Published in Biochemistry on March 05, 2002
Evolutionary families of peptidase inhibitors. Biochem J (2004) 3.57
Protease signalling: the cutting edge. EMBO J (2012) 1.24
Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin. Mol Cell Biol (2006) 1.22
Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest (2010) 1.11
The many faces of protease-protein inhibitor interaction. EMBO J (2005) 1.11
NF-kappaB protects from the lysosomal pathway of cell death. EMBO J (2003) 1.00
A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol (2010) 0.90
Hepatic progenitor cells express SerpinB3. BMC Cell Biol (2014) 0.89
The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families. Biochem J (2007) 0.88
Potential use of a serpin from Arabidopsis for pest control. PLoS One (2011) 0.80
Multiple domains of endopin 2A for serpin cross-class inhibition of papain. Arch Biochem Biophys (2007) 0.80
The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk. Curr Protein Pept Sci (2012) 0.77
Adaptive evolution and divergence of SERPINB3: a young duplicate in great Apes. PLoS One (2014) 0.75
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The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem (2006) 5.92
MUSTANG: a multiple structural alignment algorithm. Proteins (2006) 4.69
The price of freedom. Cranio (2011) 3.85
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature (2006) 3.65
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52
Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell (2011) 3.49
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity (2003) 3.41
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Hum Mol Genet (2010) 3.00
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat Immunol (2005) 2.52
Diversity and dynamics of the Drosophila transcriptome. Nature (2014) 2.47
Spermatozoal RNA profiles of normal fertile men. Lancet (2002) 2.46
The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod (2012) 2.46
A de novo mutation in the β-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum. Am J Hum Genet (2013) 2.42
Prostate cancer, version 2.2014. J Natl Compr Canc Netw (2014) 2.40
A divergent external loop confers antagonistic activity on floral regulators FT and TFL1. EMBO J (2006) 2.29
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res (2010) 2.27
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15
An overview of the serpin superfamily. Genome Biol (2006) 2.14
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. J Biol Chem (2006) 2.05
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65. PLoS Pathog (2010) 2.03
Quantitative CT indexes in idiopathic pulmonary fibrosis: relationship with physiologic impairment. Radiology (2003) 2.01
The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity (2009) 1.98
The cognitive impact of anticholinergics: a clinical review. Clin Interv Aging (2009) 1.86
A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications. Trends Biotechnol (2013) 1.85
Prostate cancer, Version 3.2012: featured updates to the NCCN guidelines. J Natl Compr Canc Netw (2012) 1.84
Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design. Chem Rev (2002) 1.81
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. Mol Microbiol (2006) 1.79
Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences. Genome Res (2009) 1.79
Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J (2009) 1.79
Smallpox and pan-orthopox virus detection by real-time 3'-minor groove binder TaqMan assays on the roche LightCycler and the Cepheid smart Cycler platforms. J Clin Microbiol (2004) 1.77
qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles. PLoS One (2012) 1.77
A field investigation of Bacillus anthracis contamination of U.S. Department of Agriculture and other Washington, D.C., buildings during the anthrax attack of October 2001. Appl Environ Microbiol (2003) 1.76
Reproductive biology: delivering spermatozoan RNA to the oocyte. Nature (2004) 1.76
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity (2011) 1.73
Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res (2005) 1.70
Idiopathic pulmonary fibrosis: physiologic tests, quantitative CT indexes, and CT visual scores as predictors of mortality. Radiology (2008) 1.66
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A (2009) 1.63
Understanding the accommodating intraocular lens. J Cataract Refract Surg (2003) 1.63
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. PLoS One (2010) 1.62
The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment. Structure (2003) 1.61
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol (2007) 1.56
An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell (2007) 1.56
Impact and recognition of cognitive impairment among hospitalized elders. J Hosp Med (2010) 1.56
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood (2013) 1.53
Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development. Epigenetics (2012) 1.53
Increasing access to specialty care: a pilot, randomized controlled trial of telemedicine for Parkinson's disease. Mov Disord (2010) 1.50
Computational analysis of evolution and conservation in a protein superfamily. Methods (2004) 1.49
The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol (2006) 1.48
The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics. Adv Drug Deliv Rev (2005) 1.47
Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. Am J Hum Genet (2013) 1.46
Regulation of collagenase activities of human cathepsins by glycosaminoglycans. J Biol Chem (2003) 1.46
Green space and stress: evidence from cortisol measures in deprived urban communities. Int J Environ Res Public Health (2013) 1.44
Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design. Chem Biol (2002) 1.42
A single, early magnetic resonance imaging study in the diagnosis of multiple sclerosis. Arch Neurol (2009) 1.41
Fear of statins? CMAJ (2009) 1.39
Airborne endotoxin is associated with respiratory illness in the first 2 years of life. Environ Health Perspect (2006) 1.38
Indicators of perceived naturalness as drivers of landscape preference. J Environ Manage (2008) 1.38
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer. EMBO Rep (2011) 1.37
Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. Lancet Neurol (2007) 1.36
Simple sequence repeat-based consensus linkage map of Bombyx mori. Proc Natl Acad Sci U S A (2005) 1.35
Pivotal role of cathepsin K in lung fibrosis. Am J Pathol (2004) 1.35
Cascleave: towards more accurate prediction of caspase substrate cleavage sites. Bioinformatics (2010) 1.34
Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum (2002) 1.34
Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr (2008) 1.33
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem (2010) 1.32
Prostate cancer, version 1.2014. J Natl Compr Canc Netw (2013) 1.32
Perforin: structure, function, and role in human immunopathology. Immunol Rev (2010) 1.30
PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites. PLoS One (2012) 1.28
Imported Lassa fever, Pennsylvania, USA, 2010. Emerg Infect Dis (2010) 1.28
Automatic generation of protein structure cartoons with Pro-origami. Bioinformatics (2011) 1.28
Paternal contributions: new functional insights for spermatozoal RNA. J Cell Biochem (2008) 1.27
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell (2005) 1.26
Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens. Mol Cancer Ther (2011) 1.25
Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer (2014) 1.24
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J Biol Chem (2004) 1.24
Monkeypox virus detection in rodents using real-time 3'-minor groove binder TaqMan assays on the Roche LightCycler. Lab Invest (2004) 1.23
PoPS: a computational tool for modeling and predicting protease specificity. J Bioinform Comput Biol (2005) 1.23
Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates. J Biol Chem (2008) 1.23
Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol (2015) 1.23
The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis. J Mol Biol (2006) 1.23
The X-ray crystal structure of full-length human plasminogen. Cell Rep (2012) 1.22
Serpins in prokaryotes. Mol Biol Evol (2002) 1.22
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends Biochem Sci (2009) 1.21
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.21
Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions. BMC Biochem (2009) 1.21