The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model.

PubWeight™: 1.03‹?› | Rank: Top 15%

🔗 View Article (PMC 3682836)

Published in Invest Ophthalmol Vis Sci on March 05, 2009

Authors

Grace Byfield1, Steve Budd, M Elizabeth Hartnett

Author Affiliations

1: Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599-7041, USA.

Articles citing this

Mechanisms and management of retinopathy of prematurity. N Engl J Med (2012) 3.52

Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci (2013) 1.23

Pathophysiology and mechanisms of severe retinopathy of prematurity. Ophthalmology (2014) 1.11

VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression. Am J Pathol (2012) 1.02

Cross-talk between KLF4 and STAT3 regulates axon regeneration. Nat Commun (2013) 1.02

VEGFA activates erythropoietin receptor and enhances VEGFR2-mediated pathological angiogenesis. Am J Pathol (2014) 0.99

Endothelial NADPH oxidase 4 mediates vascular endothelial growth factor receptor 2-induced intravitreal neovascularization in a rat model of retinopathy of prematurity. Mol Vis (2014) 0.97

Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev (2012) 0.95

Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. Am J Pathol (2011) 0.93

Vascular endothelial growth factor antagonist therapy for retinopathy of prematurity. Clin Perinatol (2014) 0.80

Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity. Mol Vis (2011) 0.79

Molecular mechanisms of curcumin on diabetes-induced endothelial dysfunctions: Txnip, ICAM-1, and NOX2 expressions. Biomed Res Int (2014) 0.79

Inhibition of retinopathy of prematurity in rat by intravitreal injection of sorafenib. Int J Ophthalmol (2014) 0.77

Breaking barriers: insight into the pathogenesis of neovascular age-related macular degeneration. Eye Brain (2011) 0.76

Gene expression changes in a rat model of oxygen-induced retinopathy. Korean J Ophthalmol (2011) 0.76

DJC Suppresses Advanced Glycation End Products-Induced JAK-STAT Signaling and ROS in Mesangial Cells. Evid Based Complement Alternat Med (2017) 0.75

ADVANCES IN UNDERSTANDING AND MANAGEMENT OF RETINOPATHY OF PREMATURITY. Surv Ophthalmol (2016) 0.75

Roles of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase in Angiogenesis: Isoform-Specific Effects. Antioxidants (Basel) (2017) 0.75

Articles cited by this

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med (1995) 7.88

Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol (1954) 5.98

Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation. Arch Dis Child Fetal Neonatal Ed (2001) 4.38

Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med (2007) 4.36

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature (1996) 4.04

Retinopathy of prematurity. Angiogenesis (2007) 3.20

Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants? Pediatrics (2003) 2.89

Oxygen studies in retrolental fibroplasia. II. The production of the microscopic changes of retrolental fibroplasia in experimental animals. Am J Ophthalmol (1953) 2.64

Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest (2008) 2.45

Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol (1998) 2.37

Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase. Mol Cell Biochem (2004) 2.19

Transcutaneous oxygen levels in retinopathy of prematurity. Lancet (1995) 1.89

Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat. Pediatr Res (1994) 1.88

IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A (2007) 1.88

Lower oxygen saturation alarm limits decrease the severity of retinopathy of prematurity. J AAPOS (2006) 1.84

Variable oxygen exposure causes preretinal neovascularization in the newborn rat. Invest Ophthalmol Vis Sci (1993) 1.77

IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci U S A (2007) 1.77

Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy. Am J Pathol (2005) 1.68

VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal (2007) 1.61

Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice. Invest Ophthalmol Vis Sci (2001) 1.57

The progression of retinopathy of prematurity and fluctuation in blood gas tension. Graefes Arch Clin Exp Ophthalmol (1993) 1.44

Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases. J Biol Chem (2003) 1.42

Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy. Invest Ophthalmol Vis Sci (2008) 1.38

Tyrphostins--potential antiproliferative agents and novel molecular tools. Biochem Pharmacol (1990) 1.31

JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion. Circulation (2001) 1.30

The retinal vasculature and function of the neural retina in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci (2006) 1.29

Neutralizing antibody to VEGF reduces intravitreous neovascularization and may not interfere with ongoing intraretinal vascularization in a rat model of retinopathy of prematurity. Mol Vis (2008) 1.29

IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab (2002) 1.29

Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model. Invest Ophthalmol Vis Sci (2008) 1.28

Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli. Am J Physiol Renal Physiol (2003) 1.27

Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization. Invest Ophthalmol Vis Sci (1994) 1.25

Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity. Mol Vis (2007) 1.24

Rod photoreceptor function predicts blood vessel abnormality in retinopathy of prematurity. Invest Ophthalmol Vis Sci (2007) 1.24

Vaso-obliteration in the canine model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci (1996) 1.15

High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity. Invest Ophthalmol Vis Sci (2007) 1.14

Hypoxic oxygen fluctuations produce less severe retinopathy than hyperoxic fluctuations in a rat model of retinopathy of prematurity. Pediatr Res (2003) 1.11

Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization. Invest Ophthalmol Vis Sci (2006) 1.04

Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci (2006) 1.03

Autoxidative damage to the retina: potential role in retinopathy of prematurity. Birth Defects Orig Artic Ser (1988) 1.02

STAT3 activation protects retinal ganglion cell layer neurons in response to stress. Exp Eye Res (2008) 1.02

Angiostatic effect of penetrating ocular injury: role of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci (2006) 0.97

Oxygen-induced retinopathy in the rat: possible contribution of peroxidation reactions. Doc Ophthalmol (1990) 0.91

Interleukin-6 stimulates alpha-MG uptake in renal proximal tubule cells: involvement of STAT3, PI3K/Akt, MAPKs, and NF-kappaB. Am J Physiol Renal Physiol (2007) 0.89

Incidence of severe retinopathy of prematurity before and after a modest reduction in target oxygen saturation levels. J AAPOS (2006) 0.87

Vitamin E in kitten oxygen-induced retinopathy. II. Blockage of vitreal neovascularization. Arch Ophthalmol (1979) 0.87

Articles by these authors

CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature (2009) 2.39

Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci (2009) 1.86

VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP. Mol Vis (2004) 1.40

Neutralizing antibody to VEGF reduces intravitreous neovascularization and may not interfere with ongoing intraretinal vascularization in a rat model of retinopathy of prematurity. Mol Vis (2008) 1.29

Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model. Invest Ophthalmol Vis Sci (2008) 1.28

Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity. Mol Vis (2007) 1.24

Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci (2013) 1.23

Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway. Am J Pathol (2009) 1.22

Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture. Curr Eye Res (2006) 1.20

MicroRNA-433 inhibits liver cancer cell migration by repressing the protein expression and function of cAMP response element-binding protein. J Biol Chem (2013) 1.11

The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization. Am J Pathol (2010) 1.06

Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor. Exp Eye Res (2005) 1.06

Upregulation of CCR3 by age-related stresses promotes choroidal endothelial cell migration via VEGF-dependent and -independent signaling. Invest Ophthalmol Vis Sci (2011) 1.05

CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis. Circ Res (2007) 1.04

VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression. Am J Pathol (2012) 1.02

Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1. Exp Eye Res (2006) 1.02

The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE. Invest Ophthalmol Vis Sci (2011) 0.99

Soluble mediators of diabetic macular edema: the diagnostic role of aqueous VEGF and cytokine levels in diabetic macular edema. Curr Diab Rep (2013) 0.99

Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity. Arch Ophthalmol (2010) 0.98

Short hairpin RNA-mediated knockdown of VEGFA in Müller cells reduces intravitreal neovascularization in a rat model of retinopathy of prematurity. Am J Pathol (2013) 0.94

Targeting Müller cell-derived VEGF164 to reduce intravitreal neovascularization in the rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci (2014) 0.91

The small GTPase Rap1 is a novel regulator of RPE cell barrier function. Invest Ophthalmol Vis Sci (2011) 0.89

Association of retinal vascular endothelial growth factor with avascular retina in a rat model of retinopathy of prematurity. Arch Ophthalmol (2010) 0.89

Fluorescein angiography to estimate normal peripheral retinal nonperfusion in children. J AAPOS (2012) 0.89

New-onset maternal gestational hypertension and risk of retinopathy of prematurity. Invest Ophthalmol Vis Sci (2010) 0.84

Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis. Exp Eye Res (2006) 0.83

Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo. PLoS One (2013) 0.83

Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. FASEB J (2013) 0.81

Quantitative analyses of retinal vascular area and density after different methods to reduce VEGF in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci (2014) 0.81

Mechanisms and management of retinopathy of prematurity. N Engl J Med (2013) 0.81

Association between assisted reproductive technology and advanced retinopathy of prematurity. Clin Ophthalmol (2010) 0.79

Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity. Mol Vis (2011) 0.79

Prothrombin gene mutation G20210A, homocysteine, antiphospholipid antibodies and other hypercoagulable states in ocular thrombosis. Blood Coagul Fibrinolysis (2004) 0.79

Quantification of macular and optic disc hyperfluorescence after phacoemulsification in diabetes mellitus. J Cataract Refract Surg (2006) 0.77

Predicting glaucoma diagnosis in an elderly sample: revisiting the established populations for epidemiologic studies of the elderly. J Natl Med Assoc (2011) 0.77

The incidence of central serous chorioretinopathy after photorefractive keratectomy and laser in situ keratomileusis. J Ophthalmol (2012) 0.75