Published in Chem Biol on January 30, 2014
Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol Biol Cell (2015) 0.95
Nanoparticle-Based and Bioengineered Probes and Sensors to Detect Physiological and Pathological Biomarkers in Neural Cells. Front Neurosci (2015) 0.81
Recent Advances in Biosensor Technology for Potential Applications - An Overview. Front Bioeng Biotechnol (2016) 0.79
Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. Physiol Rep (2016) 0.78
Exploring cells with targeted biosensors. J Gen Physiol (2016) 0.75
The genetically encoded tool set for investigating cAMP: more than the sum of its parts. Front Pharmacol (2015) 0.75
Temporal Analysis of PP2A Phosphatase Activity During Insulin Stimulation Using a Direct Activity Probe. ACS Chem Biol (2016) 0.75
Cell Density-Dependent Increase in Tyrosine-Monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf. PLoS One (2016) 0.75
Genome engineering using the CRISPR-Cas9 system. Nat Protoc (2013) 15.98
A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein. Nat Biotechnol (2001) 8.45
In vivo genome editing using a high-efficiency TALEN system. Nature (2012) 7.11
FRET imaging. Nat Biotechnol (2003) 6.57
Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci U S A (2004) 6.33
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science (2002) 4.96
Visualizing the mechanical activation of Src. Nature (2005) 4.63
Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs. Chem Biol (2006) 4.52
Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol (2003) 4.38
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature (2008) 4.33
Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2. Nature (1986) 4.21
An engineered protein tag for multiprotein labeling in living cells. Chem Biol (2008) 3.92
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77
Activation of CaMKII in single dendritic spines during long-term potentiation. Nature (2009) 3.76
Mechanisms of CaMKII action in long-term potentiation. Nat Rev Neurosci (2012) 3.59
Visualization of the spatial and temporal dynamics of intracellular signaling. Dev Cell (2003) 3.38
Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science (2010) 2.99
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc Natl Acad Sci U S A (2001) 2.77
An optimized fluorescent probe for visualizing glutamate neurotransmission. Nat Methods (2013) 2.75
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem (2006) 2.73
Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochem Biophys Res Commun (2006) 2.66
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol (2009) 2.59
Multicolor bimolecular fluorescence complementation reveals simultaneous formation of alternative CBL/CIPK complexes in planta. Plant J (2008) 2.44
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell (2013) 2.37
A genetically encoded fluorescent sensor of ERK activity. Proc Natl Acad Sci U S A (2008) 2.34
A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34
PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase. Neuron (2010) 2.30
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol (2007) 2.28
Development of an optimized backbone of FRET biosensors for kinases and GTPases. Mol Biol Cell (2011) 2.28
Glutamate induces de novo growth of functional spines in developing cortex. Nature (2011) 2.24
Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors. Proc Natl Acad Sci U S A (2008) 1.97
Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation. Science (2010) 1.93
Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis. J Cell Biol (2010) 1.89
Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons. J Neurosci (2005) 1.86
Chemical approaches for investigating phosphorylation in signal transduction networks. Trends Cell Biol (2005) 1.81
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters. Proc Natl Acad Sci U S A (2008) 1.80
Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacol Rev (2012) 1.73
Molecular imaging of Akt kinase activity. Nat Med (2007) 1.68
Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol (2009) 1.65
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO Rep (2005) 1.62
Design and application of genetically encoded biosensors. Trends Biotechnol (2011) 1.59
Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains. Mol Biol Cell (2008) 1.57
Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem (2006) 1.56
A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metab (2011) 1.55
AKAP signaling complexes in regulation of excitatory synaptic plasticity. Neuroscientist (2011) 1.52
Visualization of PKA activity in plasma membrane microdomains. Mol Biosyst (2010) 1.51
Semaphorin3A regulates neuronal polarization by suppressing axon formation and promoting dendrite growth. Neuron (2011) 1.50
Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J Mol Cell Biol (2010) 1.43
Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure. J Cell Biol (2011) 1.34
Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity. Proc Natl Acad Sci U S A (2005) 1.34
Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation. J Neurosci (2010) 1.33
Chapter 22: Quantitation of protein-protein interactions: confocal FRET microscopy. Methods Cell Biol (2008) 1.32
Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. J Biol Chem (2003) 1.31
Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems. Annu Rev Biochem (2011) 1.30
Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A (2012) 1.27
Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells. FEBS Lett (2004) 1.27
Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons. J Neurosci (2010) 1.24
Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res (2011) 1.23
Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity. Biochem Biophys Res Commun (2008) 1.22
Genetically encoded fluorescent indicators to visualize protein phosphorylation by extracellular signal-regulated kinase in single living cells. Anal Chem (2007) 1.21
Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proc Natl Acad Sci U S A (2010) 1.20
AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors. J Biol Chem (2010) 1.19
Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells. FASEB J (2012) 1.17
Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation. Mol Biol Cell (2006) 1.15
Fluorescent proteins: shine on, you crazy diamond. J Am Chem Soc (2013) 1.15
FRET microscopy in the living cell: different approaches, strengths and weaknesses. Bioessays (2012) 1.14
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. J Mol Cell Cardiol (2011) 1.14
Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels. J Neurosci (2010) 1.09
Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol (2010) 1.08
Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med (2011) 1.08
mRNA display selection of a high-affinity, modification-specific phospho-IkappaBalpha-binding fibronectin. ACS Chem Biol (2008) 1.07
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun (2011) 1.06
Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation. J Biol Chem (2007) 1.06
Rapid development of genetically encoded FRET reporters. ACS Chem Biol (2011) 1.05
FRET and colocalization analyzer--a method to validate measurements of sensitized emission FRET acquired by confocal microscopy and available as an ImageJ Plug-in. Microsc Res Tech (2006) 1.04
Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction. J Mol Biol (2005) 1.04
Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor. Mol Biosyst (2008) 1.04
Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors. Cell Struct Funct (2012) 1.03
Optogenetic reporters: Fluorescent protein-based genetically encoded indicators of signaling and metabolism in the brain. Prog Brain Res (2012) 1.03
AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems. J Biol Chem (2010) 1.03
Förster resonance energy transfer microscopy and spectroscopy for localizing protein-protein interactions in living cells. Cytometry A (2013) 1.01
Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity. Biol Psychiatry (2011) 1.01
FRET by fluorescence polarization microscopy. Methods Cell Biol (2008) 0.99
FRET-based detection of different conformations of MK2. EMBO Rep (2001) 0.99
T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering. Mol Cell Biol (2010) 0.99
Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. J Neurosci (2012) 0.99
Fluorescent proteins for FRET microscopy: monitoring protein interactions in living cells. Bioessays (2012) 0.99
Signal/noise analysis of FRET-based sensors. Biophys J (2010) 0.98
Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate. J Physiol (2010) 0.97
Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. FASEB J (2010) 0.96
Imaging protein phosphorylation by fluorescence in single living cells. Methods (2004) 0.96
Luminescent kinase activity biosensors based on a versatile bimolecular switch. J Am Chem Soc (2011) 0.95
Signaling in dendritic spines and spine microdomains. Curr Opin Neurobiol (2012) 0.95
From FRET imaging to practical methodology for kinase activity sensing in living cells. Prog Mol Biol Transl Sci (2013) 0.95
The mechanisms underlying the spatial spreading of signaling activity. Curr Opin Neurobiol (2011) 0.95
Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels. J Neurosci (2012) 0.93
The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. EMBO J (2006) 0.93
Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. J Biol Chem (2010) 0.93
FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes. Biochem Biophys Res Commun (2010) 0.93