Le Xu

Author PubWeight™ 49.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks. Biophys J 2002 1.80
2 Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor). J Biol Chem 2003 1.80
3 Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants. J Biol Chem 2003 1.58
4 (De)constructing the ryanodine receptor: modeling ion permeation and selectivity of the calcium release channel. J Phys Chem B 2005 1.57
5 Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1. Am J Physiol Cell Physiol 2011 1.55
6 Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest 2007 1.53
7 p21-activated kinase 1 predicts recurrence and survival in patients with non-metastatic clear cell renal cell carcinoma. Int J Urol 2015 1.40
8 The evolution of Helicobacter pylori antibiotics resistance over 10 years in Beijing, China. Helicobacter 2010 1.26
9 Probing the role of negatively charged amino acid residues in ion permeation of skeletal muscle ryanodine receptor. Biophys J 2005 1.20
10 Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes. J Biol Chem 2006 1.20
11 Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel. J Biol Chem 2002 1.19
12 Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione. Biochemistry 2008 1.17
13 Characterization of recessive RYR1 mutations in core myopathies. Hum Mol Genet 2006 1.12
14 Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum. J Gen Physiol 2010 1.08
15 Structural determinants of skeletal muscle ryanodine receptor gating. J Biol Chem 2013 1.03
16 A role for the RNA-binding protein MOS2 in microRNA maturation in Arabidopsis. Cell Res 2013 1.02
17 High Jagged1 expression predicts poor outcome in clear cell renal cell carcinoma. Jpn J Clin Oncol 2010 1.02
18 Diketopyridylryanodine has three concentration-dependent effects on the cardiac calcium-release channel/ryanodine receptor. J Biol Chem 2003 0.99
19 Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3β/Snail signaling in renal cell carcinoma. Cancer Sci 2013 0.96
20 Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel. Biochemistry 2005 0.96
21 Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma. PLoS One 2013 0.95
22 A structural model of the pore-forming region of the skeletal muscle ryanodine receptor (RyR1). PLoS Comput Biol 2009 0.94
23 Different regions in skeletal and cardiac muscle ryanodine receptors are involved in transducing the functional effects of calmodulin. J Biol Chem 2004 0.93
24 Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing Snail protein. Cancer Sci 2012 0.92
25 Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells. Cancer Sci 2013 0.90
26 Sorafenib suppresses growth and survival of hepatoma cells by accelerating degradation of enhancer of zeste homolog 2. Cancer Sci 2013 0.88
27 Two central core disease (CCD) deletions in the C-terminal region of RYR1 alter muscle excitation-contraction (EC) coupling by distinct mechanisms. Hum Mutat 2007 0.87
28 Silencing genes of sarcoplasmic reticulum proteins clarifies their roles in excitation-contraction coupling. J Physiol 2009 0.86
29 Low Expression of Mucin-4 Predicts Poor Prognosis in Patients With Clear-Cell Renal Cell Carcinoma. Medicine (Baltimore) 2016 0.85
30 Clinical and functional effects of a deletion in a COOH-terminal lumenal loop of the skeletal muscle ryanodine receptor. Hum Mol Genet 2003 0.84
31 Tumor miR-125b predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection. Cancer Sci 2014 0.83
32 Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1. Am J Physiol Heart Circ Physiol 2013 0.81
33 A recessive ryanodine receptor 1 mutation in a CCD patient increases channel activity. Cell Calcium 2008 0.81
34 Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. PLoS One 2013 0.80
35 Analysis of energy utilization and body composition in kidney, bladder, and adrenal cancer patients. Urol Oncol 2010 0.80
36 Prognostic significance of p21-activated kinase 6 expression in patients with clear cell renal cell carcinoma. Ann Surg Oncol 2014 0.79
37 Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma. Tumour Biol 2015 0.79
38 ST6Gal-I predicts postoperative clinical outcome for patients with localized clear-cell renal cell carcinoma. Asian Pac J Cancer Prev 2014 0.79
39 Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma. Medicine (Baltimore) 2015 0.79
40 Singular diffraction-free surface plasmon beams generated by overlapping phase-shifted sources. Opt Lett 2013 0.79
41 One-pot synthesis of benzamide over a robust tandem catalyst based on center radially fibrous silica encapsulated TS-1. Chem Commun (Camb) 2013 0.78
42 Continuous modulations of femtosecond laser-induced periodic surface structures and scanned line-widths on silicon by polarization changes. Opt Express 2013 0.78
43 Treatment of non-alcoholic fatty liver disease by Qianggan Capsule. Chin J Integr Med 2010 0.78
44 [The clinical features and risk factors for 89 cases of ischemic colitis]. Zhonghua Nei Ke Za Zhi 2012 0.77
45 Prognostic value of purinergic P2X7 receptor expression in patients with hepatocellular carcinoma after curative resection. Tumour Biol 2015 0.77
46 [Efficacy of second-line treatment based on moxifloxacin triple therapy for Helicobacter pylori infection]. Zhonghua Yi Xue Za Zhi 2010 0.77
47 [Electroacupuncture Intervention Inhibits the Decline of Learning-memory Ability and Overex- pression of Cleaved Caspase-3 and Bax in Hippocampus Induced by Isoflurane in APPswe/PS 1]. Zhen Ci Yan Jiu 2016 0.76
48 Cardiac Valve Noise Reduction by Non-Drug Interventions Improves the Sleep Quality of Patients after Mechanical Cardiac Valve Implantation. Ann Thorac Cardiovasc Surg 2016 0.75
49 Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms. Biochem Biophys Res Commun 2010 0.75
50 Clinical symptoms and chemotherapy completion in elderly patients with newly diagnosed acute leukemia: a retrospective comparison study with a younger cohort. BMC Cancer 2011 0.75
51 Efficient cycloaddition of epoxides and carbon dioxide over novel organic-inorganic hybrid zeolite catalysts. Chem Commun (Camb) 2014 0.75
52 [Genotypic homogeneity and susceptibility to clarithromycin for clarithromycin-resistant Helicobacter pylori strains]. Zhonghua Yi Xue Za Zhi 2009 0.75
53 [Epidemiological investigation of hospitalized children with burn injuries in a hospital of Fuzhou]. Zhonghua Shao Shang Za Zhi 2016 0.75
54 [Identification and characterization of partner proteins interacting with fatty acid activation enzyme Slr1609 in Synechocystis sp. PCC 6803]. Sheng Wu Gong Cheng Xue Bao 2015 0.75
55 [Cpx two-component regulatory system in gram-negative bacteria--a review]. Wei Sheng Wu Xue Bao 2014 0.75
56 Modified single-port minilaparoscopic extraperitoneal repair for pediatric hydrocele: a single-center experience with 279 surgeries. World J Urol 2014 0.75
57 Effects of the chemical bonding on the optical and mechanical properties for germanium carbide films used as antireflection and protection coating of ZnS windows. J Phys Condens Matter 2006 0.75
58 [Investigation and analysis of factors influencing rehabilitation of burn patients]. Zhonghua Shao Shang Za Zhi 2009 0.75
59 [Effect of NaF on proliferation and mineralization of human periodontal ligament cells]. Shanghai Kou Qiang Yi Xue 2017 0.75
60 [Effects of vascular endothelial growth factor on apoptosis of sinusoidal endothelial cells caused by ethanol: experiment with rats]. Zhonghua Yi Xue Za Zhi 2007 0.75
61 [Combination therapy of azintamid and domperidone in functional dyspepsia: a randomised, double-blind, placebo-controlled trial]. Zhonghua Nei Ke Za Zhi 2011 0.75
62 [Efficacy and safety of compound azintamide on dyspepsia symptoms in a multicentre self-controlled trial]. Zhonghua Nei Ke Za Zhi 2008 0.75
63 [Detection of Helicobacter pylori by immunoblot: a multiple-center study]. Zhonghua Yi Xue Za Zhi 2016 0.75