Published in J Biol Chem on April 03, 2009
Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci U S A (1992) 61.33
The alpha/beta hydrolase fold. Protein Eng (1992) 9.94
Exposure of tryptophanyl residues in proteins. Quantitative determination by fluorescence quenching studies. Biochemistry (1976) 3.91
Fluorescence quenching studies with proteins. Anal Biochem (1981) 3.87
Structure of human pancreatic lipase. Nature (1990) 3.49
Fluorescence-polarization spectrum and electronic-energy transfer in tyrosine, tryptophan and related compounds. Biochem J (1960) 3.45
Fluorescence and the location of tryptophan residues in protein molecules. Photochem Photobiol (1973) 3.24
Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms. Curr Protein Pept Sci (2000) 2.95
Suggestions for "safe" residue substitutions in site-directed mutagenesis. J Mol Biol (1991) 2.80
Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. Nature (1993) 2.00
The triglyceride lipases of the pancreas. J Lipid Res (2002) 1.43
The 2.46 A resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate. Biochemistry (1995) 1.15
Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization. Protein Expr Purif (1998) 1.11
Lipase activation by nonionic detergents. The crystal structure of the porcine lipase-colipase-tetraethylene glycol monooctyl ether complex. J Biol Chem (1996) 1.05
Purification and characterization of human procolipase expressed in yeast cells. Protein Expr Purif (1998) 1.01
Neutron crystallographic evidence of lipase-colipase complex activation by a micelle. EMBO J (1997) 1.00
Fluorescence studies with tryptophyl peptides. Biochemistry (1967) 0.98
The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions. Biochemistry (2002) 0.94
Probing the opening of the pancreatic lipase lid using site-directed spin labeling and EPR spectroscopy. Biochemistry (2007) 0.93
Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. J Biol Chem (2001) 0.93
Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC. Eur J Biochem (2002) 0.93
The open lid mediates pancreatic lipase function. J Lipid Res (2000) 0.92
Structure and activity of rat pancreatic lipase-related protein 2. J Biol Chem (1998) 0.91
Crystallization of pancreatic procolipase and of its complex with pancreatic lipase. J Mol Biol (1993) 0.88
Critical role of micelles in pancreatic lipase activation revealed by small angle neutron scattering. J Biol Chem (2000) 0.88
Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles. J Biol Chem (2006) 0.88
Amino acid substitution matrices. Adv Protein Chem (2000) 0.87
Detergent-induced conformational changes of Humicola lanuginosa lipase studied by fluorescence spectroscopy. Biophys J (2000) 0.86
Time-resolved fluorescence allows selective monitoring of Trp30 environmental changes in the seven-Trp-containing human pancreatic lipase. Biochemistry (2003) 0.85
Human pancreatic lipase: an exposed hydrophobic loop from the C-terminal domain may contribute to interfacial binding. Biochemistry (1998) 0.84
Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations. Proteins (1998) 0.84
Ion pairing between lipase and colipase plays a critical role in catalysis. J Biol Chem (1998) 0.82
Colipase stabilizes the lid domain of pancreatic triglyceride lipase. J Biol Chem (1997) 0.79
A conformational transition between an open and closed form of human pancreatic lipase revealed by a monoclonal antibody. Biochim Biophys Acta (2000) 0.78
Inhibition of pancreatic lipase by mixed micelles of diethyl p-nitrophenyl phosphate and bile salts. Biochim Biophys Acta (1978) 0.78
Inactivation of pancreatic lipases by amphiphilic reagents 5-(dodecyldithio)-2-nitrobenzoic acid and tetrahydrolipstatin. Dependence upon partitioning between micellar and oil phases. Biochemistry (1993) 0.77
Large spectral changes accompany the conformational transition of human pancreatic lipase induced by acylation with the inhibitor tetrahydrolipstatin. Eur J Biochem (1992) 0.77
Gastrointestinal outcomes and confounders in cystic fibrosis. J Pediatr Gastroenterol Nutr (2005) 1.87
What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr (2011) 1.85
Human pancreatic digestive enzymes. Dig Dis Sci (2007) 1.51
Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis. Hepatology (2010) 1.48
Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr (2012) 1.43
Etiology and outcome of acute pancreatitis in infants and toddlers. J Pediatr (2007) 1.37
Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible? Pancreas (2010) 1.23
Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry. J Pediatr Gastroenterol Nutr (2016) 1.20
Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. J Biol Chem (2001) 1.13
Pancreatic lipase-related protein 2 is the major colipase-dependent pancreatic lipase in suckling mice. J Nutr (2004) 0.94
The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions. Biochemistry (2002) 0.94
Genetic issues in pediatric pancreatitis. Curr Gastroenterol Rep (2006) 0.94
Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression. Physiol Genomics (2003) 0.93
Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns. J Biol Chem (2011) 0.89
Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis. Pancreas (2007) 0.88
Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles. J Biol Chem (2006) 0.88
Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem (2002) 0.85
Inhibition of lipases by epsilon-polylysine. J Lipid Res (2003) 0.85
Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr (2014) 0.85
Effect of long-term high-fat feeding on the expression of pancreatic lipases and adipose tissue uncoupling proteins in mice. Pancreas (2003) 0.85
Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice. J Nutr (2008) 0.84
A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. J Lipid Res (2007) 0.84
Persistent hyperlipasemia caused by macrolipase in an adolescent. J Pediatr (2002) 0.83
Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion. J Lipid Res (2011) 0.82
Expression of a novel cadherin in the mouse and human intestine. Pediatr Res (2004) 0.82
Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase. Biochim Biophys Acta (2013) 0.81
Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. Pediatr Res (2013) 0.79
IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules. PLoS One (2012) 0.79
The histopathology of PRSS1 hereditary pancreatitis. Am J Surg Pathol (2014) 0.79
Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). Cell Biochem Funct (2009) 0.78
The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding. J Lipid Res (2012) 0.77
Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice. Am J Physiol Endocrinol Metab (2009) 0.77
Pediatric pancreatitis. Pediatr Rev (2013) 0.76
The Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group. J Pediatr Gastroenterol Nutr (2016) 0.76
A carboxyl ester lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosis. J Biol Chem (2017) 0.76
Identification of amino acids in human colipase that mediate adsorption to lipid emulsions and mixed micelles. Biochim Biophys Acta (2013) 0.75
Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol (2009) 0.75
Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas (2016) 0.75
Childhood cancer survival: a risk factor for GI disease. Gastroenterology (2011) 0.75
Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review. J Clin Gastroenterol (2017) 0.75
ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children. J Pediatr Gastroenterol Nutr (2015) 0.75
Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link? JOP (2006) 0.75