Published in Arthritis Res Ther on February 18, 2009
IL-33 regulates TNF-α dependent effects in synovial fibroblasts. Int J Mol Med (2012) 0.95
SPA0355, a thiourea analogue, inhibits inflammatory responses and joint destruction in fibroblast-like synoviocytes and mice with collagen-induced arthritis. Br J Pharmacol (2011) 0.92
Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk. PLoS One (2014) 0.86
Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo. J Cell Mol Med (2012) 0.83
Effects of testosterone, estrogen and progesterone on TNF-α mediated cellular damage in rat arthritic synovial fibroblasts. Rheumatol Int (2011) 0.81
A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose. Arthritis Res Ther (2013) 0.81
Effect of acetaminophen (paracetamol) on human osteosarcoma cell line MG63. Acta Pharmacol Sin (2010) 0.80
Applying refinement to the use of mice and rats in rheumatoid arthritis research. Inflammopharmacology (2015) 0.78
MicroRNA-126 affects rheumatoid arthritis synovial fibroblast proliferation and apoptosis by targeting PIK3R2 and regulating PI3K-AKT signal pathway. Oncotarget (2016) 0.76
Profiling the secretion of soluble mediators by end stage osteoarthritis synovial tissue explants reveals a reduced responsiveness to an inflammatory trigger. PLoS One (2013) 0.75
Human tissue in the evaluation of safety and efficacy of new medicines: a viable alternative to animal models? ISRN Pharm (2011) 0.75
Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Res Ther (2014) 0.75
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum (1988) 111.05
The matrix-degrading metalloproteinases. Bioessays (1992) 4.84
Matrix metalloproteinases: role in arthritis. Front Biosci (2006) 4.52
Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol (1996) 3.59
Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res (2000) 3.27
Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. J Biol Chem (1992) 2.58
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes. Biochem J (1987) 2.54
Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology (Oxford) (2006) 2.44
Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem (2003) 1.93
The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther (2006) 1.93
Early osteoarthritic changes of human femoral head cartilage subsequent to femoro-acetabular impingement. Osteoarthritis Cartilage (2003) 1.91
Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol (1992) 1.83
Cells of the synovium in rheumatoid arthritis. Macrophages. Arthritis Res Ther (2007) 1.83
Animal models of rheumatoid arthritis. J Musculoskelet Neuronal Interact (2001) 1.79
Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells. Arthritis Res (2000) 1.62
Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford) (2003) 1.58
Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10. Ann Rheum Dis (2002) 1.57
Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures. Arthritis Rheum (1997) 1.45
The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis. Arthritis Rheum (1990) 1.40
Interleukin-6: a new therapeutic target. Arthritis Res Ther (2006) 1.36
Cartilage oligomeric matrix protein and thrombospondin 1. Purification from articular cartilage, electron microscopic structure, and chondrocyte binding. Eur J Biochem (1994) 1.30
Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther (2007) 1.29
Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. Arthritis Res Ther (2008) 1.28
Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs. Matrix Biol (2003) 1.27
Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis Cartilage (2005) 1.24
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity. Arthritis Rheum (1999) 1.22
Studies on the ability of 65-kDa and 92-kDa tumor cell gelatinases to degrade type IV collagen. J Biol Chem (1990) 1.21
Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation. Osteoarthritis Cartilage (2006) 1.19
Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro. Biochem J (1999) 1.18
Influence of pro-inflammatory (IL-1 alpha, IL-6, TNF-alpha, IFN-gamma) and anti-inflammatory (IL-4) cytokines on chondrocyte function. Osteoarthritis Cartilage (2003) 1.15
Pannus invasion and cartilage degradation in rheumatoid arthritis: involvement of MMP-3 and interleukin-1beta. Clin Exp Rheumatol (2005) 1.15
A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis. Osteoarthritis Cartilage (2005) 1.07
Physiological and pathological secretion of cartilage oligomeric matrix protein by cells in culture. J Biol Chem (1998) 1.06
Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis. Arthritis Rheum (2001) 1.05
Anti-interleukin-1 and anti-CD44 interventions producing significant inhibition of cartilage destruction in an in vitro model of cartilage invasion by rheumatoid arthritis synovial fibroblasts. Arthritis Rheum (2000) 1.04
Interleukin-1beta-stimulated invasion of articular cartilage by rheumatoid synovial fibroblasts is inhibited by antibodies to specific integrin receptors and by collagenase inhibitors. Arthritis Rheum (1997) 1.04
Direct activation of human neutrophil procollagenase by recombinant stromelysin. Biochem J (1993) 1.03
Rheumatoid arthritis synovial fibroblast and U937 macrophage/monocyte cell line interaction in cartilage degradation. Arthritis Rheum (1997) 1.02
Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo. Arthritis Rheum (2003) 1.02
The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers. Arthritis Rheum (1996) 1.01
The effect of IL-1beta on the expression of inflammatory cytokines and their receptors in human chondrocytes. Life Sci (2006) 0.96
pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B. Biophys J (2000) 0.95
Collagen and proteoglycan turnover in focally damaged human ankle cartilage: evidence for a generalized response and active matrix remodeling across the entire joint surface. Arthritis Rheum (2006) 0.94
Interleukin-6 inhibition and clinical efficacy in rheumatoid arthritis treatment--data from randomized clinical trials. Bull NYU Hosp Jt Dis (2007) 0.92
Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants. Osteoarthritis Cartilage (2007) 0.92
Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation. Ann Rheum Dis (2004) 0.90
Using fluorogenic peptide substrates to assay matrix metalloproteinases. Methods Mol Biol (2001) 0.88
Development of in vitro model systems for destructive joint diseases: novel strategies for establishing inflammatory pannus. Arthritis Rheum (1997) 0.84
Development of a high-throughput screening assay based on the 3-dimensional pannus model for rheumatoid arthritis. J Biomol Screen (2007) 0.81
T and B cell-dependent pathways in rheumatoid arthritis. Curr Opin Rheumatol (1995) 0.81
Invasion of human cartilage by cultured multicellular spheroids of rheumatoid synovial cells--a novel in vitro model system for rheumatoid arthritis. J Rheumatol (1998) 0.80
TGF-beta and fibrosis in different organs - molecular pathway imprints. Biochim Biophys Acta (2009) 2.44
Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther (2007) 1.29
Reproducibility of allergen, endotoxin and fungi measurements in the indoor environment. J Expo Anal Environ Epidemiol (2003) 1.27
Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther (2011) 1.19
Cytokine mRNA and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis. Arthritis Res (2001) 1.01
Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane. Arthritis Res Ther (2008) 1.00
Batch correction of microarray data substantially improves the identification of genes differentially expressed in rheumatoid arthritis and osteoarthritis. BMC Med Genomics (2012) 0.95
Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha. Mol Biol Cell (2010) 0.95
IL-33 regulates TNF-α dependent effects in synovial fibroblasts. Int J Mol Med (2012) 0.95
Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis. Arthritis Res Ther (2005) 0.94
Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue. Am J Pathol (2003) 0.94
Preferential induction of prodestructive matrix metalloproteinase-1 and proinflammatory interleukin 6 and prostaglandin E2 in rheumatoid arthritis synovial fibroblasts via tumor necrosis factor receptor-55. J Rheumatol (2003) 0.93
Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha. EMBO Rep (2010) 0.93
Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis. Arthritis Res Ther (2005) 0.91
Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP. J Immunol (2009) 0.91
Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis. Arthritis Res Ther (2010) 0.91
Hepatic Fibrosis in a Long-term Murine Model of Sepsis. Shock (2012) 0.90
Robust computational reconstitution - a new method for the comparative analysis of gene expression in tissues and isolated cell fractions. BMC Bioinformatics (2006) 0.89
Design and validation of a bioreactor for simulating the cardiac niche: a system incorporating cyclic stretch, electrical stimulation, and constant perfusion. Tissue Eng Part A (2012) 0.88
Surgical preparation for articular cartilage regeneration without penetration of the subchondral bone plate: in vitro and in vivo studies in humans and sheep. Am J Sports Med (2011) 0.87
S100B and NSE as useful postmortem biochemical markers of traumatic brain injury in autopsy cases. J Neurotrauma (2013) 0.86
Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue. Eur J Pharmacol (2013) 0.84
Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-kappaB binding activity and TNF-alpha secretion of T cells. Arthritis Res (2002) 0.84
Adapted Boolean network models for extracellular matrix formation. BMC Syst Biol (2009) 0.84
ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling. Arthritis Rheum (2013) 0.83
Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation. Arthritis Res Ther (2014) 0.82
Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients. J Cell Physiol (2015) 0.82
Expression of platelet-derived growth factors C and D in the synovial membrane of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum (2006) 0.82
Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients. Arthritis Res Ther (2011) 0.81
Ephrin-A1/EphA4-mediated adhesion of monocytes to endothelial cells. Biochim Biophys Acta (2013) 0.81
A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose. Arthritis Res Ther (2013) 0.81
OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway. Basic Res Cardiol (2011) 0.80
Gastric epithelial expression of IL-12 cytokine family in Helicobacter pylori infection in human: is it head or tail of the coin? PLoS One (2013) 0.80
Effects of the PPARγ agonist pioglitazone on coronary atherosclerotic plaque composition and plaque progression in non-diabetic patients: a double-center, randomized controlled VH-IVUS pilot-trial. Heart Vessels (2014) 0.79
Site-specific intraoperative efficacy of arthroscopic knee joint synovectomy in rheumatoid arthritis. Arthroscopy (2005) 0.78
An ovine in vitro model for chondrocyte-based scaffold-assisted cartilage grafts. J Orthop Surg Res (2012) 0.78
A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts. Ann Rheum Dis (2011) 0.77
Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients. BMC Med Genomics (2014) 0.77
(Auto)immunity to cartilage matrix proteins - a time bomb? Arthritis Res Ther (2013) 0.75
Cytocompatibility of polymer-based periodontal bone substitutes in gingival fibroblast and MC3T3 osteoblast cell cultures. Dent Mater (2012) 0.75
[What can experimental research offer to rheumatology today--the viewpoint of molecular biology? Contribution of molecular biology to pathogenesis research in rheumatology using the example of rheumatoid arthritis]. Z Rheumatol (2002) 0.75