Robust fluorescent detection of protein fatty-acylation with chemical reporters.

Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nat Chem Biol (2010) 2.76

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity. Nat Chem Biol (2011) 2.03

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem (2013) 1.95

Comparative analysis of cleavable azobenzene-based affinity tags for bioorthogonal chemical proteomics. Chem Biol (2010) 1.91

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. Nature (2013) 1.79

Site-specific analysis of protein S-acylation by resin-assisted capture. J Lipid Res (2010) 1.77

Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc (2010) 1.71

Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. PLoS Biol (2013) 1.68

S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. J Biol Chem (2012) 1.67

Bioorthogonal chemistry: recent progress and future directions. Chem Commun (Camb) (2010) 1.58

Protein myristoylation in health and disease. J Chem Biol (2009) 1.57

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani. Chem Biol (2015) 1.47

Cleavable biotin probes for labeling of biomolecules via azide-alkyne cycloaddition. J Am Chem Soc (2010) 1.47

Tandem fluorescence imaging of dynamic S-acylation and protein turnover. Proc Natl Acad Sci U S A (2010) 1.44

Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants. Mol Cell Proteomics (2010) 1.43

The chemical toolbox for monitoring protein fatty acylation and prenylation. Nat Chem Biol (2010) 1.42

Bioorthogonal chemical reporters for analyzing protein lipidation and lipid trafficking. Acc Chem Res (2011) 1.28

Sulfenic acid chemistry, detection and cellular lifetime. Biochim Biophys Acta (2013) 1.23

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1. Proc Natl Acad Sci U S A (2011) 1.21

Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res (2009) 1.20

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun (2014) 1.19

Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. J Biol Chem (2010) 1.18

Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry. Nat Protoc (2011) 1.17

Exploring protein lipidation with chemical biology. Chem Rev (2011) 1.15

Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation. Chem Biol Drug Des (2010) 1.12

Global profiling of protein lipidation using chemical proteomic technologies. Curr Opin Chem Biol (2014) 1.10

Orthogonal alkynyl amino acid reporter for selective labeling of bacterial proteomes during infection. Angew Chem Int Ed Engl (2010) 1.10

Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding. Mol Cell Biol (2013) 1.06

Palmitoylation on conserved and nonconserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity. J Virol (2013) 1.03

The physiology of protein S-acylation. Physiol Rev (2015) 1.03

Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. Mol Biosyst (2010) 1.02

Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation. J Am Chem Soc (2012) 1.02

A chemical reporter for protein AMPylation. J Am Chem Soc (2011) 1.01

Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Circ Res (2012) 1.00

Rapid visualization and large-scale profiling of bacterial lipoproteins with chemical reporters. J Am Chem Soc (2010) 1.00

Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform. Proc Natl Acad Sci U S A (2013) 0.99

Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. J Neurosci (2013) 0.97

Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23. PLoS One (2012) 0.95

Proteomic analysis of fatty-acylated proteins. Curr Opin Chem Biol (2015) 0.94

Differential regulation of two palmitoylation sites in the cytoplasmic tail of the beta1-adrenergic receptor. J Biol Chem (2011) 0.92

Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc Natl Acad Sci U S A (2013) 0.92

Emerging roles for protein S-palmitoylation in immunity from chemical proteomics. Curr Opin Chem Biol (2013) 0.92

Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding. Eur J Immunol (2011) 0.91

Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells. J Am Chem Soc (2015) 0.91

Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease. Chem Biol (2013) 0.90

Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification. J Am Chem Soc (2014) 0.90

Profiling and inhibiting reversible palmitoylation. Curr Opin Chem Biol (2013) 0.89

Integrative chemical biology approaches for identification and characterization of "erasers" for fatty-acid-acylated lysine residues within proteins. Angew Chem Int Ed Engl (2014) 0.89

Mass spectrometry in studies of protein thiol chemistry and signaling: opportunities and caveats. Free Radic Biol Med (2014) 0.89

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish. Chem Sci (2014) 0.88

cat-ELCCA: a robust method to monitor the fatty acid acyltransferase activity of ghrelin O-acyltransferase (GOAT). Angew Chem Int Ed Engl (2010) 0.88

Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation. Proc Natl Acad Sci U S A (2016) 0.87

Chemoproteomics reveals Toll-like receptor fatty acylation. BMC Biol (2014) 0.86

Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe. Chem Biol (2009) 0.86

Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells. PLoS One (2013) 0.86

Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ. Mol Cell (2015) 0.86

Identification of lysine acetyltransferase p300 substrates using 4-pentynoyl-coenzyme A and bioorthogonal proteomics. Bioorg Med Chem Lett (2011) 0.86

A mechanism regulating G protein-coupled receptor signaling that requires cycles of protein palmitoylation and depalmitoylation. J Biol Chem (2014) 0.86

Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. PLoS One (2014) 0.86

The yeast kinase Yck2 has a tripartite palmitoylation signal. Mol Biol Cell (2011) 0.83

Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells. J Biol Chem (2011) 0.83

Chemical proteomics approaches for identifying the cellular targets of natural products. Nat Prod Rep (2016) 0.83

Ion channel regulation by protein S-acylation. J Gen Physiol (2014) 0.82

Chemical reporters for exploring protein acylation. Biochem Soc Trans (2015) 0.82

A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome. PLoS Pathog (2015) 0.81

MARTX effector cross kingdom activation by Golgi-associated ADP-ribosylation factors. Cell Microbiol (2016) 0.81

Identifying the functional contribution of the defatty-acylase activity of SIRT6. Nat Chem Biol (2016) 0.80

The palmitoylation state of PMP22 modulates epithelial cell morphology and migration. ASN Neuro (2012) 0.80

Redox-based probes as tools to monitor oxidized protein tyrosine phosphatases in living cells. Eur J Med Chem (2014) 0.80

Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins. Chembiochem (2016) 0.79

Chemical reporter for visualizing metabolic cross-talk between carbohydrate metabolism and protein modification. ACS Chem Biol (2014) 0.79

IFITMs from Mycobacteria Confer Resistance to Influenza Virus When Expressed in Human Cells. Viruses (2015) 0.79

Single-cell in situ imaging of palmitoylation in fatty-acylated proteins. Nat Protoc (2014) 0.79

Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy. PLoS One (2014) 0.78

Palmitoylation of plakophilin is required for desmosome assembly. J Cell Sci (2014) 0.78

Chemical approaches for profiling dynamic palmitoylation. Biochem Soc Trans (2013) 0.78

Nonradioactive analysis of dynamic protein palmitoylation. Curr Protoc Protein Sci (2013) 0.77

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei. ACS Infect Dis (2016) 0.77

Bioorthogonal click chemistry to assay mu-opioid receptor palmitoylation using 15-hexadecynoic acid and immunoprecipitation. Anal Biochem (2014) 0.77

Extracellular Toxoplasma gondii tachyzoites metabolize and incorporate unnatural sugars into cellular proteins. Microbes Infect (2015) 0.76

Comparative analysis of S-fatty acylation of gel-separated proteins by stable isotope-coded fatty acid transmethylation and mass spectrometry. Nat Protoc (2011) 0.76

Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability. PLoS One (2015) 0.76

Host Cell-catalyzed S-Palmitoylation Mediates Golgi Targeting of the Legionella Ubiquitin Ligase GobX. J Biol Chem (2015) 0.76

Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1). PLoS One (2016) 0.76

Targeting the N terminus for site-selective protein modification. Nat Chem Biol (2017) 0.76

Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation. Methods Mol Biol (2014) 0.75

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi. PLoS Negl Trop Dis (2016) 0.75

Detecting N-myristoylation and S-acylation of host and pathogen proteins in plants using click chemistry. Plant Methods (2016) 0.75

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Proc Natl Acad Sci U S A (2017) 0.75

Palmitoylation of Sindbis virus TF protein regulates its plasma membrane localization and subsequent incorporation into virions. J Virol (2016) 0.75

Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation. MBio (2016) 0.75

Protein S-palmitoylation in cellular differentiation. Biochem Soc Trans (2017) 0.75

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. Elife (2017) 0.75

Mass-Tag Labeling Using Acyl-PEG Exchange for the Determination of Endogenous Protein S-Fatty Acylation. Curr Protoc Protein Sci (2017) 0.75

Fluorescent imaging of protein myristoylation during cellular differentiation and development. J Lipid Res (2017) 0.75

A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A (2003) 2.97

Free radical scavenging properties of wheat extracts. J Agric Food Chem (2002) 2.84

Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nat Genet (2004) 2.82

A necrotic uterus after a B-Lynch Suture: fertility sparing surgery. Aust N Z J Obstet Gynaecol (2013) 2.77

Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nat Chem Biol (2010) 2.76

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep (2008) 2.65

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52

Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging. J Clin Oncol (2003) 2.35

A multi-institutional analysis of the socioeconomic determinants of breast reconstruction: a study of the National Comprehensive Cancer Network. Ann Surg (2006) 2.29

Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation. J Am Chem Soc (2002) 2.26

Volunteering and depression: the role of psychological and social resources in different age groups. Soc Sci Med (2003) 2.26

Comparative analysis of cleavable azobenzene-based affinity tags for bioorthogonal chemical proteomics. Chem Biol (2010) 1.91

Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell (2012) 1.89

Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex). J Immunother (2010) 1.81

Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling. Chem Biol (2004) 1.78

Near-roadway pollution and childhood asthma: implications for developing "win-win" compact urban development and clean vehicle strategies. Environ Health Perspect (2012) 1.73

Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc (2010) 1.71

Chemical reporters for biological discovery. Nat Chem Biol (2013) 1.69

Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. PLoS Biol (2013) 1.68

S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. J Biol Chem (2012) 1.67

Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis. PLoS One (2012) 1.58

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol (2005) 1.50

Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem (2008) 1.48

Contralateral prophylactic mastectomy for unilateral breast cancer: an increasing trend at a single institution. Ann Surg Oncol (2009) 1.46

EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. Cancer Cell (2013) 1.44

Tandem fluorescence imaging of dynamic S-acylation and protein turnover. Proc Natl Acad Sci U S A (2010) 1.44

Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants. Mol Cell Proteomics (2010) 1.43

Chemical tools for understanding protein lipidation in eukaryotes. Curr Opin Chem Biol (2009) 1.40

Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection. PLoS Pathog (2011) 1.28

The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling. J Virol (2011) 1.26

Impact of hormone receptor status on patterns of recurrence and clinical outcomes among patients with human epidermal growth factor-2-positive breast cancer in the National Comprehensive Cancer Network: a prospective cohort study. Breast Cancer Res (2012) 1.26

Estimation of oxygen uptake during fast running using accelerometry and heart rate. Med Sci Sports Exerc (2007) 1.25

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1. Proc Natl Acad Sci U S A (2011) 1.21

Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1. J Virol (2014) 1.19

Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. J Biol Chem (2010) 1.18

Outer segment formation of transplanted photoreceptor precursor cells. PLoS One (2012) 1.16

Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI. NMR Biomed (2002) 1.16

The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells. PLoS One (2010) 1.15

Constructing azide-labeled cell surfaces using polysaccharide biosynthetic pathways. Methods Enzymol (2003) 1.12

Orthogonal alkynyl amino acid reporter for selective labeling of bacterial proteomes during infection. Angew Chem Int Ed Engl (2010) 1.10

The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses. Int J Oncol (2002) 1.08

Oxygen uptake and muscle desaturation kinetics during intermittent cycling. Med Sci Sports Exerc (2006) 1.07

Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? PLoS One (2010) 1.06

Older women with breast carcinoma are less likely to receive adjuvant chemotherapy: evidence of possible age bias? Cancer (2003) 1.05

Sendai virus infection induces efficient adaptive immunity independently of type I interferons. J Virol (2006) 1.03

Palmitoylation on conserved and nonconserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity. J Virol (2013) 1.03

Subcellular targeting of Salmonella virulence proteins by host-mediated S-palmitoylation. Cell Host Microbe (2011) 1.02

Alkynyl-farnesol reporters for detection of protein S-prenylation in cells. Mol Biosyst (2010) 1.02

Receipt of preventive health services by IBD patients is significantly lower than by primary care patients. Inflamm Bowel Dis (2008) 1.01

Multiplexed staining of live human embryonic stem cells for flow cytometric analysis of pluripotency markers. Stem Cells Dev (2009) 1.01

A chemical reporter for protein AMPylation. J Am Chem Soc (2011) 1.01

Effects of single bout of very high-intensity exercise on metabolic health biomarkers in overweight/obese sedentary men. Metabolism (2012) 1.01

Rapid visualization and large-scale profiling of bacterial lipoproteins with chemical reporters. J Am Chem Soc (2010) 1.00

Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination. J Biol Chem (2014) 1.00

Glioma surgical aspirate: a viable source of tumor tissue for experimental research. Cancers (Basel) (2013) 0.99

Effective gene transfer to solid tumors using different nonviral gene delivery techniques: electroporation, liposomes, and integrin-targeted vector. Cancer Gene Ther (2002) 0.99

Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform. Proc Natl Acad Sci U S A (2013) 0.99

Longitudinal study of childhood wheezy bronchitis and asthma: outcome at age 42. BMJ (2003) 0.98

Toll-like receptor-independent triggering of dendritic cell maturation by viruses. J Virol (2006) 0.97

Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol (2004) 0.97

Antioxidant properties of bran extracts from "Akron" wheat grown at different locations. J Agric Food Chem (2003) 0.97

Blood lactate clearance during active recovery after an intense running bout depends on the intensity of the active recovery. J Sports Sci (2010) 0.97

Platelet-rich plasma for treatment of Achilles tendinopathy. JAMA (2010) 0.96

Factors associated with sphincter-preserving surgery for rectal cancer at national comprehensive cancer network centers. Ann Surg (2009) 0.96

cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii. Mol Biochem Parasitol (2003) 0.95

Seeing small molecules in action with bioorthogonal chemistry. Drug Discov Today (2008) 0.95

Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetic enzymes. Bioorg Med Chem (2011) 0.94

Practice parameter: utility of electrodiagnostic techniques in evaluating patients with suspected peroneal neuropathy: an evidence-based review. Muscle Nerve (2005) 0.94

Chemotherapy use for hormone receptor-positive, lymph node-negative breast cancer. J Clin Oncol (2008) 0.93

Lethal serotonin syndrome after methylone and butylone ingestion. J Med Toxicol (2012) 0.93

Chronic fatigue syndrome: new evidence for a central fatigue disorder. Clin Sci (Lond) (2003) 0.92

Differential regulation of two palmitoylation sites in the cytoplasmic tail of the beta1-adrenergic receptor. J Biol Chem (2011) 0.92

Religiosity, psychological resources, and physical health. J Sci Study Relig (2011) 0.92

Emerging roles for protein S-palmitoylation in immunity from chemical proteomics. Curr Opin Chem Biol (2013) 0.92

Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding. Eur J Immunol (2011) 0.91

Chemical approaches for the detection and synthesis of acetylated proteins. Chembiochem (2011) 0.91

Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells. J Am Chem Soc (2015) 0.91

Endothelial activation and increased heparan sulfate expression in cystic fibrosis. Am J Respir Crit Care Med (2005) 0.91

The potential importance of nut removal by rodents from Australian macadamia orchards. J Environ Manage (2005) 0.90

Improved outcomes from acute severe asthma in Australian intensive care units (1996 2003). Thorax (2007) 0.90

Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial tumors. Nanomedicine (Lond) (2011) 0.90

The effect of lace-up ankle braces on injury rates in high school football players. Am J Sports Med (2011) 0.90

Visualization and Identification of Fatty Acylated Proteins Using Chemical Reporters. Curr Protoc Chem Biol (2011) 0.89

Integrative chemical biology approaches for identification and characterization of "erasers" for fatty-acid-acylated lysine residues within proteins. Angew Chem Int Ed Engl (2014) 0.89

Clickable fluorescent dyes for multimodal bioorthogonal imaging. Org Biomol Chem (2009) 0.88

Identification of speckle-type POZ protein somatic mutations in African American prostate cancer. Asian J Androl (2014) 0.88

Effectiveness of vaccination with recombinant HpaA from Helicobacter pylori is influenced by host genetic background. FEMS Immunol Med Microbiol (2007) 0.88

Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol (2008) 0.88

Estimating the probability of lymphedema after breast cancer surgery. Am J Clin Oncol (2011) 0.87

Identification of lysine acetyltransferase p300 substrates using 4-pentynoyl-coenzyme A and bioorthogonal proteomics. Bioorg Med Chem Lett (2011) 0.86