Published in Science on October 04, 1991
Structural analysis of substrate binding by the molecular chaperone DnaK. Science (1996) 6.13
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Specific chemical and structural damage to proteins produced by synchrotron radiation. Proc Natl Acad Sci U S A (2000) 3.53
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Structural interactions of fibroblast growth factor receptor with its ligands. Proc Natl Acad Sci U S A (2000) 1.76
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Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr. EMBO J (2002) 1.56
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The copper-iron connection in biology: structure of the metallo-oxidase Fet3p. Proc Natl Acad Sci U S A (2005) 1.55
Structural basis of replication origin recognition by the DnaA protein. Nucleic Acids Res (2003) 1.54
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A (2002) 1.53
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Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis. Proc Natl Acad Sci U S A (2003) 1.52
Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding. Proc Natl Acad Sci U S A (2011) 1.51
Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase. Proc Natl Acad Sci U S A (2006) 1.50
Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool. Proc Natl Acad Sci U S A (2006) 1.49
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J (1997) 1.48
Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. EMBO J (2000) 1.48
Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export. J Cell Biol (2001) 1.47
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Proc Natl Acad Sci U S A (2002) 1.47
Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. Mol Cell (2009) 1.46
The use of workflows in the design and implementation of complex experiments in macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2012) 1.46
Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis. Proc Natl Acad Sci U S A (2001) 1.46
Structural basis for glycosphingolipid transfer specificity. Nature (2004) 1.46
Crystal structure of potato tuber ADP-glucose pyrophosphorylase. EMBO J (2005) 1.42
Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2. Proc Natl Acad Sci U S A (1999) 1.40
X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. Proc Natl Acad Sci U S A (2001) 1.40
X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix. EMBO J (1995) 1.37
Chemical ligation of folded recombinant proteins: segmental isotopic labeling of domains for NMR studies. Proc Natl Acad Sci U S A (1999) 1.36
Structure of RsrI methyltransferase, a member of the N6-adenine beta class of DNA methyltransferases. Nucleic Acids Res (2000) 1.35
Structural insights into mechanisms of the small RNA methyltransferase HEN1. Nature (2009) 1.34
Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid. Plant Cell (2010) 1.33
Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. EMBO J (2001) 1.31
Multi-crystal anomalous diffraction for low-resolution macromolecular phasing. Acta Crystallogr D Biol Crystallogr (2010) 1.29
Structural basis for type VI secretion effector recognition by a cognate immunity protein. PLoS Pathog (2012) 1.28
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J (2004) 1.27
A serendipitous discovery that in situ proteolysis is essential for the crystallization of yeast CPSF-100 (Ydh1p). Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 1.27
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Structural and functional features of the Escherichia coli hydroperoxide resistance protein OsmC. Protein Sci (2003) 1.26
Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes Dev (2011) 1.26
The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure (2006) 1.25
Crystal structure of a potassium ion transporter, TrkH. Nature (2011) 1.25
Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family. Nucleic Acids Res (2006) 1.23
Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J Biol Chem (2009) 1.23
Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1. Nat Struct Mol Biol (2011) 1.22
Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Protein Sci (2008) 1.20
Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation. Proc Natl Acad Sci U S A (2013) 1.17
Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain. EMBO J (2002) 1.17
Crystal structures of nitroalkane oxidase: insights into the reaction mechanism from a covalent complex of the flavoenzyme trapped during turnover. Biochemistry (2006) 1.16
Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe. J Am Chem Soc (2009) 1.16
The unusual metal clusters of nitrogenase: structural features revealed by x-ray anomalous diffraction studies of the MoFe protein from Clostridium pasteurianum. Proc Natl Acad Sci U S A (1993) 1.15
The use of in situ proteolysis in the crystallization of murine CstF-77. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 1.13
Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A. Proc Natl Acad Sci U S A (2013) 1.12
Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. Proc Natl Acad Sci U S A (1998) 1.12
Structure of bacterial cellulose synthase subunit D octamer with four inner passageways. Proc Natl Acad Sci U S A (2010) 1.11
Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. J Biol Chem (2010) 1.10
Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4. J Mol Biol (2007) 1.10
Structural genomics: an approach to the protein folding problem. Proc Natl Acad Sci U S A (2001) 1.10
Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis. EMBO J (2000) 1.10
Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase. J Biol Chem (2001) 1.10
Crystal structures of Escherichia coli ATP-dependent glucokinase and its complex with glucose. J Bacteriol (2004) 1.09
Crystal structure of the conserved protein TTHA0727 from Thermus thermophilus HB8 at 1.9 A resolution: A CMD family member distinct from carboxymuconolactone decarboxylase (CMD) and AhpD. Protein Sci (2006) 1.08
Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site. Structure (2000) 1.08
Anomalous diffraction in crystallographic phase evaluation. Q Rev Biophys (2014) 1.08
Exploiting the anisotropy of anomalous scattering boosts the phasing power of SAD and MAD experiments. Acta Crystallogr D Biol Crystallogr (2008) 1.08
Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J (1995) 1.07
Improved technologies now routinely provide protein NMR structures useful for molecular replacement. Structure (2011) 1.07
Atomic structure of a tryptophan-zipper pentamer. Proc Natl Acad Sci U S A (2004) 1.01
Structure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosis. Protein Sci (2006) 1.00
Analysis of solvent content and oligomeric states in protein crystals--does symmetry matter? Protein Sci (2008) 1.00
Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination. FEBS J (2013) 0.99