Published in J Cell Biol on January 02, 2017
From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2. Int J Mol Sci (2017) 0.75
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology. Biochim Biophys Acta (2017) 0.75
Treatment with a JNK inhibitor increases, whereas treatment with a p38 inhibitor decreases, H2O2-induced calf pulmonary arterial endothelial cell death. Oncol Lett (2017) 0.75
Stochastic gene expression in a single cell. Science (2002) 34.54
CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol (2006) 32.51
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell (1995) 21.15
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet (2005) 14.39
Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science (2000) 13.20
Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc Natl Acad Sci U S A (2002) 11.46
Coordination of growth with cell division in the yeast Saccharomyces cerevisiae. Exp Cell Res (1977) 10.42
The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81
Origins of cell polarity. Cell (1996) 7.99
Mutations affecting sexual conjugation and related processes in Saccharomyces cerevisiae. I. Isolation and phenotypic characterization of nonmating mutants. Genetics (1974) 7.34
A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature (2003) 6.25
Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol (2002) 6.05
Regulated cell-to-cell variation in a cell-fate decision system. Nature (2005) 5.68
Entropic contributions to rate accelerations in enzymic and intramolecular reactions and the chelate effect. Proc Natl Acad Sci U S A (1971) 5.46
Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis. Science (1997) 5.27
Insulin--receptor interactions in adipose tissue cells: direct measurement and properties. Proc Natl Acad Sci U S A (1971) 5.00
The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science (2008) 4.94
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol (2007) 4.75
Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature (2008) 4.63
Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell (1994) 4.60
A module of negative feedback regulators defines growth factor signaling. Nat Genet (2007) 4.35
A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway. Cell (2007) 4.21
The effects of molecular noise and size control on variability in the budding yeast cell cycle. Nature (2007) 4.15
Scaffold proteins: hubs for controlling the flow of cellular information. Science (2011) 4.00
Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science (2003) 3.92
Single-cell quantification of molecules and rates using open-source microscope-based cytometry. Nat Methods (2007) 3.77
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science (2006) 3.64
FAR1 links the signal transduction pathway to the cell cycle machinery in yeast. Cell (1993) 3.59
Positive feedback of G1 cyclins ensures coherent cell cycle entry. Nature (2008) 3.32
Orientation of chemotactic cells and growth cones: models and mechanisms. J Cell Sci (1999) 3.31
STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev (1989) 3.28
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature (2007) 3.23
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 3.07
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
A systems-level analysis of perfect adaptation in yeast osmoregulation. Cell (2009) 2.91
Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling. Nat Cell Biol (2007) 2.91
Courtship in S. cerevisiae: both cell types choose mating partners by responding to the strongest pheromone signal. Cell (1990) 2.87
FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. Mol Biol Cell (1993) 2.82
Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev (1997) 2.77
Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell (2001) 2.76
Polarization of yeast cells in spatial gradients of alpha mating factor. Proc Natl Acad Sci U S A (1993) 2.71
Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell (2007) 2.61
Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Lett (2008) 2.59
Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex. Curr Biol (2008) 2.56
Signal processing by the HOG MAP kinase pathway. Proc Natl Acad Sci U S A (2008) 2.56
Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway. Genes Dev (1998) 2.55
Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell (2012) 2.54
Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1. Science (1994) 2.53
Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol (1999) 2.52
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell (2009) 2.50
Dynamics and variability of ERK2 response to EGF in individual living cells. Mol Cell (2009) 2.42
MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. EMBO J (1994) 2.32
The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating. Science (1998) 2.29
Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1. Mol Cell Biol (1996) 2.29
The cost of gene expression underlies a fitness trade-off in yeast. Proc Natl Acad Sci U S A (2009) 2.28
Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell (2012) 2.28
Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae. J Biol Chem (1995) 2.26
Negative feedback that improves information transmission in yeast signalling. Nature (2008) 2.21
Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit). Mol Cell Biol (1996) 2.20
Comparison of dose-response curves for alpha factor-induced cell division arrest, agglutination, and projection formation of yeast cells. Implication for the mechanism of alpha factor action. J Biol Chem (1983) 2.13
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11
On the spontaneous emergence of cell polarity. Nature (2008) 2.07
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell (2008) 2.00
Singularity in polarization: rewiring yeast cells to make two buds. Cell (2009) 2.00
Regulation of the yeast pheromone response pathway by G protein subunits. EMBO J (1990) 1.97
Signal-dependent dynamics of transcription factor translocation controls gene expression. Nat Struct Mol Biol (2011) 1.94
Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science (2012) 1.92
The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature (2010) 1.90
Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p. Science (1995) 1.88
A system of counteracting feedback loops regulates Cdc42p activity during spontaneous cell polarization. Dev Cell (2005) 1.81
A Cdc24p-Far1p-Gbetagamma protein complex required for yeast orientation during mating. J Cell Biol (1999) 1.80
A super-assembly of Whi3 encodes memory of deceptive encounters by single cells during yeast courtship. Cell (2013) 1.78
Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating. Nat Cell Biol (2000) 1.78
Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases. Nature (1998) 1.77
Dual modes of cdc42 recycling fine-tune polarized morphogenesis. Dev Cell (2009) 1.73
Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo. Curr Biol (2000) 1.68
Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.66
Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade. Curr Biol (2008) 1.66
Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction. Sci Signal (2009) 1.65
Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Mol Cell (2013) 1.62
A walk-through of the yeast mating pheromone response pathway. Peptides (2004) 1.58
Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network. Science (2015) 1.58
Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Genes Dev (1999) 1.56
Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4. EMBO J (2000) 1.54
Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform. Proc Natl Acad Sci U S A (2009) 1.52
Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment. Curr Biol (2011) 1.49
Angiotensin receptors. Am J Physiol (1970) 1.49
Daughter-specific transcription factors regulate cell size control in budding yeast. PLoS Biol (2009) 1.48
A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway. Curr Biol (2007) 1.47
The binding of thyrotropin to isolated bovine thyroid plasma membranes. J Biol Chem (1973) 1.43
Negative feedback enhances robustness in the yeast polarity establishment circuit. Cell (2012) 1.42
Pheromone-dependent G1 cell cycle arrest requires Far1 phosphorylation, but may not involve inhibition of Cdc28-Cln2 kinase, in vivo. Mol Cell Biol (1998) 1.38
ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2003) 1.38
Distinct interactions select and maintain a specific cell fate. Mol Cell (2011) 1.38
Tracking shallow chemical gradients by actin-driven wandering of the polarization site. Curr Biol (2012) 1.37
Symmetry breaking and the establishment of cell polarity in budding yeast. Curr Opin Genet Dev (2011) 1.37
Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast. Biochemistry (1998) 1.35
Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae. FEBS Lett (2009) 1.34
Regulation of MAPK function by direct interaction with the mating-specific Galpha in yeast. Science (2002) 1.29
Modularity and predictability in cell signaling and decision making. Mol Biol Cell (2014) 0.82
Mitosis is swell. J Cell Biol (2015) 0.75