Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.

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Published in J Mol Biol on February 26, 2009

Authors

Kathleen M Frey1, Jieying Liu, Michael N Lombardo, David B Bolstad, Dennis L Wright, Amy C Anderson

Author Affiliations

1: Department of Pharmaceutical Sciences, University of Connecticut, 69 N. Eagleville Rd., Storrs, CT 06269, USA.

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