Published in PLoS Genet on March 06, 2009
Nuclear speckles. Cold Spring Harb Perspect Biol (2011) 3.04
Trinucleotide repeats in human genome and exome. Nucleic Acids Res (2010) 1.35
Natural selection drives the accumulation of amino acid tandem repeats in human proteins. Genome Res (2010) 1.21
The role of AUTS2 in neurodevelopment and human evolution. Trends Genet (2013) 0.97
HRaP: database of occurrence of HomoRepeats and patterns in proteomes. Nucleic Acids Res (2013) 0.92
Understanding and identifying amino acid repeats. Brief Bioinform (2014) 0.90
Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. PLoS One (2011) 0.86
Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope. J Biol Chem (2010) 0.84
Dissecting the role of low-complexity regions in the evolution of vertebrate proteins. BMC Evol Biol (2012) 0.82
Increased polymorphism near low-complexity sequences across the genomes of Plasmodium falciparum isolates. Genome Biol Evol (2011) 0.82
NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins. Nucleic Acids Res (2013) 0.82
ProRepeat: an integrated repository for studying amino acid tandem repeats in proteins. Nucleic Acids Res (2011) 0.82
Length polymorphism and head shape association among genes with polyglutamine repeats in the stalk-eyed fly, Teleopsis dalmanni. BMC Evol Biol (2010) 0.82
Impact of nuclear organization and dynamics on epigenetic regulation in the central nervous system: implications for neurological disease states. Ann N Y Acad Sci (2010) 0.82
Non-random distribution of homo-repeats: links with biological functions and human diseases. Sci Rep (2016) 0.82
The FF4 and FF5 domains of transcription elongation regulator 1 (TCERG1) target proteins to the periphery of speckles. J Biol Chem (2012) 0.81
Concurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior. PLoS One (2014) 0.79
Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control. Mol Cell Biol (2014) 0.79
Phyloproteomic Analysis of 11780 Six-Residue-Long Motifs Occurrences. Biomed Res Int (2015) 0.78
Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B. PLoS One (2016) 0.77
Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors. Mol Biol Evol (2015) 0.77
Regulation of voltage-gated calcium channels by proteolysis. Sheng Li Xue Bao (2012) 0.76
Profiles of low complexity regions in Apicomplexa. BMC Evol Biol (2016) 0.76
Variation and Evolution in the Glutamine-Rich Repeat Region of Drosophila Argonaute-2. G3 (Bethesda) (2016) 0.76
From vestigial to vestigial-like: the Drosophila gene that has taken wing. Dev Genes Evol (2016) 0.76
Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study. PLoS Med (2016) 0.75
Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates Novel Localization Sequences That Target the Periphery of the Host Erythrocyte. J Biol Chem (2016) 0.75
dAPE: a web server to detect homorepeats and follow their evolution. Bioinformatics (2016) 0.75
An endogenous 'non-specific' protein detected by a His-tag antibody is human transcription regulator YY1. Data Brief (2014) 0.75
A cytoplasmic RNA virus alters the function of the cell splicing protein SRSF2. J Virol (2017) 0.75
Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1. PLoS One (2015) 0.75
The Eighth Central European Conference "Chemistry towards Biology": Snapshot. Molecules (2016) 0.75
HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner. Nucleic Acids Res (2016) 0.75
Transcriptional Complexity and Distinct Expression Patterns of auts2 Paralogs in Danio rerio. G3 (Bethesda) (2017) 0.75
The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37
Ensembl 2008. Nucleic Acids Res (2007) 20.67
Mutation of human short tandem repeats. Hum Mol Genet (1993) 14.03
An extensive network of coupling among gene expression machines. Nature (2002) 11.84
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics (1996) 11.71
High mobility of proteins in the mammalian cell nucleus. Nature (2000) 9.39
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79
Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol (2003) 6.98
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol (2007) 5.79
Repeat instability: mechanisms of dynamic mutations. Nat Rev Genet (2005) 5.37
Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J (2005) 5.36
Molecular origins of rapid and continuous morphological evolution. Proc Natl Acad Sci U S A (2004) 4.75
Diseases of unstable repeat expansion: mechanisms and common principles. Nat Rev Genet (2005) 4.66
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron (2003) 4.49
Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J (1991) 4.38
Paraspeckles: a novel nuclear domain. Curr Biol (2002) 4.19
Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science (1994) 3.92
The concept of self-organization in cellular architecture. J Cell Biol (2001) 3.49
Simple sequence repeats as advantageous mutators in evolution. Trends Genet (2006) 3.12
An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet (2005) 3.00
Sticky fingers: zinc-fingers as protein-recognition motifs. Trends Biochem Sci (2007) 2.47
Evidence of en bloc duplication in vertebrate genomes. Nat Genet (2002) 2.30
Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem (1998) 2.29
Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity. EMBO J (1997) 2.27
Amino acid runs in eukaryotic proteomes and disease associations. Proc Natl Acad Sci U S A (2002) 2.17
Sequential entry of components of the gene expression machinery into daughter nuclei. Mol Biol Cell (2003) 2.15
Proteomic analysis of interchromatin granule clusters. Mol Biol Cell (2004) 2.12
Subnuclear organelles: new insights into form and function. Trends Cell Biol (2005) 2.10
HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. Mol Cell Biol (1999) 2.06
Purification and biochemical characterization of interchromatin granule clusters. EMBO J (1999) 1.99
Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat Cell Biol (2007) 1.98
An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor. Proc Natl Acad Sci U S A (1995) 1.92
Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles. J Cell Biol (1999) 1.87
The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. J Cell Sci (2001) 1.82
Comparative analysis of amino acid repeats in rodents and humans. Genome Res (2004) 1.78
Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res (2005) 1.70
Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol Cell Biol (2002) 1.68
The other trinucleotide repeat: polyalanine expansion disorders. Curr Opin Genet Dev (2005) 1.62
Statistical significance of sequence patterns in proteins. Curr Opin Struct Biol (1995) 1.54
The nuclear ubiquitin-proteasome system. J Cell Sci (2006) 1.53
An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles. Exp Cell Res (2001) 1.50
SUMOrganization of the nucleus. Curr Opin Cell Biol (2007) 1.49
Functional diversification of duplicate genes through subcellular adaptation of encoded proteins. Genome Biol (2008) 1.37
DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly. J Cell Sci (2003) 1.36
Simple sequences are rare in the Protein Data Bank. Proteins (2002) 1.34
Amino acid reiterations in yeast are overrepresented in particular classes of proteins and show evidence of a slippage-like mutational process. J Mol Evol (1999) 1.32
Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc Natl Acad Sci U S A (2004) 1.30
Codon reiteration and the evolution of proteins. Proc Natl Acad Sci U S A (1994) 1.29
Polymorphism, shared functions and convergent evolution of genes with sequences coding for polyalanine domains. Hum Mol Genet (2003) 1.28
Retracted Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell (2008) 1.27
A role for selection in regulating the evolutionary emergence of disease-causing and other coding CAG repeats in humans and mice. Mol Biol Evol (2001) 1.25
POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution. Mol Cell Biol (1997) 1.21
Multiple activities contribute to Pc2 E3 function. EMBO J (2004) 1.19
Protein subcellular relocalization: a new perspective on the origin of novel genes. Trends Ecol Evol (2007) 1.15
Intracellular localization of homopolymeric amino acid-containing proteins expressed in mammalian cells. J Biol Chem (2004) 1.12
Highly constrained proteins contain an unexpectedly large number of amino acid tandem repeats. Genomics (2006) 1.09
Trinucleotide expansion mutations in the cartilage oligomeric matrix protein (COMP) gene. Hum Mol Genet (1999) 1.08
The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol (2003) 1.05
Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals. J Mol Evol (1996) 1.03
Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factors. Mol Biol Evol (1997) 1.01
Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1. J Cell Sci (2000) 1.00
Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J (1999) 0.99
Evolution of N-terminal sequences of the vertebrate HOXA13 protein. Mamm Genome (2000) 0.98
Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. Mol Cell Biol (2008) 0.97
Expansion of amino acid homo-sequences in proteins: insights into the role of amino acid homo-polymers and of the protein context in aggregation. Cell Mol Life Sci (2006) 0.97
Identification of a sequence element directing a protein to nuclear speckles. Proc Natl Acad Sci U S A (2001) 0.95
Coding repeats and evolutionary "agility". Bioessays (2005) 0.93
Possible association of NTDs with a polyhistidine tract polymorphism in the ZIC2 gene. Am J Med Genet (2002) 0.93
DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding. Mol Biol Cell (2007) 0.92
Morphological change caused by loss of the taxon-specific polyalanine tract in Hoxd-13. Mol Biol Evol (2006) 0.91
A novel role for PA28gamma-proteasome in nuclear speckle organization and SR protein trafficking. Mol Biol Cell (2008) 0.91
Genomic and evolutionary insights into genes encoding proteins with single amino acid repeats. Mol Biol Evol (2006) 0.90
Regulation of the development of tectal neurons and their projections by transcription factors Brn3a and Pax7. Dev Biol (2008) 0.89
Compositional biases and polyalanine runs in humans. Genetics (2003) 0.87
Genome comparisons and analysis. Curr Opin Struct Biol (2003) 0.86
Polyhistidine tract expansions in HOXA1 result in intranuclear aggregation and increased cell death. Biochem Biophys Res Commun (2005) 0.85
Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. J Biol Chem (2007) 0.84
Trinucleotide repeats are prevalent among cancer-related genes. Trends Genet (2007) 0.81
Enhanced autophagic cell death in expanded polyhistidine variants of HOXA1 reduces PBX1-coupled transcriptional activity and inhibits neuronal differentiation. J Neurosci Res (2007) 0.80
S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity. Biol Cell (2008) 0.79
Simple sequence in brain and nervous system specific proteins. Genome (2005) 0.77
CAC--the neglected repeat. Bioessays (1996) 0.76
PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics (2002) 4.74
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res (2003) 4.00
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A (2009) 2.63
Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J (2007) 2.30
Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes. Genome Biol (2004) 2.05
Origin of primate orphan genes: a comparative genomics approach. Mol Biol Evol (2008) 1.95
Exploring massive, genome scale datasets with the GenometriCorr package. PLoS Comput Biol (2012) 1.89
DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J (2010) 1.55
DNA transposon Hermes inserts into DNA in nucleosome-free regions in vivo. Proc Natl Acad Sci U S A (2010) 1.50
ABS: a database of Annotated regulatory Binding Sites from orthologous promoters. Nucleic Acids Res (2006) 1.40
DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly. J Cell Sci (2003) 1.36
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev Cell (2008) 1.31
Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system. Brain Res (2003) 1.25
Identification of PatL1, a human homolog to yeast P body component Pat1. Biochim Biophys Acta (2007) 1.21
Natural selection drives the accumulation of amino acid tandem repeats in human proteins. Genome Res (2010) 1.21
Differences in the evolutionary history of disease genes affected by dominant or recessive mutations. BMC Genomics (2006) 1.17
Housekeeping genes tend to show reduced upstream sequence conservation. Genome Biol (2007) 1.16
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proc Natl Acad Sci U S A (2012) 1.12
Identification of new herpesvirus gene homologs in the human genome. Genome Res (2002) 1.10
Highly constrained proteins contain an unexpectedly large number of amino acid tandem repeats. Genomics (2006) 1.09
Accelerated evolution after gene duplication: a time-dependent process affecting just one copy. Mol Biol Evol (2013) 1.04
Positional bias of general and tissue-specific regulatory motifs in mouse gene promoters. BMC Genomics (2007) 1.00
Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain. Eur J Neurosci (2007) 0.97
Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. Mol Cell Biol (2008) 0.97
Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Cell Stem Cell (2010) 0.97
The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators. Proc Natl Acad Sci U S A (2009) 0.94
Dynamics and adaptive benefits of modular protein evolution. Curr Opin Struct Biol (2013) 0.94
Interaction of the plant glycine-rich RNA-binding protein MA16 with a novel nucleolar DEAD box RNA helicase protein from Zea mays. Plant J (2004) 0.93
Role of low-complexity sequences in the formation of novel protein coding sequences. Mol Biol Evol (2011) 0.92
Heterogeneous patterns of gene-expression diversification in mammalian gene duplicates. Mol Biol Evol (2009) 0.92
DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding. Mol Biol Cell (2007) 0.92
Mutation patterns of amino acid tandem repeats in the human proteome. Genome Biol (2006) 0.91
Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. J Biol Chem (2010) 0.88
Improving genome-wide scans of positive selection by using protein isoforms of similar length. Genome Biol Evol (2013) 0.88
Lineage-specific variation in intensity of natural selection in mammals. Mol Biol Evol (2010) 0.88
Sequence shortening in the rodent ancestor. Genome Res (2011) 0.88
Virus bioinformatics: databases and recent applications. Appl Bioinformatics (2002) 0.86
Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229, impairs cytokine production. Immunol Cell Biol (2011) 0.85
Clustering of genes coding for DNA binding proteins in a region of atypical evolution of the human genome. J Mol Evol (2004) 0.84
Evolution of primate orphan proteins. Biochem Soc Trans (2009) 0.84
Emergence of novel domains in proteins. BMC Evol Biol (2013) 0.83
Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation. Cell Signal (2009) 0.83
The human cytomegalovirus-specific UL1 gene encodes a late-phase glycoprotein incorporated in the virion envelope. J Virol (2012) 0.82
Stop codons in bacteria are not selectively equivalent. Biol Direct (2012) 0.80
Structure and age jointly influence rates of protein evolution. PLoS Comput Biol (2012) 0.79
Deciphering the modulation of gene expression by type I and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis. Nucleic Acids Res (2013) 0.75
Detecting correlations among functional-sequence motifs. Phys Rev E Stat Nonlin Soft Matter Phys (2012) 0.75