Published in Am J Physiol Renal Physiol on February 25, 2009
Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. PLoS One (2010) 1.77
Role of microRNA 1207-5P and its host gene, the long non-coding RNA Pvt1, as mediators of extracellular matrix accumulation in the kidney: implications for diabetic nephropathy. PLoS One (2013) 1.58
Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice. J Clin Invest (2011) 1.56
A miR-1207-5p binding site polymorphism abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy. PLoS One (2012) 1.08
The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium. J Biol Chem (2011) 1.02
Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells. Biochim Biophys Acta (2010) 1.00
Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine. Front Immunol (2013) 0.91
Epidermal growth factors in the kidney and relationship to hypertension. Am J Physiol Renal Physiol (2013) 0.88
The transcriptome of a complete episode of acute otitis media. BMC Genomics (2015) 0.82
Slug overexpression induces stemness and promotes hepatocellular carcinoma cell invasion and metastasis. Oncol Lett (2014) 0.80
Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor. Am J Cancer Res (2015) 0.77
Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells. PLoS One (2015) 0.75
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol (2000) 21.15
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol (2000) 15.78
Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest (2003) 12.56
The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol (2004) 9.80
The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (2000) 7.03
A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res (2003) 6.76
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem (2003) 4.55
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell (2003) 3.87
Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol (1997) 3.67
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res (2007) 3.53
Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science (1994) 3.52
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80
ErbB receptors: from oncogenes to targeted cancer therapies. J Clin Invest (2007) 2.78
Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res (2006) 2.73
Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach. Nat Med (2005) 2.61
Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci U S A (2000) 2.46
Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol Cell Biol (2003) 2.46
Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal (2005) 2.20
The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol (1998) 2.13
The EGF receptor: a nexus for trafficking and signaling. Bioessays (2000) 2.02
Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor. J Cell Sci (2005) 1.87
Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem (1994) 1.76
Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure. J Clin Invest (1989) 1.73
Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J Clin Invest (2000) 1.68
Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal (2007) 1.61
Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci (2006) 1.55
SLUG in cancer development. Oncogene (2005) 1.42
Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol (2007) 1.39
Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol (2003) 1.30
Snail1 is involved in the renal epithelial-mesenchymal transition. Biochem Biophys Res Commun (2007) 1.29
Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest (1997) 1.22
Transcriptional defects underlie loss of E-cadherin expression in breast cancer. Cell Growth Differ (1997) 1.16
A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor. J Biol Chem (2001) 1.15
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. FASEB J (2004) 1.13
Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. J Clin Invest (1995) 1.11
Changes in gene expression after temporary renal ischemia. Kidney Int (1990) 1.10
Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes. Nephron Exp Nephrol (2007) 1.09
Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell Cycle (2007) 1.03
Quantitative detection for low levels of Helicobacter pylori infection in experimentally infected mice by real-time PCR. J Microbiol Methods (2003) 0.97
Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J Cell Sci (2004) 0.97
Reduced renal prepro-epidermal growth factor mRNA and decreased EGF excretion in ARF. Kidney Int (1989) 0.96
Slug expression during organogenesis in mice. Anat Rec A Discov Mol Cell Evol Biol (2003) 0.92
Control of the epidermal growth factor receptor and its ligands during renal injury. Nephron (2001) 0.87
Activation of epidermal growth factor receptor in the early phase after renal ischemia-reperfusion in rat. Nephron (1999) 0.86
Mouse models of diabetic nephropathy. J Am Soc Nephrol (2004) 3.95
Mouse models of diabetic nephropathy. J Am Soc Nephrol (2009) 3.74
Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol (2006) 3.19
Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am J Physiol Renal Physiol (2003) 3.06
Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest (2005) 3.02
The juxtamembrane region of the EGF receptor functions as an activation domain. Mol Cell (2009) 2.90
Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene (2002) 2.41
Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal (2005) 2.20
Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res (2002) 2.19
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res (2006) 2.14
Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors. Kidney Int (2002) 2.01
CSF-1 signaling mediates recovery from acute kidney injury. J Clin Invest (2012) 1.98
Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol (2007) 1.95
Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe (2009) 1.91
Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney Int (2002) 1.90
Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest (2010) 1.90
EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci (2004) 1.82
Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J Am Soc Nephrol (2008) 1.81
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Mol Cancer Res (2005) 1.77
S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol (2009) 1.74
Overexpression of cyclooxygenase-2 predisposes to podocyte injury. J Am Soc Nephrol (2007) 1.73
TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol (2010) 1.70
Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem (2003) 1.68
EGFR signaling promotes TGFβ-dependent renal fibrosis. J Am Soc Nephrol (2011) 1.64
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation (2002) 1.62
Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ Res (2005) 1.61
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest (2006) 1.59
Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol (2008) 1.59
HER2 as a therapeutic target in the gastric cancer: is it sufficient? Indian J Gastroenterol (2012) 1.58
Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization. J Invest Dermatol (2006) 1.54
The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Exp Cell Res (2008) 1.53
Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res (2009) 1.53
Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension. J Clin Invest (2015) 1.51
CAS promotes invasiveness of Src-transformed cells. Oncogene (2004) 1.49
Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats. J Mol Cell Cardiol (2013) 1.49
Phosphatidylinositol 3-kinase signaling determines kidney size. J Clin Invest (2015) 1.46
Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. J Biol Chem (2007) 1.46
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A (2004) 1.42
Claudin family of proteins and cancer: an overview. J Oncol (2010) 1.42
Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. J Am Soc Nephrol (2005) 1.39
Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Diabetes (2012) 1.39
Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. J Clin Invest (2011) 1.38
Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol (2007) 1.37
Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A (2006) 1.35
Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol (2004) 1.34
Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol (2004) 1.33
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes (2011) 1.33
Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol (2003) 1.30
Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology (2003) 1.28
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development (2009) 1.27
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res (2006) 1.26
eNOS deficiency predisposes podocytes to injury in diabetes. J Am Soc Nephrol (2012) 1.26
Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells. Gastroenterology (2011) 1.25
Reduction of renal superoxide dismutase in progressive diabetic nephropathy. J Am Soc Nephrol (2009) 1.23
Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol (2004) 1.23
Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Proc Natl Acad Sci U S A (2002) 1.21
Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. J Biol Chem (2006) 1.20
Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res (2007) 1.19
Histone deacetylase inhibitor enhances recovery after AKI. J Am Soc Nephrol (2013) 1.19
EET signaling in cancer. Cancer Metastasis Rev (2011) 1.18
Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury. Kidney Int (2012) 1.17
Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. J Biol Chem (2008) 1.17
Intrarenal dopaminergic system regulates renin expression. Hypertension (2009) 1.17
Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest (2014) 1.16
Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest (2009) 1.14
Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer (2005) 1.14
Macula densa sensing and signaling mechanisms of renin release. J Am Soc Nephrol (2010) 1.12
Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice. Kidney Int (2012) 1.12
Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes. Nephron Exp Nephrol (2007) 1.09
Single amino acid substitution in aquaporin 11 causes renal failure. J Am Soc Nephrol (2008) 1.09
Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy. J Am Soc Nephrol (2006) 1.08
Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int (2004) 1.06
CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci (2005) 1.04
Cyclooxygenases and lipoxygenases in cancer. Cancer Metastasis Rev (2011) 1.04
Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c. Am J Physiol Endocrinol Metab (2008) 1.04
Apoptosis of the thick ascending limb results in acute kidney injury. J Am Soc Nephrol (2008) 1.03
alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner. Blood (2007) 1.03
Integrins in renal development. Pediatr Nephrol (2011) 1.03
Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. J Biol Chem (2007) 1.03
Cyclooxygenases, the kidney, and hypertension. Hypertension (2004) 1.03
Diabetic nephropathy: of mice and men. Adv Chronic Kidney Dis (2005) 1.02
Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Am J Physiol Cell Physiol (2007) 1.01
Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. Am J Physiol Regul Integr Comp Physiol (2005) 1.01
Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. J Am Soc Nephrol (2011) 1.01
Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. J Biol Chem (2006) 1.01
Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol (2006) 1.01
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood (2009) 1.01