Published in Dev Biol on January 08, 2009
A comprehensive map of insulator elements for the Drosophila genome. PLoS Genet (2010) 3.25
Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome. PLoS Biol (2012) 2.29
Insulators and promoters: closer than we think. Nat Rev Genet (2010) 1.66
Epigenomics reveals a functional genome anatomy and a new approach to common disease. Nat Biotechnol (2010) 1.56
A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber. Proc Natl Acad Sci U S A (2011) 1.45
Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. PLoS Genet (2011) 1.41
RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function. Genes Dev (2011) 1.38
A view of nuclear Polycomb bodies. Curr Opin Genet Dev (2011) 1.31
Comprehensive identification and annotation of cell type-specific and ubiquitous CTCF-binding sites in the human genome. PLoS One (2012) 1.23
Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks. Bioessays (2013) 1.13
Insulator protein Su(Hw) recruits SAGA and Brahma complexes and constitutes part of Origin Recognition Complex-binding sites in the Drosophila genome. Nucleic Acids Res (2013) 1.10
The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity. PLoS One (2009) 1.07
H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex. Elife (2014) 1.03
Roles of chromatin insulator proteins in higher-order chromatin organization and transcription regulation. Nucleus (2011) 1.02
Identifying regulatory elements in eukaryotic genomes. Brief Funct Genomic Proteomic (2009) 1.02
The CCCTC-binding factor (CTCF) of Drosophila contributes to the regulation of the ribosomal DNA and nucleolar stability. PLoS One (2011) 1.00
Surviving an identity crisis: a revised view of chromatin insulators in the genomics era. Biochim Biophys Acta (2013) 0.98
The phylogenetic distribution of non-CTCF insulator proteins is limited to insects and reveals that BEAF-32 is Drosophila lineage specific. J Mol Evol (2009) 0.95
Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster. BMC Biol (2015) 0.92
Selective interactions of boundaries with upstream region of Abd-B promoter in Drosophila bithorax complex and role of dCTCF in this process. Nucleic Acids Res (2010) 0.92
Initiator elements function to determine the activity state of BX-C enhancers. PLoS Genet (2010) 0.92
The chromatin insulator CTCF and the emergence of metazoan diversity. Proc Natl Acad Sci U S A (2012) 0.90
DNA topoisomerase II modulates insulator function in Drosophila. PLoS One (2011) 0.89
Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development. Nucleic Acids Res (2014) 0.89
Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions. Genome Biol (2015) 0.88
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin. J Biol Chem (2010) 0.87
A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking. PLoS One (2014) 0.86
The Drosophila homolog of the mammalian imprint regulator, CTCF, maintains the maternal genomic imprint in Drosophila melanogaster. BMC Biol (2010) 0.86
Chromatin domain boundary element search tool for Drosophila. Nucleic Acids Res (2012) 0.84
Highly conserved ENY2/Sus1 protein binds to Drosophila CTCF and is required for barrier activity. Epigenetics (2014) 0.84
A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. Nucleic Acids Res (2011) 0.83
The Drosophila eve insulator Homie promotes eve expression and protects the adjacent gene from repression by polycomb spreading. PLoS Genet (2013) 0.82
Chromatin insulators specifically associate with different levels of higher-order chromatin organization in Drosophila. Chromosoma (2009) 0.82
Chromosomal organization at the level of gene complexes. Cell Mol Life Sci (2010) 0.80
CTCF terminal segments are unstructured. Protein Sci (2010) 0.79
Functional Requirements for Fab-7 Boundary Activity in the Bithorax Complex. Mol Cell Biol (2015) 0.79
A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts. FEBS Lett (2009) 0.78
The boundary paradox in the Bithorax complex. Mech Dev (2015) 0.77
An Organizational Hub of Developmentally Regulated Chromatin Loops in the Drosophila Antennapedia Complex. Mol Cell Biol (2015) 0.76
Insulators: linking genome architecture to gene regulation. F1000 Biol Rep (2009) 0.75
CTCF interacts with the lytic HSV-1 genome to promote viral transcription. Sci Rep (2017) 0.75
Different Evolutionary Strategies to Conserve Chromatin Boundary Function in the Bithorax Complex. Genetics (2016) 0.75
Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters. World J Biol Chem (2016) 0.75
Topological organization and dynamic regulation of human tRNA genes during macrophage differentiation. Genome Biol (2017) 0.75
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
GObar: a gene ontology based analysis and visualization tool for gene sets. BMC Bioinformatics (2005) 10.55
A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature (2006) 9.88
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
From silencing to gene expression: real-time analysis in single cells. Cell (2004) 7.73
Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68
Detection of splice junctions from paired-end RNA-seq data by SpliceMap. Nucleic Acids Res (2010) 6.95
KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science (2003) 6.60
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol (2007) 6.54
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med (2010) 5.54
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell (2008) 4.57
Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ (2011) 4.50
AGRIS: Arabidopsis gene regulatory information server, an information resource of Arabidopsis cis-regulatory elements and transcription factors. BMC Bioinformatics (2003) 3.61
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res (2008) 3.57
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet (2004) 3.56
Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin Chem (2012) 3.35
Comprehensive splice-site analysis using comparative genomics. Nucleic Acids Res (2006) 3.30
Mapping of long-range associations throughout the fission yeast genome reveals global genome organization linked to transcriptional regulation. Nucleic Acids Res (2010) 2.96
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev (2009) 2.95
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res (2010) 2.82
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. Proc Natl Acad Sci U S A (2010) 2.81
CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep (2005) 2.80
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet (2013) 2.76
AGRIS and AtRegNet. a platform to link cis-regulatory elements and transcription factors into regulatory networks. Plant Physiol (2006) 2.62
High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Nat Methods (2012) 2.62
Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods (2004) 2.62
Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells. Curr Biol (2011) 2.53
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J (2010) 2.51
A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev (2007) 2.48
Bacterial argonaute samples the transcriptome to identify foreign DNA. Mol Cell (2013) 2.47
Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing. PLoS One (2011) 2.29
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24
piRNA production requires heterochromatin formation in Drosophila. Curr Biol (2011) 2.16
Screening pelvic examinations in asymptomatic, average-risk adult women: an evidence report for a clinical practice guideline from the American College of Physicians. Ann Intern Med (2014) 2.13
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature (2011) 2.11
Gramene 2013: comparative plant genomics resources. Nucleic Acids Res (2013) 2.08
CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol (2007) 2.07
A comparison of RNA-Seq and high-density exon array for detecting differential gene expression between closely related species. Nucleic Acids Res (2010) 2.07
Quantitative hepatic CT perfusion measurement: comparison of Couinaud's hepatic segments with dual-source 128-slice CT. Eur J Radiol (2012) 2.06
Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proc Natl Acad Sci U S A (2013) 2.05
Does CTCF mediate between nuclear organization and gene expression? Bioessays (2010) 2.02
Identification and remediation of biases in the activity of RNA ligases in small-RNA deep sequencing. Nucleic Acids Res (2011) 2.01
Kismeth: analyzer of plant methylation states through bisulfite sequencing. BMC Bioinformatics (2008) 2.01
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature (2013) 1.86
NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol (2007) 1.84
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF. J Biol Chem (2002) 1.81
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling. Proc Natl Acad Sci U S A (2011) 1.78
Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proc Natl Acad Sci U S A (2010) 1.77
Maternal plasma DNA analysis with massively parallel sequencing by ligation for noninvasive prenatal diagnosis of trisomy 21. Clin Chem (2009) 1.76
Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA. Clin Chem (2013) 1.72
Determinants of the inherent strength of human 5' splice sites. RNA (2005) 1.69
Intrinsic differences between authentic and cryptic 5' splice sites. Nucleic Acids Res (2003) 1.66
Nonhematopoietically derived DNA is shorter than hematopoietically derived DNA in plasma: a transplantation model. Clin Chem (2011) 1.63
In vivo tibiofemoral contact analysis using 3D MRI-based knee models. J Biomech (2004) 1.62
Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc Natl Acad Sci U S A (2003) 1.61
A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. EMBO J (2011) 1.58
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (2009) 1.57
An examination of physiological mechanisms underlying the frequency-doubling illusion. Invest Ophthalmol Vis Sci (2002) 1.57
Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development. Genome Res (2011) 1.52
Inappropriate prescribing of proton pump inhibitors in older patients: effects of an educational strategy. Drugs Aging (2012) 1.52
Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. J Neurosci (2010) 1.52
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A (2010) 1.52
Conservation of small RNA pathways in platypus. Genome Res (2008) 1.51
Responses of primate retinal ganglion cells to perimetric stimuli. Invest Ophthalmol Vis Sci (2011) 1.51
Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray. Nucleic Acids Res (2004) 1.50
Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Mol Cell Biol (2002) 1.49
Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor. EMBO J (2003) 1.49
Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol (2013) 1.47
Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS One (2009) 1.45
Gender differences in efficacy of primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction. Chin Med J (Engl) (2008) 1.42
Widespread establishment and regulatory impact of Alu exons in human genes. Proc Natl Acad Sci U S A (2011) 1.40
A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator. J Biol Chem (2002) 1.34
The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol Cell (2012) 1.34
Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Nucleic Acids Res (2014) 1.34
Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes Dev (2009) 1.34
Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development (2008) 1.32
MPromDb update 2010: an integrated resource for annotation and visualization of mammalian gene promoters and ChIP-seq experimental data. Nucleic Acids Res (2010) 1.32
Inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes transdifferentiation of mouse myoblasts into myofibroblasts. PLoS One (2012) 1.30
A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo. Genes Dev (2010) 1.30
Short hairpin activated gene silencing in mammalian cells. Methods Mol Biol (2004) 1.28
CTCF binds the proximal exonic region of hTERT and inhibits its transcription. Nucleic Acids Res (2005) 1.27
High-density single-nucleotide polymorphism maps of the human genome. Genomics (2005) 1.27
OMGProm: a database of orthologous mammalian gene promoters. Bioinformatics (2004) 1.27
A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol Cell (2012) 1.26