Published in Proc Natl Acad Sci U S A on February 19, 2002
Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59
Mitochondria in neuroplasticity and neurological disorders. Neuron (2008) 3.35
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A (2004) 3.07
Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell (2007) 2.13
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol (2008) 2.09
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta (2009) 2.05
Role of carnitine in disease. Nutr Metab (Lond) (2010) 1.63
An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc Natl Acad Sci U S A (2004) 1.61
Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci U S A (2006) 1.48
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 1.46
Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxid Redox Signal (2010) 1.37
Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy. Exp Gerontol (2008) 1.36
Mitochondria and neuroplasticity. ASN Neuro (2010) 1.36
Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. J Neurochem (2008) 1.35
RNA under attack: cellular handling of RNA damage. Crit Rev Biochem Mol Biol (2009) 1.32
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci U S A (2002) 1.29
Obesity and vulnerability of the CNS. Biochim Biophys Acta (2008) 1.29
Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2007) 1.20
Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev (2012) 1.13
Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword. J Alzheimers Dis (2011) 1.13
The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. J Neuropathol Exp Neurol (2012) 1.09
(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci (2005) 1.06
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. J Neurol Sci (2009) 1.04
N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology (2011) 1.02
Magnesium and muscle performance in older persons: the InCHIANTI study. Am J Clin Nutr (2006) 1.00
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. J Cell Mol Med (2008) 0.98
Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp Neurol (2009) 0.97
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. J Neurosci (2014) 0.97
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res (2008) 0.96
Oxidative damage to RNA in neurodegenerative diseases. J Biomed Biotechnol (2006) 0.96
Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies. Drugs Aging (2010) 0.95
Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med (2008) 0.95
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Antioxid Redox Signal (2013) 0.94
Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson's disease. Front Aging Neurosci (2010) 0.93
Biology of ageing and role of dietary antioxidants. Biomed Res Int (2014) 0.93
Mechanisms of chemotherapy-induced behavioral toxicities. Front Neurosci (2015) 0.92
Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior. Mol Cell Biol (2010) 0.92
Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging. Vet Clin North Am Small Anim Pract (2008) 0.90
Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease. J Cell Mol Med (2010) 0.89
Characterization of RNA damage under oxidative stress in Escherichia coli. Biol Chem (2012) 0.88
Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. PLoS One (2013) 0.88
Marine Carotenoids against Oxidative Stress: Effects on Human Health. Mar Drugs (2015) 0.87
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Free Radic Biol Med (2012) 0.87
Are ancient proteins responsible for the age-related decline in health and fitness? Rejuvenation Res (2010) 0.87
Aging--RNA in development and disease. Wiley Interdiscip Rev RNA (2011) 0.87
Mitochondria in the elderly: Is acetylcarnitine a rejuvenator? Adv Drug Deliv Rev (2009) 0.87
Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction. PLoS One (2012) 0.86
Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb. Pulm Pharmacol Ther (2012) 0.85
Mitochondrial Dysfunction during Brain Aging: Role of Oxidative Stress and Modulation by Antioxidant Supplementation. Aging Dis (2011) 0.85
Age-related memory impairments due to reduced blood glucose responses to epinephrine. Neurobiol Aging (2009) 0.85
Metabolic disturbances in diseases with neurological involvement. Aging Dis (2013) 0.84
Novel therapeutics for Alzheimer's disease: an update. Curr Opin Drug Discov Devel (2010) 0.84
Frontiers in Alzheimer's disease therapeutics. Ther Adv Chronic Dis (2011) 0.84
α-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet. Nutr Res Pract (2012) 0.84
n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice. Front Aging Neurosci (2014) 0.83
Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal (2010) 0.83
Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients. EMBO Rep (2005) 0.83
Sublethal RNA oxidation as a mechanism for neurodegenerative disease. Int J Mol Sci (2008) 0.83
Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. J Cereb Blood Flow Metab (2013) 0.82
Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. J Nucleic Acids (2010) 0.82
Changes in expression of manganese superoxide dismutase, copper and zinc superoxide dismutase and catalase in Brachionus calyciflorus during the aging process. PLoS One (2013) 0.82
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol (2009) 0.81
Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass. Neurosci Bull (2014) 0.81
Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. PLoS One (2013) 0.81
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. Mech Ageing Dev (2012) 0.81
Evaluation of lenticular antioxidant and redox system components in the lenses of acetyl-L-carnitine treatment in BSO-induced glutathione deprivation. Mol Vis (2009) 0.81
Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease. Exp Mol Med (2015) 0.80
Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults. Am J Epidemiol (2010) 0.79
An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe. Free Radic Res (2010) 0.79
Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. PLoS One (2015) 0.79
Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation. Biochim Biophys Acta (2015) 0.79
Plasma carotenoids and tocopherols and cognitive function: a prospective study. Neurobiol Aging (2007) 0.79
Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study. Pharmacol Res (2012) 0.78
The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men. Int J Endocrinol (2014) 0.78
D-galactose induces a mitochondrial complex I deficiency in mouse skeletal muscle: potential benefits of nutrient combination in ameliorating muscle impairment. J Med Food (2014) 0.78
Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes. Biochim Biophys Acta (2014) 0.78
Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103. Sci Rep (2015) 0.78
A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol (2013) 0.78
Oxidative damage, aging and anti-aging strategies. Age (Dordr) (2005) 0.78
Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice. Exp Gerontol (2014) 0.78
Quality control of chemically damaged RNA. Cell Mol Life Sci (2016) 0.78
A nutraceutical a day may keep the doctor away. Consumers are turning increasingly to food supplements to improve well-being when pharmaceuticals fail. EMBO Rep (2005) 0.77
Quantification of oxidized levels of specific RNA species using an aldehyde reactive probe. Anal Biochem (2011) 0.77
Cognitive Aging and Time Perception: Roles of Bayesian Optimization and Degeneracy. Front Aging Neurosci (2016) 0.77
Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease. Pharmaceuticals (Basel) (2010) 0.76
Metabolite profile of a mouse model of Charcot-Marie-Tooth type 2D neuropathy: implications for disease mechanisms and interventions. Biol Open (2016) 0.76
Pifithrin-µ prevents cisplatin-induced chemobrain by preserving neuronal mitochondrial function. Cancer Res (2016) 0.76
Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants. PLoS One (2015) 0.76
Functional and Structural Benefits Induced by Omega-3 Polyunsaturated Fatty Acids During Aging. Curr Neuropharmacol (2017) 0.76
Reply to Arduini et al.: Acetyl-l-carnitine and the brain: Epigenetics, energetics, and stress. Proc Natl Acad Sci U S A (2016) 0.75
Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxid Med Cell Longev (2016) 0.75
A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome. Int J Clin Exp Med (2015) 0.75
Increased Consumption of Fruit and Vegetables Is Related to a Reduced Risk of Cognitive Impairment and Dementia: Meta-Analysis. Front Aging Neurosci (2017) 0.75
Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats. Neurotox Res (2016) 0.75
Protein lysine-Nζ alkylation and O-phosphorylation mediated by DTT-generated reactive oxygen species. Protein Sci (2013) 0.75
Selective deposition of dietary α-lipoic acid in mitochondrial fraction and its synergistic effect with α-tocoperhol acetate on broiler meat oxidative stability. Lipids Health Dis (2013) 0.75
Collaborative Power of Nrf2 and PPARγ Activators against Metabolic and Drug-Induced Oxidative Injury. Oxid Med Cell Longev (2017) 0.75
Prospects for therapeutic mitochondrial transplantation. Mitochondrion (2017) 0.75
Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods (1984) 16.43
Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A (1993) 13.27
Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A (1994) 6.84
Alzheimer's disease: a disorder of cortical cholinergic innervation. Science (1983) 4.40
Mitochondrial abnormalities in Alzheimer's disease. J Neurosci (2001) 4.39
Inactivation of key metabolic enzymes by mixed-function oxidation reactions: possible implication in protein turnover and ageing. Proc Natl Acad Sci U S A (1983) 2.98
RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci (1999) 2.86
Carnitine. Annu Rev Biochem (1988) 2.74
Protein oxidation. Ann N Y Acad Sci (2000) 2.57
Age-related reductions in human recognition memory due to impaired encoding. Science (1995) 2.53
Isolation of an internal clock. J Exp Psychol Anim Behav Process (1981) 2.46
Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci (1999) 2.41
The use of the Morris Water Maze in the study of memory and learning. Int J Neurosci (1989) 2.28
Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med (1997) 1.99
Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc Natl Acad Sci U S A (1996) 1.97
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Proc Natl Acad Sci U S A (1991) 1.96
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. Proc Natl Acad Sci U S A (1992) 1.76
Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions. Exp Brain Res (1985) 1.59
Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task. Neurobiol Learn Mem (1999) 1.55
Carnitine function and requirements during the life cycle. FASEB J (1992) 1.54
Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J Neurosci (1990) 1.51
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 1.46
Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci U S A (1998) 1.41
(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J (1999) 1.40
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci U S A (2002) 1.29
Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription. Adv Pharmacol (1997) 1.27
Oxidative base damage in RNA detected by reverse transcriptase. Nucleic Acids Res (1995) 1.26
(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal (2000) 1.20
Adjusting to changes in the time of reinforcement: peak-interval transitions in rats. J Exp Psychol Anim Behav Process (1997) 1.15
Psychomotor and spatial memory performance in aging male Fischer 344 rats. Exp Gerontol (1998) 1.12
Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task. Brain Res (1998) 1.10
Chronic antioxidant treatment improves the cognitive performance of aged rats. Brain Res (1995) 1.09
Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. Am J Otol (2000) 1.07
Spatial learning and memory as a function of age in the dog. Behav Neurosci (1995) 1.07
Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome. Ann N Y Acad Sci (1999) 1.05
Acetyl-1-carnitine. 2: Effects on learning and memory performance of aged rats in simple and complex mazes. Neurobiol Aging (1990) 0.97
Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone. Ann N Y Acad Sci (1998) 0.97
A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev (1999) 0.97
Alpha-lipoic acid as a new treatment option for Alzheimer [corrected] type dementia. Arch Gerontol Geriatr (2001) 0.94
Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats. Neurosci Lett (1996) 0.92
The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits. Pharmacol Biochem Behav (1993) 0.92
Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain. Int J Clin Pharmacol Ther Toxicol (1986) 0.90
The basic pattern of activation in motor and sensory temporal tasks: positron emission tomography data. Neurosci Lett (1997) 0.89
Rotation of water in the Morris water maze interferes with path integration mechanisms of place navigation. Neurobiol Learn Mem (1997) 0.89
Quantification of swim patterns in the Morris water maze. Behav Res Methods Instrum Comput (2000) 0.88
Possible confounding influence of strain, age and gender on cognitive performance in rats. Brain Res Cogn Brain Res (1996) 0.87
Arginine vasopressin innoculates against age-related increases in sodium-dependent high affinity choline uptake and discrepancies in the content of temporal memory. Eur J Pharmacol (1986) 0.87
Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine. Mech Ageing Dev (1995) 0.87
Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res (1990) 0.86
Role of protein oxidation in aging and in age-associated neurodegenerative diseases. Life Sci (1994) 0.86
Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Curr Med Res Opin (1990) 0.86
The effects of AMPA-induced lesions of the medial septum and vertical limb nucleus of the diagonal band of Broca on spatial delayed non-matching to sample and spatial learning in the water maze. Eur J Neurosci (1995) 0.85
Maze performance: a direct comparison of food vs. water mazes. Pharmacol Biochem Behav (1988) 0.85
Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. J Neurosci Res (2001) 0.85
Effects of vitamin E on ozone-induced memory deficits and lipid peroxidation in rats. Neuroreport (1999) 0.84
Acquisition and long-term retention of a two-lever DRL schedule: comparison between mature and aged rats. Neurobiol Aging (1991) 0.84
The effects of dietary antioxidants on psychomotor performance in aged mice. Exp Gerontol (1999) 0.84
Dynamic morphology of the synaptic junctional areas during aging: the effect of chronic acetyl-L-carnitine administration. Brain Res (1994) 0.82
Characterization of enzymatic acetylcholine synthesis by mouse brain, rat sperm, and purified carnitine acetyltransferase. Biochem Pharmacol (1981) 0.82
Spatial memory and NGF levels in aged rats: natural variability and effects of acetyl-L-carnitine treatment. Exp Gerontol (1998) 0.82
Active avoidance learning in old rats chronically treated with levocarnitine acetyl. Physiol Behav (1992) 0.82
In search of molecular memory: experience-driven protein synthesis. Cell Mol Life Sci (2000) 0.81
Animal models of declining memory in the aged: short-term and spatial memory in the aged rat. J Gerontol (1980) 0.81
Acute exposure to a 60 Hz magnetic field affects rats' water-maze performance. Bioelectromagnetics (1998) 0.81
Decline and preservation of reversal learning abilities and acquisition in the course of senescence. Neurosci Lett (1995) 0.80
Spatial memory in aged rats: population heterogeneity and effect of levocarnitine acetyl. J Neurosci Res (1992) 0.79
Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in mitochondria of aged rats. J Nutr Biochem (2001) 0.78
Effects of age on long-term memory: retention of fixed interval responding. J Gerontol (1981) 0.78
Age-dependent deficits in radial maze performance in the rat: effect of chronic treatment with acetyl-L-carnitine. Prog Neuropsychopharmacol Biol Psychiatry (1990) 0.77
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (2003) 18.18
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods (2005) 7.62
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A (2006) 4.64
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener (2007) 4.15
Neurobiology of exercise. Obesity (Silver Spring) (2006) 3.39
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci (2005) 3.27
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A (2004) 3.07
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80
Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci (2009) 2.48
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A (2008) 2.29
Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr (2005) 2.21
Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J (2007) 2.17
Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J (2003) 2.14
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis (2009) 2.12
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta (2009) 2.05
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr (2007) 2.05
Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem (2008) 2.04
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol (2003) 2.02
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc Natl Acad Sci U S A (2002) 1.93
Retracted Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun (2008) 1.91
Patterned cell culture inside microfluidic devices. Lab Chip (2004) 1.89
Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc (2002) 1.81
APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Neurology (2009) 1.74
Microfluidic Multicompartment Device for Neuroscience Research. Langmuir (2003) 1.72
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell (2013) 1.71
Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol (2011) 1.62
Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma (2005) 1.60
Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich) (2007) 1.59
Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis (2011) 1.58
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation (2012) 1.57
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci (2004) 1.54
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci U S A (2002) 1.54
Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem (2011) 1.53
Retracted Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem (2009) 1.53
gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci U S A (2004) 1.52
Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis (2002) 1.51
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.48
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free Radic Biol Med (2002) 1.46
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 1.46
Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol Cell Biochem (2011) 1.45
Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB J (2007) 1.44
The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging (2005) 1.44
Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. PLoS One (2008) 1.42
Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci U S A (2002) 1.41
Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis. J Neurosci (2007) 1.40
Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. Transl Res (2010) 1.40
Nutrition, brain aging, and neurodegeneration. J Neurosci (2009) 1.40
Unusual clustering of coefficients of variation in published articles from a medical biochemistry department in India. FASEB J (2008) 1.39
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation (2008) 1.38
Glutathione metabolism during aging and in Alzheimer disease. Ann N Y Acad Sci (2004) 1.36
Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci (2002) 1.36
Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement (2009) 1.36
Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging (2002) 1.34
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Mol Neurodegener (2010) 1.34
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem (2003) 1.32
Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull (2012) 1.32
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis (2008) 1.31
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J Neurosci (2007) 1.31
Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res (2007) 1.30
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci U S A (2002) 1.29
The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci Lett (2004) 1.28
Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging (2007) 1.26
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr (2003) 1.25
Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol (2004) 1.24
Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress. Free Radic Biol Med (2003) 1.24
Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol Aging (2005) 1.24
The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr (2005) 1.24
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24
Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. Arch Neurol (2007) 1.22
Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation (2007) 1.21
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr (2009) 1.20
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis (2012) 1.20
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci (2007) 1.20
Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. Am J Pathol (2006) 1.20
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem (2007) 1.19
Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid. FASEB J (2002) 1.19
Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci (2003) 1.19
Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis (2010) 1.19
The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. Arch Biochem Biophys (2002) 1.18
Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci (2008) 1.18
Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma (2004) 1.17