Pathogenic mechanisms in simian immunodeficiency virus infection.

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med (2009) 7.33

New paradigms for HIV/AIDS vaccine development. Annu Rev Med (2011) 2.21

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Nat Med (2012) 1.86

Hidden memories: frontline memory T cells and early pathogen interception. J Immunol (2012) 1.73

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. J Exp Med (2009) 1.51

Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys. PLoS Pathog (2009) 0.98

Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells. PLoS Biol (2011) 0.96

Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection. J Exp Med (2012) 0.91

Conditionally-live attenuated SIV upregulates global T effector memory cell frequency under replication permissive conditions. Retrovirology (2013) 0.83

Efficient mucosal transmissibility but limited pathogenicity of R5 SHIV SF162P3N in Chinese-origin rhesus macaques. J Acquir Immune Defic Syndr (2013) 0.81

Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol (2016) 0.75

CXCL10/CXCR3-Dependent Mobilization of HSV-Specific CD8(+) TEM and CD8(+) TRM Cells within Infected Tissues Allows Efficient Protection Against Recurrent Herpes Infection and Disease. J Virol (2017) 0.75

Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med (2006) 24.38

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature (2011) 9.30

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med (2009) 7.33

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med (2005) 7.18

Development and homeostasis of T cell memory in rhesus macaque. J Immunol (2002) 6.88

T cell dynamics in HIV-1 infection. Annu Rev Immunol (2001) 5.29

Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. J Virol (2006) 4.68

Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat Med (2006) 4.23

Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med (2007) 3.45

Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science (2010) 3.31

Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science (2013) 3.27

Immune clearance of highly pathogenic SIV infection. Nature (2013) 3.15

Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses. J Virol (2003) 3.06

Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection. J Infect Dis (2006) 3.04

Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239. J Virol (2002) 2.63

Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection. J Virol (2002) 2.50

Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals. J Infect Dis (2002) 2.33

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Nat Med (2012) 1.86

Hidden memories: frontline memory T cells and early pathogen interception. J Immunol (2012) 1.73

CD4(+) T-cell depletion in HIV infection: mechanisms of immunological failure. Immunol Rev (2013) 1.58

Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates. Proc Natl Acad Sci U S A (2007) 1.53

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. J Exp Med (2009) 1.51

HIV pathogenesis: the first cut is the deepest. Nat Immunol (2005) 1.39

Mapping T cell epitopes by flow cytometry. Methods (2003) 1.27

Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population. J Virol (2009) 1.22

HIV-1 vaccines and adaptive trial designs. Sci Transl Med (2011) 1.21

Direct ex vivo analysis of human CD4(+) memory T cell activation requirements at the single clonotype level. J Immunol (2002) 1.15

Multicolor flow cytometric analysis in SIV-infected rhesus macaque. Methods Cell Biol (2004) 1.13

The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor. Blood (2009) 1.11

Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques. J Immunol (2008) 1.10

Polyinosinic-polycytidylic acid is the most effective TLR adjuvant for SIV Gag protein-induced T cell responses in nonhuman primates. J Immunol (2013) 1.09

Replication in a superficial epithelial cell niche explains the lack of pathogenicity of primate foamy virus infections. J Virol (2008) 1.08

Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. J Virol (2011) 1.07

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques. J Immunol (2011) 1.07

Anti-OX40 (CD134) administration to nonhuman primates: immunostimulatory effects and toxicokinetic study. J Immunother (2006) 1.01

IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment. Curr HIV Res (2009) 1.00

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses. J Immunol (2010) 0.98

Development of replication-competent viral vectors for HIV vaccine delivery. Curr Opin HIV AIDS (2013) 0.96

Differences between T cell epitopes recognized after immunization and after infection. J Immunol (2002) 0.95

Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection. J Exp Med (2012) 0.91

In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques. Retrovirology (2010) 0.90

Skewed maturation of virus-specific CTLs? Nat Immunol (2002) 0.89

Cytomegalovirus pp65 limits dissemination but is dispensable for persistence. J Clin Invest (2014) 0.86

Another HIV vaccine failure: where to next? Nat Med (2013) 0.83

An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons. J Infect Dis (2002) 0.81

Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control. J Virol (2012) 0.77

Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: an AACTG study. AIDS Res Hum Retroviruses (2005) 0.76

Novel vaccine vectors for HIV-1. Nat Rev Microbiol (2017) 0.75

Addendum: Immune clearance of highly pathogenic SIV infection. Nature (2017) 0.75