|
1
|
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
|
Cell
|
2007
|
17.98
|
|
2
|
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
|
Nat Biotechnol
|
2004
|
7.69
|
|
3
|
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
|
Sci Signal
|
2009
|
5.57
|
|
4
|
Signaling networks assembled by oncogenic EGFR and c-Met.
|
Proc Natl Acad Sci U S A
|
2008
|
5.08
|
|
5
|
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance.
|
Proc Natl Acad Sci U S A
|
2007
|
3.32
|
|
6
|
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.
|
EMBO J
|
2004
|
3.29
|
|
7
|
Profiling of UV-induced ATM/ATR signaling pathways.
|
Proc Natl Acad Sci U S A
|
2007
|
3.12
|
|
8
|
Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs.
|
J Biol Chem
|
2002
|
2.79
|
|
9
|
Activating alleles of JAK3 in acute megakaryoblastic leukemia.
|
Cancer Cell
|
2006
|
2.69
|
|
10
|
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
|
Mol Cell
|
2011
|
2.61
|
|
11
|
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
|
Cancer Cell
|
2007
|
2.56
|
|
12
|
A proteomics approach for the identification and cloning of monoclonal antibodies from serum.
|
Nat Biotechnol
|
2012
|
2.51
|
|
13
|
Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody.
|
Am J Surg Pathol
|
2009
|
2.51
|
|
14
|
Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib.
|
Mol Cell Biol
|
2006
|
2.28
|
|
15
|
Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer.
|
Clin Cancer Res
|
2009
|
2.13
|
|
16
|
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
|
Proc Natl Acad Sci U S A
|
2007
|
1.87
|
|
17
|
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.
|
Blood
|
2008
|
1.86
|
|
18
|
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).
|
J Biol Chem
|
2004
|
1.85
|
|
19
|
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice.
|
Cancer Res
|
2005
|
1.83
|
|
20
|
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.
|
RNA
|
2008
|
1.69
|
|
21
|
Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.
|
Blood
|
2006
|
1.65
|
|
22
|
Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice.
|
J Clin Invest
|
2004
|
1.53
|
|
23
|
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
|
J Clin Invest
|
2010
|
1.50
|
|
24
|
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.
|
Mol Cell Biol
|
2011
|
1.42
|
|
25
|
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.
|
Blood
|
2006
|
1.41
|
|
26
|
HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization.
|
J Biol Chem
|
2008
|
1.31
|
|
27
|
PTMScan direct: identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS.
|
Mol Cell Proteomics
|
2012
|
1.18
|
|
28
|
A common phosphotyrosine signature for the Bcr-Abl kinase.
|
Blood
|
2006
|
1.16
|
|
29
|
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.
|
Blood
|
2007
|
1.15
|
|
30
|
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.
|
Blood
|
2009
|
1.08
|
|
31
|
Proteomics-directed cloning of circulating antiviral human monoclonal antibodies.
|
Nat Biotechnol
|
2012
|
1.08
|
|
32
|
Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells.
|
Int J Cancer
|
2002
|
1.00
|
|
33
|
Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2.
|
Cell Signal
|
2006
|
0.96
|
|
34
|
Survey of activated FLT3 signaling in leukemia.
|
PLoS One
|
2011
|
0.88
|
|
35
|
Morphine induces desensitization of insulin receptor signaling.
|
Mol Cell Biol
|
2003
|
0.83
|
|
36
|
Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2.
|
J Biol Chem
|
2006
|
0.83
|
|
37
|
Quantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan Direct.
|
Int J Mol Sci
|
2012
|
0.77
|