Published in Circulation on January 22, 2002
Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol (2003) 2.19
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction. Circ Res (2012) 2.16
Altered intracellular Ca2+ handling in heart failure. J Clin Invest (2005) 1.70
Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochem J (2004) 1.33
Paradoxical SR Ca2+ release in guinea-pig cardiac myocytes after beta-adrenergic stimulation revealed by two-photon photolysis of caged Ca2+. J Physiol (2005) 1.19
Heart failure -- a challenge to our current concepts of excitation-contraction coupling. J Physiol (2003) 1.14
Calcium and the heart: a question of life and death. J Clin Invest (2003) 1.09
Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res (2011) 1.07
Apelin increases contractility in failing cardiac muscle. Eur J Pharmacol (2006) 0.94
Excitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach. Biophys J (2005) 0.81
Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors. Br J Pharmacol (2009) 0.79
Dantrolene: from better bacon to a treatment for ventricular fibrillation. Circulation (2014) 0.79
The therapeutic potential of new insights into myocardial excitation-contraction coupling. Heart (2003) 0.78
Imidapril treatment improves the attenuated inotropic and intracellular calcium responses to ATP in heart failure due to myocardial infarction. Br J Pharmacol (2005) 0.77
Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy? Diabetes Metab Syndr Obes (2012) 0.76
Comparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6. Physiol Rep (2013) 0.76
Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts. Exp Physiol (2008) 0.75
Mechanisms of SR calcium release in healthy and failing human hearts. Biophys Rev (2014) 0.75
Murine Electrophysiological Models of Cardiac Arrhythmogenesis. Physiol Rev (2017) 0.75
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science (2002) 4.49
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med (2009) 3.27
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01
Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease. N Engl J Med (2015) 2.97
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest (2008) 2.45
The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest (2002) 2.26
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A (2008) 2.16
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab (2011) 2.06
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A (2005) 1.99
A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm (2007) 1.98
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87
Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res (2012) 1.80
Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest (2010) 1.77
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A (2010) 1.67
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A (2010) 1.63
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest (2010) 1.60
A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest (2014) 1.52
Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms. J Biol Chem (2004) 1.51
Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. J Clin Invest (2011) 1.41
Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. EMBO J (2004) 1.41
Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest (2015) 1.38
Defining the BK channel domains required for beta1-subunit modulation. Proc Natl Acad Sci U S A (2006) 1.38
Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits. Circ Res (2007) 1.36
Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines. Proc Natl Acad Sci U S A (2009) 1.35
Locations of the beta1 transmembrane helices in the BK potassium channel. Proc Natl Acad Sci U S A (2008) 1.34
Position and role of the BK channel alpha subunit S0 helix inferred from disulfide crosslinking. J Gen Physiol (2008) 1.31
Location of modulatory beta subunits in BK potassium channels. J Gen Physiol (2010) 1.17
Activation of the BK (SLO1) potassium channel by mallotoxin. J Biol Chem (2005) 1.17
Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem (2010) 1.14
Location of the beta 4 transmembrane helices in the BK potassium channel. J Neurosci (2009) 1.14
Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties. J Am Coll Cardiol (2005) 1.13
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A (2006) 1.13
The BK potassium channel in the vascular smooth muscle and kidney: α- and β-subunits. Kidney Int (2010) 1.10
Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. J Biol Chem (2002) 1.09
Reprogramming of the microRNA transcriptome mediates resistance to rapamycin. J Biol Chem (2013) 1.06
Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart. Circ Res (2010) 1.02
Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c). Biochemistry (2009) 1.00
Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. FEBS Lett (2004) 0.97
Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor. J Physiol (2012) 0.97
Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers. Trends Cardiovasc Med (2002) 0.96
A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium. Circ Res (2011) 0.96
Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy. Skelet Muscle (2012) 0.95
Nonshivering thermogenesis protects against defective calcium handling in muscle. FASEB J (2008) 0.95
Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias. Circulation (2011) 0.95
Molecular BKology: the study of splicing and dicing. Sci STKE (2002) 0.95
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. FASEB J (2011) 0.94
Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1. J Gen Physiol (2012) 0.92
Immunophilins and coupled gating of ryanodine receptors. Curr Top Med Chem (2003) 0.91
Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits. FASEB J (2010) 0.91
Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors. Proc Natl Acad Sci U S A (2008) 0.90
Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest (2015) 0.87
Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel. J Gen Physiol (2013) 0.87
Bradycardic therapy improves left ventricular function and remodeling in dogs with coronary embolization-induced chronic heart failure. J Pharmacol Exp Ther (2007) 0.85
Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure. J Heart Lung Transplant (2013) 0.83
Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice. FASEB J (2013) 0.82
Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels. PLoS One (2013) 0.78
Ion channels, transporters, and pumps as targets for heart failure therapy. J Cardiovasc Pharmacol (2009) 0.78
Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. FASEB J (2013) 0.77
Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. J Clin Invest (2015) 0.77
Reply from Daniel C. Andersson, Matthew J. Betzenhauser, Steven Reiken, Alisa Umanskaya, Takayuki Shiomi and Andrew R. Marks. J Physiol (2013) 0.75