Published in Proc Natl Acad Sci U S A on April 03, 2009
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Facile and efficient reprogramming of ciliary body epithelial cells into induced pluripotent stem cells. Stem Cells Dev (2013) 0.82
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Adult ciliary epithelial stem cells generate functional neurons and differentiate into both early and late born retinal neurons under non-cell autonomous influences. BMC Neurosci (2013) 0.81
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Jagged1 is necessary for postnatal and adult neurogenesis in the dentate gyrus. Dev Biol (2014) 0.80
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One (2012) 0.80
Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency. Stem Cells (2013) 0.79
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RPE and neuronal differentiation of allotransplantated porcine ciliary epithelium-derived cells. Mol Vis (2011) 0.79
Proliferation of the ciliary epithelium with retinal neuronal and photoreceptor cell differentiation in human eyes with retinal detachment and proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol (2011) 0.79
Generating retinal neurons by reprogramming retinal pigment epithelial cells. Expert Opin Biol Ther (2010) 0.78
Lgr5⁺ amacrine cells possess regenerative potential in the retina of adult mice. Aging Cell (2015) 0.78
Restricted perinatal retinal degeneration induces retina reshaping and correlated structural rearrangement of the retinotopic map. Nat Commun (2013) 0.78
Does the adult human ciliary body epithelium contain "true" retinal stem cells? Biomed Res Int (2013) 0.77
The Retinal Pigment Epithelium: a Convenient Source of New Photoreceptor cells? J Ophthalmic Vis Res (2014) 0.76
Photoreceptor structure and development analyses using GFP transgenes. Methods Cell Biol (2010) 0.76
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Isolation of retinal stem cells from the mouse eye. J Vis Exp (2010) 0.75
Chitosan feasibility to retain retinal stem cell phenotype and slow proliferation for retinal transplantation. Biomed Res Int (2014) 0.75
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Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell (2009) 3.66
Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell (2007) 2.61
Facile isolation and the characterization of human retinal stem cells. Proc Natl Acad Sci U S A (2004) 2.18
p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations. J Neurosci (2001) 1.94
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p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina. Development (2000) 1.63
Potential of Müller glia to become neurogenic retinal progenitor cells. Glia (2003) 1.63
Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development (2004) 1.58
High efficacy of clonal growth and expansion of adult neural stem cells. Lab Invest (2003) 1.47
Embryonic stem cell-derived neural progenitors incorporate into degenerating retina and enhance survival of host photoreceptors. Stem Cells (2005) 1.42
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Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant. Dev Biol (2001) 1.09
Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. J Biol Chem (2003) 1.09
Growth factors induce neurogenesis in the ciliary body. Dev Biol (2003) 1.03
Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor. Hum Mol Genet (2005) 1.03
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Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo. Eur J Neurosci (2006) 0.98
Mosaic deletion of Rb arrests rod differentiation and stimulates ectopic synaptogenesis in the mouse retina. J Comp Neurol (2006) 0.97
Adult retinal pigment epithelium cells express neural progenitor properties and the neuronal precursor protein doublecortin. Brain Res (2005) 0.94
Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1. Stem Cells (2008) 0.93
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Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature (2012) 5.02
Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J Clin Oncol (2010) 4.94
PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol (2009) 4.83
Novel mutations target distinct subgroups of medulloblastoma. Nature (2012) 4.82
Inactivation of the p53 pathway in retinoblastoma. Nature (2006) 4.57
Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol (2011) 3.56
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet (2013) 3.51
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem (2004) 3.10
Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev (2007) 3.00
Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell (2011) 2.87
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Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res (2004) 2.75
Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci U S A (2002) 2.74
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci U S A (2003) 2.68
Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell (2007) 2.61
Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA (2012) 2.49
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Genotoxicity of retroviral integration in hematopoietic cells. Mol Ther (2006) 2.34
Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell (2009) 2.18
PTEN function in normal and neoplastic growth. Cancer Lett (2006) 2.10
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood (2002) 1.96
Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet (2004) 1.94
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. Nat Cell Biol (2012) 1.89
Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem (2010) 1.85
PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. Clin Cancer Res (2006) 1.83
Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res (2011) 1.79
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood (2006) 1.78
The first knockout mouse model of retinoblastoma. Cell Cycle (2004) 1.74
Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development (2002) 1.73
Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection. Blood (2009) 1.73
EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol (2007) 1.72
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol (2003) 1.68
Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell (2011) 1.67
Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy. Proc Natl Acad Sci U S A (2006) 1.67
The effects of transdermal nicotine on cognition in nonsmokers with schizophrenia and nonpsychiatric controls. Neuropsychopharmacology (2007) 1.67
Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol (2007) 1.67
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc Natl Acad Sci U S A (2014) 1.62
Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell (2010) 1.54
Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol (2006) 1.54
Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol (2010) 1.51
MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells (2013) 1.49
Preparation and square wave electroporation of retinal explant cultures. Nat Protoc (2006) 1.48
Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations. Genesis (2006) 1.43
Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A (2009) 1.37
Topotecan combination chemotherapy in two new rodent models of retinoblastoma. Clin Cancer Res (2005) 1.37
Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains. Genes Dev (2009) 1.34
A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. Blood (2010) 1.33
Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells. Blood (2003) 1.31
Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma. Cancer (2010) 1.30
Retinoblastoma: one world, one vision. Pediatrics (2008) 1.29
The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation. J Biol Chem (2005) 1.28
Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells. Cancer Res (2003) 1.25
Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration. J Physiol (2011) 1.24
Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res (2008) 1.23
Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Cancer Res (2013) 1.23
Low levels of ABCG2 expression in adult AML blast samples. Blood (2002) 1.23
Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction. Genes Dev (2013) 1.21
Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc Natl Acad Sci U S A (2008) 1.21
Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. Cancer Res (2011) 1.21
Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev Dyn (2006) 1.20
Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface. J Biol Chem (2004) 1.19
Digital sorting of complex tissues for cell type-specific gene expression profiles. BMC Bioinformatics (2013) 1.18
A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. Blood (2005) 1.18
Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size. J Biol Chem (2005) 1.18
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. J Clin Invest (2009) 1.17
Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res (2011) 1.17
Measuring apoptosis at the single cell level. Methods (2008) 1.13
Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood (2004) 1.12
Regulation of proliferation during central nervous system development. Semin Cell Dev Biol (2005) 1.11
Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma. Cancer (2010) 1.11
Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma. Nat Rev Cancer (2014) 1.10
Neuronal differentiation and synaptogenesis in retinoblastoma. Cancer Res (2007) 1.10
Preclinical models for neuroblastoma: establishing a baseline for treatment. PLoS One (2011) 1.09
Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy. Cancer Res (2007) 1.08
Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele. Stem Cells (2006) 1.07
Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. PLoS One (2012) 1.06
The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer Res (2006) 1.04
N-myc coordinates retinal growth with eye size during mouse development. Genes Dev (2008) 1.03
Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. Nat Cell Biol (2013) 1.03
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Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma. Clin Cancer Res (2009) 1.02
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