Published in J Biol Chem on July 31, 2002
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics (2008) 4.36
Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell (2012) 3.50
Phospho.ELM: a database of phosphorylation sites--update 2011. Nucleic Acids Res (2010) 3.38
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol (2009) 3.32
Profiling of UV-induced ATM/ATR signaling pathways. Proc Natl Acad Sci U S A (2007) 3.12
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol (2009) 2.76
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64
A semisynthetic epitope for kinase substrates. Nat Methods (2007) 2.40
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J Neurochem (2003) 2.15
Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res (2009) 2.07
Bio-orthogonal affinity purification of direct kinase substrates. J Am Chem Soc (2005) 1.67
Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis. Mol Biosyst (2011) 1.62
Musite, a tool for global prediction of general and kinase-specific phosphorylation sites. Mol Cell Proteomics (2010) 1.55
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem J (2004) 1.43
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell (2003) 1.42
Mapping and analysis of phosphorylation sites: a quick guide for cell biologists. Mol Biol Cell (2013) 1.33
Protein kinases and phosphatases in the control of cell fate. Enzyme Res (2011) 1.23
PTMScan direct: identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS. Mol Cell Proteomics (2012) 1.18
Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry. Biochim Biophys Acta (2007) 1.11
Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J (2008) 1.10
Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission. Proc Natl Acad Sci U S A (2005) 1.08
Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. Mol Cell Biol (2011) 1.06
Clinical and technical phosphoproteomic research. Proteome Sci (2011) 1.04
The coming of age of phosphoproteomics--from large data sets to inference of protein functions. Mol Cell Proteomics (2013) 1.03
Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A (2012) 1.02
The tumor suppressor CDKN3 controls mitosis. J Cell Biol (2013) 1.01
Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling. Circ Res (2014) 0.98
Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors. Cancer Res (2007) 0.98
Achieving specificity in Akt signaling in cancer. Adv Biol Regul (2012) 0.97
Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1). Mol Hum Reprod (2011) 0.96
Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2). Mol Biol Cell (2011) 0.95
Deep, Quantitative Coverage of the Lysine Acetylome Using Novel Anti-acetyl-lysine Antibodies and an Optimized Proteomic Workflow. Mol Cell Proteomics (2015) 0.94
Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle. Diabetologia (2014) 0.93
Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics. Mol Cell Proteomics (2013) 0.93
Discovery of cellular substrates for protein kinase A using a peptide array screening protocol. Biochem J (2011) 0.93
Systems kinomics demonstrates Congo Basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus. Mol Cell Proteomics (2011) 0.92
VDAC proteomics: post-translation modifications. Biochim Biophys Acta (2011) 0.90
Phosphoproteomics: new insights into cellular signaling. Genome Biol (2005) 0.90
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death. J Cell Biochem (2007) 0.89
Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. J Cell Biol (2014) 0.87
Signal processing by protein tyrosine phosphorylation in plants. Plant Signal Behav (2011) 0.87
The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth. EMBO J (2016) 0.86
PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes Dev (2014) 0.86
Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metab (2015) 0.85
Sperm phosphoproteomics: historical perspectives and current methodologies. Expert Rev Proteomics (2012) 0.84
AMPK couples p73 with p53 in cell fate decision. Cell Death Differ (2014) 0.83
Technical phosphoproteomic and bioinformatic tools useful in cancer research. J Clin Bioinforma (2011) 0.83
Morphine induces desensitization of insulin receptor signaling. Mol Cell Biol (2003) 0.83
Toward a systems-level view of dynamic phosphorylation networks. Front Genet (2014) 0.82
Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev (2016) 0.81
eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts: Ser⁵³ is a novel substrate for protein kinase C βI. Mol Cell Proteomics (2010) 0.81
Multiple post-translational modifications affect heterologous protein synthesis. J Biol Chem (2012) 0.81
Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction. Dev Neurobiol (2013) 0.78
Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1. Sci Rep (2016) 0.78
Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt. J Virol (2011) 0.78
Quantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan Direct. Int J Mol Sci (2012) 0.77
Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes. Cell Death Differ (2014) 0.77
The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway. Oncogene (2014) 0.77
A Comparison of the Chicken and Turkey Proteomes and Phosphoproteomes in the Development of Poultry-Specific Immuno-Metabolism Kinome Peptide Arrays. Front Vet Sci (2014) 0.77
Mapping sites of protein phosphorylation by mass spectrometry utilizing a chemical-enzymatic approach: characterization of products from alpha-S1 casein phosphopeptides. J Proteome Res (2005) 0.76
Identification of the lamin A/C phosphoepitope recognized by the antibody P-STM in mitotic HeLa S3 cells. BMC Biochem (2013) 0.76
Differential regulation of FGFR3 by PTPN1 and PTPN2. Proteomics (2014) 0.76
UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. Oncogene (2016) 0.76
Mechanistic Parameterization of the Kinomic Signal in Peptide Arrays. J Proteomics Bioinform (2016) 0.75
High throughput profiling of serum phosphoproteins/peptides using the SELDI-TOF-MS platform. Methods Mol Biol (2012) 0.75
Quantitative analysis of global phosphorylation changes with high-resolution tandem mass spectrometry and stable isotopic labeling. Methods (2013) 0.75
Advances in mass spectrometry based strategies to study receptor tyrosine kinases. IUCrJ (2017) 0.75
Studies on quantitative phosphopeptide analysis by matrix-assisted laser desorption/ionization mass spectrometry without label, chromatography or calibration curves. Rapid Commun Mass Spectrom (2014) 0.75
Complementary PTM Profiling of Drug Response in Human Gastric Carcinoma by Immunoaffinity and IMAC Methods with Total Proteome Analysis. Proteomes (2015) 0.75
Interrogating the hidden phosphoproteome. Proteomics (2017) 0.75
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 15.73
Metformin and reduced risk of cancer in diabetic patients. BMJ (2005) 13.04
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J (2004) 10.82
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol (2004) 7.69
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J (2008) 7.18
The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol (2010) 6.91
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care (2009) 6.17
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal (2009) 5.57
PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol (2004) 5.10
Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A (2008) 5.08
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol (2004) 4.85
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J (2005) 4.82
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J (2008) 4.51
Emerging roles of pseudokinases. Trends Cell Biol (2006) 4.48
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science (2006) 4.42
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J (2005) 4.31
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem J (2009) 4.12
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem J (2007) 3.89
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J (2003) 3.77
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J (2005) 3.52
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol (2012) 3.42
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2007) 3.32
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J (2004) 3.29
Profiling of UV-induced ATM/ATR signaling pathways. Proc Natl Acad Sci U S A (2007) 3.12
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J (2007) 3.11
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One (2011) 3.10
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J (2007) 3.08
Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci (2008) 3.07
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J (2010) 2.98
Essential role of PDK1 in regulating cell size and development in mice. EMBO J (2002) 2.93
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate. Curr Biol (2002) 2.92
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat Chem Biol (2011) 2.91
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J (2010) 2.82
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation. EMBO J (2003) 2.74
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell (2006) 2.69
Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem J (2008) 2.67
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell (2013) 2.64
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell (2011) 2.61
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab (2004) 2.61
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell (2007) 2.56
A proteomics approach for the identification and cloning of monoclonal antibodies from serum. Nat Biotechnol (2012) 2.51
Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol (2009) 2.51
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization. Biochem J (2010) 2.43
Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med (2010) 2.36
Protein lipid overlay assay. Sci STKE (2002) 2.33
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J (2009) 2.33
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. J Cell Sci (2008) 2.31
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci U S A (2009) 2.30
Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib. Mol Cell Biol (2006) 2.28
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
LKB1, a protein kinase regulating cell proliferation and polarity. FEBS Lett (2003) 2.16
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem J (2003) 2.15
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science (2009) 2.13
Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer. Clin Cancer Res (2009) 2.13
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem J (2006) 2.12
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J (2003) 2.11
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J (2004) 2.11
Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J (2011) 2.10
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab (2005) 2.04
A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. J Biol Chem (2005) 2.03
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors. Biochem J (2013) 2.03
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol (2005) 2.00
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J (2002) 1.93
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc Natl Acad Sci U S A (2007) 1.87
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem (2004) 1.85
Kinase drug discovery--what's next in the field? ACS Chem Biol (2012) 1.84
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer Res (2005) 1.83
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J (2002) 1.80
Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. FEBS Lett (2005) 1.79
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology (2012) 1.77
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J (2004) 1.77
Canonical Wnt signaling is critical to estrogen-mediated uterine growth. Mol Endocrinol (2004) 1.76
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. J Biol Chem (2003) 1.75
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J (2002) 1.74
LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC Biol (2013) 1.73
Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A (2012) 1.73
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA (2008) 1.69
Spatial dynamics of human-origin H1 influenza A virus in North American swine. PLoS Pathog (2011) 1.68
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. J Cell Biol (2006) 1.68
Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci (2004) 1.65
Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Blood (2006) 1.65
Regulation of Akt/PKB Ser473 phosphorylation. Mol Cell (2005) 1.64
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol (2008) 1.63
Fast photoacoustic imaging system based on 320-element linear transducer array. Phys Med Biol (2004) 1.63
The insulin signalling pathway. Curr Biol (2002) 1.58