Published in FEBS J on October 01, 2005
Linking folding and binding. Curr Opin Struct Biol (2009) 5.19
Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33
Global topological features of cancer proteins in the human interactome. Bioinformatics (2006) 4.17
Intrinsic disorder and functional proteomics. Biophys J (2006) 3.84
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol (2006) 3.23
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins. Proc Natl Acad Sci U S A (2007) 2.98
The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72
Intrinsically disordered proteins in cellular signalling and regulation. Nat Rev Mol Cell Biol (2015) 2.69
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics (2008) 2.50
What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae? Genome Biol (2006) 2.27
The HTLV-1 Tax interactome. Retrovirology (2008) 2.02
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93
Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res (2007) 1.92
From sequence and forces to structure, function, and evolution of intrinsically disordered proteins. Structure (2013) 1.76
A decade and a half of protein intrinsic disorder: biology still waits for physics. Protein Sci (2013) 1.74
The many faces of protein-protein interactions: A compendium of interface geometry. PLoS Comput Biol (2006) 1.71
TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder. Protein Pept Lett (2008) 1.70
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad Sci U S A (2007) 1.65
Improved disorder prediction by combination of orthogonal approaches. PLoS One (2009) 1.63
Prions, protein homeostasis, and phenotypic diversity. Trends Cell Biol (2010) 1.63
Expanding the proteome: disordered and alternatively folded proteins. Q Rev Biophys (2011) 1.60
Prediction of amyloidogenic and disordered regions in protein chains. PLoS Comput Biol (2006) 1.58
Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes. J Virol (2008) 1.53
Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits. Biochemistry (2008) 1.50
The role of disorder in interaction networks: a structural analysis. Mol Syst Biol (2008) 1.50
Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49
Accurate prediction of peptide binding sites on protein surfaces. PLoS Comput Biol (2009) 1.48
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Simple sequence repeats in prokaryotic genomes. Proc Natl Acad Sci U S A (2007) 1.45
Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. PLoS Genet (2009) 1.43
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Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics (2009) 1.41
Recent advances in MeCP2 structure and function. Biochem Cell Biol (2009) 1.41
Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins. Nucleic Acids Res (2006) 1.39
Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review). Mol Membr Biol (2008) 1.39
The protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation. Prog Biophys Mol Biol (2010) 1.38
How random are intrinsically disordered proteins? A small angle scattering perspective. Curr Protein Pept Sci (2012) 1.37
Identification of essential host factors affecting tombusvirus RNA replication based on the yeast Tet promoters Hughes Collection. J Virol (2006) 1.36
SPINE-D: accurate prediction of short and long disordered regions by a single neural-network based method. J Biomol Struct Dyn (2012) 1.32
Assemblages: functional units formed by cellular phase separation. J Cell Biol (2014) 1.30
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. Structure (2009) 1.28
Conservation of intrinsic disorder in protein domains and families: II. functions of conserved disorder. J Proteome Res (2006) 1.27
Topology of protein interaction network shapes protein abundances and strengths of their functional and nonspecific interactions. Proc Natl Acad Sci U S A (2011) 1.26
Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metab (2013) 1.25
Conformation of receptor-bound visual arrestin. Proc Natl Acad Sci U S A (2012) 1.24
A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell (2012) 1.23
Structure, function and networks of transcription factors involved in abiotic stress responses. Int J Mol Sci (2013) 1.23
Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding. Protein Sci (2013) 1.23
Hub promiscuity in protein-protein interaction networks. Int J Mol Sci (2010) 1.22
Substrate-dependent unfolding of the energy coupling motif of a membrane transport protein determined by double electron-electron resonance. Biochemistry (2006) 1.20
Natively unstructured loops differ from other loops. PLoS Comput Biol (2007) 1.19
The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome. J Biomed Biotechnol (2010) 1.16
Proteome-wide discovery of evolutionary conserved sequences in disordered regions. Sci Signal (2012) 1.15
Identification of transient hub proteins and the possible structural basis for their multiple interactions. Protein Sci (2008) 1.14
Evolution of pharmacologic specificity in the pregnane X receptor. BMC Evol Biol (2008) 1.14
PEP-19, an intrinsically disordered regulator of calmodulin signaling. J Biol Chem (2008) 1.13
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness. ACS Chem Neurosci (2011) 1.13
Protein disorder in the human diseasome: unfoldomics of human genetic diseases. BMC Genomics (2009) 1.11
Distinctive features of large complex virus genomes and proteomes. Proc Natl Acad Sci U S A (2007) 1.09
Amyloidogenesis of natively unfolded proteins. Curr Alzheimer Res (2008) 1.08
Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective. Genome Biol (2008) 1.08
Residual structures, conformational fluctuations, and electrostatic interactions in the synergistic folding of two intrinsically disordered proteins. PLoS Comput Biol (2012) 1.08
Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol (2009) 1.08
Intrinsic disorder: signaling via highly specific but short-lived association. Trends Biochem Sci (2011) 1.08
Biophysics of protein evolution and evolutionary protein biophysics. J R Soc Interface (2014) 1.08
Structural disorder promotes assembly of protein complexes. BMC Struct Biol (2007) 1.07
Structural modeling of protein interactions by analogy: application to PSD-95. PLoS Comput Biol (2006) 1.07
Ligand specificity and evolution of liver X receptors. J Steroid Biochem Mol Biol (2008) 1.06
Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions. Proc Natl Acad Sci U S A (2013) 1.06
Large-scale prediction of long disordered regions in proteins using random forests. BMC Bioinformatics (2009) 1.05
Analysis of structured and intrinsically disordered regions of transmembrane proteins. Mol Biosyst (2009) 1.05
A majority of the cancer/testis antigens are intrinsically disordered proteins. J Cell Biochem (2011) 1.05
Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometry. Proteins (2009) 1.05
Nanoimaging for protein misfolding and related diseases. J Cell Biochem (2006) 1.05
Impacts of protein-protein interaction domains on organism and network complexity. Genome Res (2008) 1.05
Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population. PLoS One (2011) 1.05
Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity. Proteins (2007) 1.04
Prediction of leucine-rich nuclear export signal containing proteins with NESsential. Nucleic Acids Res (2011) 1.03
Regulation of Escherichia coli SOS mutagenesis by dimeric intrinsically disordered umuD gene products. Proc Natl Acad Sci U S A (2008) 1.03
CDF it all: consensus prediction of intrinsically disordered proteins based on various cumulative distribution functions. FEBS Lett (2009) 1.03
Protein-protein interaction detection: methods and analysis. Int J Proteomics (2014) 1.03
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. Biophys J (2008) 1.03
Large-scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome. J Proteome Res (2009) 1.02
Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II? Protein Sci (2010) 1.02
Extreme multifunctional proteins identified from a human protein interaction network. Nat Commun (2015) 1.02
Disease mutations in disordered regions--exception to the rule? Mol Biosyst (2011) 1.01
The importance of being flexible: the case of basic region leucine zipper transcriptional regulators. Curr Protein Pept Sci (2009) 1.01
OKCAM: an ontology-based, human-centered knowledgebase for cell adhesion molecules. Nucleic Acids Res (2008) 1.01
Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions. BMC Genomics (2008) 1.01
e-Driver: a novel method to identify protein regions driving cancer. Bioinformatics (2014) 1.00
Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function. Chem Rev (2014) 1.00
Structural analysis of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) intracellular domain reveals a conserved interaction epitope. J Biol Chem (2012) 1.00
Allostery within a transcription coactivator is predominantly mediated through dissociation rate constants. Proc Natl Acad Sci U S A (2014) 0.99
The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin. J Biol Chem (2010) 0.99
Substrate-dependent transmembrane signaling in TonB-dependent transporters is not conserved. Proc Natl Acad Sci U S A (2007) 0.99
Domain distribution and intrinsic disorder in hubs in the human protein-protein interaction network. Protein Sci (2010) 0.99
Prediction of calcium-binding sites by combining loop-modeling with machine learning. BMC Struct Biol (2009) 0.98
The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations. Biophys J (2012) 0.98
The Pathway Tools software. Bioinformatics (2002) 14.89
Mapping copy number variation by population-scale genome sequencing. Nature (2011) 12.55
Intrinsic disorder and protein function. Biochemistry (2002) 8.54
Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13
TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86
DisProt: the Database of Disordered Proteins. Nucleic Acids Res (2006) 4.46
Function and structure of inherently disordered proteins. Curr Opin Struct Biol (2008) 4.19
Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell (2012) 4.03
Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97
Intrinsic disorder and functional proteomics. Biophys J (2006) 3.84
PONDR-FIT: a meta-predictor of intrinsically disordered amino acids. Biochim Biophys Acta (2010) 3.62
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res (2004) 3.59
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature (2011) 3.51
Analysis of molecular recognition features (MoRFs). J Mol Biol (2006) 3.40
Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. J Clin Invest (2011) 3.28
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol (2006) 3.23
Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI). Cancer Immunol Immunother (2007) 3.16
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest (2005) 3.11
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments. Bioinformatics (2006) 3.00
Tumour immunity: effector response to tumour and role of the microenvironment. Lancet (2008) 2.94
Coupled folding and binding with alpha-helix-forming molecular recognition elements. Biochemistry (2005) 2.94
"MIATA"-minimal information about T cell assays. Immunity (2009) 2.90
The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms. Proc Natl Acad Sci U S A (2006) 2.57
Identification, analysis, and prediction of protein ubiquitination sites. Proteins (2010) 2.53
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics (2008) 2.50
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Comparing and combining predictors of mostly disordered proteins. Biochemistry (2005) 2.45
Assessing protein disorder and induced folding. Proteins (2006) 2.33
Predicting intrinsic disorder in proteins: an overview. Cell Res (2009) 2.24
A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23
Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23
Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum (2008) 2.15
A bimodal distribution of two distinct categories of intrinsically disordered structures with separate functions in FG nucleoporins. Mol Cell Proteomics (2010) 2.09
DisProt: a database of protein disorder. Bioinformatics (2004) 1.99
The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J Biol Chem (2001) 1.99
Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93
Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res (2007) 1.92
Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils. Chem Biol (2004) 1.91
EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming. J Biol Chem (2006) 1.91
Harmonization of immune biomarker assays for clinical studies. Sci Transl Med (2011) 1.84
Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression. Eur J Immunol (2009) 1.81
Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR. Immunity (2005) 1.81
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions. Blood (2003) 1.78
Malleable machines take shape in eukaryotic transcriptional regulation. Nat Chem Biol (2008) 1.76
D²P²: database of disordered protein predictions. Nucleic Acids Res (2012) 1.75
New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J Immunol (2006) 1.74
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J Clin Invest (2009) 1.71
Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro. Biochemistry (2002) 1.71
TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder. Protein Pept Lett (2008) 1.70
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits. Biochemistry (2006) 1.68
Melan-A/MART-1-specific CD8 T cells: from thymus to tumor. Trends Immunol (2002) 1.68
Introducing protein intrinsic disorder. Chem Rev (2014) 1.66
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A (2007) 1.65
Composition Profiler: a tool for discovery and visualization of amino acid composition differences. BMC Bioinformatics (2007) 1.64
Harmonization guidelines for HLA-peptide multimer assays derived from results of a large scale international proficiency panel of the Cancer Vaccine Consortium. Cancer Immunol Immunother (2009) 1.63
Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses. Proc Natl Acad Sci U S A (2009) 1.61
Do viral proteins possess unique biophysical features? Trends Biochem Sci (2008) 1.60
Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen. Proc Natl Acad Sci U S A (2008) 1.59
Rational drug design via intrinsically disordered protein. Trends Biotechnol (2006) 1.57
Common features at the start of the neurodegeneration cascade. PLoS Biol (2012) 1.56
Close encounters of the third kind: disordered domains and the interactions of proteins. Bioessays (2009) 1.56
Toll-like receptor 3 expressed by melanoma cells as a target for therapy? Clin Cancer Res (2007) 1.55
Calmodulin signaling: analysis and prediction of a disorder-dependent molecular recognition. Proteins (2006) 1.51
Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes. Biochemistry (2003) 1.51
Combining prediction, computation and experiment for the characterization of protein disorder. Curr Opin Struct Biol (2004) 1.51
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity (2013) 1.51
Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life. J Biomol Struct Dyn (2012) 1.51
Improving protein order-disorder classification using charge-hydropathy plots. BMC Bioinformatics (2014) 1.50
Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49
MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins. Bioinformatics (2012) 1.49
The effect of macromolecular crowding on protein aggregation and amyloid fibril formation. J Mol Recognit (2004) 1.48
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res (2007) 1.48
Transcriptional profiling of Caulobacter crescentus during growth on complex and minimal media. J Bacteriol (2004) 1.46
Unfoldomics of human genetic diseases: illustrative examples of ordered and intrinsically disordered members of the human diseasome. Protein Pept Lett (2009) 1.45
Thymic selection generates a large T cell pool recognizing a self-peptide in humans. J Exp Med (2002) 1.44
High stability of Discosoma DsRed as compared to Aequorea EGFP. Biochemistry (2003) 1.44
Α-synuclein misfolding and Parkinson's disease. Biochim Biophys Acta (2011) 1.43
Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity. Oncogene (2002) 1.42