Published in Neurology on September 24, 2002
BONSAI: Biomarkers of Nonsteroidal Anti-Inflammatories | NCT00239746
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest (2003) 3.50
Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol (2008) 2.86
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ (2003) 2.74
Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med (2012) 2.36
Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology (2009) 2.32
The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation (2005) 2.23
NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type. Neurology (2007) 1.88
The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease. Int J Geriatr Psychiatry (2012) 1.82
Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ (2008) 1.70
Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease. J Neuroinflammation (2011) 1.68
No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology (2008) 1.45
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain (2008) 1.42
Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. J Neuroinflammation (2011) 1.41
Dementia and its implications for public health. Prev Chronic Dis (2006) 1.30
Population-based neuropathological studies of dementia: design, methods and areas of investigation--a systematic review. BMC Neurol (2006) 1.27
Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy. Alzheimers Res Ther (2010) 1.20
Does aspirin protect against Alzheimer's dementia? A study in a Swedish population-based sample aged > or =80 years. Eur J Clin Pharmacol (2003) 1.11
Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia. Curr Psychiatry Rev (2009) 1.09
Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study. BMC Geriatr (2005) 1.03
Anticholinergic drug use and risk for dementia: target for dementia prevention. Eur Arch Psychiatry Clin Neurosci (2010) 1.03
Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment? Front Aging Neurosci (2010) 0.98
Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiol Aging (2010) 0.97
Mechanisms of action of non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease. CNS Neurol Disord Drug Targets (2010) 0.95
The association between cognition and histamine-2 receptor antagonists in African Americans. J Am Geriatr Soc (2007) 0.93
Immune aging, dysmetabolism, and inflammation in neurological diseases. Front Neurosci (2015) 0.92
Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity. Brain Pathol (2005) 0.92
Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study. Alzheimers Dement (2008) 0.91
Nonsteroidal anti-inflammatory drugs, aspirin, and cognitive function in the Baltimore longitudinal study of aging. J Am Geriatr Soc (2010) 0.90
Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies. Int Psychogeriatr (2008) 0.89
Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease. Curr Neuropharmacol (2011) 0.89
Clinicopathological outcomes of prospectively followed normal elderly brain bank volunteers. J Neuropathol Exp Neurol (2014) 0.89
Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases. J Neurochem (2010) 0.89
Estrogen or estrogen receptor agonist inhibits lipopolysaccharide induced microglial activation and death. Neurochem Res (2010) 0.88
Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease. J Alzheimers Dis (2011) 0.87
Inhibition of microglia activation as a phenotypic assay in early drug discovery. J Biomol Screen (2013) 0.86
Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex. Neurobiol Aging (2009) 0.86
Medications and diet: protective factors for AD? Alzheimer Dis Assoc Disord (2006) 0.85
Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging. J Neuroinflammation (2014) 0.85
Vascular consequences of passive Abeta immunization for Alzheimer's disease. Is avoidance of "malactivation" of microglia enough? J Neuroinflammation (2005) 0.85
The Cache County Study on Memory in Aging: factors affecting risk of Alzheimer's disease and its progression after onset. Int Rev Psychiatry (2013) 0.84
Neuronal death in Alzheimer's disease and therapeutic opportunities. J Cell Mol Med (2009) 0.84
Pathways towards an effective immunotherapy for Parkinson's disease. Expert Rev Neurother (2011) 0.84
Alzheimer's disease and type 2 diabetes via chronic inflammatory mechanisms. Saudi J Biol Sci (2014) 0.84
Estrogen receptor β in Alzheimer's disease: From mechanisms to therapeutics. Ageing Res Rev (2015) 0.84
Does low-dose acetylsalicylic acid prevent cognitive decline in women with high cardiovascular risk? A 5-year follow-up of a non-demented population-based cohort of Swedish elderly women. BMJ Open (2012) 0.84
Can peripheral leukocytes be used as Alzheimer's disease biomarkers? Expert Rev Neurother (2009) 0.82
Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study. Am J Geriatr Psychiatry (2008) 0.82
Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models. Brain Behav Immun (2016) 0.80
Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity? J Neuroinflammation (2006) 0.80
Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice. Neurobiol Aging (2013) 0.80
Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology. Neurobiol Aging (2011) 0.80
Young microglia restore amyloid plaque clearance of aged microglia. EMBO J (2016) 0.80
Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease. Mol Neurodegener (2011) 0.79
Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression. Alzheimers Dement (2012) 0.79
Genetic aspects of behavioral neurotoxicology. Neurotoxicology (2009) 0.79
Current therapeutic options for Alzheimer's disease. Curr Genomics (2007) 0.79
Role of APOE and Age at Enrollment in the Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT). Dement Geriatr Cogn Dis Extra (2012) 0.78
A role for cyclooxygenase-1 in beta-amyloid-induced neuroinflammation. Aging (Albany NY) (2009) 0.78
Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies. Int J Mol Sci (2016) 0.78
Identification and modification of amyloid-independent phenotypes of APOE4 mice. Exp Neurol (2016) 0.77
Microglial immunophenotype in dementia with Alzheimer's pathology. J Neuroinflammation (2016) 0.76
NSAID Use and Incident Cognitive Impairment in a Population-based Cohort. Alzheimer Dis Assoc Disord (2016) 0.76
Obesity and sex interact in the regulation of Alzheimer's disease. Neurosci Biobehav Rev (2015) 0.76
The Role of Microglia in the Etiology and Evolution of Chronic Traumatic Encephalopathy. Shock (2017) 0.75
Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer's Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan. J Diabetes Res (2016) 0.75
Commonly prescribed drugs associate with cognitive function: a cross-sectional study in UK Biobank. BMJ Open (2016) 0.75
Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study. BMJ Open (2012) 0.75
Histamine-2 receptor antagonist use and incident dementia in an older cohort. J Am Geriatr Soc (2011) 0.75
Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach. Comput Struct Biotechnol J (2016) 0.75
Untangling the Web: Toxic and Protective Effects of Neuroinflammation and PGE2 Signaling in Alzheimer's Disease. ACS Chem Neurosci (2016) 0.75
Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats. Front Aging Neurosci (2017) 0.75
The role of APOE on lipid homeostasis and inflammation in normal brains. J Lipid Res (2017) 0.75
Association Between Proton Pump Inhibitor Use and Cognitive Function in Women. Gastroenterology (2017) 0.75
Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys. JAMA (2004) 22.38
Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. JAMA (2002) 6.72
Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative. World Psychiatry (2007) 6.46
A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement (2008) 6.39
Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimers Dement (2010) 4.85
Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys. PLoS Med (2008) 4.01
From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. Neuropsychopharmacology (2002) 3.56
Incidence and prevalence of dementia in the Cardiovascular Health Study. J Am Geriatr Soc (2004) 3.43
Into the world of illegal drug use: exposure opportunity and other mechanisms linking the use of alcohol, tobacco, marijuana, and cocaine. Am J Epidemiol (2002) 3.13
Early-onset drug use and risk for drug dependence problems. Addict Behav (2008) 3.01
Propensity score techniques and the assessment of measured covariate balance to test causal associations in psychological research. Psychol Methods (2010) 2.99
Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol (2008) 2.86
Mortality risk stratification in chronic kidney disease: one size for all ages? J Am Soc Nephrol (2006) 2.78
Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Arch Neurol (2006) 2.71
Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology (2004) 2.63
Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol (2004) 2.62
Who becomes cannabis dependent soon after onset of use? Epidemiological evidence from the United States: 2000-2001. Drug Alcohol Depend (2005) 2.57
Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples. Alzheimers Dement (2006) 2.51
The adolescent behavioral repertoire as a context for drug exposure: behavioral autarcesis at play. Addiction (2004) 2.39
Age-varying association between statin use and incident Alzheimer's disease. J Am Geriatr Soc (2010) 2.34
Geography matters: relationships among urban residential segregation, dialysis facilities, and patient outcomes. Ann Intern Med (2007) 2.33
Risk of becoming cocaine dependent: epidemiological estimates for the United States, 2000-2001. Neuropsychopharmacology (2005) 2.33
Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry (2008) 2.32
Incidence of drug problems in young adults exposed to trauma and posttraumatic stress disorder: do early life experiences and predispositions matter? Arch Gen Psychiatry (2007) 2.19
Head injury in early adulthood and the lifetime risk of depression. Arch Gen Psychiatry (2002) 1.97
Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study. Neurology (2012) 1.96
Occupational exposure to pesticides increases the risk of incident AD: the Cache County study. Neurology (2010) 1.95
Epidemiological patterns of extra-medical drug use in the United States: evidence from the National Comorbidity Survey Replication, 2001-2003. Drug Alcohol Depend (2007) 1.94
Male-female differences in the risk of progression from first use to dependence upon cannabis, cocaine, and alcohol. Drug Alcohol Depend (2006) 1.90
An adaptation of the modified mini-mental state examination: analysis of demographic influences and normative data: the cache county study. Neuropsychiatry Neuropsychol Behav Neurol (2002) 1.89
Possible age-associated bias in reporting of clinical features of drug dependence: epidemiological evidence on adolescent-onset marijuana use. Addiction (2003) 1.87
Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study. Alzheimer Dis Assoc Disord (2006) 1.85
Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. Am J Geriatr Psychiatry (2011) 1.83
Developmentally inspired drug prevention: middle school outcomes in a school-based randomized prevention trial. Drug Alcohol Depend (2004) 1.81
Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. Arch Gen Psychiatry (2005) 1.78
Evaluating the drug use "gateway" theory using cross-national data: consistency and associations of the order of initiation of drug use among participants in the WHO World Mental Health Surveys. Drug Alcohol Depend (2010) 1.78
The impact of two universal randomized first- and second-grade classroom interventions on young adult suicide ideation and attempts. Drug Alcohol Depend (2008) 1.75
Greater risk of dementia when spouse has dementia? The Cache County study. J Am Geriatr Soc (2010) 1.73
Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking. Ann Neurol (2009) 1.71
Trauma exposure and posttraumatic stress disorder: a study of youths in urban America. J Urban Health (2004) 1.71
Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study. Arch Gen Psychiatry (2004) 1.67
Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study. Arch Neurol (2009) 1.63
Adolescent cannabis problems and young adult depression: male-female stratified propensity score analyses. Am J Epidemiol (2008) 1.63
White matter lesions, quantitative magnetic resonance imaging, and dementia. Alzheimer Dis Assoc Disord (2002) 1.59
Mental disorders in megacities: findings from the São Paulo megacity mental health survey, Brazil. PLoS One (2012) 1.56
Marijuana use and cessation of tobacco smoking in adults from a community sample. Drug Alcohol Depend (2002) 1.54
Epidemiological estimates of risk in the process of becoming dependent upon cocaine: cocaine hydrochloride powder versus crack cocaine. Psychopharmacology (Berl) (2003) 1.53
The structure of posttraumatic stress disorder: latent class analysis in 2 community samples. Arch Gen Psychiatry (2005) 1.49
A randomized controlled trial of two primary school intervention strategies to prevent early onset tobacco smoking. Drug Alcohol Depend (2002) 1.48
Behavioral outcome of preschoolers exposed prenatally to cocaine: role of maternal behavioral health. J Pediatr Psychol (2002) 1.47
Empirically derived latent classes of tobacco dependence syndromes observed in recent-onset tobacco smokers: epidemiological evidence from a national probability sample survey. Nicotine Tob Res (2004) 1.47
The persistence of neuropsychiatric symptoms in dementia: the Cache County Study. Int J Geriatr Psychiatry (2004) 1.46
In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy. Leuk Res (2008) 1.45
Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults. J Am Geriatr Soc (2007) 1.44
Firesetting in adolescence and being aggressive, shy, and rejected by peers: new epidemiologic evidence from a national sample survey. J Am Acad Psychiatry Law (2003) 1.44
The PACARDO research project: youthful drug involvement in Central America and the Dominican Republic. Rev Panam Salud Publica (2004) 1.41
Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action. Biol Psychiatry (2004) 1.39
Genome-wide scan of copy number variation in late-onset Alzheimer's disease. J Alzheimers Dis (2010) 1.35
Caregiver-recipient closeness and symptom progression in Alzheimer disease. The Cache County Dementia Progression Study. J Gerontol B Psychol Sci Soc Sci (2009) 1.33
The association of neuropsychiatric symptoms and environment with quality of life in assisted living residents with dementia. Gerontologist (2005) 1.30
Double placebo design in a prevention trial for Alzheimer's disease. Control Clin Trials (2002) 1.30
Longitudinal influence of prenatal cocaine exposure on child language functioning. Neurotoxicol Teratol (2002) 1.28
Alzheimer's Disease Anti-inflammatory Prevention Trial: design, methods, and baseline results. Alzheimers Dement (2009) 1.28
Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1. Alzheimers Dement (2011) 1.26
Early childhood misbehavior and the estimated risk of becoming tobacco-dependent. Am J Epidemiol (2004) 1.26
Biomarkers for cognitive impairment and dementia in elderly people. Lancet Neurol (2008) 1.25
Depressed mood in childhood and subsequent alcohol use through adolescence and young adulthood. Arch Gen Psychiatry (2008) 1.24
Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": association with functional and cognitive impairment: The Cache County Study. Am J Geriatr Psychiatry (2005) 1.23
Examining the range of normal intraindividual variability in neuropsychological test performance. J Int Neuropsychol Soc (2003) 1.22
Predictors of functional impairment in residents of assisted-living facilities: the Maryland Assisted Living study. J Gerontol A Biol Sci Med Sci (2005) 1.22
Risk estimates for starting tobacco, alcohol, and other drug use in the United States: male-female differences and the possibility that 'limiting time with friends' is protective. Drug Alcohol Depend (2013) 1.21
Severity of prenatal cocaine exposure and child language functioning through age seven years: a longitudinal latent growth curve analysis. Subst Use Misuse (2004) 1.20
Impact of prenatal cocaine exposure on attention and response inhibition as assessed by continuous performance tests. J Dev Behav Pediatr (2007) 1.19
Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry. Twin Res Hum Genet (2006) 1.19
Maternal cocaine use: estimated effects on mother-child play interactions in the preschool period. J Dev Behav Pediatr (2002) 1.19
Religiosity and the earliest stages of adolescent drug involvement in seven countries of Latin America. Am J Epidemiol (2004) 1.19
Assessing cannabis dependence in community surveys: methodological issues. Int J Methods Psychiatr Res (2007) 1.19
The incidence of mental and behavioral disturbances in dementia: the cache county study. J Neuropsychiatry Clin Neurosci (2003) 1.18
Marijuana use and the risk of Major Depressive Episode. Epidemiological evidence from the United States National Comorbidity Survey. Soc Psychiatry Psychiatr Epidemiol (2002) 1.18
Atrial fibrillation and risk of dementia: a prospective cohort study. J Am Geriatr Soc (2011) 1.18
Has 'lifetime prevalence' reached the end of its life? An examination of the concept. Int J Methods Psychiatr Res (2009) 1.18
Case ascertainment of alcohol dependence in general population surveys: 'gated' versus 'ungated' approaches. Int J Methods Psychiatr Res (2007) 1.17
Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study. J Am Geriatr Soc (2007) 1.16
Childhood antecedents of exposure to traumatic events and posttraumatic stress disorder. Am J Psychiatry (2007) 1.16
Extramedical use of prescription pain relievers by youth aged 12 to 21 years in the United States: national estimates by age and by year. Arch Pediatr Adolesc Med (2012) 1.16
Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial. Int J Geriatr Psychiatry (2011) 1.16
Epidemiological evidence on count processes in the formation of tobacco dependence. Nicotine Tob Res (2010) 1.16
Assessment of cocaine and other drug dependence in the general population: "gated" versus "ungated" approaches. Drug Alcohol Depend (2007) 1.15
Gender differences in the sensitivity to posttraumatic stress disorder: An epidemiological study of urban young adults. J Abnorm Psychol (2007) 1.14
Opportunities to use drugs and stages of drug involvement outside the United States: Evidence from the Republic of Chile. Drug Alcohol Depend (2009) 1.13
Characteristics of a two-stage screen for incident dementia. J Clin Epidemiol (2003) 1.13
Hanging out with the wrong crowd: how much difference can parents make in an urban environment? J Urban Health (2003) 1.12
Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. BMC Med Genet (2008) 1.12
Influences of parenting practices on the risk of having a chance to try cannabis. Pediatrics (2005) 1.11
Is there epidemiological evidence to support the idea that a cocaine dependence syndrome emerges soon after onset of cocaine use? Neuropsychopharmacology (2006) 1.11
Association between APOE epsilon4 allele and vascular dementia: The Cache County study. Dement Geriatr Cogn Disord (2010) 1.10