| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.
|
Proc Natl Acad Sci U S A
|
2006
|
4.64
|
|
2
|
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.
|
Proc Natl Acad Sci U S A
|
2004
|
3.07
|
|
3
|
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.
|
Proc Natl Acad Sci U S A
|
2002
|
2.28
|
|
4
|
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
|
Biochim Biophys Acta
|
2009
|
2.05
|
|
5
|
Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.
|
J Clin Hypertens (Greenwich)
|
2007
|
1.59
|
|
6
|
Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis.
|
J Neurosci
|
2007
|
1.40
|
|
7
|
Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes.
|
Transl Res
|
2010
|
1.40
|
|
8
|
Glutathione metabolism during aging and in Alzheimer disease.
|
Ann N Y Acad Sci
|
2004
|
1.36
|
|
9
|
Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.
|
Free Radic Biol Med
|
2003
|
1.24
|
|
10
|
Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.
|
Circulation
|
2007
|
1.21
|
|
11
|
Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid.
|
FASEB J
|
2002
|
1.19
|
|
12
|
Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.
|
IUBMB Life
|
2008
|
1.15
|
|
13
|
Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation.
|
Antioxid Redox Signal
|
2008
|
1.15
|
|
14
|
(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis.
|
Arch Biochem Biophys
|
2004
|
1.14
|
|
15
|
Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.
|
Aging Cell
|
2006
|
1.06
|
|
16
|
Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.
|
Annu Rev Nutr
|
2013
|
1.02
|
|
17
|
Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response.
|
Biochim Biophys Acta
|
2012
|
1.00
|
|
18
|
Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.
|
Arch Biochem Biophys
|
2003
|
0.98
|
|
19
|
Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age.
|
Arch Biochem Biophys
|
2006
|
0.97
|
|
20
|
Oxidative stress, redox imbalance, and the aging process.
|
Antioxid Redox Signal
|
2003
|
0.97
|
|
21
|
Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production?
|
Semin Cell Dev Biol
|
2012
|
0.96
|
|
22
|
Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion.
|
Arch Biochem Biophys
|
2009
|
0.93
|
|
23
|
Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?
|
Aging Cell
|
2012
|
0.91
|
|
24
|
Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart.
|
Arch Biochem Biophys
|
2009
|
0.91
|
|
25
|
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
|
Biogerontology
|
2008
|
0.89
|
|
26
|
Mass tagging approach for mitochondrial thiol proteins.
|
J Proteome Res
|
2005
|
0.88
|
|
27
|
Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.
|
Redox Rep
|
2005
|
0.88
|
|
28
|
Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations.
|
Biochem Biophys Res Commun
|
2010
|
0.86
|
|
29
|
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
|
Antioxid Redox Signal
|
2003
|
0.85
|
|
30
|
Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element.
|
Pharmacol Res
|
2009
|
0.85
|
|
31
|
(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria.
|
Pharmacol Res
|
2010
|
0.84
|
|
32
|
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
|
Am J Physiol Regul Integr Comp Physiol
|
2011
|
0.84
|
|
33
|
Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.
|
Ann N Y Acad Sci
|
2010
|
0.84
|
|
34
|
Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes.
|
Redox Rep
|
2004
|
0.84
|
|
35
|
Thiol supplementation inhibits metalloproteinase activity independent of glutathione status.
|
Biochem Biophys Res Commun
|
2007
|
0.84
|
|
36
|
Nutritional strategies for healthy cardiovascular aging: focus on micronutrients.
|
Pharmacol Res
|
2007
|
0.81
|
|
37
|
Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1.
|
Am J Physiol Cell Physiol
|
2009
|
0.81
|
|
38
|
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
|
Mech Ageing Dev
|
2012
|
0.81
|
|
39
|
A rat primary hepatocyte culture model for aging studies.
|
Curr Protoc Toxicol
|
2008
|
0.81
|
|
40
|
Antioxidants to enhance fertility: role of eNOS and potential benefits.
|
Pharmacol Res
|
2011
|
0.80
|
|
41
|
OLAM: A wearable, non-contact sensor for continuous heart-rate and activity monitoring.
|
Conf Proc IEEE Eng Med Biol Soc
|
2011
|
0.79
|
|
42
|
A new twist on an old vitamin: human polymorphisms in the gene encoding the sodium-dependent vitamin C transporter 1.
|
Am J Clin Nutr
|
2010
|
0.78
|
|
43
|
Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.
|
Pharmacol Res
|
2012
|
0.78
|
|
44
|
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
|
Biochem Biophys Res Commun
|
2004
|
0.78
|
|
45
|
Transcription factor Nrf2: examination of nuclear protein levels by immunoblotting and promoter response element binding by chromatin immunoprecipitation (ChIP).
|
Curr Protoc Toxicol
|
2010
|
0.77
|
|
46
|
Safety of long-term feeding of dl-alpha-lipoic acid and its effect on reduced glutathione:oxidized glutathione ratios in beagles.
|
Vet Ther
|
2002
|
0.76
|
|
47
|
Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats.
|
Biochem Pharmacol
|
2005
|
0.76
|