Published in J Med Ethics on March 01, 2009
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The therapeutic misconception: informed consent in psychiatric research. Int J Law Psychiatry (1982) 3.98
Informing study participants of research results: an ethical imperative. IRB (2003) 3.65
Distributive justice and clinical trials in the Third World. Theor Med Bioeth (2001) 2.42
Justice and the human development approach to international research. Hastings Cent Rep (2005) 2.33
Offering participants results of a clinical trial: sharing results of a negative study. Lancet (2005) 1.90
Oncology physician and nurse practices and attitudes regarding offering clinical trial results to study participants. J Natl Cancer Inst (2004) 1.51
AZT trials and tribulations. Hastings Cent Rep (1999) 1.44
Guinea pigs on the payroll: the ethics of paying research subjects. Account Res (1999) 1.39
Enrolling the uninsured in clinical trials: an ethical perspective. Crit Care Med (2003) 1.37
Reciprocity and post-trial access for participants in antiretroviral therapy trials. AIDS (2006) 1.26
Fiduciary obligation in clinical research. J Law Med Ethics (2006) 1.26
Equitable treatment for HIV/AIDS clinical trial participants: a focus group study of patients, clinician researchers, and administrators in Western Kenya. J Med Ethics (2006) 1.24
The challenge of assuring continued post-trial access to beneficial treatment. Yale J Health Policy Law Ethics (2005) 1.05
Research in developing countries: taking "benefit" seriously. Hastings Cent Rep (1999) 1.04
Post-trial access to tested interventions: the views of IRB/REC chair, investigators, and research participants in a multinational HIV/AIDS study. AIDS Res Hum Retroviruses (2006) 0.94
The obligation to provide antiretroviral treatment in HIV prevention trials. AIDS (2007) 0.92
Creation of a drug fund for post-clinical trial access to antiretrovirals. Lancet (2004) 0.89
Freebies for subject 641: a discussion of the ethical prospect of providing drug trial subjects with post-trial access to the drug tested--a Canadian perspective. Health Law J (1998) 0.85
Research-related injury: problems and solutions. J Law Med Ethics (2003) 0.82
For the uninsured, drug trials are health care. N Y Times Web (1999) 0.78
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell (2000) 13.44
Unmet health needs of uninsured adults in the United States. JAMA (2000) 7.37
The effect of patients' preferences on racial differences in access to renal transplantation. N Engl J Med (1999) 6.02
Preparedness for clinical practice: reports of graduating residents at academic health centers. JAMA (2001) 5.56
Racial disparities in access to renal transplantation--clinically appropriate or due to underuse or overuse? N Engl J Med (2000) 4.67
Risk factors for pancreatic cellular injury after cardiopulmonary bypass. N Engl J Med (1991) 4.66
A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion. Cell (1998) 4.25
A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions. Proc Natl Acad Sci U S A (2000) 4.19
Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science (2000) 3.87
Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum. Mol Cell (1998) 3.57
The emergency department as a pathway to admission for poor and high-cost patients. JAMA (1991) 3.47
Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion. Cell (2001) 3.29
Molecular basis of a yeast prion species barrier. Cell (2000) 3.27
Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell. Cell (1994) 2.91
The association of payer with utilization of cardiac procedures in Massachusetts. JAMA (1990) 2.74
Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein. Science (2000) 2.66
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Status of clinical research in academic health centers: views from the research leadership. JAMA (2001) 2.54
Quality of care by race and gender for congestive heart failure and pneumonia. Med Care (1999) 2.50
Fentanyl and sufentanil anesthesia revisited: how much is enough? Anesthesiology (1990) 2.48
Conformational diversity in a yeast prion dictates its seeding specificity. Nature (2001) 2.44
The social missions of academic health centers. N Engl J Med (1997) 2.42
Deadly conformations--protein misfolding in prion disease. Cell (1997) 2.30
Variation in institutional review board responses to a standard protocol for a multicenter clinical trial. Acad Emerg Med (2001) 2.28
Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals. J Neurophysiol (1975) 2.04
Solubilization of active opiate receptors. Proc Natl Acad Sci U S A (1980) 1.98
Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions. Methods (2006) 1.96
To protect those who serve. N Engl J Med (2000) 1.87
Inbreeding and juvenile mortality in small populations of ungulates. Science (1979) 1.76
The action of molecular chaperones in the early secretory pathway. Annu Rev Genet (2001) 1.76
Relationship between market competition and the activities and attitudes of medical school faculty. JAMA (1997) 1.68
Racial differences in cardiac revascularization rates: does "overuse" explain higher rates among white patients? Ann Intern Med (2001) 1.61
Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis. Proc Natl Acad Sci U S A (1981) 1.56
Research involving human subjects in developing countries. N Engl J Med (2001) 1.47
Induction and localization of Plasmodium falciparum stress proteins related to the heat shock protein 70 family. Mol Biochem Parasitol (1991) 1.42
Oral iron and the Hemoccult test: a controversy on the teaching wards. N Engl J Med (1989) 1.40
Quantitative estimates of soil ingestion in normal children between the ages of 2 and 7 years: population-based estimates using aluminum, silicon, and titanium as soil tracer elements. Arch Environ Health (1990) 1.37
Discussion of preferences for life-sustaining care by persons with AIDS. Predictors of failure in patient-physician communication. Arch Intern Med (1993) 1.35
Quality of care for two common illnesses in teaching and nonteaching hospitals. Health Aff (Millwood) (1999) 1.26
Physician discretion and racial variation in the use of surgical procedures. Arch Intern Med (1994) 1.26
Satisfaction with ambulatory care of persons with AIDS: predictors of patient ratings of quality. J Gen Intern Med (1995) 1.25
Release of both native and non-native proteins from a cis-only GroEL ternary complex. Nature (1996) 1.18
Measuring patient expectations: does the instrument affect satisfaction or expectations? Med Care (2001) 1.14
Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. J Mol Biol (1995) 1.12
The biochemistry of opsonization: central role of the reactive thiolester of the third component of complement. J Infect Dis (1984) 1.11
Factors in cerebrospinal fluid from goats that affect sleep and activity in rats. J Physiol (1971) 1.05
Calcium signaling inhibits interleukin-12 production and activates CD83(+) dendritic cells that induce Th2 cell development. Blood (2001) 1.02
Trust and the ethics of health care institutions. Hastings Cent Rep (2003) 1.02
Selling teaching hospitals to investor-owned hospital chains: three case studies. Health Aff (Millwood) (2000) 1.01
The Boston AIDS Survival Score (BASS): a multidimensional AIDS severity instrument. Am J Public Health (1997) 1.00
'Rationing' health care. Not all definitions are created equal. Arch Intern Med (1998) 1.00
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase. J Biol Chem (1982) 1.00
Amidation of C3 at the thiolester site: stimulation of chemiluminescence and phagocytosis by a new inflammatory mediator. J Immunol (1985) 0.98
GroEL-GroES-mediated protein folding requires an intact central cavity. Proc Natl Acad Sci U S A (1998) 0.97
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Maintaining trust in the surgeon-patient relationship: challenges for the new millennium. Arch Surg (2000) 0.93
Intrathecal magnesium sulfate protects the spinal cord from ischemic injury during thoracic aortic cross-clamping. Anesthesiology (1994) 0.92
Construction of single-ring and two-ring hybrid versions of bacterial chaperonin GroEL. Methods Enzymol (1998) 0.91
Guanine nucleotides inhibit binding of agonists and antagonists to soluble opiate receptors. J Biol Chem (1981) 0.87
Thinking outside the box: new insights into the mechanism of GroEL-mediated protein folding. Nat Struct Biol (1999) 0.87
Academic health centers on the front lines: survival strategies in highly competitive markets. Acad Med (1999) 0.86
Costs of medical care and out-of-pocket expenditures for persons with AIDS in the Boston Health Study. Inquiry (1995) 0.86
Malaria transmission-blocking immunity. Identification of epitopes and evaluation of immunogenicity. Adv Exp Med Biol (1995) 0.86
Captive breeding programs for populations with a small number of founders. Trends Ecol Evol (1986) 0.85
A multimedia intervention on cardiopulmonary resuscitation and advance directives. J Gen Intern Med (1999) 0.85
On the mechanism of receptor-mediated inhibition of adenylate cyclase. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 0.84
Cyclophosphates VI. Cyclophosphates as substrates and effectors of phosphodiesterase. Pharmacol Res Commun (1974) 0.83
Heparin-enhanced plasma phospholipase A2 activity and prostacyclin synthesis in patients undergoing cardiac surgery. J Clin Invest (1995) 0.83
Functional genomic approaches to understanding molecular chaperones and stress responses. Adv Protein Chem (2001) 0.83
Putting a lid on protein folding: structure and function of the co-chaperonin, GroES. Chem Biol (1996) 0.82
Correlates of employment after AIDS diagnosis in the Boston Health Study. Am J Public Health (1994) 0.81
Risks, benefits, and conflicts of interest in human research: ethical evolution in the changing world of science. J Law Med Ethics (2000) 0.80
Effect of inbreeding on juvenile mortality in some small mammal species. Lab Anim (1982) 0.80
Pathologic quiz case 2. Benign capillary hemangioma. Arch Otolaryngol Head Neck Surg (1988) 0.80
Kinesis of polypeptide during GroEL-mediated folding. Cold Spring Harb Symp Quant Biol (1995) 0.80
Doctors and ethics, morals and manuals. Ann Intern Med (1998) 0.80
How does market competition affect resident physicians' views toward managed care? Am J Med (2000) 0.79
Protecting human subjects in research--occasional views along a road less traveled. Bioethics Forum (2000) 0.79
Market competition and patient-oriented research: the results of a national survey of medical school faculty. Acad Med (2001) 0.78
Effect of chronic ethanol on calcium currents and calcium uptake in undifferentiated PC12 cells. Brain Res (1993) 0.78
Calcium administration augments pancreatic injury and ectopic trypsinogen activation after temporary systemic hypotension in rats. Anesthesiology (1995) 0.78
The relation of rural alcoholism to farm economy. Community Ment Health J (1989) 0.77
Between Scylla and Charybdis: charting an ethical course for research into financial incentives for living kidney donation. Am J Transplant (2015) 0.76
Peptides in cerebrospinal fluid and their relation to sleep and activity. Res Publ Assoc Res Nerv Ment Dis (1974) 0.76
Point and counterpoint. Is distance critical for clinical ethicists? A reply to Glenn McGee. HEC Forum (1997) 0.75
Physician-assisted suicide and euthanasia in the United States. N Engl J Med (1998) 0.75
Internal mammary artery spasm: is calcium the culprit? J Cardiothorac Vasc Anesth (2000) 0.75
Recruiting and retaining medical technologists. Clin Lab Manage Rev (1993) 0.75
The doing and undoing of surgical sterilization: a psychosocial profile of the tubal reimplantation patient. Psychiatry (1983) 0.75
Pneumocystis carinii infection presenting as necrotizing thyroiditis and hypothyroidism. Am J Clin Pathol (1991) 0.75
The significance of reconciliative themes in the psychology of pregnancy. Bull Menninger Clin (1978) 0.75
Understanding the relationship between market competition and students' ratings of the managed care content of their undergraduate medical education. Acad Med (2001) 0.75
The relationship of market forces to the satisfaction of faculty at academic health centers. Am J Med (2001) 0.75
Norepinephrine infusion following cardiopulmonary bypass: effect of infusion site. J Surg Res (1995) 0.75
Costs and outcomes of AIDS care: comparing a health maintenance organization with fee-for-service systems in the Boston Health Study. J Acquir Immune Defic Syndr Hum Retrovirol (1998) 0.75
Long term catheter care with infected urine. R I Med J (1981) 0.75
Epileptiform activity during opioid anesthesia. Electroencephalogr Clin Neurophysiol (1993) 0.75
Effect of hypothermic hemodilutional cardiopulmonary bypass on plasma sufentanil and catecholamine concentrations in humans. Anesth Analg (1988) 0.75
For-profit health plans. N Engl J Med (1996) 0.75