Published in J Cardiovasc Pharmacol on October 01, 2009
The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium. Am J Physiol Heart Circ Physiol (2012) 0.92
ProBLM web server: protein and membrane placement and orientation package. Comput Math Methods Med (2014) 0.79
Cardiac excitation-contraction coupling. Nature (2002) 18.48
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med (1996) 12.77
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell (2000) 10.25
Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet (1999) 10.07
Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol (2000) 9.88
Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation (1993) 9.24
Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science (1991) 6.80
Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol (2003) 5.05
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science (1997) 4.81
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res (2004) 4.11
Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev (2007) 3.75
Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation (1992) 3.46
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (2004) 3.45
Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res (1996) 3.23
FK506 binding protein associated with the calcium release channel (ryanodine receptor). J Biol Chem (1992) 3.02
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81
Coupled gating between cardiac calcium release channels (ryanodine receptors). Circ Res (2001) 2.71
Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation (2003) 2.57
FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure. Circulation (2003) 2.57
CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J Cell Biol (2005) 2.47
Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. J Am Coll Cardiol (2008) 2.29
Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation (1995) 2.27
Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. Cardiovasc Res (2004) 2.15
Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure. J Card Fail (2008) 2.09
Cardiac KATP channels in health and disease. J Mol Cell Cardiol (2005) 2.04
Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum. Nature (1989) 2.03
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A (2005) 1.99
Calcium and cardiac excitation-contraction coupling. Annu Rev Physiol (1979) 1.96
Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure. J Clin Invest (1990) 1.94
Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium. Circ Res (1999) 1.87
Distinct transient outward potassium current (Ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J Gen Physiol (1999) 1.86
Gene therapy in heart failure. Circ Res (2008) 1.79
Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. J Physiol (2006) 1.70
Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle. Circ Res (1996) 1.62
Potassium channel down-regulation in heart failure. Cardiovasc Res (1998) 1.60
Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ Res (1999) 1.55
Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ Res (2001) 1.46
Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. J Physiol (2004) 1.44
Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion. Circulation (2008) 1.30
Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity. Am J Physiol Heart Circ Physiol (2003) 1.24
Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. Diabetes (2004) 1.23
Calmodulin and CaMKII as molecular switches for cardiac ion channels. Cardiovasc Res (2006) 1.22
Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg (2008) 1.21
The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol (2001) 1.16
Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. Circ Res (2002) 1.12
A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure. Am J Physiol Heart Circ Physiol (2002) 1.12
The ryanodine receptor from canine heart sarcoplasmic reticulum is associated with a novel FK-506 binding protein. Biochem Biophys Res Commun (1994) 1.12
Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy. Cardiovasc Res (1987) 1.12
KATP channel openers: structure-activity relationships and therapeutic potential. Med Res Rev (2004) 1.10
Increased Na+/H+-exchange activity is the cause of increased [Na+]i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model. Cardiovasc Res (2003) 1.10
Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. J Biol Chem (1998) 1.09
The role of NHE-1 in myocardial hypertrophy and remodelling. J Mol Cell Cardiol (2008) 1.08
Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias. Pharmacol Ther (2005) 1.08
Molecular mechanism of regulation of Ca2+ pump ATPase by phospholamban in cardiac sarcoplasmic reticulum. Effects of synthetic phospholamban peptides on Ca2+ pump ATPase. J Biol Chem (1992) 1.07
Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. Am J Physiol Heart Circ Physiol (2008) 1.03
Regulation of ryanodine receptors in the heart. Circ Res (2007) 1.00
Altered diastolic [Ca2+]i handling in human ventricular myocytes from patients with terminal heart failure. Am Heart J (1995) 0.99
Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts. Cardiovasc Res (1996) 0.93
Decreased expression of cardiac sarcoplasmic reticulum Ca(2+)-pump ATPase in congestive heart failure due to myocardial infarction. Mol Cell Biochem (1997) 0.93
Phospholamban overexpression in transgenic rabbits. Transgenic Res (2007) 0.91
Endothelin-1 stimulates the Na+/Ca2+ exchanger reverse mode through intracellular Na+ (Na+i)-dependent and Na+i-independent pathways. Hypertension (2004) 0.91
Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition. Am J Physiol Heart Circ Physiol (2008) 0.89
NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: prevention by NHE-1 inhibitor. J Mol Cell Cardiol (2005) 0.89
Phospholamban as a therapeutic modality in heart failure. Novartis Found Symp (2006) 0.88
The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility. Basic Res Cardiol (1997) 0.88
Chronic inhibition of the Na+/H+ - exchanger causes regression of hypertrophy, heart failure, and ionic and electrophysiological remodelling. Br J Pharmacol (2008) 0.88
Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban. Am J Physiol Heart Circ Physiol (2008) 0.87
Role of phospholamban in the pathogenesis of heart failure. Heart Fail Clin (2005) 0.83
Sodium ion transporters as new therapeutic targets in heart failure. Cardiovasc Hematol Agents Med Chem (2008) 0.81
Role of sarcoplasmic reticulum in loss of load-sensitive relaxation in pressure overload cardiac hypertrophy. Am J Physiol (1994) 0.80
Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo. Cardiovasc Drugs Ther (1993) 0.78
Tedisamil: master switch of nature? Expert Opin Investig Drugs (2001) 0.78
Rescuing a failing heart: putting on the squeeze. Nat Med (2009) 0.78
Cardiac and hemodynamic effects of the sinus node inhibitor tedisamil dihydrochloride in patients with congestive heart failure due to dilated cardiomyopathy. J Cardiovasc Pharmacol (1998) 0.76
Keeping the heart going: a new role for KATP channels. J Physiol (2006) 0.75
Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease. N Engl J Med (2015) 2.97
A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest (2014) 1.52
Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms. J Biol Chem (2004) 1.51
Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. EMBO J (2004) 1.41
Defining the BK channel domains required for beta1-subunit modulation. Proc Natl Acad Sci U S A (2006) 1.38
Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits. Circ Res (2007) 1.36
Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines. Proc Natl Acad Sci U S A (2009) 1.35
Locations of the beta1 transmembrane helices in the BK potassium channel. Proc Natl Acad Sci U S A (2008) 1.34
Position and role of the BK channel alpha subunit S0 helix inferred from disulfide crosslinking. J Gen Physiol (2008) 1.31
Location of modulatory beta subunits in BK potassium channels. J Gen Physiol (2010) 1.17
Activation of the BK (SLO1) potassium channel by mallotoxin. J Biol Chem (2005) 1.17
Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor? Circulation (2002) 1.16
Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem (2010) 1.14
Location of the beta 4 transmembrane helices in the BK potassium channel. J Neurosci (2009) 1.14
The BK potassium channel in the vascular smooth muscle and kidney: α- and β-subunits. Kidney Int (2010) 1.10
Reprogramming of the microRNA transcriptome mediates resistance to rapamycin. J Biol Chem (2013) 1.06
Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart. Circ Res (2010) 1.02
Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c). Biochemistry (2009) 1.00
Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. FEBS Lett (2004) 0.97
Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers. Trends Cardiovasc Med (2002) 0.96
Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias. Circulation (2011) 0.95
Molecular BKology: the study of splicing and dicing. Sci STKE (2002) 0.95
Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1. J Gen Physiol (2012) 0.92
Immunophilins and coupled gating of ryanodine receptors. Curr Top Med Chem (2003) 0.91
Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits. FASEB J (2010) 0.91
Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors. Proc Natl Acad Sci U S A (2008) 0.90
Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel. J Gen Physiol (2013) 0.87
Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice. FASEB J (2013) 0.82
Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels. PLoS One (2013) 0.78
Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. FASEB J (2013) 0.77
Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. J Clin Invest (2015) 0.77