Published in Neurobiol Aging on April 05, 2009
Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nat Rev Neurosci (2012) 1.69
Imaging of microglia in patients with neurodegenerative disorders. Front Pharmacol (2012) 0.96
Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1-42-infused mouse model of Alzheimer's disease. Cell Death Dis (2013) 0.87
Neuronal and axonal loss are selectively linked to fibrillar amyloid-{beta} within plaques of the aged primate cerebral cortex. Am J Pathol (2010) 0.87
Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age (Dordr) (2013) 0.81
Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies. Int J Mol Sci (2016) 0.78
Postmortem Adult Human Microglia Proliferate in Culture to High Passage and Maintain Their Response to Amyloid-β. J Alzheimers Dis (2016) 0.75
Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms. Front Neurol (2017) 0.75
The fourth element targeting hypothesis of Alzheimer's disease pathogenesis and pathophysiology. Front Neurol (2010) 0.75
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology (1991) 23.01
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (2002) 19.36
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA (2003) 6.34
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol (1997) 6.12
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science (1990) 6.03
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med (2007) 5.87
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A (1994) 4.33
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem (2004) 4.33
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem (2005) 4.23
Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature (1996) 3.92
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci (1999) 3.92
Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron (1996) 3.14
Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron (1996) 2.89
Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease. Biochemistry (1999) 2.87
Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry (2003) 2.85
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem (2002) 2.85
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ (2003) 2.74
CD36 mediates the innate host response to beta-amyloid. J Exp Med (2003) 2.65
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci (2000) 2.58
Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc Natl Acad Sci U S A (1999) 2.40
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med (1998) 2.32
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem (2003) 2.31
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol (2002) 2.22
Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies. J Neurochem (2001) 2.14
Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study. Neurology (2002) 2.12
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J (2004) 2.00
Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology (2004) 1.92
Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J Neurosci (1996) 1.59
Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. Curr Biol (1998) 1.48
Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem Int (2001) 1.47
Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation. J Neurochem (2007) 1.46
Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J Neurosci (1993) 1.35
Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol (1997) 1.31
NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice. J Neurosci (2008) 1.27
Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes. Neuroscience (1995) 1.27
From bone marrow to microglia: barriers and avenues. Trends Immunol (2008) 1.25
Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss. J Comp Neurol (2003) 1.25
Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]. J Neuroimmunol (1999) 1.25
Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience (2006) 1.24
Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson's disease. Neurobiol Dis (2005) 1.12
Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. Neurobiol Aging (2006) 1.09
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem (2003) 1.04
Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. J Immunol (2001) 1.03
Amyloid load and neural elements in Alzheimer's disease and nondemented individuals with high amyloid plaque density. Exp Neurol (1996) 0.95
The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected beta-amyloid in the rat brain. Neurobiol Aging (1993) 0.94
Progressive reduction of synaptophysin message in single neurons in Alzheimer disease. J Neuropathol Exp Neurol (2002) 0.92
The macrophage-activating tetrapeptide tuftsin induces nitric oxide synthesis and stimulates murine macrophages to kill Leishmania parasites in vitro. Infect Immun (1994) 0.92
Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles. Neurobiol Aging (2003) 0.91
Tuftsin deficiency in AIDS. Lancet (1991) 0.86
Tuftsin, a natural activator of phagocyte cells: an overview. Ann N Y Acad Sci (1983) 0.84
Impaired tuftsin activity in cirrhosis: relationship with splenic function and clinical outcome. Gut (2002) 0.84
Engagement of the scavenger receptor is not responsible for beta-amyloid stimulation of monocytes to a neurocytopathic state. Exp Neurol (2000) 0.84
Non-steroidal anti-inflammatory drug (NSAID) use and Alzheimer disease in community-dwelling elderly patients. Am J Geriatr Psychiatry (2003) 0.83
Phagocytosis and microbicidal capacity of human monocytes in the course of HIV infection. Immunol Lett (1992) 0.78
Immunosuppressive activity of analogs of tripeptide Lys-Arg-Pro with D-amino acid residues. Arch Immunol Ther Exp (Warsz) (1994) 0.78
The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides (1994) 0.76
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol (2009) 5.87
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med (2007) 5.87
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet (2006) 4.61
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci (2008) 3.90
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem (2002) 2.85
The microglial sensome revealed by direct RNA sequencing. Nat Neurosci (2013) 2.73
Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy. Arch Gen Psychiatry (2008) 2.43
Neurobiology of butyrylcholinesterase. Nat Rev Neurosci (2003) 2.41
Quality assessment of maize assembled genomic islands (MAGIs) and large-scale experimental verification of predicted genes. Proc Natl Acad Sci U S A (2005) 2.27
Genetic dissection of intermated recombinant inbred lines using a new genetic map of maize. Genetics (2006) 1.89
Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med (2009) 1.84
A strategy for assembling the maize (Zea mays L.) genome. Bioinformatics (2004) 1.83
DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem (2006) 1.68
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet (2005) 1.66
Single-molecule studies of repressor-DNA interactions show long-range interactions. Proc Natl Acad Sci U S A (2005) 1.60
Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial. J Natl Cancer Inst (2011) 1.56
Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primary progressive aphasia. Brain (2014) 1.54
Similarity and divergence of phylogenies, antimicrobial susceptibilities, and virulence factor profiles of Escherichia coli isolates causing recurrent urinary tract infections that persist or result from reinfection. J Clin Microbiol (2012) 1.53
Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor. Stress (2007) 1.52
Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy (2010) 1.47
Nearly identical paralogs: implications for maize (Zea mays L.) genome evolution. Genetics (2006) 1.45
HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages. J Clin Invest (2003) 1.39
Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. J Neurosci (2006) 1.39
Corticosteroid Therapy Benefits Septic Mice With Adrenal Insufficiency But Harms Septic Mice Without Adrenal Insufficiency. Crit Care Med (2015) 1.39
Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Mol Microbiol (2004) 1.39
Population fitness and the regulation of Escherichia coli genes by bacterial viruses. PLoS Biol (2005) 1.32
Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men. Cancer Sci (2011) 1.32
Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation. PLoS One (2011) 1.30
The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nat Immunol (2013) 1.29
Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia. Brain (2012) 1.26
Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss. J Comp Neurol (2003) 1.25
Postradiation nasopharyngeal necrosis in the patients with nasopharyngeal carcinoma. Head Neck (2009) 1.24
Recurrent postural vasovagal syncope: sympathetic nervous system phenotypes. Circ Arrhythm Electrophysiol (2011) 1.22
Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress. Clin Exp Pharmacol Physiol (2008) 1.21
Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits. Bioorg Med Chem Lett (2006) 1.18
Types and frequencies of sequencing errors in methyl-filtered and high c0t maize genome survey sequences. Plant Physiol (2004) 1.18
DNA sequence-based "bar codes" for tracking the origins of expressed sequence tags from a maize cDNA library constructed using multiple mRNA sources. Plant Physiol (2003) 1.16
Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case-control study in the ChinaPCa consortium. Carcinogenesis (2011) 1.15
HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner. J Clin Invest (2003) 1.15
Retracted Hypercholesterolemia promotes a CD36-dependent and endothelial nitric-oxide synthase-mediated vascular dysfunction. J Biol Chem (2002) 1.14
Quantitative transcription factor binding kinetics at the single-molecule level. Biophys J (2009) 1.13
GOLPH3 overexpression correlates with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer. J Transl Med (2012) 1.12
Evaluation of five ab initio gene prediction programs for the discovery of maize genes. Plant Mol Biol (2005) 1.09
Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: findings from a randomised trial. Eur J Cancer (2013) 1.07
Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex. Exp Neurol (2003) 1.07
Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Nat Commun (2013) 1.05
Flotillin-2 is associated with breast cancer progression and poor survival outcomes. J Transl Med (2013) 1.04
Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease. CNS Neurol Disord Drug Targets (2010) 1.03
A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J Biol Chem (2005) 1.03
Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma. J Transl Med (2010) 1.02
Salt inactivates endothelial nitric oxide synthase in endothelial cells. J Nutr (2009) 1.01
Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project. J Cogn Neurosci (2013) 1.01
A novel onco-miR-365 induces cutaneous squamous cell carcinoma. Carcinogenesis (2013) 1.01
Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer's disease. Acta Neuropathol (2011) 1.01
Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen. J Med Food (2012) 1.01
Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii. J Infect Dis (2009) 1.01
Formation of short chain length/medium chain length polyhydroxyalkanoate copolymers by fatty acid beta-oxidation inhibited Ralstonia eutropha. Biomacromolecules (2002) 1.00
Temperature gradient capillary electrophoresis (TGCE)--a tool for the high-throughput discovery and mapping of SNPs and IDPs. Theor Appl Genet (2005) 0.99
Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro. Exp Neurol (2003) 0.98
Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma. J Transl Med (2011) 0.97
Honokiol: a non-adipogenic PPARγ agonist from nature. Biochim Biophys Acta (2013) 0.97
Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. Int J Alzheimers Dis (2012) 0.96
Distribution, progression and chemical composition of cortical amyloid-beta deposits in aged rhesus monkeys: similarities to the human. Acta Neuropathol (2002) 0.96
Scavenger receptor BI prevents nitric oxide-induced cytotoxicity and endotoxin-induced death. Circ Res (2006) 0.96
Deficiency of scavenger receptor BI leads to impaired lymphocyte homeostasis and autoimmune disorders in mice. Arterioscler Thromb Vasc Biol (2011) 0.96
A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. J Biol Chem (2011) 0.96
A randomized trial of induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Oral Oncol (2012) 0.95
Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease. J Neuropathol Exp Neurol (2012) 0.95
The neuronal noradrenaline transporter, anxiety and cardiovascular disease. J Psychopharmacol (2006) 0.94
Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease. Exp Neurol (2005) 0.93
Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun (2013) 0.93
Elevated apolipoprotein A-I levels are associated with favorable prognosis in metastatic nasopharyngeal carcinoma. Med Oncol (2014) 0.93
Standardizing scavenger receptor nomenclature. J Immunol (2014) 0.93
NDM-1-producing strains, family Enterobacteriaceae, in hospital, Beijing, China. Emerg Infect Dis (2014) 0.93
Cytoplasmic regulation of the accumulation of nuclear-encoded proteins in the mitochondrial proteome of maize. Plant J (2004) 0.93
Transducin β-like 1 X-linked receptor 1 suppresses cisplatin sensitivity in Nasopharyngeal Carcinoma via activation of NF-κB pathway. Mol Cancer (2014) 0.92
Prevalence of β-lactamases and 16S rRNA methylase genes amongst clinical Klebsiella pneumoniae isolates carrying plasmid-mediated quinolone resistance determinants. Int J Antimicrob Agents (2011) 0.92
The neuroimmune system in Alzheimer's disease: the glass is half full. J Alzheimers Dis (2013) 0.92
Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. J Med Chem (2002) 0.92
Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis. Chin J Cancer (2013) 0.92
Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome. Arterioscler Thromb Vasc Biol (2012) 0.92
Retracted Nucleoside reverse transcriptase inhibitors prevent HIV protease inhibitor-induced atherosclerosis by ubiquitination and degradation of protein kinase C. Am J Physiol Cell Physiol (2006) 0.91
Ambient fabrication of large-area graphene films via a synchronous reduction and assembly strategy. Adv Mater (2013) 0.91
Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid. Acta Neuropathol (2013) 0.91
Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles. Neurobiol Aging (2003) 0.91
The size of mesenchymal stem cells is a significant cause of vascular obstructions and stroke. Stem Cell Rev (2014) 0.90
Circadian rhythm in dihydropyrimidine dehydrogenase activity and reduced glutathione content in peripheral blood of nasopharyngeal carcinoma patients. Chronobiol Int (2005) 0.90
Resveratrol attenuates early diabetic nephropathy by down-regulating glutathione s-transferases Mu in diabetic rats. J Med Food (2013) 0.89
Effects of high-dose ulinastatin on inflammatory response and pulmonary function in patients with type-A aortic dissection after cardiopulmonary bypass under deep hypothermic circulatory arrest. J Cardiothorac Vasc Anesth (2013) 0.88
Neuronal and axonal loss are selectively linked to fibrillar amyloid-{beta} within plaques of the aged primate cerebral cortex. Am J Pathol (2010) 0.87
Caveolin-1 protects against sepsis by modulating inflammatory response, alleviating bacterial burden, and suppressing thymocyte apoptosis. J Biol Chem (2010) 0.87
The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies. PLoS One (2013) 0.87
Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder. Ann N Y Acad Sci (2008) 0.87
Rivastigmine is a potent inhibitor of acetyl- and butyrylcholinesterase in Alzheimer's plaques and tangles. Brain Res (2005) 0.87
Neurodegeneration and the neuroimmune system. Nat Med (2010) 0.86
Morphine-induced conditioned place preference in mice: metabolomic profiling of brain tissue to find "molecular switch" of drug abuse by gas chromatography/mass spectrometry. Anal Chim Acta (2011) 0.86