Published in Sci Signal on March 24, 2009
Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity (2012) 3.47
Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast. Mol Syst Biol (2011) 2.37
Controlling gene expression in response to stress. Nat Rev Genet (2011) 2.33
Response to hyperosmotic stress. Genetics (2012) 1.95
High-sensitivity measurements of multiple kinase activities in live single cells. Cell (2014) 1.76
Multilayered control of gene expression by stress-activated protein kinases. EMBO J (2009) 1.61
Moment-based inference predicts bimodality in transient gene expression. Proc Natl Acad Sci U S A (2012) 1.58
A quantitative study of the Hog1 MAPK response to fluctuating osmotic stress in Saccharomyces cerevisiae. PLoS One (2010) 1.11
Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast. Mol Syst Biol (2012) 1.05
Information transfer by leaky, heterogeneous, protein kinase signaling systems. Proc Natl Acad Sci U S A (2014) 0.99
Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress. PLoS Genet (2012) 0.97
The FgHOG1 pathway regulates hyphal growth, stress responses, and plant infection in Fusarium graminearum. PLoS One (2012) 0.96
Specialized or flexible feed-forward loop motifs: a question of topology. BMC Syst Biol (2009) 0.95
Late phase of the endoplasmic reticulum stress response pathway is regulated by Hog1 MAP kinase. J Biol Chem (2010) 0.90
The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Mol Biol Cell (2012) 0.89
Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function. Mol Cell Biol (2010) 0.88
The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress. J Biol Chem (2013) 0.88
The activity of yeast Hog1 MAPK is required during endoplasmic reticulum stress induced by tunicamycin exposure. J Biol Chem (2010) 0.87
Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. EMBO Rep (2011) 0.86
Characterizing the relationship between steady state and response using analytical expressions for the steady states of mass action models. PLoS Comput Biol (2013) 0.86
An integrated view on a eukaryotic osmoregulation system. Curr Genet (2015) 0.85
Mediator phosphorylation prevents stress response transcription during non-stress conditions. J Biol Chem (2012) 0.85
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell (2012) 0.85
Metabolic activation of the HOG MAP kinase pathway by Snf1/AMPK regulates lipid signaling at the Golgi. Traffic (2012) 0.84
Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance. MBio (2015) 0.83
Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks. J R Soc Interface (2013) 0.82
Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast. PLoS One (2011) 0.82
MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast. Sci Signal (2015) 0.82
Identification of collaborative driver pathways in breast cancer. BMC Genomics (2014) 0.81
Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38α. PLoS One (2012) 0.81
A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi. BMC Res Notes (2012) 0.81
Cell-to-Cell Communication Circuits: Quantitative Analysis of Synthetic Logic Gates. Front Physiol (2012) 0.80
How informative is your kinetic model?: using resampling methods for model invalidation. BMC Syst Biol (2014) 0.80
Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment. Toxicol Sci (2015) 0.80
Osmosensing and scaffolding functions of the oligomeric four-transmembrane domain osmosensor Sho1. Nat Commun (2015) 0.80
Systems Level Analysis of the Yeast Osmo-Stat. Sci Rep (2016) 0.79
Dynamic single cell measurements of kinase activity by synthetic kinase activity relocation sensors. BMC Biol (2015) 0.79
Analysis of osmoadaptation system in budding yeast suggests that regulated degradation of glycerol synthesis enzyme is key to near-perfect adaptation. Syst Synth Biol (2013) 0.77
Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae. BMC Syst Biol (2015) 0.77
Differential role of HAMP-like linkers in regulating the functionality of the group III histidine kinase DhNik1p. J Biol Chem (2014) 0.77
New connections, new components, real dynamics. Sci Signal (2009) 0.76
Spatial and temporal signal processing and decision making by MAPK pathways. J Cell Biol (2017) 0.76
Nuclear relocation of Kss1 contributes to the specificity of the mating response. Sci Rep (2017) 0.75
Qualitative, semi-quantitative, and quantitative simulation of the osmoregulation system in yeast. Biosystems (2015) 0.75
Dynamic processes at stress promoters regulate the bimodal expression of HOG response genes. Commun Integr Biol (2011) 0.75
Untargeted metabolomics unravels functionalities of phosphorylation sites in Saccharomyces cerevisiae. BMC Syst Biol (2016) 0.75
Information processing in the adaptation of Saccharomyces cerevisiae to osmotic stress: an analysis of the phosphorelay system. Syst Synth Biol (2014) 0.75
Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS One (2011) 0.75
The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. Nature (2004) 2.62
Controlling gene expression in response to stress. Nat Rev Genet (2011) 2.33
Coordinated control of replication and transcription by a SAPK protects genomic integrity. Nature (2012) 2.28
Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase. Mol Cell Biol (2003) 2.23
Distributed biological computation with multicellular engineered networks. Nature (2010) 2.13
Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1. Nat Cell Biol (2004) 2.07
Dealing with osmostress through MAP kinase activation. EMBO Rep (2002) 2.04
Response to hyperosmotic stress. Genetics (2012) 1.95
Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II. EMBO J (2003) 1.90
The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress. Mol Cell (2006) 1.85
The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11. Mol Biol Cell (2006) 1.83
Multilayered control of gene expression by stress-activated protein kinases. EMBO J (2009) 1.61
The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast. Mol Biol Cell (2006) 1.57
Transient activation of the HOG MAPK pathway regulates bimodal gene expression. Science (2011) 1.54
Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity. EMBO J (2006) 1.50
The sequential activation of the yeast HOG and SLT2 pathways is required for cell survival to cell wall stress. Mol Biol Cell (2008) 1.45
Selective requirement for SAGA in Hog1-mediated gene expression depending on the severity of the external osmostress conditions. Mol Cell Biol (2007) 1.40
Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes. EMBO J (2009) 1.40
Whole genome analysis of p38 SAPK-mediated gene expression upon stress. BMC Genomics (2010) 1.25
The serine/threonine kinase Cmk2 is required for oxidative stress response in fission yeast. J Biol Chem (2002) 1.24
The HOG pathway dictates the short-term translational response after hyperosmotic shock. Mol Biol Cell (2010) 1.21
The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. EMBO J (2012) 1.12
Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae. Mol Cell Biol (2009) 1.09
The Rpd3L HDAC complex is essential for the heat stress response in yeast. Mol Microbiol (2010) 1.06
Biophysical properties of Saccharomyces cerevisiae and their relationship with HOG pathway activation. Eur Biophys J (2010) 1.06
Accelerated discovery via a whole-cell model. Nat Methods (2013) 1.01
The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress. Mol Biol Cell (2009) 1.00
Time-dependent quantitative multicomponent control of the G₁-S network by the stress-activated protein kinase Hog1 upon osmostress. Sci Signal (2011) 0.99
Measuring the hierarchy of feedforward networks. Chaos (2011) 0.98
The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses. FEBS Lett (2012) 0.97
Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling. Genome Biol (2012) 0.96
Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress. EMBO J (2011) 0.95
Control of cell cycle progression by the stress-activated Hog1 MAPK. Cell Cycle (2005) 0.95
Specialized or flexible feed-forward loop motifs: a question of topology. BMC Syst Biol (2009) 0.95
Mucins, osmosensors in eukaryotic cells? Trends Cell Biol (2007) 0.94
Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways. J Biol Chem (2004) 0.93
Why are cellular switches Boolean? General conditions for multistable genetic circuits. J Theor Biol (2009) 0.93
The p38 SAPK is recruited to chromatin via its interaction with transcription factors. J Biol Chem (2010) 0.92
Validation of regulated protein phosphorylation events in yeast by quantitative mass spectrometry analysis of purified proteins. Proteomics (2012) 0.91
Ecology: scaling laws in the drier. Nature (2007) 0.91
The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Mol Biol Cell (2012) 0.89
The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress. J Biol Chem (2013) 0.88
Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. EMBO Rep (2011) 0.86
Emergence of multicellularity in a model of cell growth, death and aggregation under size-dependent selection. J R Soc Interface (2015) 0.85
Distributed computation: the new wave of synthetic biology devices. Trends Biotechnol (2012) 0.84
Evolvability of feed-forward loop architecture biases its abundance in transcription networks. BMC Syst Biol (2012) 0.83
A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress. Cell Cycle (2012) 0.83
Sic1 plays a role in timing and oscillatory behaviour of B-type cyclins. Biotechnol Adv (2011) 0.83
Monomeric bistability and the role of autoloops in gene regulation. PLoS One (2009) 0.83
Language: syntax for free? Nature (2005) 0.82
The stress-activated protein kinase Hog1 develops a critical role after resting state. Mol Microbiol (2011) 0.81
3D-printing of transparent bio-microfluidic devices in PEG-DA. Lab Chip (2016) 0.80
Initiation of the transcriptional response to hyperosmotic shock correlates with the potential for volume recovery. FEBS J (2013) 0.79
A novel role for lncRNAs in cell cycle control during stress adaptation. Curr Genet (2014) 0.78
Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade. Integr Biol (Camb) (2015) 0.77
A morphospace for synthetic organs and organoids: the possible and the actual. Integr Biol (Camb) (2016) 0.77
Dealing with transcriptional outbursts during S phase to protect genomic integrity. J Mol Biol (2013) 0.77
Gene expression profiling of yeasts overexpressing wild type or misfolded Pma1 variants reveals activation of the Hog1 MAPK pathway. Mol Microbiol (2011) 0.76
Sir2 plays a key role in cell fate determination upon SAPK activation. Aging (Albany NY) (2011) 0.76
A Synthetic Multicellular Memory Device. ACS Synth Biol (2016) 0.76
Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS One (2011) 0.75
Elongating under Stress. Genet Res Int (2011) 0.75
Synthetic biology: insights into biological computation. Integr Biol (Camb) (2016) 0.75