Published in Genome Res on July 15, 2004
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet (2010) 10.71
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84
Widespread plasticity in CTCF occupancy linked to DNA methylation. Genome Res (2012) 2.45
CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol (2008) 2.24
CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex. PLoS Genet (2007) 2.12
CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol (2007) 2.07
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res (2007) 1.89
CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin. EMBO J (2005) 1.81
Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences. Genome Res (2009) 1.79
Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites. Mol Cell Biol (2005) 1.66
CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin. Chromosoma (2010) 1.56
Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity. PLoS Genet (2013) 1.50
Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1. Mol Cell Biol (2007) 1.40
Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Mol Cell Biol (2009) 1.40
DXZ4 chromatin adopts an opposing conformation to that of the surrounding chromosome and acquires a novel inactive X-specific role involving CTCF and antisense transcripts. Genome Res (2008) 1.40
Distinct epigenomic features in end-stage failing human hearts. Circulation (2011) 1.39
The CTCF insulator protein is posttranslationally modified by SUMO. Mol Cell Biol (2008) 1.37
Effects of cytosine methylation on transcription factor binding sites. BMC Genomics (2014) 1.31
Genome-wide studies of CCCTC-binding factor (CTCF) and cohesin provide insight into chromatin structure and regulation. J Biol Chem (2012) 1.25
Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation. Mol Cell Biol (2009) 1.14
CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization. Nucleic Acids Res (2012) 1.13
Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II. J Cell Biol (2011) 1.12
Architectural proteins: regulators of 3D genome organization in cell fate. Trends Cell Biol (2014) 1.12
CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer. Cell Rep (2014) 1.11
Epigenetic boundaries of tumour suppressor gene promoters: the CTCF connection and its role in carcinogenesis. J Cell Mol Med (2006) 1.11
Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch. Genome Res (2011) 1.10
Dynamic DNA cytosine methylation in the Populus trichocarpa genome: tissue-level variation and relationship to gene expression. BMC Genomics (2012) 1.10
Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression. PLoS One (2009) 1.05
Identifying regulatory elements in eukaryotic genomes. Brief Funct Genomic Proteomic (2009) 1.02
Applying whole-genome studies of epigenetic regulation to study human disease. Cytogenet Genome Res (2006) 1.01
Probe signal correction for differential methylation hybridization experiments. BMC Bioinformatics (2008) 0.99
Nuclear organization in the 3D space of the nucleus - cause or consequence? Curr Opin Genet Dev (2009) 0.97
The CTCF insulator protein forms an unusual DNA structure. BMC Mol Biol (2010) 0.96
A genetic screen supports a broad role for the Drosophila insulator proteins BEAF-32A and BEAF-32B in maintaining patterns of gene expression. Mol Genet Genomics (2006) 0.95
A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain. Mol Cell Biol (2006) 0.94
Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos. PLoS One (2012) 0.91
Macrosatellite epigenetics: the two faces of DXZ4 and D4Z4. Chromosoma (2009) 0.90
Context differences reveal insulator and activator functions of a Su(Hw) binding region. PLoS Genet (2008) 0.89
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin. J Biol Chem (2010) 0.87
Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity. Curr Genomics (2009) 0.87
Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites. PLoS One (2010) 0.87
The Drosophila homolog of the mammalian imprint regulator, CTCF, maintains the maternal genomic imprint in Drosophila melanogaster. BMC Biol (2010) 0.86
The insulator protein CTCF binding sites in the orf73/LANA promoter region of herpesvirus saimiri are involved in conferring episomal stability in latently infected human T cells. J Virol (2011) 0.86
Genome-wide and parental allele-specific analysis of CTCF and cohesin DNA binding in mouse brain reveals a tissue-specific binding pattern and an association with imprinted differentially methylated regions. Genome Res (2013) 0.84
Epigenetic methodologies for behavioral scientists. Horm Behav (2010) 0.82
The influence of cis-regulatory elements on DNA methylation fidelity. PLoS One (2012) 0.81
De-SUMOylation of CCCTC binding factor (CTCF) in hypoxic stress-induced human corneal epithelial cells. J Biol Chem (2012) 0.81
Distinct epigenetic domains separated by a CTCF bound insulator between the tandem genes, BLU and RASSF1A. PLoS One (2010) 0.81
Identification, genome mapping, and CTCF binding of potential insulators within the FXYD5-COX7A1 locus of human chromosome 19q13.12. Mamm Genome (2006) 0.79
Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus. Nucleic Acids Res (2013) 0.78
Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling. BMC Genomics (2015) 0.78
Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus. Am J Physiol Renal Physiol (2008) 0.76
CCCTC-binding factor controls its own nuclear transport via regulating the expression of importin 13. Mol Cells (2013) 0.76
Maps of cis-Regulatory Nodes in Megabase Long Genome Segments are an Inevitable Intermediate Step Toward Whole Genome Functional Mapping. Curr Genomics (2007) 0.75
CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells. PLoS One (2016) 0.75
CpG distribution and methylation pattern in porcine parvovirus. PLoS One (2013) 0.75
Variation of DNA Methylome of Zebrafish Cells under Cold Pressure. PLoS One (2016) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (2000) 12.97
CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet (2001) 6.80
In vivo cross-linking and immunoprecipitation for studying dynamic Protein:DNA associations in a chromatin environment. Methods (1999) 6.76
Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol Cell Biol (1986) 5.77
An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol (1996) 5.74
Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. Science (2001) 5.37
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr Biol (2000) 5.34
CTCF maintains differential methylation at the Igf2/H19 locus. Nat Genet (2002) 3.15
The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin Cancer Biol (2002) 2.66
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62
Methyl-CpG-binding proteins. Targeting specific gene repression. Eur J Biochem (2001) 2.25
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24
Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene. Nucleic Acids Res (2000) 1.59
CpG methylation regulates the Igf2/H19 insulator. Curr Biol (2001) 1.55
The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication. Curr Biol (2000) 1.55
Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF. Mol Cell Biol (2001) 1.48
A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator. J Biol Chem (2002) 1.34
Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Mol Cell Biol (2003) 1.21
EICO (Expression-based Imprint Candidate Organizer): finding disease-related imprinted genes. Nucleic Acids Res (2004) 1.05
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell (2008) 9.76
The epigenetic progenitor origin of human cancer. Nat Rev Genet (2006) 9.65
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet (2006) 8.99
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet (2004) 3.56
CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep (2005) 2.80
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science (2005) 2.72
The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin Cancer Biol (2002) 2.66
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24
CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol (2007) 2.07
Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest (2012) 2.03
Does CTCF mediate between nuclear organization and gene expression? Bioessays (2010) 2.02
Characterization of the RNA content of chromatin. Genome Res (2010) 1.99
Chromosome crosstalk in three dimensions. Nature (2009) 1.91
CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin. EMBO J (2005) 1.81
Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development (2010) 1.78
Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia. Blood (2011) 1.74
FOXP3 promoter demethylation reveals the committed Treg population in humans. PLoS One (2008) 1.73
Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development. Genes Dev (2009) 1.68
An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region. Mol Cell Biol (2004) 1.62
Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation. Hum Mol Genet (2005) 1.60
Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination. Leuk Lymphoma (2008) 1.54
Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Mol Cell Biol (2002) 1.49
Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor. EMBO J (2003) 1.49
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. Hum Mol Genet (2008) 1.47
Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res (2003) 1.46
Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS One (2009) 1.45
High-resolution circular chromosome conformation capture assay. Nat Protoc (2008) 1.44
Regulation of the mammalian epigenome by long noncoding RNAs. Biochim Biophys Acta (2008) 1.42
DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms. Semin Cancer Biol (2002) 1.41
Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization. Dev Biol (2009) 1.39
Epigenetics of imprinted long noncoding RNAs. Epigenetics (2009) 1.36
A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator. J Biol Chem (2002) 1.34
Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development (2008) 1.32
Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region. Mol Cell Biol (2008) 1.31
CTCF binds the proximal exonic region of hTERT and inhibits its transcription. Nucleic Acids Res (2005) 1.27
Heightened expression of CTCF in breast cancer cells is associated with resistance to apoptosis. Cancer Res (2005) 1.26
Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes. EMBO J (2008) 1.24
Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors. Nucleic Acids Res (2007) 1.23
Replication timing and epigenetic reprogramming of gene expression: a two-way relationship? Nat Rev Genet (2009) 1.22
Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. Genome Res (2009) 1.22
Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism. J Cell Sci (2006) 1.21
Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF. J Neurochem (2009) 1.20
CTCF regulates growth and erythroid differentiation of human myeloid leukemia cells. J Biol Chem (2005) 1.18
The KCNQ1OT1 imprinting control region and non-coding RNA: new properties derived from the study of Beckwith-Wiedemann syndrome and Silver-Russell syndrome cases. Hum Mol Genet (2011) 1.17
Immunoprecipitation techniques for the analysis of transcription factor complexes. Methods (2002) 1.16
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation. Mol Cell Biol (2009) 1.14
The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation. J Biol Chem (2006) 1.14
Bidirectional silencing and DNA methylation-sensitive methylation-spreading properties of the Kcnq1 imprinting control region map to the same regions. J Biol Chem (2003) 1.13
Regulation of the transcription factor, CTCF, by phosphorylation with protein kinase CK2. FEBS Lett (2005) 1.13
Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing. Development (2012) 1.11
Poly(ADP-ribosyl)ation and epigenetics. Is CTCF PARt of the plot? Cell Cycle (2005) 1.10
Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression. Clin Cancer Res (2007) 1.10
BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells. Nucleic Acids Res (2010) 1.04
Dynamic association of the mammalian insulator protein CTCF with centrosomes and the midbody. Exp Cell Res (2004) 1.03
Evolutionary diversification of SPANX-N sperm protein gene structure and expression. PLoS One (2007) 1.02
The structural complexity of the human BORIS gene in gametogenesis and cancer. PLoS One (2010) 1.02
Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome. Br J Haematol (2006) 1.02
Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colon. HFSP J (2008) 1.01