism of aliphatic hydroxylation. Tetralin hydroperoxide as an intermediate in the hydroxylation of tetralin in rat-liver homogenate. Biochim Biophys Acta (1968) 1.08
Hepatocellular carcinoma and hepatitis B virus. Semin Liver Dis (1984) 1.07
Identification of partial 12 trisomy by quinacrine fluorescence. J Pediatr (1973) 1.07
Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. Cancer Lett (1997) 1.07
Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Am J Chin Med (2000) 1.06
Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb. Am J Chin Med (2001) 1.06
An outbreak of N-hexane induced polyneuropathy among press proofing workers in Taipei. Am J Ind Med (1986) 1.06