Published in Proc Natl Acad Sci U S A on April 21, 2009
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation (2011) 2.21
Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Hum Mol Genet (2012) 1.64
New roles of calsequestrin and triadin in cardiac muscle. J Physiol (2009) 1.48
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Nat Commun (2013) 1.35
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail (2011) 1.32
Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27
Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Rev (2011) 1.23
Molecular and genetic basis of sudden cardiac death. J Clin Invest (2013) 1.23
There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling. J Biomed Biotechnol (2010) 1.17
Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles. J Mol Cell Cardiol (2011) 1.13
Calsequestrin 2 and arrhythmias. Am J Physiol Heart Circ Physiol (2011) 1.08
Ryanodine receptor luminal Ca2+ regulation: swapping calsequestrin and channel isoforms. Biophys J (2009) 1.05
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res (2010) 1.05
Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. PLoS One (2012) 1.04
Genetics of sudden cardiac death syndromes. Curr Opin Cardiol (2011) 1.02
Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity. J Gen Physiol (2010) 1.01
Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. Basic Res Cardiol (2013) 0.97
Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks. Biophys J (2013) 0.96
Store-dependent deactivation: cooling the chain-reaction of myocardial calcium signaling. J Mol Cell Cardiol (2012) 0.95
Quantification of calsequestrin 2 (CSQ2) in sheep cardiac muscle and Ca2+-binding protein changes in CSQ2 knockout mice. Am J Physiol Heart Circ Physiol (2010) 0.95
Ryanodine receptor studies using genetically engineered mice. FEBS Lett (2010) 0.92
Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. J Physiol (2011) 0.91
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression. Am J Physiol Heart Circ Physiol (2011) 0.87
Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling. Biochim Biophys Acta (2012) 0.86
AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure. PLoS One (2012) 0.85
Calsequestrin mutations and catecholaminergic polymorphic ventricular tachycardia. Pediatr Cardiol (2012) 0.85
Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovasc Res (2012) 0.85
Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1. J Biol Chem (2012) 0.85
Triadin regulation of the ryanodine receptor complex. J Physiol (2014) 0.84
Ca²⁺ microdomains organized by junctophilins. Cell Calcium (2015) 0.84
Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis. J Mol Cell Cardiol (2012) 0.84
Dynamic changes in sarcoplasmic reticulum structure in ventricular myocytes. J Biomed Biotechnol (2011) 0.83
A skeletal muscle ryanodine receptor interaction domain in triadin. PLoS One (2012) 0.82
Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background. Am J Physiol Heart Circ Physiol (2011) 0.81
Triadin regulates cardiac muscle couplon structure and microdomain Ca(2+) signalling: a path towards ventricular arrhythmias. Cardiovasc Res (2013) 0.78
Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response. Biochem J (2013) 0.78
A "rough" journey to the sarcoplasmic reticulum--implications of altered calsequestrin trafficking for cardiac arrhythmia. J Mol Cell Cardiol (2010) 0.77
Commentaries on viewpoint: The cardiac contraction cycle: is Ca2+ going local? Counterpoint. J Appl Physiol (1985) (2009) 0.75
Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling. J Physiol (2016) 0.75
Modification of distinct ion channels differentially modulates Ca(2+) dynamics in primary cultured rat ventricular cardiomyocytes. Sci Rep (2017) 0.75
Impaired calcium-calmodulin-dependent inactivation of Cav1.2 contributes to loss of sarcoplasmic reticulum calcium release refractoriness in mice lacking calsequestrin 2. J Mol Cell Cardiol (2015) 0.75
Excitation-Contraction Coupling Alterations in Myopathies. J Neuromuscul Dis (2016) 0.75
Cardiac cytoarchitecture - why the "hardware" is important for heart function! Biochim Biophys Acta (2015) 0.75
Congenital myopathy associated with the triadin knockout syndrome. Neurology (2017) 0.75
Calcium Signaling and Cardiac Arrhythmias. Circ Res (2017) 0.75
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm. Nat Commun (2017) 0.75
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature (1984) 10.27
Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes. Science (1989) 5.23
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science (1997) 4.81
Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. J Physiol (1985) 4.69
Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest (2006) 4.06
Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. J Biol Chem (1997) 3.50
The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. Biophys J (2004) 3.42
Calcium fluxes involved in control of cardiac myocyte contraction. Circ Res (2000) 3.28
Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves: threshold sarcoplasmic reticulum calcium content is required. Circ Res (2006) 2.57
Cross-signaling between L-type Ca2+ channels and ryanodine receptors in rat ventricular myocytes. J Gen Physiol (1996) 2.27
Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice. Circ Res (2007) 2.18
Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle. Proc Natl Acad Sci U S A (1996) 2.17
Triadin overexpression stimulates excitation-contraction coupling and increases predisposition to cellular arrhythmia in cardiac myocytes. Circ Res (2005) 2.10
Macromolecular complexes regulating cardiac ryanodine receptor function. J Mol Cell Cardiol (2004) 1.93
Regulation of sarcoplasmic reticulum calcium release by luminal calcium in cardiac muscle. Front Biosci (2002) 1.84
Localization and partial characterization of the oligomeric disulfide-linked molecular weight 95,000 protein (triadin) which binds the ryanodine and dihydropyridine receptors in skeletal muscle triadic vesicles. Biochemistry (1991) 1.69
Changes in the calcium current of rat heart ventricular myocytes during development. J Physiol (1988) 1.54
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation (2007) 1.51
Localization and characterization of the calsequestrin-binding domain of triadin 1. Evidence for a charged beta-strand in mediating the protein-protein interaction. J Biol Chem (2000) 1.51
Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. Biophys J (2005) 1.49
Identification of triadin 1 as the predominant triadin isoform expressed in mammalian myocardium. J Biol Chem (1999) 1.48
Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle. J Biol Chem (2007) 1.48
Retracted Calmodulin kinase and a calmodulin-binding 'IQ' domain facilitate L-type Ca2+ current in rabbit ventricular myocytes by a common mechanism. J Physiol (2001) 1.34
Biochemical characterization and molecular cloning of cardiac triadin. J Biol Chem (1996) 1.33
Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. J Biol Chem (2007) 1.25
Junctin and calsequestrin overexpression in cardiac muscle: the role of junctin and the synthetic and delivery pathways for the two proteins. J Mol Cell Cardiol (2003) 1.23
Pathophysiologic mechanisms of cardiac arrhythmias. Am Heart J (1983) 1.19
Structural alterations in cardiac calcium release units resulting from overexpression of junctin. J Mol Cell Cardiol (2001) 1.18
Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1. J Biol Chem (2000) 1.15
Effects of changes in left ventricular contractility on indexes of contractility in mice. Am J Physiol Heart Circ Physiol (2002) 1.12
On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure. Am J Physiol Heart Circ Physiol (2007) 1.09
Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists. Cardiovasc Res (2004) 0.97
Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction coupling. J Biol Chem (2007) 0.94
The role of subunit composition on prepulse facilitation of the cardiac L-type calcium channel. FEBS Lett (1999) 0.93
Timing of new black box warnings and withdrawals for prescription medications. JAMA (2002) 9.65
Altered microRNA expression in human heart disease. Physiol Genomics (2007) 5.64
Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest (2006) 4.06
The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect (2006) 3.81
The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. Biophys J (2004) 3.42
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med (2009) 3.35
Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01
Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. J Mol Cell Cardiol (2009) 2.98
Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation (2002) 2.98
Dimorphic effects of Notch signaling in bone homeostasis. Nat Med (2008) 2.82
Ca2+ blinks: rapid nanoscopic store calcium signaling. Proc Natl Acad Sci U S A (2005) 2.56
Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest (2008) 2.54
Unmasking of brugada syndrome by lithium. Circulation (2005) 2.30
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest (2010) 2.29
Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29
Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice. Circ Res (2007) 2.18
A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem (2007) 2.09
IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes. Am J Physiol Heart Circ Physiol (2007) 2.06
Mitochondrial dysfunction in autism. JAMA (2010) 2.04
Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. J Clin Invest (2008) 2.02
Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB J (2005) 1.97
Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology (2006) 1.97
Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Hum Mol Genet (2010) 1.95
(E)-3-Bromo-N'-(5-bromo-2-hydroxy-benzyl-idene)benzohydrazide. Acta Crystallogr Sect E Struct Rep Online (2008) 1.92
Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. J Biol Chem (2007) 1.91
Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation. Circulation (2009) 1.91
Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun (2008) 1.89
Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. J Am Coll Cardiol (2011) 1.89
Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology (2007) 1.87
Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds. Heart Rhythm (2010) 1.87
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection). Circulation (2006) 1.86
Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. Kidney Int (2005) 1.83
In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect (2008) 1.82
Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clustering. Mol Cell (2006) 1.80
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol (2004) 1.80
Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun (2008) 1.79
Toll-like receptor 9: a new target of ischemic preconditioning in the brain. J Cereb Blood Flow Metab (2008) 1.79
Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1. J Physiol (2007) 1.78
A flexible domain is essential for the large step size and processivity of myosin VI. Mol Cell (2005) 1.78
Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol (2009) 1.77
Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice. Cardiovasc Res (2012) 1.77
A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment. Mol Cell Biol (2004) 1.73
CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis. Hepatology (2015) 1.70
Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci (2007) 1.68
NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ Res (2003) 1.67
Heart and skeletal muscle are targets of dengue virus infection. Pediatr Infect Dis J (2010) 1.67
The beta 1a subunit is essential for the assembly of dihydropyridine-receptor arrays in skeletal muscle. Proc Natl Acad Sci U S A (2005) 1.64
Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice. Cardiovasc Res (2012) 1.60
Aryl hydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-cell differentiation. Immunol Cell Biol (2013) 1.60
A genetic screen identifies genes essential for development of myelinated axons in zebrafish. Dev Biol (2006) 1.60
Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors. Nat Neurosci (2011) 1.58
Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genomics (2002) 1.57
Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia. Circulation (2004) 1.57
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res (2006) 1.56
Predictive factors of type 2 diabetes mellitus remission following bariatric surgery: a meta-analysis. Obes Surg (2015) 1.55
Gene expression changes in children with autism. Genomics (2007) 1.55
Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene. Mol Pharmacol (2008) 1.55
Altered T cell responses in children with autism. Brain Behav Immun (2010) 1.53
Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex. J Cereb Blood Flow Metab (2009) 1.52
2-Chloro-N'-(4-nitro-benzyl-idene)benzo-hydrazide. Acta Crystallogr Sect E Struct Rep Online (2010) 1.52
Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proc Natl Acad Sci U S A (2004) 1.51
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation (2007) 1.51
CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol (2006) 1.51
The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry. J Gen Physiol (2009) 1.50
Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. Biophys J (2005) 1.49
Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4). Proc Natl Acad Sci U S A (2011) 1.48
Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle. J Biol Chem (2007) 1.48
Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol (2010) 1.46
Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia. Circ Arrhythm Electrophysiol (2011) 1.44
2-Chloro-N'-(5-hydr-oxy-2-nitro-benzyl-idene)benzohydrazide. Acta Crystallogr Sect E Struct Rep Online (2010) 1.44
The effects of atmosphere and calcined temperature on photocatalytic activity of TiO2 nanofibers prepared by electrospinning. Nanoscale Res Lett (2013) 1.43
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol (2012) 1.43
Type 3 ryanodine receptors of skeletal muscle are segregated in a parajunctional position. Proc Natl Acad Sci U S A (2002) 1.42
Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach. Mol Cell (2009) 1.42
Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol (2008) 1.41
Adaptability of myosin V studied by simultaneous detection of position and orientation. EMBO J (2006) 1.40
The relative position of RyR feet and DHPR tetrads in skeletal muscle. J Mol Biol (2004) 1.39
Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. Am J Pathol (2002) 1.38
Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling. J Biol Chem (2003) 1.38
PBDEs in 2-5 year-old children from California and associations with diet and indoor environment. Environ Sci Technol (2010) 1.38
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation (2011) 1.38
Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res (2008) 1.37