Published in BMC Neurosci on March 27, 2009
Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex. EMBO J (2010) 1.10
Spatiotemporally regulated protein kinase A activity is a critical regulator of growth factor-stimulated extracellular signal-regulated kinase signaling in PC12 cells. Mol Cell Biol (2011) 0.90
Calmodulin and calmodulin kinase II mediate emergent bursting activity in the brainstem respiratory network (preBötzinger complex). J Physiol (2012) 0.88
cAMP signaling microdomains and their observation by optical methods. Front Cell Neurosci (2014) 0.86
Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation. Chem Biol (2014) 0.85
Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding. Am J Physiol Cell Physiol (2010) 0.83
Approaches and tools for modeling signaling pathways and calcium dynamics in neurons. J Neurosci Methods (2013) 0.82
Sensing Positive versus Negative Reward Signals through Adenylyl Cyclase-Coupled GPCRs in Direct and Indirect Pathway Striatal Medium Spiny Neurons. J Neurosci (2015) 0.76
Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine Integration. PLoS Comput Biol (2016) 0.75
β-adrenergic signaling broadly contributes to LTP induction. PLoS Comput Biol (2017) 0.75
Novel single chain cAMP sensors for receptor-induced signal propagation. J Biol Chem (2004) 5.00
Looking for inspiration: new perspectives on respiratory rhythm. Nat Rev Neurosci (2006) 4.70
Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45
Calcium regulation of neuronal gene expression. Proc Natl Acad Sci U S A (2001) 4.31
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep (2004) 2.98
Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains. Physiol Rev (2007) 2.91
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circ Res (2006) 2.66
A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem (2002) 2.12
Calcium and cardiac excitation-contraction coupling. Annu Rev Physiol (1979) 1.96
Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala. Neuron (1998) 1.87
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol (2006) 1.81
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem (2005) 1.80
Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area. Gene Ther (2003) 1.74
Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice. J Physiol (2008) 1.55
High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices. J Neurosci (2006) 1.53
Techniques for gene transfer into neurons. Curr Opin Neurobiol (2002) 1.50
Facilitation of L-type Ca2+ channels in dendritic spines by activation of beta2 adrenergic receptors. J Neurosci (2004) 1.25
Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors. Br J Pharmacol (1992) 1.21
Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3. J Cell Biol (2005) 1.13
Imaging of respiratory network topology in living brainstem slices. Mol Cell Neurosci (2007) 1.12
L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol (1998) 1.07
Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells. Sci STKE (2006) 1.04
Second messenger pas de deux: the coordinated dance between calcium and cAMP. Sci STKE (2006) 1.01
Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through G-protein-coupled receptors. J Neurosci (2003) 0.99
Imaging living central neurones using viral gene transfer. Adv Drug Deliv Rev (2005) 0.98
Gene transfer methods for CNS organotypic cultures: a comparison of three nonviral methods. Mol Ther (2001) 0.98
Imaging second messenger dynamics in developing neural circuits. Dev Neurobiol (2008) 0.95
Perinatal brain injury and regulation of transcription. Curr Opin Neurol (2006) 0.94
Mechanisms of Na+ and Ca2+ influx into respiratory neurons during hypoxia. Neuropharmacology (2005) 0.90
Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice. PLoS One (2008) 0.89
Prolonged presynaptic posttetanic cyclic GMP signaling in Drosophila motoneurons. Proc Natl Acad Sci U S A (2008) 0.87
Transgenic fruit-flies expressing a FRET-based sensor for in vivo imaging of cAMP dynamics. Cell Signal (2007) 0.86
Approximate analytical time-dependent solutions to describe large-amplitude local calcium transients in the presence of buffers. Biophys J (2007) 0.85
Modulation of synaptic and channel activities in the respiratory network of the mice by NO/cGMP signalling pathways. Brain Res (2006) 0.83
Metabotropic ATP receptor in hippocampal and thalamic neurones: pharmacology and modulation of Ca2+ mobilizing mechanisms. Neuropharmacology (1994) 0.81
Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation (1993) 4.52
Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci U S A (1999) 3.13
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol (1998) 2.43
The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature (1988) 2.13
Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac geometry and function in normal and failing murine hearts. Circ Res (2001) 2.08
Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor. Proc Natl Acad Sci U S A (1996) 2.08
Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol (2004) 1.95
Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization. Mol Pharmacol (1995) 1.93
Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice. Mol Pharmacol (2001) 1.88
Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo. Exp Physiol (2004) 1.85
Neural cell adhesion molecules influence second messenger systems. Neuron (1989) 1.76
Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. Circ Res (1994) 1.66
Phosducin is a protein kinase A-regulated G-protein regulator. Nature (1992) 1.55
Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. J Biol Chem (1993) 1.47
Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity. Biochem Biophys Res Commun (1999) 1.33
Two affinity states of Ri adenosine receptors in brain membranes. Analysis of guanine nucleotide and temperature effects on radioligand binding. Mol Pharmacol (1984) 1.28
Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes. Mol Pharmacol (2008) 1.24
Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open. Br J Pharmacol (2007) 1.23
Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation (1999) 1.22
Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. Biochemistry (1992) 1.19
Agonist photoaffinity labeling of A1 adenosine receptors: persistent activation reveals spare receptors. Mol Pharmacol (1986) 1.17
2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol (1989) 1.16
Crosstalk between Galpha(i)- and Galpha(q)-coupled receptors is mediated by Gbetagamma exchange. Proc Natl Acad Sci U S A (1999) 1.16
Activation of beta-adrenergic receptor kinase during myocardial ischemia. Circ Res (1996) 1.15
Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1991) 1.13
Analysis of beta-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: progressive reduction of beta 1-adrenergic receptor mRNA in heart failure. J Am Coll Cardiol (1996) 1.12
Imaging of respiratory network topology in living brainstem slices. Mol Cell Neurosci (2007) 1.12
Kinetics of G-protein-coupled receptor signals in intact cells. Br J Pharmacol (2008) 1.12
Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases. Proc Natl Acad Sci U S A (1999) 1.11
Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol (1985) 1.11
Photoaffinity labeling of A1-adenosine receptors. J Biol Chem (1985) 1.11
Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma. Cell Death Differ (1999) 1.11
Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents. J Biol Chem (2001) 1.07
Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin. J Biol Chem (2000) 1.07
Identification of inhibitor-of-differentiation 2 (Id2) as a modulator of neuronal apoptosis. J Neurochem (2002) 1.06
Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering. J Physiol (2009) 1.05
Interactions of phosducin with defined G protein beta gamma-subunits. J Biol Chem (1996) 1.05
Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo. Neurobiol Dis (2000) 1.05
Activation of the A3 adenosine receptor affects cell cycle progression and cell growth. Naunyn Schmiedebergs Arch Pharmacol (2000) 1.02
The human vigilin gene: identification, chromosomal localization and expression pattern. Hum Genet (1994) 1.02
Ligand-induced phosphorylation/dephosphorylation of the endogenous bradykinin B2 receptor from human fibroblasts. J Biol Chem (1996) 1.01
Evidence for a novel cytoplasmic tRNA-protein complex containing the KH-multidomain protein vigilin. Biochem J (1996) 1.01
Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C. Proc Natl Acad Sci U S A (1996) 1.01
Specific enhancement of beta-adrenergic receptor kinase activity by defined G-protein beta and gamma subunits. Proc Natl Acad Sci U S A (1993) 1.00
Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure. Gene Ther (2003) 1.00
Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Mol Pharmacol (2001) 1.00
Pharmacological characterization of A1 adenosine receptors in isolated rat ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol (1987) 0.99
Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. Br J Clin Pharmacol (1990) 0.98
Interactions between intracellular cyclic AMP and agonist-induced inositol phospholipid breakdown in isolated gastric mucosal cells of the rat. Naunyn Schmiedebergs Arch Pharmacol (1987) 0.98
A1 adenosine receptors expressed in CHO-cells couple to adenylyl cyclase and to phospholipase C. Naunyn Schmiedebergs Arch Pharmacol (1994) 0.96
Phosducin inhibits receptor phosphorylation by the beta-adrenergic receptor kinase in a PKA-regulated manner. FEBS Lett (1994) 0.96
Inhibition of G-protein betagamma-subunit functions by phosducin-like protein. Proc Natl Acad Sci U S A (1996) 0.96
Dual actions of adenosine on rat peritoneal mast cells. Naunyn Schmiedebergs Arch Pharmacol (1987) 0.96
The role of G-protein beta gamma subunits in signal transduction. Biochem Soc Trans (1995) 0.95
Chemical modification of A1 adenosine receptors in rat brain membranes. Evidence for histidine in different domains of the ligand binding site. J Biol Chem (1988) 0.95
Long-term in vivo inhibition of CNS neurodegeneration by Bcl-XL gene transfer. Mol Ther (2005) 0.95
A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization. Proc Natl Acad Sci U S A (1997) 0.95
Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor. FASEB J (2001) 0.95
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. J Med Chem (1992) 0.93
Detection and characterization by differential PCR of host eukaryotic cell genes differentially transcribed following uptake of intracellular bacteria. Infect Immun (1996) 0.93
Mechanism of activation of A2 adenosine receptors. II. A restricted collision-coupling model of receptor-effector interaction. Mol Pharmacol (1991) 0.93
Phosducin is a ubiquitous G-protein regulator. Proc Natl Acad Sci U S A (1996) 0.93
Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals. J Neurochem (2001) 0.93
Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6. J Physiol (2009) 0.93
Kinetics of G-protein-coupled receptor signalling and desensitization. Biochem Soc Trans (2004) 0.92
Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome. Neuropharmacology (2011) 0.91
Agonist regulation of human beta2-adrenergic receptor mRNA stability occurs via a specific AU-rich element. J Biol Chem (1998) 0.90
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. J Med Chem (1988) 0.90
Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies. J Am Coll Cardiol (2000) 0.90
Quantification of the tissue levels and function of the G-protein regulator phosducin-like protein (PhlP). Naunyn Schmiedebergs Arch Pharmacol (2000) 0.90
Adenovirus-mediated GDNF and CNTF pretreatment protects against striatal injury following transient middle cerebral artery occlusion in mice. Neurobiol Dis (2001) 0.90
Characterization of the solubilized A1 adenosine receptor from rat brain membranes. J Neurochem (1986) 0.90
Quantification of beta-adrenoceptors and beta-adrenoceptor kinase on protein and mRNA levels in heart failure. Eur Heart J (1994) 0.89
Evaluation of epitope tags for protein detection after in vivo CNS gene transfer. Eur J Neurosci (2006) 0.89
Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. Vitam Horm (1991) 0.89
Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor. Circulation (2001) 0.89
Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. Symp Soc Exp Biol (1990) 0.89
Compartmentation of cAMP signalling in cardiomyocytes in health and disease. Acta Physiol (Oxf) (2013) 0.88
Phosducin, potential role in modulation of olfactory signaling. J Biol Chem (1997) 0.88
Immunofluorescent imaging of beta 1- and beta 2-adrenergic receptors in rat kidney. Kidney Int (2001) 0.88
Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2. J Biol Chem (2000) 0.88
Binding of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor signalling. Curr Biol (1999) 0.87
Suppression of major histocompatibility complex class I and class II gene expression in Listeria monocytogenes-infected murine macrophages. FEMS Immunol Med Microbiol (1998) 0.87
Mutations of Tyr326 in the beta 2-adrenoceptor disrupt multiple receptor functions. Eur J Pharmacol (1996) 0.87
Paradoxical block of parathormone secretion is mediated by increased activity of G alpha subunits. J Biol Chem (2000) 0.86
Labelling of Ri adenosine receptors in rat fat cell membranes with (-)-[125iodo]N6-hydroxyphenylisopropyladenosine. Naunyn Schmiedebergs Arch Pharmacol (1984) 0.86
Interaction of barbiturates with adenosine receptors in rat brain. Naunyn Schmiedebergs Arch Pharmacol (1984) 0.86
Cascade of caspase activation in potassium-deprived cerebellar granule neurons: targets for treatment with peptide and protein inhibitors of apoptosis. Mol Cell Neurosci (2001) 0.86
[3H]-8-cyclopentyl-1,3-dipropylxanthine binding to A1 adenosine receptors of intact rat ventricular myocytes. Circ Res (1988) 0.86
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Naunyn Schmiedebergs Arch Pharmacol (1989) 0.86
Xenon-induced inhibition of Ca2+-regulated transitions in the cell cycle of human endothelial cells. Pflugers Arch (1999) 0.86
Potentiation of in vivo neuroprotection by BclX(L) and GDNF co-expression depends on post-lesion time in deafferentiated CNS neurons. Gene Ther (2006) 0.85
Demonstration of Ri-type adenosine receptors in bovine myocardium by radioligand binding. Naunyn Schmiedebergs Arch Pharmacol (1985) 0.85
Tocolytic therapy with fenoterol induces selective down-regulation of beta-adrenergic receptors in human myometrium. J Clin Endocrinol Metab (1997) 0.85