Published in Proc Natl Acad Sci U S A on December 04, 2007
Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood (2011) 2.16
Understanding immunosenescence to improve responses to vaccines. Nat Immunol (2013) 2.09
Diversity and clonal selection in the human T-cell repertoire. Proc Natl Acad Sci U S A (2014) 1.63
Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice. J Immunol (2009) 1.53
Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire. J Clin Immunol (2011) 1.48
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. J Immunol (2010) 1.41
Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc Natl Acad Sci U S A (2009) 1.34
Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J Immunol (2014) 1.31
Nonhuman primate models of human immunology. Antioxid Redox Signal (2010) 1.26
The effect of age on thymic function. Front Immunol (2013) 1.20
Immune aging and autoimmunity. Cell Mol Life Sci (2012) 1.19
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J Immunol (2014) 1.18
Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment. Semin Immunol (2012) 1.18
Age-related changes in CD8 T cell homeostasis and immunity to infection. Semin Immunol (2012) 1.14
Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age. Proc Natl Acad Sci U S A (2012) 1.11
Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell (2008) 1.09
The janus head of T cell aging - autoimmunity and immunodeficiency. Front Immunol (2013) 1.09
Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques. J Immunol (2011) 1.07
Immune memory and aging: an infinite or finite resource? Curr Opin Immunol (2010) 1.05
The narrowing of the CD8 T cell repertoire in old age. Curr Opin Immunol (2011) 1.04
Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults. J Immunol (2011) 1.03
Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects. Semin Immunol (2012) 1.01
Age-related deregulation of naive T cell homeostasis in elderly humans. Age (Dordr) (2010) 1.00
Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J Immunol (2010) 0.98
Tracing thymic output in older individuals. Clin Exp Immunol (2010) 0.97
Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication. J Immunol (2008) 0.97
Immune senescence in aged nonhuman primates. Exp Gerontol (2010) 0.96
Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging. J Immunol (2013) 0.96
Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function. PLoS Pathog (2012) 0.95
Use it or lose it: establishment and persistence of T cell memory. Front Immunol (2012) 0.95
Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3. Mech Ageing Dev (2009) 0.92
Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses. Nat Immunol (2016) 0.92
Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover. Aging Cell (2015) 0.90
Age-associated parallel increase of Foxp3(+)CD4(+) regulatory and CD44(+)CD4(+) memory T cells in SJL/J mice. Cell Immunol (2009) 0.89
Thymopoiesis in elderly human is associated with systemic inflammatory status. Age (Dordr) (2009) 0.88
Extraction and characterization of the rhesus macaque T-cell receptor beta-chain genes. Immunol Cell Biol (2009) 0.87
Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations. Aging Cell (2011) 0.87
Narrowing of human influenza A virus-specific T cell receptor α and β repertoires with increasing age. J Virol (2015) 0.86
Immune response to the West Nile virus in aged non-human primates. PLoS One (2010) 0.86
Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa. Vaccine (2011) 0.84
A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging. Immunology (2014) 0.83
'"Why me, why now?" Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection. BMC Med (2016) 0.82
Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells. Immun Ageing (2014) 0.79
Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques. J Immunol (2015) 0.78
The interplay between immune maturation, age, chronic viral infection and environment. Immun Ageing (2015) 0.77
Improving immunity in the elderly: current and future lessons from nonhuman primate models. Age (Dordr) (2011) 0.76
Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. PLoS Pathog (2013) 0.76
Contributions of Nonhuman Primates to Research on Aging. Vet Pathol (2016) 0.76
On the Role of CD8(+) T Cells in Determining Recovery Time from Influenza Virus Infection. Front Immunol (2016) 0.75
Successful and Maladaptive T Cell Aging. Immunity (2017) 0.75
Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors. Front Microbiol (2016) 0.75
Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence. Sci Rep (2017) 0.75
Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection. Front Immunol (2017) 0.75
Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol (1984) 17.76
Development and homeostasis of T cell memory in rhesus macaque. J Immunol (2002) 6.88
Age-related changes in lymphocyte development and function. Nat Immunol (2004) 6.16
Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med (2002) 5.09
The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci U S A (1993) 4.97
The aging immune system: primer and prospectus. Science (1996) 4.86
Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J Exp Med (1994) 4.41
The influence of age on T cell generation and TCR diversity. J Immunol (2005) 4.36
T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today (1995) 3.60
The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol (2005) 3.51
Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med (2002) 3.43
Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects. J Immunol (1993) 2.73
Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med (2004) 2.47
An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci (2005) 2.15
Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev (1998) 2.12
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03
Unexpected expansions of CD8-bearing cells in old mice. J Immunol (1993) 1.98
Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly. Exp Gerontol (2004) 1.55
Recombinant interleukin-7 induces proliferation of naive macaque CD4+ and CD8+ T cells in vivo. J Virol (2004) 1.44
Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates. Exp Gerontol (2005) 1.43
Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice. J Immunol (2001) 1.42
Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol (1999) 1.32
Naïve and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: implications for therapy. J Virol (2006) 1.31
Age-related dysregulation in CD8 T cell homeostasis: kinetics of a diversity loss. J Immunol (2000) 1.29
Regulation of naïve and memory T-cell homeostasis. Microbes Infect (2002) 1.25
Evolutionary theories of aging and longevity. ScientificWorldJournal (2002) 1.24
Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets. Blood (2003) 1.20
Conserved T-cell receptor repertoire in simian immunodeficiency virus-infected rhesus monkeys. J Immunol (1993) 1.19
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood (2007) 1.17
Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo. J Immunol (2006) 1.11
Between Scylla and Charybdis: p53 links tumor suppression and aging. Mech Ageing Dev (2002) 1.05
From Hayflick to Walford: the role of T cell replicative senescence in human aging. Exp Gerontol (2004) 1.04
Current concepts of thymic aging. Springer Semin Immunopathol (2002) 1.04
Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med (2006) 24.38
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature (2011) 9.30
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med (2009) 7.33
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med (2005) 7.18
Development and homeostasis of T cell memory in rhesus macaque. J Immunol (2002) 6.88
T cell dynamics in HIV-1 infection. Annu Rev Immunol (2001) 5.29
Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. J Virol (2006) 4.68
Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat Med (2006) 4.23
The many important facets of T-cell repertoire diversity. Nat Rev Immunol (2004) 3.83
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med (2004) 3.62
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med (2007) 3.45
Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet (2003) 3.36
MIFlowCyt: the minimum information about a Flow Cytometry Experiment. Cytometry A (2008) 3.33
Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science (2010) 3.31
Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science (2013) 3.27
Immune clearance of highly pathogenic SIV infection. Nature (2013) 3.15
Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection. J Infect Dis (2006) 3.04
How accurate is clinician reporting of chemotherapy adverse effects? A comparison with patient-reported symptoms from the Quality-of-Life Questionnaire C30. J Clin Oncol (2004) 2.92
Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense. Science (2002) 2.61
Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection. J Virol (2002) 2.50
Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med (2004) 2.47
IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J Clin Invest (2006) 2.41
Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals. J Infect Dis (2002) 2.33
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03
Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection. Eur J Immunol (2007) 1.92
C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: results from the ASCENT trial. Cancer (2008) 1.92
BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML. Blood (2006) 1.89
A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol (2002) 1.88
West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. J Virol (2007) 1.86
Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Nat Med (2012) 1.86
Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum Mol Genet (2004) 1.86
Improved detection of prostate cancer using classification and regression tree analysis. J Clin Oncol (2005) 1.85
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Simian varicella virus infection of rhesus macaques recapitulates essential features of varicella zoster virus infection in humans. PLoS Pathog (2009) 1.82
Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates. Proc Natl Acad Sci U S A (2013) 1.81
Hidden memories: frontline memory T cells and early pathogen interception. J Immunol (2012) 1.73
West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection. J Immunol (2008) 1.71
Protective immunity following vaccination: how is it defined? Hum Vaccin (2008) 1.70
IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathog (2013) 1.67
Endoscopic measurement of cardia circumference as an indicator of GERD. Gastrointest Endosc (2006) 1.59
Geoclimatic influences on invasive aspergillosis after hematopoietic stem cell transplantation. Clin Infect Dis (2010) 1.58
CD4(+) T-cell depletion in HIV infection: mechanisms of immunological failure. Immunol Rev (2013) 1.58
In chronic myeloid leukemia white cells from cytogenetic responders and non-responders to imatinib have very similar gene expression signatures. Haematologica (2005) 1.56
Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. J Exp Med (2009) 1.51
Key role of T cell defects in age-related vulnerability to West Nile virus. J Exp Med (2009) 1.50
Interest in physician-assisted suicide among Oregon cancer patients. J Clin Ethics (2006) 1.45
Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates. Exp Gerontol (2005) 1.43
Flow cytometric chemosensitivity assay as a predictive tool of early clinical response in acute lymphoblastic leukemia. Pediatr Blood Cancer (2009) 1.42
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. J Immunol (2010) 1.41
HIV pathogenesis: the first cut is the deepest. Nat Immunol (2005) 1.39
The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML. Blood (2002) 1.39
Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques. Reprod Sci (2009) 1.37
Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies. J Virol (2011) 1.33
The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells. Cancer (2007) 1.29
Mapping T cell epitopes by flow cytometry. Methods (2003) 1.27
Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PLoS Pathog (2012) 1.25
A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. PLoS Negl Trop Dis (2011) 1.23
HIV-1 vaccines and adaptive trial designs. Sci Transl Med (2011) 1.21
Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets. Blood (2003) 1.20
Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing (2011) 1.19
West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. J Virol (2008) 1.19
Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection. J Immunol (2005) 1.19
Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals. J Immunol (2006) 1.19
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J Immunol (2014) 1.18
Evolving preoperative evaluation of patients with pancreatic cancer: does laparoscopy have a role in the current era? J Am Coll Surg (2009) 1.18
CMV and Immunosenescence: from basics to clinics. Immun Ageing (2012) 1.17
Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma: animal model for KSHV-associated malignancies. Blood (2008) 1.17