|
1
|
A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis.
|
Clin Infect Dis
|
2006
|
4.29
|
|
2
|
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock.
|
Crit Care Med
|
2004
|
4.24
|
|
3
|
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
|
JAMA
|
2012
|
4.13
|
|
4
|
Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC.
|
Intensive Care Med
|
2013
|
2.08
|
|
5
|
Variability in outcome and resource use in intensive care units.
|
Intensive Care Med
|
2007
|
2.04
|
|
6
|
The pulmonary artery catheter: in medio virtus.
|
Crit Care Med
|
2008
|
2.01
|
|
7
|
Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism.
|
Crit Care Med
|
2006
|
1.95
|
|
8
|
Global trend according to estimated number of occupational accidents and fatal work-related diseases at region and country level.
|
J Safety Res
|
2009
|
1.90
|
|
9
|
Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial.
|
Crit Care
|
2009
|
1.87
|
|
10
|
Global estimates of fatal work-related diseases.
|
Am J Ind Med
|
2007
|
1.64
|
|
11
|
Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation.
|
Intensive Care Med
|
2008
|
1.63
|
|
12
|
Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler.
|
Intensive Care Med
|
2003
|
1.55
|
|
13
|
Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).
|
Crit Care Med
|
2004
|
1.51
|
|
14
|
Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach.
|
Crit Care
|
2013
|
1.50
|
|
15
|
Comparison of continuous and intermittent renal replacement therapy for acute renal failure.
|
Nephrol Dial Transplant
|
2005
|
1.50
|
|
16
|
Angiotensin II in septic shock: effects on tissue perfusion, organ function, and mitochondrial respiration in a porcine model of fecal peritonitis.
|
Crit Care Med
|
2014
|
1.49
|
|
17
|
Arterial blood pressure during early sepsis and outcome.
|
Intensive Care Med
|
2009
|
1.49
|
|
18
|
Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion.
|
Intensive Care Med
|
2008
|
1.48
|
|
19
|
Safe long-distance interhospital ground transfer of critically ill patients with acute severe unstable respiratory and circulatory failure.
|
Intensive Care Med
|
2002
|
1.48
|
|
20
|
Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.
|
Blood
|
2005
|
1.48
|
|
21
|
Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function.
|
Crit Care
|
2013
|
1.44
|
|
22
|
Early prognostic value of the medical emergency team calling criteria in patients admitted to intensive care from the emergency department.
|
Crit Care Med
|
2008
|
1.40
|
|
23
|
A clinical prediction model to identify patients at high risk of death in the emergency department.
|
Intensive Care Med
|
2015
|
1.40
|
|
24
|
Causes of death and determinants of outcome in critically ill patients.
|
Crit Care
|
2006
|
1.40
|
|
25
|
Jejunal luminal microdialysate lactate in cardiac tamponade--effect of low systemic blood flow on gut mucosa.
|
Intensive Care Med
|
2002
|
1.39
|
|
26
|
Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction.
|
Intensive Care Med
|
2003
|
1.39
|
|
27
|
Increased splanchnic oxygen extraction because of routine nursing procedures.
|
Crit Care Med
|
2009
|
1.38
|
|
28
|
Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study.
|
Crit Care
|
2010
|
1.33
|
|
29
|
Effect of fluid resuscitation on mortality and organ function in experimental sepsis models.
|
Crit Care
|
2009
|
1.16
|
|
30
|
Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study.
|
Crit Care
|
2010
|
1.14
|
|
31
|
Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study.
|
Crit Care
|
2007
|
1.12
|
|
32
|
Review of estimates of the global burden of injury and illness due to occupational exposures.
|
Am J Ind Med
|
2005
|
1.11
|
|
33
|
The Richmond Agitation-Sedation Scale Should Not Be Used to Evaluate Neurologic Function.
|
Crit Care Med
|
2016
|
1.09
|
|
34
|
Diagnosis and management of electrolyte emergencies.
|
Best Pract Res Clin Endocrinol Metab
|
2003
|
1.08
|
|
35
|
Safety of modern starches used during surgery: misleading conclusions.
|
Anesth Analg
|
2013
|
1.08
|
|
36
|
Night-time intensivists--waste of resources or failure of process optimization?
|
Crit Care
|
2013
|
1.08
|
|
37
|
Shedding light on microcirculation?
|
Intensive Care Med
|
2009
|
1.08
|
|
38
|
Physiologic response to changing positive end-expiratory pressure during neurally adjusted ventilatory assist in sedated, critically ill adults.
|
Chest
|
2010
|
1.07
|
|
39
|
Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions.
|
PLoS One
|
2010
|
1.07
|
|
40
|
Estimation of central venous pressure by ultrasound.
|
Resuscitation
|
2005
|
1.05
|
|
41
|
Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study.
|
Crit Care
|
2009
|
1.03
|
|
42
|
Mitochondrial function in sepsis.
|
Eur J Clin Invest
|
2013
|
0.99
|
|
43
|
Sedation and weaning from mechanical ventilation: effects of process optimization outside a clinical trial.
|
J Crit Care
|
2007
|
0.99
|
|
44
|
Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration.
|
Crit Care
|
2008
|
0.98
|
|
45
|
Delayed heart perforation after blunt trauma.
|
Eur J Cardiothorac Surg
|
2002
|
0.97
|
|
46
|
Outcome after acute traumatic subdural and epidural haematoma in Switzerland: a single-centre experience.
|
Swiss Med Wkly
|
2008
|
0.95
|
|
47
|
Severe hypercapnia due to pulmonary embolism of polymethylmethacrylate during vertebroplasty.
|
Anesth Analg
|
2004
|
0.95
|
|
48
|
The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects.
|
Anesth Analg
|
2006
|
0.95
|
|
49
|
Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function.
|
Crit Care
|
2006
|
0.94
|
|
50
|
Identification of adequate neurally adjusted ventilatory assist (NAVA) during systematic increases in the NAVA level.
|
IEEE Trans Biomed Eng
|
2011
|
0.93
|
|
51
|
Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock.
|
Anesthesiology
|
2007
|
0.93
|
|
52
|
Influenza A(H1N1) infection and severe cardiac dysfunction in adults: A case series.
|
Wien Klin Wochenschr
|
2011
|
0.92
|
|
53
|
Resource use and outcome in critically ill patients with hematological malignancy: a retrospective cohort study.
|
Crit Care
|
2008
|
0.92
|
|
54
|
Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes.
|
Liver Int
|
2009
|
0.92
|
|
55
|
Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis.
|
Crit Care Med
|
2012
|
0.92
|
|
56
|
Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study.
|
Crit Care
|
2008
|
0.91
|
|
57
|
Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients.
|
Anesth Analg
|
2009
|
0.91
|
|
58
|
Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow.
|
Crit Care
|
2007
|
0.90
|
|
59
|
Effects of dopamine on systemic and regional blood flow and metabolism in septic and cardiac surgery patients.
|
Shock
|
2002
|
0.90
|
|
60
|
Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study.
|
Crit Care
|
2009
|
0.90
|
|
61
|
Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes.
|
Mitochondrion
|
2010
|
0.89
|
|
62
|
Pulmonary capillary pressures during the acute respiratory distress syndrome.
|
Intensive Care Med
|
2003
|
0.89
|
|
63
|
Risk assessment in the first fifteen minutes: a prospective cohort study of a simple physiological scoring system in the emergency department.
|
Crit Care
|
2011
|
0.88
|
|
64
|
A new rabbit model for the study of early brain injury after subarachnoid hemorrhage.
|
J Neurosci Methods
|
2012
|
0.87
|
|
65
|
A european, multicenter, observational study to assess the value of gastric-to-end tidal PCO2 difference in predicting postoperative complications.
|
Anesth Analg
|
2004
|
0.87
|
|
66
|
Different contribution of splanchnic organs to hyperlactatemia in fecal peritonitis and cardiac tamponade.
|
Biomed Res Int
|
2013
|
0.87
|
|
67
|
The ratification status of ILO conventions related to occupational safety and health and its relationship with reported occupational fatality rates.
|
J Occup Health
|
2007
|
0.87
|
|
68
|
Current approach to the haemodynamic management of septic shock patients in European intensive care units: a cross-sectional, self-reported questionnaire-based survey.
|
Eur J Anaesthesiol
|
2011
|
0.86
|
|
69
|
Neurally adjusted ventilatory assist in patients with critical illness-associated polyneuromyopathy.
|
Intensive Care Med
|
2011
|
0.86
|
|
70
|
Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs.
|
Innate Immun
|
2011
|
0.86
|
|
71
|
Surgery: risky business?
|
Anesth Analg
|
2011
|
0.85
|
|
72
|
Can outcome prediction data change patient outcomes and organizational outcomes?
|
Curr Opin Crit Care
|
2008
|
0.85
|
|
73
|
Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study.
|
Crit Care
|
2009
|
0.84
|
|
74
|
Intensive care sedation: the past, present and the future.
|
Crit Care
|
2013
|
0.84
|
|
75
|
Tonometry revisited: perfusion-related, metabolic, and respiratory components of gastric mucosal acidosis in acute cardiorespiratory failure.
|
Shock
|
2008
|
0.83
|
|
76
|
Hydroxyethyl starches: what do we still know?
|
Anesth Analg
|
2011
|
0.83
|
|
77
|
Extra-intracranial blood shunt mimicking aneurysm rupture: intracranial-pressure-controlled rabbit subarachnoid hemorrhage model.
|
J Neurosci Methods
|
2010
|
0.83
|
|
78
|
Moving knowledge of global burden into preventive action.
|
Am J Ind Med
|
2005
|
0.83
|
|
79
|
No evidence for a local renin-angiotensin system in liver mitochondria.
|
Sci Rep
|
2013
|
0.82
|
|
80
|
Hemodynamic assessment of critically ill patients using a miniaturized transesophageal echocardiography probe.
|
Crit Care
|
2013
|
0.82
|
|
81
|
Effects of endotoxin and catecholamines on hepatic mitochondrial respiration.
|
Inflammation
|
2009
|
0.82
|
|
82
|
Randomized, double-blind trial of the effect of fluid composition on electrolyte, acid-base, and fluid homeostasis in patients early after subarachnoid hemorrhage.
|
Neurocrit Care
|
2013
|
0.81
|
|
83
|
Continuous flow left ventricular assist devices: a valid option for heart failure patients.
|
Swiss Med Wkly
|
2012
|
0.81
|
|
84
|
ARDS. Monitoring tissue perfusion.
|
Crit Care Clin
|
2002
|
0.81
|
|
85
|
Decreasing gut wall glucose as an early marker of impaired intestinal perfusion.
|
Crit Care Med
|
2006
|
0.81
|
|
86
|
Usefulness of a clinical diagnosis of ICU-acquired paresis to predict outcome in patients with SIRS and acute respiratory failure.
|
Intensive Care Med
|
2009
|
0.80
|
|
87
|
Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes.
|
PLoS One
|
2012
|
0.80
|
|
88
|
Severe transfusion-related acute lung injury.
|
Anesth Analg
|
2005
|
0.80
|
|
89
|
Splanchnic vasoregulation after major abdominal surgery in pigs.
|
World J Surg
|
2010
|
0.79
|
|
90
|
Left ventricular torsion abnormalities in septic shock and corrective effect of volume loading: a pilot study.
|
Can J Cardiol
|
2013
|
0.79
|
|
91
|
Measuring depth of sedation with auditory evoked potentials during controlled infusion of propofol and remifentanil in healthy volunteers.
|
Anesth Analg
|
2004
|
0.79
|
|
92
|
Global estimates of fatal work-related diseases by region and disease group, 2002.
|
Int J Occup Environ Health
|
2011
|
0.79
|
|
93
|
Tracheal tear and tension pneumothorax complicating bronchoscopy-guided percutaneous tracheostomy.
|
Heart Lung
|
2006
|
0.79
|
|
94
|
Dangers of growth hormone therapy in critically ill patients.
|
Curr Opin Clin Nutr Metab Care
|
2002
|
0.79
|
|
95
|
Increasing abdominal pressure with and without PEEP: effects on intra-peritoneal, intra-organ and intra-vascular pressures.
|
BMC Gastroenterol
|
2010
|
0.78
|
|
96
|
Postoperative splanchnic blood flow redistribution in response to fluid challenges in the presence and absence of endotoxemia in a porcine model.
|
Shock
|
2012
|
0.78
|
|
97
|
Assessment of splanchnic blood flow using magnetic resonance imaging.
|
Eur J Gastroenterol Hepatol
|
2009
|
0.78
|
|
98
|
Changes in splanchnic circulation during an alveolar recruitment maneuver in healthy porcine lungs.
|
Anesth Analg
|
2004
|
0.78
|
|
99
|
Physical and occupational therapy during sedation stops.
|
Lancet
|
2009
|
0.78
|
|
100
|
Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits.
|
Acta Neurochir (Wien)
|
2009
|
0.78
|
|
101
|
The immediate and sustained effects of volume challenge on regional blood flows in pigs.
|
Anesth Analg
|
2008
|
0.78
|
|
102
|
Early changes of muscle membrane properties in porcine faecal peritonitis.
|
Crit Care
|
2014
|
0.78
|
|
103
|
Does fluid loading influence measurements of intestinal permeability?
|
Crit Care
|
2005
|
0.77
|
|
104
|
Eliminating occupational cancer.
|
Ind Health
|
2015
|
0.77
|
|
105
|
Effect of dopamine-induced changes in splanchnic blood flow on MEGX production from lidocaine in septic and cardiac surgery patients.
|
Shock
|
2002
|
0.77
|
|
106
|
Haemodynamic variables and functional outcome in hypothermic patients following out-of-hospital cardiac arrest.
|
Resuscitation
|
2012
|
0.77
|
|
107
|
Effects of low abdominal blood flow and dobutamine on blood flow distribution and on the hepatic arterial buffer response in anaesthetized pigs.
|
Shock
|
2006
|
0.77
|
|
108
|
Effect of endotoxin, dobutamine and dopamine on muscle mitochondrial respiration in vitro.
|
J Endotoxin Res
|
2006
|
0.77
|
|
109
|
Hemodynamic management of the critically ill patient: craft meets science.
|
Curr Opin Crit Care
|
2007
|
0.77
|
|
110
|
Splanchnic vasoregulation during mesenteric ischemia and reperfusion in pigs.
|
Shock
|
2002
|
0.77
|
|
111
|
Heart-lung interactions during neurally adjusted ventilatory assist.
|
Crit Care
|
2014
|
0.77
|
|
112
|
Inverse thermodilution with conventional pulmonary artery catheters for the assessment of cerebral, hepatic, renal, and femoral blood flow.
|
Shock
|
2009
|
0.77
|
|
113
|
Clinical significance of monitoring perfusion in non-vital organs.
|
Intensive Care Med
|
2014
|
0.76
|
|
114
|
Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia.
|
Am J Physiol Gastrointest Liver Physiol
|
2012
|
0.76
|
|
115
|
Impact of reimbursement schemes on quality of care: a European perspective.
|
Am J Respir Crit Care Med
|
2012
|
0.76
|
|
116
|
Hepatosplanchnic blood flow control and oxygen extraction are modified by the underlying mechanism of impaired perfusion.
|
Crit Care Med
|
2005
|
0.76
|
|
117
|
Effects of lung recruitment maneuvers on splanchnic organ perfusion during endotoxin-induced pulmonary arterial hypertension.
|
Shock
|
2010
|
0.76
|
|
118
|
Science, medicine and industry: are we getting out of the black hole in sepsis research?
|
Intensive Care Med
|
2008
|
0.75
|
|
119
|
CO(2)-Dependent vasomotor reactivity of cerebral arteries in patients with severe traumatic brain injury: time course and effect of augmentation of cardiac output with dobutamine.
|
J Neurotrauma
|
2012
|
0.75
|
|
120
|
Intraperitoneal microdialysis: critique of an editorial.
|
Crit Care Med
|
2007
|
0.75
|
|
121
|
Different patterns of Siglec-9-mediated neutrophil death responses in septic shock.
|
Shock
|
2009
|
0.75
|
|
122
|
Target blood pressure in sepsis: between a rock and a hard place.
|
Crit Care
|
2013
|
0.75
|
|
123
|
Hemodynamic support: focus on monitoring tools or treatments?
|
Crit Care Med
|
2012
|
0.75
|
|
124
|
Sedation level and prevalence of delirium: response to Brummel and Ely.
|
Intensive Care Med
|
2013
|
0.75
|
|
125
|
Evolution of Blood Lactate and 90-Day Mortality in Septic Shock. A Post Hoc Analysis of the Finnaki Study.
|
Shock
|
2016
|
0.75
|
|
126
|
Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage.
|
Intensive Care Med Exp
|
2014
|
0.75
|
|
127
|
Brain herniation in a patient with apparently normal intracranial pressure: a case report.
|
J Med Case Rep
|
2010
|
0.75
|
|
128
|
Recent trends in ILO conventions related to occupational safety and health.
|
Int J Occup Saf Ergon
|
2006
|
0.75
|
|
129
|
Changes in mitochondrial enzymatic activities of monocytes during prolonged hypobaric hypoxia and influence of antioxidants: A randomized controlled study.
|
Redox Rep
|
2015
|
0.75
|
|
130
|
Comparison of non-calibrated pulse-contour analysis with continuous thermodilution for cardiac output assessment in patients with induced hypothermia after cardiac arrest.
|
Resuscitation
|
2011
|
0.75
|
|
131
|
Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery.
|
Surgery
|
2009
|
0.75
|
|
132
|
The Effects of Fentanyl on Hepatic Mitochondrial Function.
|
Anesth Analg
|
2016
|
0.75
|
|
133
|
Ethicalization in bioscience--a pilot study in Finland.
|
Camb Q Healthc Ethics
|
2006
|
0.75
|
|
134
|
Impact of a Potassium-enriched, Chloride-depleted 5% Glucose Solution on Gastrointestinal Function after Major Abdominopelvic Surgery: Results of a Randomized Controlled Trial.
|
Anesthesiology
|
2016
|
0.75
|
|
135
|
When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration.
|
Anesth Analg
|
2009
|
0.75
|
|
136
|
Neuroprotection with the P53-Inhibitor Pifithrin-μ After Cardiac Arrest in a Rodent Model.
|
Shock
|
2017
|
0.75
|
|
137
|
Biatrial enlargement: 6,000 ml intracardiac blood volume.
|
Intensive Care Med
|
2014
|
0.75
|
|
138
|
Subcellular Energetics and Metabolism: A Cross-Species Framework.
|
Anesth Analg
|
2017
|
0.75
|
|
139
|
Thermodilution and esophageal Doppler ultrasound in the assessment of blood flow changes induced by endotoxin and dobutamine.
|
J Trauma
|
2008
|
0.75
|
|
140
|
Esophageal versus surface recording of diaphragm compound muscle action potential.
|
Muscle Nerve
|
2015
|
0.75
|
|
141
|
Preliminary results of an ICP-controlled subarachnoid hemorrhage rabbit model for the study of delayed cerebral vasospasm.
|
Acta Neurochir Suppl
|
2011
|
0.75
|
|
142
|
Gastrointestinal Impedance Spectroscopy to Detect Hypoperfusion During Hemorrhage.
|
Shock
|
2017
|
0.75
|
|
143
|
Further Concerns About Glutamine: A Case Report on Hyperammonemic Encephalopathy.
|
Crit Care Med
|
2015
|
0.75
|