PubRank

James A Irving

Author PubWeight™ 24.29‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res 2005 1.70
2 The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J Biol Chem 2005 1.21
3 The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J Biol Chem 2005 1.20
4 MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography. PLoS One 2010 1.01
5 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. Biochemistry 2003 0.98
6 Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection. Infect Immun 2003 0.97
7 The N terminus of the serpin, tengpin, functions to trap the metastable native state. EMBO Rep 2007 0.97
8 The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases. Biochemistry 2002 0.97
9 Structural mechanisms of inactivation in scabies mite serine protease paralogues. J Mol Biol 2009 0.94
10 Characterisation of serpin polymers in vitro and in vivo. Methods 2010 0.94
11 X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation. EMBO J 2006 0.94
12 Role of the alpha-helix 163-170 in factor Xa catalytic activity. J Biol Chem 2007 0.94
13 DNA accelerates the inhibition of human cathepsin V by serpins. J Biol Chem 2007 0.92
14 The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition. J Biol Chem 2004 0.88
15 Structure of granzyme C reveals an unusual mechanism of protease autoinhibition. Proc Natl Acad Sci U S A 2009 0.88
16 A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2. Mycol Res 2008 0.88
17 Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5. J Immunol Methods 2005 0.87
18 Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap. J Biol Chem 2007 0.86
19 Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway. Biosci Rep 2013 0.86
20 Unravelling the twists and turns of the serpinopathies. FEBS J 2011 0.84
21 A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites. Int J Biochem Cell Biol 2009 0.84
22 A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. J Biol Chem 2013 0.83
23 Conformational change in the chromatin remodelling protein MENT. PLoS One 2009 0.78
24 Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity. Biochim Biophys Acta 2013 0.78
25 Targeting serpins in high-throughput and structure-based drug design. Methods Enzymol 2011 0.77
26 Serpins: finely balanced conformational traps. IUBMB Life 2002 0.77