Published in Nature on April 04, 2013
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab (2015) 2.48
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins. J Biol Chem (2013) 2.03
Chemical reporters for biological discovery. Nat Chem Biol (2013) 1.69
The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57
Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases. Mol Cell (2014) 1.56
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Dis Model Mech (2013) 1.55
Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani. Chem Biol (2015) 1.47
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
Sirtuins: guardians of mammalian healthspan. Trends Genet (2014) 1.36
Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol (2013) 1.31
Evolution and functional cross-talk of protein post-translational modifications. Mol Syst Biol (2013) 1.30
Chromatin and beyond: the multitasking roles for SIRT6. Trends Biochem Sci (2014) 1.27
Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell (2014) 1.20
Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach. Elife (2014) 1.13
Global profiling of protein lipidation using chemical proteomic technologies. Curr Opin Chem Biol (2014) 1.10
Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal (2015) 1.09
The multifaceted functions of sirtuins in cancer. Nat Rev Cancer (2015) 1.04
Acetyl-CoA and the regulation of metabolism: mechanisms and consequences. Curr Opin Cell Biol (2015) 1.01
Metabolic characterization of a Sirt5 deficient mouse model. Sci Rep (2013) 1.00
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation. Biochemistry (2015) 1.00
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
Sirtuin inhibitors as anticancer agents. Future Med Chem (2014) 0.98
Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling. Cardiovasc Res (2014) 0.98
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res (2013) 0.98
Protein acetylation in metabolism - metabolites and cofactors. Nat Rev Endocrinol (2015) 0.97
Efficient demyristoylase activity of SIRT2 revealed by kinetic and structural studies. Sci Rep (2015) 0.97
Sirtuins are evolutionarily conserved viral restriction factors. MBio (2014) 0.96
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun (2016) 0.94
SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY) (2013) 0.94
Proteomic analysis of fatty-acylated proteins. Curr Opin Chem Biol (2015) 0.94
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Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. BMB Rep (2013) 0.93
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes. Mol Cell (2016) 0.93
Sirtuins, metabolism, and DNA repair. Curr Opin Genet Dev (2014) 0.92
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell Metab (2017) 0.92
Mechanisms and Dynamics of Protein Acetylation in Mitochondria. Trends Biochem Sci (2016) 0.91
Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins. Chem Biol (2015) 0.91
Depletion of the central metabolite NAD leads to oncosis-mediated cell death. J Biol Chem (2014) 0.90
SIRT6 exhibits nucleosome-dependent deacetylase activity. Nucleic Acids Res (2013) 0.90
Integrative chemical biology approaches for identification and characterization of "erasers" for fatty-acid-acylated lysine residues within proteins. Angew Chem Int Ed Engl (2014) 0.89
The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol (2015) 0.89
SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence. Nat Struct Mol Biol (2016) 0.89
A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. Cell Metab (2017) 0.89
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell (2016) 0.88
Sirtuins in epigenetic regulation. Chem Rev (2015) 0.88
A proteomic perspective of Sirtuin 6 (SIRT6) phosphorylation and interactions and their dependence on its catalytic activity. Mol Cell Proteomics (2013) 0.88
Pharmacophore model of the quercetin binding site of the SIRT6 protein. J Mol Graph Model (2014) 0.88
Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets. PLoS Negl Trop Dis (2013) 0.88
Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Org Biomol Chem (2014) 0.87
Histone Deacetylases in Bone Development and Skeletal Disorders. Physiol Rev (2015) 0.87
Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ. Mol Cell (2015) 0.86
Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription. Proc Natl Acad Sci U S A (2014) 0.85
A fluorogenic assay for screening Sirt6 modulators. Org Biomol Chem (2013) 0.85
Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia (2016) 0.85
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming. Dis Model Mech (2014) 0.84
Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples. Anal Bioanal Chem (2015) 0.84
Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer. Cell Rep (2015) 0.83
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun (2015) 0.83
HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine. ACS Chem Biol (2016) 0.82
Sirtuins in hematological aging and malignancy. Crit Rev Oncog (2013) 0.82
Chemical reporters for exploring protein acylation. Biochem Soc Trans (2015) 0.82
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res (2014) 0.82
Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. J Biol Chem (2016) 0.82
Fatty acylation of proteins: The long and the short of it. Prog Lipid Res (2016) 0.81
Potential Modulation of Sirtuins by Oxidative Stress. Oxid Med Cell Longev (2015) 0.81
Coupling circadian rhythms of metabolism and chromatin remodelling. Diabetes Obes Metab (2015) 0.81
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc Natl Acad Sci U S A (2016) 0.81
Sirtuins, a promising target in slowing down the ageing process. Biogerontology (2017) 0.80
Identifying the functional contribution of the defatty-acylase activity of SIRT6. Nat Chem Biol (2016) 0.80
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Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins. Chembiochem (2016) 0.79
The Cysteine-rich Domain of the DHHC3 Palmitoyltransferase Is Palmitoylated and Contains Tightly Bound Zinc. J Biol Chem (2015) 0.79
Sirtuin deacetylases as therapeutic targets in the nervous system. Neurotherapeutics (2013) 0.79
Sirtuins, aging, and cardiovascular risks. Age (Dordr) (2015) 0.79
SIRT6: Novel Mechanisms and Links to Aging and Disease. Trends Endocrinol Metab (2016) 0.79
N-Acylethanolamines Bind to SIRT6. Chembiochem (2015) 0.78
SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp. BMC Mol Biol (2015) 0.78
Histone lysine crotonylation during acute kidney injury in mice. Dis Model Mech (2016) 0.78
SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones. J Am Chem Soc (2016) 0.78
Acupuncture may exert its therapeutic effect through microRNA-339/Sirt2/NFκB/FOXO1 axis. Biomed Res Int (2015) 0.78
Technologies and Challenges in Proteomic Analysis of Protein S-acylation. J Proteomics Bioinform (2014) 0.78
Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. Protein Sci (2014) 0.78
Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory. Sci Rep (2016) 0.77
Defining the orphan functions of lysine acetyltransferases. ACS Chem Biol (2015) 0.77
The role of sirtuins in cellular homeostasis. J Physiol Biochem (2016) 0.77
A Versatile Approach for Site-Specific Lysine Acylation in Proteins. Angew Chem Int Ed Engl (2017) 0.77
Lysine fatty acylation promotes lysosomal targeting of TNF-α. Sci Rep (2016) 0.77
Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Mol Metab (2015) 0.77
A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions. Sci Rep (2016) 0.77
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. Oncogene (2016) 0.76
An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3. Org Biomol Chem (2016) 0.76
Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY) (2016) 0.76
The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome. Cell Mol Life Sci (2016) 0.76
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity. Cell Rep (2017) 0.76
Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle. Ageing Res Rev (2017) 0.75
Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively. Chin Med J (Engl) (2015) 0.75
Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin. PLoS One (2016) 0.75
Epigenetic control of gene function in schistosomes: a source of therapeutic targets? Front Genet (2014) 0.75
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