Published in Mol Cell on March 27, 2009
Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol (2010) 2.37
Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci (2013) 1.63
Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry. J Mol Biol (2014) 1.41
CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain. PLoS One (2011) 1.34
A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition. Mol Cell Biol (2011) 1.23
Structural basis for spectrin recognition by ankyrin. Blood (2010) 1.21
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nat Med (2014) 1.02
Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury. J Biol Chem (2010) 1.00
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration. EMBO J (2011) 0.98
The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron (2014) 0.97
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron (2014) 0.92
Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function. Proc Natl Acad Sci U S A (2012) 0.89
Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer. Gastroenterology (2011) 0.86
The PIDDosome, DNA-damage-induced apoptosis and beyond. Cell Death Differ (2011) 0.85
The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Cell Death Differ (2011) 0.83
Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90. Cell Death Differ (2010) 0.82
Repeated evolution of identical domain architecture in metazoan netrin domain-containing proteins. Genome Biol Evol (2012) 0.81
Role of Netrin-1 Beyond the Brain: From Biomarker of Tissue Injury to Therapy for Inflammatory Diseases. Recent Pat Biomark (2012) 0.81
Multifunctional protein APPL2 contributes to survival of human glioma cells. Mol Oncol (2012) 0.80
Structurally similar but functionally diverse ZU5 domains in human erythrocyte ankyrin. J Mol Biol (2012) 0.80
De Novo Mutations of RERE Cause a Genetic Syndrome with Features that Overlap Those Associated with Proximal 1p36 Deletions. Am J Hum Genet (2016) 0.78
Super-complexes of adhesion GPCRs and neural guidance receptors. Nat Commun (2016) 0.77
An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98. J Mol Biol (2014) 0.75
UNC5B receptor deletion exacerbates DSS-induced colitis in mice by increasing epithelial cell apoptosis. J Cell Mol Med (2014) 0.75
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Nat Commun (2016) 0.75
Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer. Oncol Lett (2017) 0.75
Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier. Front Cell Neurosci (2017) 0.75
R/qtl: QTL mapping in experimental crosses. Bioinformatics (2003) 22.38
Increased methylation variation in epigenetic domains across cancer types. Nat Genet (2011) 8.92
DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science (2003) 8.81
Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res (2008) 8.62
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat Genet (2009) 5.52
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (2004) 4.81
Nicastrin functions as a gamma-secretase-substrate receptor. Cell (2005) 4.64
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature (2010) 4.61
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15
Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 3.82
The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu Rev Immunol (2007) 3.59
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem (2006) 3.51
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci (2002) 3.31
Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell (2013) 3.13
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell (2013) 3.09
De novo rates and selection of large copy number variation. Genome Res (2010) 3.08
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol (2011) 3.00
Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem (2007) 2.99
PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors. Blood (2007) 2.93
Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China. Clin Infect Dis (2013) 2.91
Cytoplasmic male sterility of rice with boro II cytoplasm is caused by a cytotoxic peptide and is restored by two related PPR motif genes via distinct modes of mRNA silencing. Plant Cell (2006) 2.91
E2 interaction and dimerization in the crystal structure of TRAF6. Nat Struct Mol Biol (2009) 2.79
Michigan Molecular Interactions (MiMI): putting the jigsaw puzzle together. Nucleic Acids Res (2006) 2.77
Structural basis for recognition of diubiquitins by NEMO. Mol Cell (2009) 2.73
Complete transfer of perceptual learning across retinal locations enabled by double training. Curr Biol (2008) 2.62
Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol (2008) 2.56
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS One (2008) 2.51
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell (2007) 2.48
BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis. Development (2004) 2.47
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev (2005) 2.44
Markov models of molecular kinetics: generation and validation. J Chem Phys (2011) 2.41
R/qtlbim: QTL with Bayesian Interval Mapping in experimental crosses. Bioinformatics (2007) 2.40
Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell (2012) 2.38
CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. Proc Natl Acad Sci U S A (2008) 2.36
Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity. J Neurosci (2006) 2.34
A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci (2005) 2.30
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A (2009) 2.30
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. PLoS Genet (2009) 2.27
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density. Nat Rev Neurosci (2009) 2.22
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell (2007) 2.21
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell (2012) 2.18
eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer Res (2011) 2.10
Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy (2009) 2.09
DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development (2005) 2.08
Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1. J Mol Biol (2007) 2.08
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol (2010) 2.08
Molecular basis of NF-κB signaling. Annu Rev Biophys (2013) 2.03
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun (2013) 2.00
Crystal structure of inhibitor of κB kinase β. Nature (2011) 1.92
A detrimental mitochondrial-nuclear interaction causes cytoplasmic male sterility in rice. Nat Genet (2013) 1.92
Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat Cell Biol (2002) 1.91
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell (2010) 1.90
Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc Natl Acad Sci U S A (2006) 1.87
Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B. Gastroenterology (2008) 1.84
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J Mol Biol (2007) 1.82
DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol (2002) 1.81
Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development (2009) 1.79
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem Biol (2007) 1.78
Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development. Blood (2007) 1.74
PDZ domains of Par-3 as potential phosphoinositide signaling integrators. Mol Cell (2007) 1.70
Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. PLoS One (2009) 1.70
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol (2011) 1.68
GJB2 mutation spectrum in 2,063 Chinese patients with nonsyndromic hearing impairment. J Transl Med (2009) 1.66
Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation. Diabetes (2007) 1.62
Antiviral inhibitory capacity of CD8+ T cells predicts the rate of CD4+ T-cell decline in HIV-1 infection. J Infect Dis (2012) 1.61
Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol (2013) 1.61
Ibrutinib resistance in chronic lymphocytic leukemia. N Engl J Med (2014) 1.60
Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry (2009) 1.60
Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A (2012) 1.59
Rule-based learning explains visual perceptual learning and its specificity and transfer. J Neurosci (2010) 1.59
TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J Biol Chem (2006) 1.56
CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection. Hepatology (2009) 1.56
Absence of the superior mesenteric artery in an adult and a new classification method for superior-inferior mesenteric arterial variations. Surg Radiol Anat (2013) 1.56
Transparent nanotubular capacitors based on transplanted anodic aluminum oxide templates. ACS Appl Mater Interfaces (2015) 1.54
Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac. J Biol Chem (2003) 1.54
Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients: pooled results from the phase 3 double-blind randomized ECHO and THRIVE Trials. J Acquir Immune Defic Syndr (2012) 1.53
A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses. J Neurosci (2004) 1.53
Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition. Mol Cell (2005) 1.53
A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data. Nucleic Acids Res (2014) 1.52
Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neurosci (2011) 1.52
Hybrid male sterility in rice controlled by interaction between divergent alleles of two adjacent genes. Proc Natl Acad Sci U S A (2008) 1.52
TNF signaling drives myeloid-derived suppressor cell accumulation. J Clin Invest (2012) 1.52
Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex. J Cell Biol (2005) 1.51
Myosin VI undergoes cargo-mediated dimerization. Cell (2009) 1.47
Both flow-mediated vasodilation procedures and acute exercise improve endothelial function in obese young men. Eur J Appl Physiol (2010) 1.47
15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome Res (2003) 1.46
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat Commun (2012) 1.46
Potent hepatitis B surface antigen response to treatment of hepatitis-B-e-antigen-positive chronic hepatitis B with α-interferon plus a nucleos(t)ide analog. J Gastroenterol Hepatol (2012) 1.46
Application of ICHD-II criteria in a headache clinic of China. PLoS One (2012) 1.46
Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine. Mol Cell (2006) 1.46
Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95. J Mol Biol (2003) 1.45
Helical assembly in the death domain (DD) superfamily. Curr Opin Struct Biol (2012) 1.44
Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly. J Mol Biol (2006) 1.44