PubRank

Gijsbertus T J van der Horst

Author PubWeight™ 97.25‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006 5.57
2 Premature aging in mice deficient in DNA repair and transcription. Science 2002 3.82
3 The cryptochromes: blue light photoreceptors in plants and animals. Annu Rev Plant Biol 2011 2.76
4 Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein. EMBO J 2002 2.52
5 DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol 2008 2.44
6 Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. Nat Med 2009 2.30
7 Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. Dev Cell 2005 2.30
8 Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol 2007 2.21
9 A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev 2003 2.09
10 MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J 2009 2.06
11 Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med 2010 1.86
12 Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet 2008 1.76
13 High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab 2013 1.57
14 Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A 2009 1.56
15 Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice. Genes Dev 2002 1.56
16 Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat Cell Biol 2009 1.55
17 Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles. PLoS Biol 2006 1.54
18 Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice. DNA Repair (Amst) 2003 1.53
19 Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J 2005 1.48
20 The BMAL1 C terminus regulates the circadian transcription feedback loop. Proc Natl Acad Sci U S A 2006 1.41
21 Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol 2005 1.39
22 Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair (Amst) 2005 1.38
23 Phase resetting of the mammalian circadian clock by DNA damage. Curr Biol 2008 1.37
24 Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei. Curr Biol 2002 1.36
25 Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrhythmic mice. Curr Biol 2003 1.35
26 Phase responses to light pulses in mice lacking functional per or cry genes. J Biol Rhythms 2004 1.33
27 Nucleocytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibroblasts. Genes Cells 2003 1.31
28 Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance. Mol Cell Biol 2006 1.29
29 Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1. Genes Dev 2010 1.28
30 Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B. Oncogene 2002 1.24
31 An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. Cancer Cell 2006 1.21
32 Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Mol Cell Biol 2002 1.20
33 Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. PLoS Genet 2006 1.19
34 Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney. Kidney Int 2005 1.18
35 Circadian behavioral rhythms in Cry1/Cry2 double-deficient mice induced by methamphetamine. J Biol Rhythms 2008 1.17
36 Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage. Mol Cell Biol 2004 1.17
37 Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. J Neurosci 2011 1.16
38 Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Res 2008 1.15
39 Histone methyltransferase MLL3 contributes to genome-scale circadian transcription. Proc Natl Acad Sci U S A 2013 1.11
40 Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice. EMBO J 2002 1.09
41 The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev 2014 1.08
42 Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome. Mol Cell Biol 2006 1.07
43 Tissue specific mutagenic and carcinogenic responses in NER defective mouse models. Mutat Res 2007 1.05
44 Nucleocytoplasmic shuttling of clock proteins. Methods Enzymol 2005 1.05
45 The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism. J Biol Chem 2009 1.04
46 Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice. Neurosci Res 2005 1.04
47 Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism. Neuron 2007 1.03
48 Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex. DNA Repair (Amst) 2004 1.02
49 Electroretinography of wild-type and Cry mutant mice reveals circadian tuning of photopic and mesopic retinal responses. J Biol Rhythms 2008 1.01
50 An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Mol Cell Biol 2008 0.99
51 Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression. J Invest Dermatol 2003 0.99
52 Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts. DNA Repair (Amst) 2008 0.98
53 Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner. Cell Cycle 2011 0.95
54 Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet 2011 0.93
55 Vagal regulation of respiratory clocks in mice. J Neurosci 2007 0.90
56 Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PLoS One 2013 0.90
57 Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer. Mol Cell Biol 2006 0.89
58 Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney. Int J Cancer 2014 0.86
59 Cockayne syndrome pathogenesis: lessons from mouse models. Mech Ageing Dev 2013 0.85
60 Daily variation of clock output gene activation in behaviorally arrhythmic mPer/mCry triple mutant mice. Chronobiol Int 2003 0.84
61 The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells. Free Radic Biol Med 2012 0.83
62 Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice. PLoS One 2008 0.83
63 Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice. Age (Dordr) 2011 0.79
64 The Potorous CPD photolyase rescues a cryptochrome-deficient mammalian circadian clock. PLoS One 2011 0.79
65 Impact of the circadian clock on in vitro genotoxic risk assessment assays. Mutat Res 2009 0.78
66 Light signalling in cryptochrome-deficient mice. Novartis Found Symp 2003 0.78
67 A day and night difference in the response of the hepatic transcriptome to cyclophosphamide treatment. Arch Toxicol 2014 0.77
68 A baculovirus photolyase with DNA repair activity and circadian clock regulatory function. J Biol Rhythms 2012 0.77
69 Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models. DNA Repair (Amst) 2012 0.77
70 Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice. PLoS One 2012 0.76
71 Circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients. Breast Cancer Res Treat 2015 0.76
72 Relationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence. Clin Pharmacokinet 2015 0.75
73 An observational study on disturbed peripheral circadian rhythms in hemodialysis patients. Chronobiol Int 2015 0.75
74 Functionality of cryopreserved juvenile ovaries from mutant mice in different genetic background strains after allotransplantation. Cryobiology 2009 0.75